利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

136 条记录 (耗时 0.041 秒)

    Eye Covering and Refractive Correction Methods and Apparatus Having Improved Tear Flow, Comfort, and/or Applicability
    72.
    发明申请
    Eye Covering and Refractive Correction Methods and Apparatus Having Improved Tear Flow, Comfort, and/or Applicability 有权
    具有改进的撕裂流，舒适性和/或适用性的眼罩和折射校正方法和装置

    公开(公告)号：US20130077044A1

    公开(公告)日：2013-03-28

    申请号：US13456168

    申请日：2012-04-25

    申请人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  Matt Clarke ,  Kuangmon Ashley Tuan ,  Brain Levy

    发明人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  Matt Clarke ,  Kuangmon Ashley Tuan ,  Brain Levy

    IPC分类号： G02C7/04 ,  G02C7/02

    CPC分类号： G02C7/049 ,  G02C7/022 ,  G02C7/024 ,  G02C7/04 ,  G02C7/047

    摘要： An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

    摘要翻译： 诸如隐形眼镜的眼睛覆盖物可以包括一个或多个结构，以将覆盖物下方的泪液泵送，使得覆盖物可以保留在眼睛中并且将视力延长一段时间。 在许多实施例中，覆盖物包括具有开窗以吸收覆盖物下方的泪液的材料和形状为在巩膜上接触结膜的外部部分，使得当眼睛闭合一个或多个眼睑的压力时，促使泪液通过一个或多个 开窗和在外部形状以接触结膜。 当眼睛眨眼时，一个或多个眼睑的压力可以促使覆盖物朝向角膜，使得泪液可以通过开窗。

    Posterior segment drug delivery
    73.
    发明授权
    Posterior segment drug delivery 有权
    后段药物递送

    公开(公告)号：US08399006B2

    公开(公告)日：2013-03-19

    申请号：US12696678

    申请日：2010-01-29

    申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela Macfarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

    发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Steven M. Chamow ,  Kathleen Cogan Farinas ,  Hanson S. Gifford, III ,  K. Angela Macfarlane ,  Cary J. Reich ,  Michael Barrett ,  Randolph E. Campbell ,  Robert George ,  Douglas Sutton

    IPC分类号： A61M37/00 ,  A61M31/00

    CPC分类号： G01N33/558 ,  A61F9/0017 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/57 ,  A61K31/573 ,  A61K31/58 ,  A61K38/385 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/55 ,  Y10T29/49826

    摘要： A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side. Each of the openings on the first side can be connected to each of the openings on the second side with the plurality of interconnecting channels, such that the rate of release of the therapeutic agent can be substantially maintained when one or more of the openings is blocked, for example with particles, cells, bacteria or tissue when the device is implanted for an extended time. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device many comprise an expandable retention structure and an expandable reservoir, such that the device can be delivered from a lumen of a delivery device and expand when positioned in the patient. The therapeutic device may comprises a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.

    摘要翻译： 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小，当耦合到多孔结构并且植入患者体内时，释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 多个互连通道可以从第一侧延伸到第二侧，以便将第一侧上的第一多个开口与第二侧上的第二多个开口连接。 第一侧的每个开口可以与多个互连通道连接到第二侧的每个开口，使得当一个或多个开口被阻塞时可以基本上保持治疗剂的释放速度 ，例如当器件长时间植入时，可以使用颗粒，细胞，细菌或组织。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置许多包括可扩张的保留结构和可扩张的储存器，使得该装置可以从输送装置的内腔输送，并且在定位在患者体内时膨胀。 治疗装置可以包括当植入患者时将治疗剂注入装置中的可穿透屏障。

    OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM
    77.
    发明申请
    OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权
    具有坚固质量的OCULAR植入物，植入和系统的方法

    公开(公告)号：US20120016286A1

    公开(公告)日：2012-01-19

    申请号：US13245802

    申请日：2011-09-26

    申请人： Thomas A. Silvestrini ,  Eugene de Juan, JR.

    发明人： Thomas A. Silvestrini ,  Eugene de Juan, JR.

    IPC分类号： A61F9/00

    CPC分类号： A61F9/00781 ,  A61F2210/0019

    摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

    摘要翻译： 本文描述了用于治疗眼睛状况的装置和方法。 描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。 细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路， 成员植入眼睛。 细长构件具有赋予细长构件刚性的壁材料。 选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。

    OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM
    79.
    发明申请
    OCULAR IMPLANT WITH STIFFNESS QUALITIES, METHODS OF IMPLANTATION AND SYSTEM 有权
    具有坚固质量的OCULAR植入物，植入和系统的方法

    公开(公告)号：US20100274258A1

    公开(公告)日：2010-10-28

    申请号：US12694691

    申请日：2010-01-27

    申请人： THOMAS A. SILVESTRINI ,  Eugene de Juan, JR.

    发明人： THOMAS A. SILVESTRINI ,  Eugene de Juan, JR.

    IPC分类号： A61F9/007 ,  A61M1/00

    CPC分类号： A61F9/00781 ,  A61F2210/0019

    摘要： Described herein are devices and methods for treating eye conditions. Described is an ocular implant including an elongate member having an internal lumen forming a flow pathway, at least one inflow port communicating with the flow pathway, and at least one outflow port communicating with the flow pathway. The elongate member is adapted to be positioned in the eye such that at least one inflow port communicates with the anterior chamber, at least one outflow port communicates with the suprachoroidal space to provide a fluid pathway between the anterior chamber and the suprachoroidal space when the elongate member is implanted in the eye. The elongate member has a wall material imparting a stiffness to the elongate member. The stiffness is selected such that after implantation the elongate member deforms eye tissue surrounding the suprachoroidal space forming a tented volume.

    摘要翻译： 本文描述了用于治疗眼睛状况的装置和方法。 描述了一种眼部植入物，其包括具有形成流动路径的内部内腔的细长构件，与流动通道连通的至少一个流入口以及与流动通路连通的至少一个流出口。 细长构件适于定位在眼睛中，使得至少一个流入端口与前房连通，至少一个流出端口与脉管外空间连通，以在前房和脉管外空间之间提供流体通路，当细长 成员植入眼睛。 细长构件具有赋予细长构件刚性的壁材料。 选择刚度使得在植入之后，细长构件使围绕脉管外空间的眼组织变形，形成帐篷体积。