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公开(公告)号:US20190077783A1
公开(公告)日:2019-03-14
申请号:US16181503
申请日:2018-11-06
申请人: SYMRISE AG
发明人: Oskar KOCH , Marcus Rudolf GÖTZ
IPC分类号: C07D311/80 , C07C37/50 , C07C69/94 , A61K31/235 , A61K31/352 , C07C39/23 , C07C67/03 , C07C67/343
摘要: Described are specific mixtures comprising one or more (cannabinoid) compounds of the formula (A) and/or one or more of their salts as well was methods for their production. Further described are a compound of the formula (A), a salt of the formula (A) and a corresponding mixture for use as a medicament or, respectively, for use in a method for therapeutic treatment of the human or animal body.Described are also corresponding pharmaceutical formulations, cosmetic preparations and preparations for pleasure and/or nutrition, suitable for consumption, as well as methods for producing CBDV and THCV.
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公开(公告)号:US20190060225A1
公开(公告)日:2019-02-28
申请号:US15904356
申请日:2018-02-24
IPC分类号: A61K9/00 , A61K36/185 , A61K47/44 , A61K47/06 , A61K31/352 , A61K47/46 , A61K47/38 , A61K31/235 , A23L33/105
摘要: The present invention relates to oral administration of water soluble cannabinoid and terpenoid concentrates on a flavored fibrous carrier. The compositions described herein provide an alternative to smoked cannabis that also avoid the slow action and unpredictable dosing of edible cannabis preparations. Water soluble concentrates of cannabinoids and terpenoids may be produced by derivatization reactions which are known in the art. Such water soluble concentrates enjoy significantly increased absorption by mucosal membranes of the mouth and may therefore be experienced by the consumer more quickly. Water soluble cannabinoid and terpenoid concentrates may be used in combination with each other and in combination with non-derivatized molecules which provides the user with fast and slow acting components in a single delivery vehicle.
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公开(公告)号:US10183004B2
公开(公告)日:2019-01-22
申请号:US15944428
申请日:2018-04-03
IPC分类号: A61K31/216 , A61K9/00 , G01N33/49 , A61K31/235 , G01N33/84 , G01N31/22
摘要: The present disclosure provides methods for evaluating daily ammonia exposure based on a single fasting ammonia blood level measurement, as well as methods that utilize this technique to adjust the dosage of a nitrogen scavenging drug, determine whether to administer a nitrogen scavenging drug, and treat nitrogen retention disorders.
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公开(公告)号:US10159687B2
公开(公告)日:2018-12-25
申请号:US15369060
申请日:2016-12-05
申请人: KAPPA BIOSCIENCE AS
IPC分类号: A61K31/661 , A61K31/222 , A61K31/235 , C07C69/78 , C07C69/76 , C07C69/34 , C07C69/017 , C07F9/09 , C07C69/16 , C07C69/28 , C07C69/40 , C07F9/12 , C07C271/22 , A61K31/325
摘要: The disclosure relates to prodrugs of vitamin K2, in particular prodrugs of MK-7 in which the diketone is converted to a monosubstituted or disubstituted ester type derivative. These compounds are shown to give MK-7 in plasma. The disclosure also relates to methods of treating conditions using prodrugs of vitamin K2.
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公开(公告)号:US20180303756A1
公开(公告)日:2018-10-25
申请号:US16019845
申请日:2018-06-27
发明人: Eric Saly , Maureen Mackay , Matthias Rischer , Wolfgang Mohr , Lena Kurz
IPC分类号: A61K9/16 , A61K38/05 , A61K31/64 , A61K31/235 , A61K31/192 , A61K9/14
CPC分类号: A61K9/1617 , A61K9/145 , A61K9/146 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K31/192 , A61K31/235 , A61K31/64 , A61K38/05
摘要: A particulate solid composition comprises a blend of dialkyl sulfosuccinate and a water-soluble polymer. The water-soluble polymer can be a cellulose ether, a polysaccharide, a polyvinyl alcohol homopolymer or copolymer, a polyvinyl pyrrolidone homopolymer or copolymer, a polyvinyl caprolactam polymer or copolymer, a poly(meth)acrylate, a poly(alkylene oxide) graft copolymer, or a combination thereof. The particulate solid composition is free flowing, water-soluble, and dissolves rapidly in water. It can be made by drying a solution of dialkyl sulfosuccinate and a water-soluble polymer. The particulate solid composition can be mixed with organic substances having low water solubility, for example a generic, a biologic, a biosimilar, an excipient, a nutraceutical, a medical diagnostic agent, an agricultural chemical, or a combination thereof, to form water-soluble compositions.
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公开(公告)号:US20180271850A1
公开(公告)日:2018-09-27
申请号:US15853103
申请日:2017-12-22
发明人: Patrick Henry Maxwell , Christopher William Pugh , Peter John Ratcliffe , Christopher Joseph Schofield
IPC分类号: A61K31/455 , A61K31/44 , A61K31/137 , A61K31/14 , A61K31/165 , A61K31/166 , A61K31/185 , A61K31/192 , G01N33/573 , C12Q1/34 , C12Q1/26 , C12N9/02 , C07K16/40 , C07K14/47 , C07D213/82 , C07D213/81 , C07D213/80 , C07C327/32 , C07C323/60 , C07C235/80 , A61K31/4412 , A61K31/327 , A61K31/265 , A61K31/24 , A61K31/235 , A61K31/225 , A61K31/223 , A61K31/221 , A61K31/21 , A61K31/198 , A61K31/197 , A61K31/195 , A61K31/194 , A61K39/395 , A61K38/00
CPC分类号: A61K31/455 , A01K2217/05 , A61K31/137 , A61K31/14 , A61K31/165 , A61K31/166 , A61K31/185 , A61K31/192 , A61K31/194 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/21 , A61K31/221 , A61K31/223 , A61K31/225 , A61K31/235 , A61K31/24 , A61K31/265 , A61K31/327 , A61K31/44 , A61K31/4412 , A61K38/00 , A61K39/3955 , C07C235/80 , C07C323/60 , C07C327/32 , C07D213/80 , C07D213/81 , C07D213/82 , C07K14/4702 , C07K16/40 , C07K2317/30 , C12N9/0071 , C12Q1/26 , C12Q1/34 , G01N33/573 , G01N2333/90245 , G01N2500/04 , G01N2500/20
摘要: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
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公开(公告)号:US20180250278A1
公开(公告)日:2018-09-06
申请号:US15972500
申请日:2018-05-07
发明人: Fei LIU , Cuixia ZHANG , Chenggang LIN , Chunyan ZHOU , Pan CHEN , Wei WANG , Lulu WANG
IPC分类号: A61K31/445 , A61K31/235 , A61K47/44 , C07D211/22 , A61K31/045
CPC分类号: A61K31/445 , A61K9/0019 , A61K9/08 , A61K9/19 , A61K31/045 , A61K31/235 , A61K47/183 , A61K47/26 , A61K47/44 , C07D211/22 , A61K2300/00
摘要: The present invention relates to a donepezil derivative of general formula (I) or a pharmaceutically acceptable salt thereof, wherein R in the formula is as disclosed herein; and a method for preparation thereof; and a composition comprising an effective amount of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to use of a compound of the general formula (I) or a pharmaceutically acceptable salt thereof in preparing a medicament for treating a disease resulted from an abnormality in acetylcholinesterase activity.
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68.
公开(公告)号:US10034879B2
公开(公告)日:2018-07-31
申请号:US15852406
申请日:2017-12-22
发明人: Brian Metcalf , Chihyuan Chuang
IPC分类号: C07D401/00 , A61K31/4985 , C07D215/14 , C07D471/04 , C07D487/04 , C07D213/80 , C07D231/56 , C07D401/04 , C07D257/04 , C07D211/62 , C07D213/30 , C07C69/76 , C07C65/30 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47
CPC分类号: A61K31/4985 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/416 , A61K31/437 , A61K31/4406 , A61K31/4439 , A61K31/445 , A61K31/47 , C07C65/30 , C07C69/76 , C07D211/62 , C07D213/30 , C07D213/80 , C07D215/14 , C07D231/56 , C07D257/04 , C07D401/04 , C07D471/04 , C07D487/04
摘要: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.
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公开(公告)号:US20180207113A1
公开(公告)日:2018-07-26
申请号:US15416207
申请日:2017-01-26
申请人: Vincent C Giampapa
发明人: Vincent C Giampapa
IPC分类号: A61K31/155 , A61K31/235 , A61K36/74 , A61K36/906 , A61K31/12 , A61K9/00 , A61K47/06 , A23L33/10
CPC分类号: A61K31/155 , A23L33/10 , A61K31/12 , A61K31/235 , A61K36/74
摘要: An in vivo intracellular reprogramming method for both somatic and stem cell pools in the mammal's body using, C60 fullerenes can be added to enhance mitochondrial ATP production and Biogenesis, Metformin, Everolimus, Seligilene, Danasitab, Venetoclaxalong with Quercitin may act as agent to enhance autophagy and apoptosis helping to decrease their ongoing formation and a novel resveratrol complex along ribonucleasies worth together to help decrease heterchromation dysregulation aid in DNA repair enhancement and nutraceuticals is disclosed. The present in vivo reprogramming invention works at the epigenetic level and promotor region of the genome inside the nucleus of the cell, and other intracellular organelles, rather than outside the body. The key genetic activity changes that the invention reverses have now been found responsible for causing aging in adult stem cells and somatic cells, the combination of the above compounds have been shown to cause improved and corrected epigenetic changes or reprogramming in vivo in gene expression to induce the necessary genetic changes to improve cellular aging and epigenetic IC changes responsible for the changes and therefore effect total body and cellular health from the organ and tissue level on upward. The key to and extended to a long and healthy life is keeping your somatic cells health and maintaining a pool of stem cells can be called on for acute situations like healing form surgery or trauma or an immune boast to frequent infection.
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70.
公开(公告)号:US20180200235A1
公开(公告)日:2018-07-19
申请号:US15875750
申请日:2018-01-19
发明人: Po-Yuan Tseng , Wei-Shu Lu , Carl Oscar Brown, III , I-Yin Lin, III , Chen-En Tsai , Chih-Kuang Chen
IPC分类号: A61K31/4375 , A61P17/00 , A61K31/235
摘要: A method for preventing or treating immunoinflammatory dermal disorders is provided. Also provided is a pharmaceutical composition for preventing or treating immunoinflammatory dermal disorders
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