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2205 条记录 (耗时 0.062 秒)

    2-Naphthylimino-1,3-thiazine derivative
    63.
    发明授权
    2-Naphthylimino-1,3-thiazine derivative 失效
    2-萘基亚氨基-1,3-噻嗪衍生物

    公开(公告)号：US07482339B2

    公开(公告)日：2009-01-27

    申请号：US10568963

    申请日：2004-08-24

    申请人： Hiroyuki Kai ,  Yasuhide Morioka ,  Katsumi Koike

    发明人： Hiroyuki Kai ,  Yasuhide Morioka ,  Katsumi Koike

    IPC分类号： C07D417/02 ,  A61K31/541

    CPC分类号： C07D417/12 ,  A61K31/54 ,  C07D279/06

    摘要： The formula (I): wherein each of R2 and R3 is, same or different, C2-C4 alkyl or the like; or R2 and R3 are taken together with the adjacent carbon atom to form a 5 to 8 membered non-aromatic carbocyclic ring; R4 is C1-C6 alkyl or the like; X is an oxygen atom or a sulfur atom; A is the group of the formula: wherein R1 is, same or different, alkyl or the like; W is C2-C6 alkylene which may contain an optionally substituted heteroatom(s) or the like; n is an integer of 0 to 7, a pharmaceutically acceptable salt, or a solvate thereof.

    摘要翻译： 式（I）：其中R2和R3各自相同或不同，为C2-C4烷基等; 或者R 2和R 3与相邻的碳原子一起形成5至8元的非芳族碳环; R4是C1-C6烷基等; X是氧原子或硫原子; A是下式的基团：其中R1是相同或不同的烷基等; W是可以含有任选取代的杂原子等的C 2 -C 6亚烷基; n为0〜7的整数，其药学上可接受的盐或其溶剂合物。

    Chemical Compounds-149
    65.
    发明申请
    Chemical Compounds-149 审中-公开
    化学成分-149

    公开(公告)号：US20080312206A1

    公开(公告)日：2008-12-18

    申请号：US12097652

    申请日：2006-12-19

    申请人： Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

    发明人： Brian Aquila ,  Donald Cook ,  Leslie Dakin ,  Stephanos Ioannidis ,  Paul Lyne ,  David Scott ,  Xiaolan Zheng

    IPC分类号： A61K31/427 ,  C07D277/46 ,  A61K31/426 ,  A61P35/00 ,  C07D417/02

    CPC分类号： C07D277/46 ,  C07D417/12

    摘要： The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

    摘要翻译： 本发明涉及具有CSF 1R激酶抑制活性的化学化合物或其药学上可接受的盐，其具有CSF 1R激酶抑制活性，因此可用于其抗癌活性，因此可用于治疗人或动物体的方法。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在制备用于在温血动物如人中产生抗癌作用的药物中的用途。

    Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes
    68.
    发明申请
    Cyanoborate, Fluoroalkylphosphate, Fluoroalkylborate or Imide Dyes 有权
    氰基硼酸盐，氟代烷基磷酸盐，氟烷基硼酸盐或酰亚胺染料

    公开(公告)号：US20080275224A1

    公开(公告)日：2008-11-06

    申请号：US10568526

    申请日：2004-07-22

    申请人： Nikolai (Mykola) Ignatyev ,  Urs Weiz-Biermann ,  Helge Willner ,  Maik Finze ,  Eduard Bernhardt ,  Andriy Kucheryna

    发明人： Nikolai (Mykola) Ignatyev ,  Urs Weiz-Biermann ,  Helge Willner ,  Maik Finze ,  Eduard Bernhardt ,  Andriy Kucheryna

    IPC分类号： C09B69/06 ,  C09B23/06 ,  C07D413/02 ,  C07D209/08 ,  C07D417/02 ,  C07D277/62 ,  C07D263/54

    CPC分类号： C07D241/46 ,  C07D263/54 ,  C07D277/62 ,  C09B23/06 ,  C09B67/0083 ,  C09B69/06

    摘要： The present invention relates to dyes of the general formula CAT+ Y− (I), where Y− is an anion selected from the group of the cyanoborates, fluoroalkylphosphates, fluoroalkylborates or imidates and CAT+ is a cation selected from the group of the azine, xanthene, polymethine, styryl, azo, tetrazolium, pyrylium, benzopyrylium, thiopyrylium, benzothiopyrylium, thiazine, oxazine, triarylmethane, diarylmethane, methine, acridine, quinoline, isoquinoline or quaternary azafluorenone dyes, for colouring plastics and plastic fibres, for the preparation of flexographic printing inks, as ball-point pen pastes, as stamp ink, for colouring leather and paper, for use in data acquisition systems, reprography, in ink microfilters, in photogalvanics, laser technology and the photo industry.

    摘要翻译： 本发明涉及通式为：其中Y为阴离子的染料，其中Y为 - 阴离子，其中Y为 - 氰基硼酸盐，氟代烷基磷酸盐，氟代烷基硼酸盐或亚胺酸盐，CAT +是选自吖嗪，呫吨，聚甲炔，苯乙烯基，偶氮，四唑，吡喃鎓，苯并吡喃鎓，硫代吡喃鎓，苯并硫代吡喃鎓，噻嗪，恶嗪 ，三芳基甲烷，二芳基甲烷，次甲基，吖啶，喹啉，异喹啉或季氮芴酮染料，用于着色塑料和塑料纤维，用于制备柔性版印刷油墨，作为圆珠笔浆料，作为印刷油墨，用于着色皮革和纸张，用于 用于数据采集系统，复印，墨水微滤器，光电子学，激光技术和照相行业。