公开(公告)号：US20220348587A1

公开(公告)日：2022-11-03

申请号：US17831592

申请日：2022-06-03

申请人： CENTRE LEON BERARD ,  HOSPICES CIVILS DE LYON ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHESCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Toufic RENNO ,  Isabelle COSTE-INVERNIZZI ,  Stéphane GIRAUD ,  Serge LEBECQUE

IPC分类号： C07D487/04 ,  A61K45/06 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing the compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.

公开(公告)号：US20220346748A1

公开(公告)日：2022-11-03

申请号：US17763268

申请日：2020-09-25

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE PARIS ,  SORBONNE UNIVERSITÉ ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIME INDUSTRIELES DE LA VILLE DE PARIS

发明人： Mathieu PERNOT ,  Thomas DEFFIEUX ,  Mickael TANTER ,  Clément PAPADACCI

IPC分类号： A61B8/08 ,  A61B8/00 ,  G16H50/20 ,  G16H20/10 ,  G01S15/89

摘要： Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.

公开(公告)号：US11484272B2

公开(公告)日：2022-11-01

申请号：US15765196

申请日：2016-09-30

申请人： SORIN CRM SAS ,  INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITE DE RENNES 1

发明人： Jean-Luc Bonnet ,  Thomas Herrmann ,  Christine Henry ,  Alfredo Hernandez ,  Guy Carrault

IPC分类号： A61B5/00 ,  G16H40/40 ,  G06F1/3206 ,  G06F1/3287 ,  G06F1/329 ,  A61B5/07 ,  A61N1/37 ,  A61B5/24 ,  A61B5/316 ,  A61B5/333 ,  A61B5/352 ,  A61B5/363 ,  A61B5/364 ,  A61B5/389 ,  G16H50/20 ,  A61B5/0245 ,  A61B5/08 ,  A61B5/11 ,  A61B5/024

摘要： The invention relates to an active implantable medical device comprising a processing unit able to be alternately operated during a predetermined period of activity and on standby during a standby period in a cyclical manner, and means for acquiring data relating to physiological and/or physical activity. The device also comprises means for calculating a frequency analysis of the data acquired, said calculating means being capable of successively perform part of the frequency analysis during periods of activity of the processing unit.

公开(公告)号：US20220333177A1

公开(公告)日：2022-10-20

申请号：US17613990

申请日：2020-05-27

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  PARIS SCIENCES ET LETTRES ,  UNIVERSITE DE PARIS

发明人： Yannick RONDELEZ ,  Guillaume GINES ,  Roberta LIMA DE CASTRO MENEZES ,  Valérie TALY

IPC分类号： C12Q1/6848 ,  C12Q1/6886

摘要： The present invention relates to a digital method for detecting and/or quantifying at least one target biomolecules in a sample, said biomolecules being selected from DNA, RNA, and proteins based on isothermal amplification. The present invention further relates to different applications of the digital method and to a kit.

公开(公告)号：US11459623B2

公开(公告)日：2022-10-04

申请号：US16611000

申请日：2018-05-04

申请人： UNIVERSITE PARIS DESCARTES ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS ,  UNIVERSITE PARIS DIDEROT ,  UNIVERSITE PARIS NORD ,  UNIVERSITE DE ROUEN ,  CHU DE ROUEN

发明人： Adeline Melard ,  Mélanie Bertine ,  Véronique Avettand Fenoel ,  Florence Damond ,  Christine Rouzioux ,  Diane Descamps ,  Marie Gueudin ,  Jean-Christophe Plantier

IPC分类号： C12P19/34 ,  C12Q1/70

摘要： The present invention relates to a method for detecting or quantifying deoxyribonucleic acid (DNA) of human immunodeficiency virus 2 (HIV-2) in a sample containing DNA comprising: a) performing a real-time polymerase chain reaction (PCR) on the sample, or a fraction thereof comprising DNA, with at least two sets of primers and probe each respectively comprising two primers and a labeled probe for the detection or quantification of HIV-2 DNA, at least one of the sets is selected from the group consisting of: a set comprising a primer comprising or consisting of a sequence SEQ ID NO: 1 or a sequence having al least 90% identity to SEQ ID NO: 1, a primer comprising or consisting of a sequence SEQ ID NO: 2 or a sequence having 90% identity to SEQ ID NO: 2 or the complement of these sequences, and a labeled probe comprising or consisting of a sequence SEQ ID NO: 3, or a sequence having at least 90% identify to SEQ ID NO: 3 or the complement of these sequences, and a set comprising a primer comprising or consisting of a sequence SEQ ID NO: 4 or a sequence having at least 90% identity to SEQ ID NO: 4, a primer comprising or consisting of a sequence SEQ ID NO: 5 or a sequence having 90% identity to SEQ ID NO: 5 or the complement of these sequences, and a labeled probe comprising or consisting of a sequence SEQ ID NO: 6 or a sequence having at least 90% identity to SEQ ID NO: 6 or the complement of these sequences, and b) determining therefrom the presence or absence and/or the quantity of HIV-2 DNA in the biological sample.

公开(公告)号：US20220301158A1

公开(公告)日：2022-09-22

申请号：US17631258

申请日：2020-06-03

申请人： UNIVERSITE DE BORDEAUX ,  CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - (INSERM)

发明人： Gael DOURNES ,  Ilyes BENLALA ,  François LAURENT ,  Patrick BERGER

IPC分类号： G06T7/00 ,  G06T7/11 ,  G06T7/136

摘要： A Method for generating a biomarker includes acquiring an image using an MRI system; processing the MRI image to generate a three-dimensional image of the lung; generating a first function corresponding to the distribution of the different signal intensity values; automatically calculating a filtering threshold of the first function from a second signal intensity value distribution function; segmenting a lung volume comprising: a main volume; a filtered volume of a volume of voxels quantified by the first function and filtered by at least the calculated filtering threshold, normalizing the values of the three-dimensional image of the lung volume; generating a biomarker indicating a normalized segmented volume ratio.

公开(公告)号：US20220288230A1

公开(公告)日：2022-09-15

申请号：US17636225

申请日：2020-08-19

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE NORMALE SUPERIEURE ,  INSERM (Institut National de la Sante et de la Recherche Medicale

发明人： Lionel NAVARRO ,  Meenu SINGLA RASTOGI

IPC分类号： A61K48/00 ,  A61K31/7088 ,  A61P31/04 ,  C12N15/113 ,  C12N15/82 ,  C12N15/85 ,  C12Q1/686

摘要： The invention relates to a method to inhibit gene expression in bacteria, which is referred to here as Antibacterial Gene Silencing (AGS). In particular embodiments, the method is used to protect plants and animals against pathogenic bacteria by targeting pathogenicity factors and/or essential genes in a sequence-specific manner via small non-coding RNAs. The method can also be used to enhance beneficial effects and/or growth of symbiotic or commensal bacteria. The invention involves the exogenous delivery of small RNA entities onto bacteria, either in the form of RNA extracts or embedded into plant extracellular vesicles (EVs), so as to reduce bacterial growth, survival and/or pathogenicity. The invention also describes a method to identify in a rapid, reliable and cost-effective manner, small RNAs that possess antibacterial activity and that have the potential to be further developed as anti-infective agents. In addition, the latter method is instrumental to rapidly characterize any gene from any bacterial species.

公开(公告)号：US11414398B2

公开(公告)日：2022-08-16

申请号：US16630082

申请日：2018-07-13

申请人： SORBONNE UNIVERSITÉ ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE PARIS DESCARTES

发明人： Sophie Gautron ,  Nicolas Pietrancosta ,  Francine Acher ,  Laetitia Chausset-Boissarie

IPC分类号： C07D401/06

摘要： Disclosed are organic cation transporters (OCTs) inhibitors of Formula (A), as well as their pharmaceutically acceptable tautomers, salts or solvates. Also disclosed are pharmaceutical compositions including such OCTs inhibitor of Formula (A) and their use for treating and/or preventing mood-related disorders such as depressive disorders.

公开(公告)号：US11407741B2

公开(公告)日：2022-08-09

申请号：US16650629

申请日：2018-09-26

申请人： UNIVERSITÉ DE PARIS ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Etienne Jacotot ,  Elodie Bosc

IPC分类号： C07D405/12 ,  C07D207/16 ,  C07D401/12 ,  C07D417/14

摘要： The present invention relates to a compound of formula (I): wherein P1, P3, P4 and P5 are amino acid residues or amino acid like structures. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.

公开(公告)号：US11406686B2

公开(公告)日：2022-08-09

申请号：US16098689

申请日：2017-05-02

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  SORBONNE UNIVERSITE ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)

发明人： Selim Aractingi ,  Mathieu Catela ,  Dany Nassar ,  Zhe Wang

IPC分类号： A61K38/19 ,  A61P19/02 ,  A61P17/02 ,  A61K45/06 ,  C07K16/28 ,  C12N15/115 ,  G01N33/50 ,  A61K47/68 ,  A61K39/395 ,  C07K14/52 ,  A61K39/00

摘要： The present invention relates to methods and pharmaceutical compositions for the treatment of tissue lesions. The inventors showed that CCR2 is expressed on FMCs, especially on a subpopulation of progenitor cells, that they call “fetal myeloid progenitor cells” (FMPCs), and mediates the recruitment of these cells to maternal wound tissue. Moreover, the inventors reported that recruited FMCs/FMPCs improve maternal skin wound healing by organizing blood vessel endothelium and secreting pro-angiogenesis peptides, particularly chemokine CXCL1, to enhance angiogenesis in wound. In particular, the present invention relates to CCR2 agonists for use in the treatment of tissue lesions in a subject in need thereof.