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公开(公告)号：US20080194685A1
公开(公告)日：2008-08-14
申请号：US12029557
申请日：2008-02-12
Applicant: Howard Glenn Damude , Anthony J. Kinney
Inventor： Howard Glenn Damude , Anthony J. Kinney
CPC classification number: C12N15/8247 , A23D9/00 , A23K10/30 , A23K20/163 , A23K50/80 , A23L33/12 , C12N9/0083 , C12N9/1029 , Y02A40/818
Abstract: Oilseed plants which have been transformed to produce arachidonic acid, recombinant constructs used in such transformations, methods for producing arachidonic acid in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.
Abstract translation: 已经转化生产花生四烯酸的油籽植物，用于这种转化的重组构建体，植物中花生四烯酸的生产方法，并描述了在各种食品和饲料应用中从这些转化植物获得的油和种子的用途。
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72.发明申请Mutant delta-8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids 有权通过靶向诱变工程改造的突变型δ-8去饱和酶基因及其在制备多不饱和脂肪酸中的应用公开(公告)号：US20080138868A1
公开(公告)日：2008-06-12
申请号：US11635258
申请日：2006-12-07
Applicant: Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
CPC classification number: C12N9/0083
Abstract: The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.
Abstract translation: 本发明涉及具有将二十碳二烯酸[20：2ω-6，EDA]转化为二高-γ-亚麻酸[20:3，DGLA]和/或二十碳三烯酸[20：3]的能力的突变型Δδ去饱和酶基因 3ω-3，ETrA]至二十碳四烯酸[20：3ω-3，ETA]。 公开了分离的核酸片段和重组构建体，其包含编码Δ8去饱和酶的片段以及使用这些突变型Delta8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。
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73.发明授权公开(公告)号：US08962917B2
公开(公告)日：2015-02-24
申请号：US11749889
申请日：2007-05-17
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: A23L1/182 , A23K10/30 , A23L7/196 , A23L19/03 , A23V2002/00 , C12N9/0071 , C12N9/0083 , C12P7/6427 , C12P7/6472 , C12Y114/19
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using this delta-5 desaturase in plants and oleaginous yeast are disclosed.
Abstract translation: 公开了分离的核酸片段和包含编码δ-5去饱和酶的片段的重组构建物，以及在植物和油质酵母中使用该δ-5去饱和酶制备长链多不饱和脂肪酸（PUFA）的方法。
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74.发明授权Delta-8 desaturases and their use in making polyunsaturated fatty acids 有权Delta-8去饱和酶及其在制备多不饱和脂肪酸中的应用公开(公告)号：US08859849B2
公开(公告)日：2014-10-14
申请号：US12944539
申请日：2010-11-11
Applicant: Howard Glenn Damude , Zhixiong Xue , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Zhixiong Xue , Quinn Qun Zhu
CPC classification number: C12N15/8247 , A23K20/158 , A23L33/12 , C12N9/0083
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-8 desaturases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-8 desaturases in plants and oleaginous yeast.
Abstract translation: 分离的核酸片段和包含编码δ-8去饱和酶的片段的重组构建物以及使用这些δ-8去饱和酶在植物和油质酵母中制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US08685682B2
公开(公告)日：2014-04-01
申请号：US12466072
申请日：2009-05-14
Applicant: Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K Picataggio , James John Ragghianti , John E Seip , Zhixiong Xue , Narendra S Yadav , Hongxiang Zhang , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Peter John Gillies , Daniel Joseph Macool , Stephen K Picataggio , James John Ragghianti , John E Seip , Zhixiong Xue , Narendra S Yadav , Hongxiang Zhang , Quinn Qun Zhu
CPC classification number: C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N1/16 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12N15/746 , C12N15/815 , C12P7/6472 , A23V2250/187 , A23V2200/30
Abstract: An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.
Abstract translation: 描述了能够在总油馏分中产生大于5.6％二十二碳六烯酸（DHA，w-3多不饱和脂肪酸）的含油酵母解脂耶氏酵母解脂耶氏酵母的改造菌株。 该菌株包含表达异源去饱和酶，延长酶和酰基转移酶的各种嵌合基因，并且任选地包含各种天然去饱和酶和酰基转移酶敲除，以使得能够合成和高浓度的DHA。 要求生产宿主细胞，以及在所述宿主细胞内产生DHA的方法。
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Patent Agency Ranking
76.发明申请DELTA-15 DESATURASES SUITABLE FOR ALTERING LEVELS OF POLYUNSATURATED FATTY ACIDS IN OILSEED PLANTS AND OLEAGINOUS YEAST 审中-公开DELTA-15适用于改变油性植物和油脂酵母中多糖脂肪酸含量的食物公开(公告)号：US20140050838A1
公开(公告)日：2014-02-20
申请号：US13897556
申请日：2013-05-20
Applicant: HOWARD GLENN DAMUDE , NARENDRA S. YADAV
Inventor： HOWARD GLENN DAMUDE , NARENDRA S. YADAV
CPC classification number: C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
Abstract: The present invention relates to fungal Δ-15 fatty acid desaturases that are able to catalyze the conversion of linoleic acid (18:2, LA) to alpha-linolenic acid (18:3, ALA). Nucleic acid sequences encoding the desaturases, nucleic acid sequences which hybridize thereto, DNA constructs comprising the desaturase genes, and recombinant host plants and microorganisms expressing increased levels of the desaturases are described. Methods of increasing production of specific omega-3 and omega-6 fatty acids by over-expression of the Δ-15 fatty acid desaturases are also described herein.
Abstract translation: 本发明涉及能够催化亚油酸（18:2，LA）转化为α-亚麻酸（18:3，ALA）的真菌Δ-15脂肪酸去饱和酶。 描述了编码去饱和酶的核酸序列，与其杂交的核酸序列，包含去饱和酶基因的DNA构建体和表达增加的去饱和酶水平的重组宿主植物和微生物。 本文还描述了通过过表达Δ-15脂肪酸去饱和酶增加特定ω-3和ω-6脂肪酸的产生的方法。
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77.发明授权Plant membrane bound O-acyl transferase (MBOAT) family protein sequences and their uses for altering fatty acid compositions 失效植物膜结合的O-酰基转移酶（MBOAT）家族蛋白序列及其用于改变脂肪酸组成的用途公开(公告)号：US08637733B2
公开(公告)日：2014-01-28
申请号：US12969782
申请日：2010-12-16
Applicant: Howard Glenn Damude , Knut Meyer
Inventor： Howard Glenn Damude , Knut Meyer
CPC classification number: C12N15/8247 , A23D9/00 , C12N9/1029
Abstract: This invention is in the field of biotechnology, in particular, this pertains to polynucleotide sequences encoding membrane bound O-acyltransferase genes and the use of these acyltransferases for altering fatty acid profiles in oilseed plants. Methods for increasing elongation and desaturation conversion efficiencies are also disclosed.
Abstract translation: 本发明涉及生物技术领域，特别涉及编码膜结合的O-酰基转移酶基因的多核苷酸序列以及这些酰基转移酶用于改变油菜植物脂肪酸分布的用途。 还公开了提高伸长率和去饱和转化效率的方法。
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78.发明授权公开(公告)号：US08470571B2
公开(公告)日：2013-06-25
申请号：US13238766
申请日：2011-09-21
Applicant: Howard Glenn Damude , Quinn Qun Zhu
Inventor： Howard Glenn Damude , Quinn Qun Zhu
CPC classification number: C12N15/8247 , C12N9/0083
Abstract: Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using this delta-8 desaturase in plants and oleaginous yeast are disclosed.
Abstract translation: 公开了分离的核酸片段和包含编码Δ-8去饱和酶的片段的重组构建物以及使用该植物中的δ-8去饱和酶和含油酵母制备长链多不饱和脂肪酸（PUFA）的方法。
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公开(公告)号：US08399736B2
公开(公告)日：2013-03-19
申请号：US13328677
申请日：2011-12-16
Applicant: Knut Meyer , Howard Glenn Damude , Kevin G. Ripp , Kevin L. Stecca
Inventor： Knut Meyer , Howard Glenn Damude , Kevin G. Ripp , Kevin L. Stecca
CPC classification number: C12N15/8247 , C12N9/1029 , C12Y203/0102
Abstract: Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from oleaginous organisms are used to achieve the increase in seed storage lipids.
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公开(公告)号：US08389808B2
公开(公告)日：2013-03-05
申请号：US12524363
申请日：2008-02-12
Applicant: Howard Glenn Damude , Anthony J. Kinney
Inventor： Howard Glenn Damude , Anthony J. Kinney
CPC classification number: C12N15/8247 , A23D9/00 , A23K10/30 , A23K20/163 , A23K50/80 , A23L33/12 , C12N9/0083 , C12N9/1029 , Y02A40/818
Abstract: Oilseed plants which have been transformed to produce arachidonic acid, recombinant constructs used in such transformations, methods for producing arachidonic acid in a plant are described and uses of oils and seeds obtained from such transformed plants in a variety of food and feed applications are described.
Abstract translation: 已经转化生产花生四烯酸的油籽植物，用于这种转化的重组构建体，植物中花生四烯酸的生产方法，并描述了在各种食品和饲料应用中从这些转化植物获得的油和种子的用途。
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