公开(公告)号：US20210102191A1

公开(公告)日：2021-04-08

申请号：US17064845

申请日：2020-10-07

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Marcella Chiari

IPC: C12N15/10 ,  C12N9/22 ,  G01N33/50 ,  G01N33/537 ,  G01N33/543

Abstract: The present invention relates to a method for the isolation of intact extracellular vesicles from biological tissues and fluids. Under a further aspect, the present invention relates intact extracellular vesicles, obtainable from the method herein described, and their use as a diagnostic and therapeutic tool.

公开(公告)号：US20210053016A1

公开(公告)日：2021-02-25

申请号：US16979030

申请日：2019-03-08

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  UNIVERSITÁ DI PISA ,  UNIVERSITÁ DELLA CALABRIA

Inventor： Alberto FIGOLI ,  Francesco GALIANO ,  Giuseppe BARBIERI ,  Adele BRUNETTI ,  Lidietta GIORNO ,  Christian Silvio POMPELLI ,  Cinzia CHIAPPE ,  Gabriele BARTOLO ,  Raffaella MANCUSO ,  Yujiro ITAMI

IPC: B01D71/40 ,  B01D67/00 ,  B01D69/12 ,  B01D71/82

Abstract: The invention relates to dense synthetic membranes made from polymerised phosphonium-based ionic liquids which were found to be particularly suitable for use in gas separation. The membranes are obtainable by copolymerization via UV-curing of a composition comprising a phosphonium-based ionic liquid monomer, a co-monomer, a cross-linker, a surfactant and a photo-initiator, the remainder of the polymerization mixture consisting of water.
The invention also relates to a process of manufacturing said membranes, resulting in solid, dense and mechanically stable membranes, and to the use of the membranes so produced in the separation of gas mixtures, particularly gas mixtures containing carbon dioxide.

公开(公告)号：US20200247882A1

公开(公告)日：2020-08-06

申请号：US16482455

申请日：2018-02-05

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Ileana ZUCCHI ,  Rolland Alvons REINBOLD

IPC: C07K16/28 ,  C12N15/113 ,  G01N33/574

Abstract: The present invention relates to agents that modulate/regulate the activity of the protein TMEM230 for use in the therapeutic treatment of pathologies in which therapeutic regulation of angiogenesis is advisable or necessary.

公开(公告)号：US20200046881A1

公开(公告)日：2020-02-13

申请号：US15755011

申请日：2016-08-31

Applicant: POLITECNICO DI MILANO ,  CONSIGLIO NAZIONALE DELLE RICERCHE ,  FONDAZIONE CARIPLO

Inventor： Manuela Teresa RAIMONDI ,  Giulio CERULLO ,  Roberto OSELLAME ,  Andrea REMUZZI

IPC: A61L27/38 ,  A61L27/56 ,  C12N5/00 ,  C12N5/0735 ,  C12N5/0775

Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix.A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.

公开(公告)号：US10525432B2

公开(公告)日：2020-01-07

申请号：US15547662

申请日：2016-02-01

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Anna Luisa Costa ,  Magda Blosi

IPC: B01J13/00 ,  A61K9/06 ,  A61K47/38 ,  A61K33/24 ,  A61K33/28 ,  A61K33/34 ,  A61K33/38 ,  C09D7/40 ,  B01J23/50 ,  B01J23/52 ,  B01J23/72 ,  B01J31/06 ,  B01J35/00 ,  B01J37/03 ,  B01J37/04 ,  C09D5/14

Abstract: There is described a versatile and environment-friendly one-pot process for the preparation of nanoparticles of noble metals in hydrogel, obtainable at room temperature using quaternized hydroxyethylcellulose.

公开(公告)号：US10525161B2

公开(公告)日：2020-01-07

申请号：US15747895

申请日：2016-07-26

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  JOINTHERAPEUTICS S.R.L.

Inventor： Luigi Ambrosio ,  Maria Grazia Raucci ,  Angela Longo ,  Gianfranco Carotenuto ,  Daniela Giugliano

IPC: A61L27/08 ,  A61L27/12

Abstract: It is disclosed a biocomposite of hydroxyapatite on graphene oxide sheets and its use for bone tissue engineering applications, such as bone repair, bone augmentation, as well as coating of biomedical implants. Processes for preparing said biocomposites are also described.

公开(公告)号：US20190339504A1

公开(公告)日：2019-11-07

申请号：US16473952

申请日：2017-12-21

Applicant: LABORATORIO EUROPEO Dl SPETTROSCOPIE NON LINEARI (LENS) ,  CONSIGLIO NAZIONALE DELLE RICERCHE - CNR ,  UNIVERSITA' DEGLI STUDI Dl FIRENZE

Inventor： Ludovico SILVESTRI ,  Marie Caroline MULLENBROICH ,  Leonardo SACCONI ,  Francesco Saverio PAVONE

IPC: G02B21/24 ,  G02B7/36 ,  G02B7/34

Abstract: A system and a method for measuring the focus state of an optical instrument are described. The system and the method provide for forming an image of the exit pupil of the objective of the optical instrument. Where the image of the exit pupil is formed, one or more optical elements are placed, deviating at least part of the rays coming from the exit pupil, so that rays coming from different non-overlapping portions of the pupil follow separate optical paths. The rays coming from the two portions of the pupil are then focused, in order to obtain two bidimensional images. A computer determines the mutual distance between these two bidimensional images as a mutual rigid lateral displacement between the two and, based on this distance, determines the corresponding defocus of the optical instrument.

公开(公告)号：US10350063B2

公开(公告)日：2019-07-16

申请号：US15319362

申请日：2015-06-17

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  HUMANITAS MIRASOLE S.P.A.

Inventor： Giorgio Soldani ,  Mattia Glauber

IPC: A61F2/24 ,  A61L27/18 ,  A61L27/50 ,  B29C41/00 ,  B29C41/08 ,  B29C43/00 ,  B29C43/02 ,  B29C43/36 ,  B29C43/52 ,  B29K69/00 ,  B29K75/00 ,  B29K83/00 ,  B29L31/00 ,  C08L83/04

Abstract: A process for the manufacture of a heart valve of polymer material which provides for the deposition of a polymer solution comprising a copolymer which is preferably a copolymer of poly(carbonato-urethane) fluoridate (F-PCU) and intracatenary polydimethylsiloxane (PDMS), a PDMS with a functional group outside the chain and a solvent onto a mould using a spray technique associated with phase inversion.

公开(公告)号：US20190185794A1

公开(公告)日：2019-06-20

申请号：US16322942

申请日：2016-08-09

Applicant: Consiglio Nazionale delle Ricerche ,  Bysea S.r.l.

Inventor： Francesco Meneguzzo ,  Lorenzo Albanese

IPC: C12C7/04 ,  C12C13/02

CPC classification number: C12C7/042 ,  C12C7/06 ,  C12C7/205 ,  C12C12/00 ,  C12C13/02

Abstract: A method, and related apparatus, for producing beer from any types of grains includes activating phenomena of controlled hydro-dynamic cavitation during all the steps of the process, from mashing to hopping, and possibly after yeast inoculation. The present method and apparatus provide a number of advantages over traditional techniques, for example, avoiding the pre-crushing of the malts or the grains, thereby increasing the efficiency of saccharification and of starch extraction, and avoiding the boiling at equal efficiency of the hopping. Another advantage is the opportunity of causing the concentration of gluten to fall in the final product simply with controlled hydraulic processes through electromechanics, and of possibly extending fermentation.

公开(公告)号：US10260152B2

公开(公告)日：2019-04-16

申请号：US15029328

申请日：2014-10-10

Applicant: Consiglio nazionale delle ricerche ,  CentroFermi Museo Storico della Fisica e Centro Studi e Ricerche

Inventor： Andrea Barucci ,  Franco Cosi ,  Stefano Pelli ,  Giancarlo Righini ,  Silvia Soria ,  Gualtiero Nunzi Conti ,  Ambra Giannetti

IPC: H01L21/67 ,  H01L21/461 ,  B05C3/10 ,  B05C3/02 ,  C03C25/68 ,  C23F1/16 ,  G01Q60/22 ,  G02B6/26

Abstract: A method, and corresponding apparatus, of fabricating a structure by chemical wet etching starting from a material rod of millimetric or sub-millemetric size, the method comprising: dipping an end portion (170) of the material rod (128,129) into a vessel (105) containing an etchant liquid (110) and a protective overlayer (175) floating on top of the etchant liquid, imparting a relative rotational movement of the etchant liquid with respect to the end portion (170) of the material rod immersed therein, wherein said imparting a relative rotational movement comprises imparting to the etchant liquid a rotational movement component with respect to a static reference system.