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118 条记录 (耗时 0.033 秒)

    Expandable fluoropolymer device for delivery of therapeutic agents and method of making
    71.
    发明授权
    Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
    用于递送治疗剂的可扩展含氟聚合物装置和制备方法

    公开(公告)号：US07740793B2

    公开(公告)日：2010-06-22

    申请号：US11068680

    申请日：2005-02-28

    申请人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    发明人： Steve A. Herweck ,  Peter Gingras ,  Paul Martakos ,  Theodore Karwoski

    IPC分类号： A61M29/00

    CPC分类号： A61M25/1029 ,  A61L29/041 ,  A61M25/10 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1075 ,  B29C47/00 ,  B29C47/0023 ,  B29C55/24 ,  B29C2049/465 ,  B29K2027/18 ,  B29L2022/022 ,  B29L2031/753 ,  B32B2305/026 ,  C08L27/18

    摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.

    摘要翻译： 一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸， 径向膨胀力。 该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。 流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的 设备的墙壁。

    Method and apparatus for indicating pressure in chest drainage devices
    72.
    发明授权
    Method and apparatus for indicating pressure in chest drainage devices 失效
    指示胸部引流装置压力的方法和装置

    公开(公告)号：US07686801B2

    公开(公告)日：2010-03-30

    申请号：US10920861

    申请日：2004-08-18

    申请人： Scott E. Corbeil ,  Nicholas Want ,  Theodore Karwoski ,  Scott Cadwallader ,  Adam Epstein

    发明人： Scott E. Corbeil ,  Nicholas Want ,  Theodore Karwoski ,  Scott Cadwallader ,  Adam Epstein

    IPC分类号： A61M27/00 ,  A61M1/00 ,  G01L7/20 ,  G01L7/00

    CPC分类号： G01L7/022 ,  A61M16/044 ,  A61M2016/0027 ,  G01L7/041 ,  G01L7/043 ,  G01L7/063

    摘要： An apparatus is provided for indicating the presence of pressure within a collection chamber of a device such as a chest drainage device. The apparatus includes a bladder configured to be positioned within the collection chamber or within another chamber in fluid flow communication with the collection chamber. The bladder has a concavity formed therein and configured to contract or expand in response to pressure in the collection chamber. The apparatus also includes surfaces associated with the bladder that are configured to move with respect to one another upon contraction or expansion of the concavity of the bladder, thereby indicating pressure within the collection chamber.

    摘要翻译： 提供一种用于指示在例如胸部引流装置的装置的收集室内存在压力的装置。 该装置包括被配置为定位在收集室内或在与收集室流体流动连通的另一个室内的囊。 气囊具有形成在其中的凹部，并且构造成响应于收集室中的压力而收缩或膨胀。 该装置还包括与膀胱相关联的表面，其被构造成在囊的凹部收缩或膨胀时相对于彼此移动，从而指示收集室内的压力。

    Method for forming expandable polymers having drugs or agents included therewith
    80.
    发明授权
    Method for forming expandable polymers having drugs or agents included therewith 失效
    形成含有药物或试剂的可发性聚合物的方法

    公开(公告)号：US06923927B2

    公开(公告)日：2005-08-02

    申请号：US10807709

    申请日：2004-03-23

    申请人： Paul Martakos ,  Roger Labrecque ,  Geoffrey Moodie ,  Steve A. Herweck ,  Theodore Karwoski

    发明人： Paul Martakos ,  Roger Labrecque ,  Geoffrey Moodie ,  Steve A. Herweck ,  Theodore Karwoski

    IPC分类号： A61F2/06 ,  B29B11/10 ,  B29B11/14 ,  B29B13/00 ,  B29B13/02 ,  B29B15/00

    CPC分类号： A61F2/06

    摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The expandable polymer can also have the drug or agent added to its structure at a polymer resin preparation stage, through use of an aqueous solution mixed with one or more fluoropolymers, or in a mixing stage. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.

    摘要翻译： 本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比 。 可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。 可膨胀聚合物还可以通过使用与一种或多种含氟聚合物混合的水溶液，或在混合阶段中，在聚合物树脂制备阶段将药物或试剂加入到其结构中。 本发明还可以实现具有独特性质和处理特性的材料。 这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。 该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。