公开(公告)号：US08784441B2

公开(公告)日：2014-07-22

申请号：US12709408

申请日：2010-02-19

申请人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti ,  Teresa L. Halverson ,  Maricela D. Walker ,  Robert Pecor

发明人： Robert F. Rosenbluth ,  George R. Green, Jr. ,  Brian J. Cox ,  Thomas R. Sternweiler ,  Sean L. Chow ,  Richard R. Monetti ,  Teresa L. Halverson ,  Maricela D. Walker ,  Robert Pecor

IPC分类号： A61B17/22

CPC分类号： A61B17/22032 ,  A61B17/135 ,  A61B17/221 ,  A61B2017/22034 ,  A61B2017/22044 ,  A61B2017/22077 ,  A61B2017/22084 ,  A61B2017/22094 ,  A61B2017/2212 ,  A61B2017/320716 ,  A61F2/013 ,  A61F2002/016 ,  A61F2002/018 ,  A61F2230/008 ,  A61F2230/0091 ,  A61M2025/0042 ,  A61M2025/0183

摘要： Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive matter (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percutaneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicaments or visualization fluids distal to the clot.

摘要翻译： 用于从血管中去除凝块或其他阻塞物（例如，血栓，血栓栓塞，动脉粥样硬化斑块的栓塞碎片，异物等）的系统和方法，快速交换微导管。 本发明特别可用于在脑卒中或脑缺血期间经皮去除血栓栓塞或其他来自脑小血管的阻塞物质。 在一些实施例中，本发明的止血栓塞导管可以在已经插入穿过凝块或围绕凝块的导丝上或之上前进。 此外，在一些实施例中，止血管切除导管包括在导管至少部分地穿过血块前进之后可从导管展开的凝块移除装置。 凝块移除装置可以包括被设计成防止血块从其中通过的可展开的线巢。 输送导管可以包括伸缩的内管和外管，其中血块去除装置由外管径向约束。 外管的收缩消除了对凝块去除装置的约束，并允许其扩展到其部署构型。 输注导丝特别适用于结肠切除术导管，并且可以输送远离凝块的药物或可视化液体。

公开(公告)号：US20130243936A1

公开(公告)日：2013-09-19

申请号：US13781385

申请日：2013-02-28

申请人： MICROVENTION, INC.

发明人： Joshua Garretson ,  John Belletto ,  Gregory M. Cruise

IPC分类号： B05D5/00 ,  C09D171/08

CPC分类号： B05D5/00 ,  A61L29/085 ,  A61L31/10 ,  A61L2420/02 ,  B05D3/142 ,  B05D2503/00 ,  C08G18/4833 ,  C08G18/7831 ,  C09D171/08 ,  C09D175/08

摘要： Described herein are methods of coating both metallic and polymeric surfaces adding hydrophilicity comprising the steps mixing a coating composition comprising at least one polyol, at least one compound having at least two isocyanate groups, and an organic solvent; introducing nucleophilic functional groups on the surface thereby creating an active surface; subjecting the active surface to the coating composition thereby forming a coated surface; and curing the coated surface. Medical devices, for example, implantable medical devices can be coated by the methods described herein.

摘要翻译： 本文描述了涂覆亲水性的金属和聚合物表面的方法，包括将包含至少一种多元醇，至少一种具有至少两个异氰酸酯基团的化合物和有机溶剂的涂料组合物混合的步骤; 在表面上引入亲核官能团从而产生活性表面; 使活性表面经受涂层组合物从而形成涂覆表面; 并固化涂层表面。 可以通过本文所述的方法来涂覆医疗装置，例如可植入医疗装置。

公开(公告)号：US08323306B2

公开(公告)日：2012-12-04

申请号：US11398081

申请日：2006-04-05

申请人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

发明人： Dean Schaefer ,  Brian J. Cox ,  George R. Greene, Jr. ,  David A. Ferrera ,  Matthew Fitz ,  Robert F. Rosenbluth

IPC分类号： A61M29/00 ,  A61F2/06

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00867

摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. Confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow.

摘要翻译： 血管闭塞装置包括形成为最小能量状态次级构造的微线圈，其包括多个弯曲段，每个弯曲段限定离散轴线，由此该装置在其最小能量状态构造中限定多个轴线。 动脉瘤内装置的限制使其呈现具有比最小能量状态更高的能量状态的三维构型。 由于装置的最小能量状态构造比动脉瘤更大（至少一个维度），因此部署的装置受到与动脉瘤壁的接触的约束，从而返回到其最小能量状态。 该装置与动脉瘤壁的接合最小化由于血流引起的移动或翻滚。

公开(公告)号：US20120245521A1

公开(公告)日：2012-09-27

申请号：US13405113

申请日：2012-02-24

申请人： Joseph Gulachenski ,  Cathy Lei ,  Nelson Peralta ,  Tadele Haile

发明人： Joseph Gulachenski ,  Cathy Lei ,  Nelson Peralta ,  Tadele Haile

IPC分类号： A61M25/10

CPC分类号： A61M25/1036 ,  A61M25/0012 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0053 ,  A61M25/10 ,  A61M25/1006 ,  A61M25/1034 ,  A61M2025/1061 ,  A61M2025/1077 ,  A61M2025/1079 ,  A61M2025/1093 ,  Y10T29/49826

摘要： One embodiment of the present invention discloses a balloon catheter employing a reinforced, co-axial, duel lumen design. In certain embodiments, at least one of the lumens is formed of a multilayer, tubular element in which one of the layers functions, in part, to provide radial reinforcement to the tubular element.

摘要翻译： 本发明的一个实施例公开了一种使用加强的，同轴的对决管腔设计的球囊导管。 在某些实施例中，至少一个管腔由多层管状元件形成，其中一个层部分地起到向管状元件提供径向增强作用。

公开(公告)号：US08252040B2

公开(公告)日：2012-08-28

申请号：US10763975

申请日：2004-01-22

申请人： Brian J. Cox

发明人： Brian J. Cox

IPC分类号： A61F2/82

CPC分类号： A61B17/12113 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/12172 ,  A61B17/12186 ,  A61B17/1219 ,  A61B2017/00526 ,  A61B2017/00867 ,  A61B2017/00898 ,  A61B2017/1205 ,  A61F2/856 ,  A61F2/88 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/065 ,  A61F2002/823 ,  A61F2230/0054 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/418 ,  B65H54/00

摘要： The present application discloses an apparatus for treating vascular aneurysms and includes a radially expandable substantially cylindrical structure formed from a plurality of support members and defining a plurality of openings, and at least one reactive material strand selectively integrated into the substantially cylindrical structure. The reactive material is configured to assume a non-reacted state and a reacted state. The reactive material in the reacted state is configured to restrict a flow of blood to an aneurysm.

摘要翻译： 本申请公开了一种用于治疗血管动脉瘤的装置，并且包括由多个支撑构件形成并限定多个开口的径向可扩张的基本上圆柱形的结构，以及选择性地集成到大致圆柱形结构中的至少一个反应性材料束。 反应性材料被配置为呈现未反应状态和反应状态。 处于反应状态的反应性物质被构造成限制血液流动到动脉瘤。

公开(公告)号：US07572288B2

公开(公告)日：2009-08-11

申请号：US09909715

申请日：2001-07-20

申请人： Brian J. Cox

发明人： Brian J. Cox

IPC分类号： A61F2/06

CPC分类号： A61F2/82 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/12172 ,  A61B17/12177 ,  A61B17/1219 ,  A61B2017/00893 ,  A61B2017/00898 ,  A61B2017/1205 ,  A61F2/88 ,  A61F2/90 ,  A61F2002/823 ,  A61F2220/0016 ,  A61F2230/0013 ,  A61F2250/0069

摘要： The present invention is directed to aneurysm treatment devices which are capable of being delivered to the situs of a vascular aneurysm through a catheter. The treatment devices comprise, in general, an expandable stent having fenestrations and a reactive material selectively applied to not all of the fenestrations. The reactive material has a non-reacted state and a reacted state and the reactive material in the reacted state is capable of increasing the resistance to blood flow through said fenestrations.

摘要翻译： 本发明涉及能够通过导管输送到血管动脉瘤部位的动脉瘤治疗装置。 治疗装置通常包括具有开窗的可扩张支架和选择性地应用于不是所有的开窗的反应材料。 反应性材料具有未反应状态和反应状态，并且反应状态下的反应性材料能够增加通过所述开窗的血流阻力。

公开(公告)号：US07494687B2

公开(公告)日：2009-02-24

申请号：US10897262

申请日：2004-07-21

申请人： Brian J. Cox

发明人： Brian J. Cox

IPC分类号： B05D3/00 ,  B05D3/12 ,  A61M25/02

CPC分类号： A61L29/085 ,  A61M25/0045 ,  A61M25/09 ,  A61M2025/0046 ,  A61M2025/09091 ,  A61M2025/09108

摘要： Medical devices for insertion into the body of human or veterinary patients, wherein the device comprises a) a working element (e.g. a wire, a guidewire, a tube, a catheter, a cannula, a scope (e.g., rigid or flexible endoscope, laparoscope, sigmoidoscope, cystoscope, etc.) a probe, an apparatus for collecting information from a location within the body (e.g., an electrode, sensor, camera, scope, sample withdrawal apparatus, biopsy or tissue sampling device, etc.) which has an outer surface and b) a continuous or non-continuous coating on the outer surface of the working element. The outer surface of the working element is prepared to create a surface topography which promotes mechanical or frictional engagement of the coating to the working element. In some embodiments the coating is a lubricious coating, such as a fluorocarbon coating or a hydrogel that becomes lubricious when contacted by a liquid. In some embodiments, the coating may expand as swell. Also disclosed as methods for manufacturing such devices.

摘要翻译： 用于插入人或兽医患者身体的医疗装置，其中所述装置包括：a）工作元件（例如线，导丝，管，导管，插管，范围（例如，刚性或柔性内窥镜，腹腔镜 ，乙状结肠镜，膀胱镜等）探针，用于从身体内的位置（例如，电极，传感器，照相机，范围，取样装置，活检或组织取样装置等）收集信息的装置，其具有 外表面和b）在工作元件的外表面上的连续或非连续涂层。 准备工作元件的外表面以产生表面形貌，其促进涂层与工作元件的机械或摩擦接合。 在一些实施方案中，涂层是润滑涂层，例如碳氟涂层或当被液体接触时变得光滑的水凝胶。 在一些实施方案中，涂层可以膨胀膨胀。 还公开了用于制造这种装置的方法。

公开(公告)号：US07201762B2

公开(公告)日：2007-04-10

申请号：US10320033

申请日：2002-12-16

申请人： George R. Greene, Jr. ,  Robert F. Rosenbluth ,  Brian J. Cox

发明人： George R. Greene, Jr. ,  Robert F. Rosenbluth ,  Brian J. Cox

IPC分类号： A61B19/00 ,  A61F2/06

CPC分类号： A61L31/146 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/12186 ,  A61B17/1219 ,  A61B34/10 ,  A61B2017/00526 ,  A61B2017/1205 ,  A61F2/06 ,  A61L31/145 ,  A61L31/18 ,  A61L2430/36 ,  B33Y50/00 ,  B33Y80/00 ,  Y10S623/901 ,  Y10S623/903 ,  Y10T29/49

摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

摘要翻译： 由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。 优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。 通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。 为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。 在进入血管部位时，植入物基本上扩张以填充血管部位。 保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。 使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。

公开(公告)号：US20060184196A1

公开(公告)日：2006-08-17

申请号：US11398082

申请日：2006-04-05

申请人： Dean Schaefer ,  Brian Cox ,  George Greene ,  David Ferrera ,  Matthew Fitz ,  Robert Rosenbluth

发明人： Dean Schaefer ,  Brian Cox ,  George Greene ,  David Ferrera ,  Matthew Fitz ,  Robert Rosenbluth

IPC分类号： A61M29/00

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00526 ,  A61B2017/00867

摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration-comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

公开(公告)号：US20040193246A1

公开(公告)日：2004-09-30

申请号：US10400138

申请日：2003-03-25

申请人： MicroVention, Inc.

发明人： David A. Ferrera

IPC分类号： A61F002/06

CPC分类号： A61F2/856 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/1214 ,  A61B2017/00867 ,  A61B2017/1205 ,  A61F2/885 ,  A61F2/90 ,  A61F2/954 ,  A61F2/962 ,  A61F2002/825 ,  A61F2002/9517

摘要： Devices and methods are disclosed for placing a barrier across the neck of a vascular aneurysm, and specifically across the neck of a cerebrovascular aneurysm. The barrier is a stent or neck bridge that completely or partially blocks the flow of blood into the aneurysm and, further, prevents the migration of embolic coils out of the aneurysm and into the parent vessel. The neck bridge or stent of the present invention comprises elements for superior flexibility and stability when placed within the parent vessel. The neck bridge or stent of the present invention is loaded into the catheter by either being rolled tightly and sheathed or stretched to permit loading into the delivery catheter in a small, highly flexible configuration that may be advanced through the cerebrovasculature to pathological aneurysms.

摘要翻译： 公开了用于在血管动脉瘤的颈部放置屏障的装置和方法，特别是在脑血管动脉瘤的颈部。 屏障是支架或颈桥，其完全或部分阻断血液流入动脉瘤，并进一步阻止栓塞线圈从动脉瘤迁移到母体血管。 本发明的颈桥或支架包括当放置在母体容器内时具有优异的柔性和稳定性的元件。 将本发明的颈桥或支架通过被压紧或套管或拉伸加载到导管中，以允许以小的，高度灵活的构造装载到输送导管中，该结构可通过脑血管系统进展到病理性动脉瘤。