公开(公告)号：US20200289840A1

公开(公告)日：2020-09-17

申请号：US16086228

申请日：2017-03-24

申请人： INSERM (institut National de la Sante et de la Recherche Medicale) ,  Universite de Lille ,  Centre Hospitalier Regional et Universitaire de Lille (CHRU)

发明人： Maximilien VERMANDEL ,  Clement Dupont ,  Nicolas REYNS ,  Pascal DELEPORTE ,  Serge Mordon ,  Nacim BETROUNI

IPC分类号： A61N5/06

摘要： System (1) for treatment by photodynamic therapy comprising an illuminating member (6) which comprises: —a core (35) carrying a light emitting surface (37), and —a hollow sheath (10) adapted to receive the core (35) with the light emitting surface (37) arranged within a balloon (11), the balloon (11) comprising a wall (12) which has an inner surface delimiting an internal space, and an outer surface, the wall (12) being flexible, wherein the internal space of the balloon (11) has a variable capacity, the wall (12) of the balloon (11) being elastically extendible and the balloon (11) presenting a plurality of inflated states in each of which the internal space is filled with a volume of light diffusing solution, and wherein the system further comprises a support provided with a transfer function relating the volume of light diffusing solution of each inflated state with at least one of a corresponding distribution of light power at the outer surface of the wall (12) of the balloon (11) and a corresponding time of illumination for providing a determined dose of light energy.

公开(公告)号：US10772884B2

公开(公告)日：2020-09-15

申请号：US16552436

申请日：2019-08-27

申请人： ALZPROTECT ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： Stéphane Burlet ,  Cécilia Estrella ,  Mathieu Barrier ,  Patricia Melnyk ,  Nicolas Sergeant ,  Luc Buee ,  Philippe Verwaerde

IPC分类号： C07D235/30 ,  A61K31/496 ,  A61P25/28 ,  A61K9/00

摘要： The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

公开(公告)号：US20200179247A1

公开(公告)日：2020-06-11

申请号：US16618195

申请日：2018-05-31

申请人： CHANEL PARFUMS BEAUTE ,  UNIVERSITE DE LILLE

发明人： Oriana BOUCENNA VERDIER ,  Véronique RATAJ-NARDELLO ,  Jean-Marie AUBRY ,  Grégory DOUYERE ,  Corentine MAINGUY

IPC分类号： A61K8/06 ,  A61K8/46 ,  A61K8/60 ,  A61Q13/00

摘要： An oil-in-water microemulsion including, in weight percentages: between 70% and 94% of water; between 1% and 15% of at least one perfumed hydrophobic substance; between 4% and 20% of at least one preferably volatile solvo-surfactant, which is a monoalkylated glycerol derivative of formula (I); and between 0.1% and 15% of at least one anionic surfactant and at least one alkyl glucoside as a hydrotropic agent. The microemulsion can therefore be used to produce a fine fragrance composition or a cosmetic or personal hygiene composition.

公开(公告)号：US20200031891A1

公开(公告)日：2020-01-30

申请号：US16498780

申请日：2018-03-27

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE DE LILLE ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Luc BUEE ,  Malika HAMDANE ,  David BLUM ,  Maxime DERISBOURG ,  Coline LEGHAY ,  Giovanni CHIAPPETTA ,  Joelle VINH ,  Yann VERDIER

IPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/68

摘要： The invention relates to the identification of a new Tau species starting at residue Met11 (Met11-Tau) which is N-alpha-terminally acetylated form (N-alpha-acetyl-Met11-Tau species: Ac-Met11-Tau). Several monoclonal antibodies specific of this new Tau species have been developed. One of this antibody, 2H2/D11, was used in THY-Tau22 mouse model (that develops with age neurofibrillary degeneration (NFD) and memory deficits), and N-alpha-Ac-Met11-Tau species were clearly detected early in neurons displaying NFD on hippocampal brain sections while it is not reactive in hippocampus from elderly controls. Finally, by using ELISA sandwich specific of Ac-Met11-Tau species, Alzheimer Disease (AD) brain samples are clearly discriminated from human elderly control brains. Thus the invention relates to this new Tau species starting from the methionine residue at position 11 said methionine being N-alpha acetylated. The invention also relates to antibody that specifically binds this new tau species, a method of detection of this new Tau species and a method of diagnosis of Tauopathy disorder.

公开(公告)号：US20190162736A1

公开(公告)日：2019-05-30

申请号：US16092027

申请日：2017-04-07

申请人： LUNGINNOV ,  INSERM (INSTITUTE NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  UNIVERSITE DE LILLE ,  INSTITUT PASTEUR DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

发明人： Philippe LASALLE ,  Sidney CHOCRON ,  Nathalie DE FREITAS CAIRES

IPC分类号： G01N33/68 ,  A61P11/00 ,  G01N33/74

摘要： The present invention relates to methods and kits for diagnosing a postoperative pulmonary infection in a patient who underwent surgery. More particularly, the present invention relates to a method for diagnosing a postoperative pulmonary infection in a patient who underwent surgery, comprising a step consisting of measuring the concentration of endocan in a blood sample obtained from said patient, at a time point comprised between 3 h and 30 h after surgery.

公开(公告)号：US10265302B2

公开(公告)日：2019-04-23

申请号：US15882548

申请日：2018-01-29

申请人： UNIVERSITE DE LILLE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT PASTEUR DE LILLE

发明人： Fabrice Lejeune ,  Benoit Deprez ,  Terence Beghyn ,  Sara Sofia Gonzalez-Hilarion

IPC分类号： A61K31/436 ,  A61K31/35 ,  A61K31/122 ,  A61K31/435 ,  A61K31/4245

摘要： The present invention relates to the compound of formula (I) for use in the treatment of a nonsense-mutation-mediated genetic disease.

公开(公告)号：US20190092721A1

公开(公告)日：2019-03-28

申请号：US16205637

申请日：2018-11-30

申请人： UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Patricia Melnyk ,  Patrick Vermersch ,  Pascal Carato ,  Bénédicte Oxombre-Vanteghem ,  Héléne Zephir ,  Marion Donnier-Marechal

IPC分类号： C07C233/78 ,  C07D209/44 ,  A61K49/00 ,  C07C237/10 ,  C07C255/60 ,  C07D209/08 ,  C07C237/34 ,  C07C255/57 ,  C07C235/50 ,  C07C211/29 ,  C07C211/27 ,  C07C311/37 ,  C07C237/20

摘要： The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

公开(公告)号：US20180186939A1

公开(公告)日：2018-07-05

申请号：US15740414

申请日：2016-07-01

申请人： UNIVERSITE DE LILLE 1, SCIENCES ET TECHNOLOGIES ,  UNIVERSITE LILLE 2 DROIT ET SANTE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE

发明人： Nicolas BLANCHEMAIN ,  Bernard MARTEL ,  Claudia FLORES ,  Frédéric CAZAUX ,  Feng CHAI ,  Nicolas TABARY ,  Marco LOPEZ HEREDIA

IPC分类号： C08J3/075 ,  C08J3/05 ,  C08J9/28 ,  C08J9/00 ,  B01J13/00 ,  A61L26/00 ,  A61L27/52 ,  A61M3/00

CPC分类号： C08J3/075 ,  A61L26/008 ,  A61L27/52 ,  A61M3/005 ,  B01J13/0056 ,  B01J13/0069 ,  C08J3/05 ,  C08J9/0066 ,  C08J9/28 ,  C08J2205/022 ,  C08J2305/08 ,  C08J2305/16 ,  C08J2405/08 ,  C08J2405/16

摘要： The present invention concerns a method for producing a hydrogel comprising the following steps in succession: a first step (i) of providing at least one powder of an anionic polymer (A) and at least one chitosan powder (B) comprising amine functions (—NH2); a second step (ii) consisting in dry mixing at least the powders (A) and (B) from the first step in order to form a mixture of powders; a third step (iii) of suspending the mixture of powders obtained from the second step in an aqueous medium having a pH that can enable the anionic polymer (A) to be dissolved without dissolving the chitosan (B); a fourth step (iv) of adding an acid to the suspension obtained from the third step in order to form the hydrogel; or the third (iii) and fourth (iv) steps are replaced by a mixing fifth step (v), comprising mixing an acidified aqueous medium including at least one compound (C) comprising at least one unit of a hexose or a unit derived from a hexose, and/or at least one phosphate of said compound (C), with said mixture comprising at least the powders (A) and (B) obtained from the second step (ii).

公开(公告)号：US20170151235A1

公开(公告)日：2017-06-01

申请号：US15388349

申请日：2016-12-22

申请人： ALZPROTECT ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： Stéphane BURLET ,  Cécilia ESTRELLA ,  Mathieu BARRIER ,  Patricia MELNYK ,  Nicolas SERGEANT ,  Luc BUEE ,  Philippe VERWAERDE

IPC分类号： A61K31/496 ,  A61K9/00

摘要： The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

公开(公告)号：US09562018B2

公开(公告)日：2017-02-07

申请号：US14655642

申请日：2013-12-27

申请人： ALZPROTECT ,  UNIVERSITE DE LILLE 2 DROIT ET SANTE ,  INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： Stéphane Burlet ,  Cécilia Estrella ,  Mathieu Barrier ,  Patricia Melnyk ,  Nicolas Sergeant ,  Luc Buee ,  Philippe Verwaerde

IPC分类号： C07D235/30 ,  A61K31/496

CPC分类号： A61K31/496 ,  A61K9/0053 ,  C07D235/30

摘要： The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.

摘要翻译： 本发明涉及N-（3-（4-（3-（二异丁基氨基）丙基）哌嗪-1-基）丙基）-1H-苯并[d]咪唑-2-胺及其药学上可接受的溶剂合物的硫酸盐， 其制备方法，含有它们的药物组合物及其用于治疗和/或预防神经变性疾病。