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71.发明申请公开(公告)号：US20110123603A1
公开(公告)日：2011-05-26
申请号：US13014240
申请日：2011-01-26
IPC分类号： A61K9/127 , A61K39/395 , A61K9/00 , A61P35/00
CPC分类号： A61K39/3955 , C07K16/24 , C07K16/2866 , C07K2317/73
摘要： The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
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72.发明申请公开(公告)号：US20110081407A1
公开(公告)日：2011-04-07
申请号：US12967816
申请日：2010-12-14
IPC分类号： A61K9/127 , A61K39/395 , A61K9/14 , A61P35/00
CPC分类号： A61K39/3955 , C07K16/24 , C07K16/2866 , C07K2317/73
摘要： The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
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73.发明授权Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms 有权用于抑制肿瘤生长的抗趋化因子和相关受体抗体公开(公告)号：US07919083B2
公开(公告)日：2011-04-05
申请号：US10712398
申请日：2003-11-14
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , C07K16/24 , C07K16/2866 , C07K2317/73
摘要： The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
摘要翻译： 本发明提供了通过施用抗趋化因子抗体来抑制癌细胞的生长和转移的方法。 可以使用本发明的方法鉴定在肿瘤中过表达的特定趋化因子，并且针对该过度表达的趋化因子施用抗体。
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公开(公告)号：US20110052709A1
公开(公告)日：2011-03-03
申请号：US12943566
申请日：2010-11-10
申请人： James W. Lillard , Rajesh Singh , Shailesh Singh
发明人： James W. Lillard , Rajesh Singh , Shailesh Singh
IPC分类号： A61K9/51 , A61K31/337 , A61K33/24 , A61K9/00 , A61K38/00 , A61K31/519 , A61P35/00 , B82Y5/00
CPC分类号： A61K31/337 , A61K9/146 , A61K9/1641 , A61K9/1652 , A61K9/5031 , A61K9/5146 , A61K9/5161 , A61K33/24 , A61K38/00 , A61K47/593 , A61K47/62 , A61K47/6939
摘要： Milled nanoparticles comprising a biologically active agent, at least one biopolymer and a coating containing at least one coating which is a polymer or ligand are produced using milling and coating techniques which have not previously been used for these applications.
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75.发明申请NEUREGULINS FOR PREVENTION AND TREATMENT OF DAMAGE FROM ACUTE ASSAULT ON VASCULAR AND NEURONAL TISSUE AND AS REGULATORS OF NEURONAL STEM CELL MIGRATION 有权用于预防和治疗急性脑血管病和神经组织损伤和神经干细胞迁移调节因子的神经病公开(公告)号：US20090156500A1
公开(公告)日：2009-06-18
申请号：US12359773
申请日：2009-01-26
申请人： Byron D. FORD
发明人： Byron D. FORD
CPC分类号： A61K38/17 , Y10S977/915
摘要： Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.
摘要翻译： 已发现神经调节蛋白是一种已知的神经蛋白，用于改善或预防由机械或化学物质侵袭血管引起的损伤，并且当施用于脑脊髓液时，可以改善由中风或炎症引起的神经元组织的损伤。 另外，已经发现神经调节蛋白可用于增强从脑室到脑损伤部位的干细胞迁移。
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公开(公告)号：US20090149386A1
公开(公告)日：2009-06-11
申请号：US12359905
申请日：2009-01-26
申请人： Byron D. Ford
发明人： Byron D. Ford
IPC分类号： A61K38/17
CPC分类号： A61K38/17 , Y10S977/915
摘要： Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.
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公开(公告)号：US07312305B2
公开(公告)日：2007-12-25
申请号：US10392324
申请日：2003-03-20
IPC分类号： C07K4/02
CPC分类号： A61K38/162
摘要： The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
摘要翻译： 本发明提供了通过施用Gp120蛋白或Nef蛋白或本发明的蛋白质（调节剂）的CXCR4特异性序列，例如在菌株HIV-1，HIV-2，SIV中发现的选择性杀死上皮细胞癌的方法， 或FIV CXCR4特异性Gp120序列或Nef蛋白或序列可以递送至粘膜或全身。 粘膜使用方法包括液体或颗粒形式的口服，鼻内，眼部，阴道内，直肠和/或尿道内给药。
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78.发明授权Immunogenic compositions comprising porphyromonas gingivalis proteins and/or peptides and methods 失效包含牙龈卟啉单胞菌蛋白质和/或肽和方法的免疫原性组合物
公开(公告)号：US6129917A
公开(公告)日：2000-10-10
申请号：US822324
申请日：1997-03-21
IPC分类号： C12N15/09 , A61K31/00 , A61K39/00 , A61K39/02 , A61P1/00 , A61P1/02 , A61P31/00 , A61P31/04 , C07K14/00 , C12N9/52 , A61K38/00 , A61K39/38 , C07K17/00
摘要： Provided herein are methods and immunogenic compositions useful for protecting mammals from infection and pathology of P. gingivalis. Specifically, arginine-specific proteases of Porphyromonas gingivalis and peptides derived therefrom offer protection against infection. Immunogenic compositions comprising a 50 kDa arginine-specific protease, the high molecular weight complex or peptides from one of the foregoing proteins are capable of protecting against P. gingivalis infection and/or gingivitis and/or periodontitis caused thereby in mammals, including humans.
摘要翻译： 本文提供了可用于保护哺乳动物免受牙龈卟啉菌感染和病理学的方法和免疫原性组合物。 具体来说，牙龈卟啉单胞菌的精氨酸特异性蛋白酶及其衍生的肽提供了针对感染的保护。 包含50kDa精氨酸特异性蛋白酶，来自上述蛋白质之一的高分子量复合物或肽的免疫原性组合物能够防止包括人在内的哺乳动物引起的牙龈卟啉菌感染和/或牙龈炎和/或牙周炎。
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公开(公告)号：US12116549B2
公开(公告)日：2024-10-15
申请号：US17452996
申请日：2021-10-31
CPC分类号： C11D11/0088 , A01N25/26 , C11D3/43 , C11D3/48 , C11D17/0013 , C11D17/0039 , A01N25/02 , A01N25/26 , A01N25/04
摘要： A method for formulating a composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the liquid loading composition. Liquid-loading compositions that can absorb liquids in many applications, including clean-up and farming, are also disclosed.
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80.发明公开公开(公告)号：US20240319208A1
公开(公告)日：2024-09-26
申请号：US18536722
申请日：2023-12-12
IPC分类号： G01N33/68 , A61K9/00 , A61K31/40 , A61K31/4025 , A61K31/422 , A61K31/505 , A61K31/506 , A61K38/12 , A61K45/06 , C12Q1/6883 , G01N33/569 , G01N33/74 , G01N33/78
CPC分类号： G01N33/6893 , A61K9/0019 , A61K31/40 , A61K31/4025 , A61K31/422 , A61K31/505 , A61K31/506 , A61K38/12 , A61K45/06 , C12Q1/6883 , G01N33/56988 , G01N33/74 , G01N33/78 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N2333/5754 , G01N2800/28 , G01N2800/347 , G01N2800/52
摘要： The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.
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