公开(公告)号：US20110190266A1

公开(公告)日：2011-08-04

申请号：US13021474

申请日：2011-02-04

Applicant: Daniel Chu ,  Bing Wang

Inventor： Daniel Chu ,  Bing Wang

IPC: A61K31/397 ,  C07D487/06 ,  A61K31/5025 ,  C07D413/14 ,  A61K31/5377 ,  A61P9/00 ,  A61P35/00 ,  A61P25/28

CPC classification number: A61K31/397 ,  A61K31/5025 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/06

Abstract: Provided herein are compounds having the structure set forth in Formula (I): wherein the variables Y, Z, A, B, R1, R2, R3, R1′, R2′, R3′, R4 and R5 are as defined herein and methods of their synthesis. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Abstract translation: 本文提供具有式（I）所示结构的化合物：其中变量Y，Z，A，B，R 1，R 2，R 3，R 1'，R 2'，R 3'，R 4和R 5如本文所定义， 的合成。 本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗通过抑制PARP活性而改善的疾病，病症和病症的药物组合物。

公开(公告)号：US07858641B2

公开(公告)日：2010-12-28

申请号：US11248040

申请日：2005-10-11

Applicant: Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

Inventor： Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

IPC: A61K31/47

CPC classification number: C07D253/08 ,  C07D217/24 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D239/96 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04

Abstract: A variety of low molecular weight, guanidino-containing dihydroisoquinolinoines capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure ID where the values of the variable are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种低分子量含胍基的二氢异喹啉基。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有其中在此定义变量的值的结构ID。

公开(公告)号：US20100035883A1

公开(公告)日：2010-02-11

申请号：US12510096

申请日：2009-07-27

Applicant: Bing Wang ,  Daniel Chu

Inventor： Bing Wang ,  Daniel Chu

IPC: A61K31/5025 ,  C07D471/06 ,  A61P35/00 ,  A61P25/00

CPC classification number: A61K31/5025 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/5377 ,  A61K33/24 ,  A61N5/10 ,  A61N2005/1098 ,  C07D471/06

Abstract: A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

Abstract translation: 具有式（I）和式（II）所示结构的化合物：其中取代基Y，Z，A，B，R 1，R 2，R 3，R 4和R 5如本文所定义。 本文提供了聚（ADP-核糖）聚合酶活性的抑制剂。 本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗通过抑制PARP活性而改善的疾病，病症和病症的药物组合物。

公开(公告)号：US07625909B2

公开(公告)日：2009-12-01

申请号：US10850967

申请日：2004-05-21

Applicant: Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher R. Conlee ,  Brian D. Thompson ,  Judith de Armas Kuntz ,  David L. Musso ,  Kevin K. Barvian ,  Stephen A. Thomson ,  William R. Swain ,  Kien S. Du ,  Brian A. Chauder ,  Jason D. Speake ,  Michael J. Bishop

Inventor： Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher R. Conlee ,  Brian D. Thompson ,  Judith de Armas Kuntz ,  David L. Musso ,  Kevin K. Barvian ,  Stephen A. Thomson ,  William R. Swain ,  Kien S. Du ,  Brian A. Chauder ,  Jason D. Speake ,  Michael J. Bishop

IPC: A61K31/517 ,  A61K31/519 ,  A61P5/50 ,  C07D239/88 ,  C07D239/95 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D217/24 ,  C07D239/91 ,  C07D239/95 ,  C07D239/96 ,  C07D253/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种小分子，含胍分子。 当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。 化合物具有结构IA，IB和IC，其中变量的值在本文中定义。

公开(公告)号：US20090186378A1

公开(公告)日：2009-07-23

申请号：US10885305

申请日：2004-07-06

Applicant: Christopher Reeves ,  Daniel Chu ,  Chaitan Khosla ,  Daniel Santi ,  Kai Wu

Inventor： Christopher Reeves ,  Daniel Chu ,  Chaitan Khosla ,  Daniel Santi ,  Kai Wu

IPC: C12P21/04 ,  C12N15/11 ,  C12P17/16 ,  C12N1/21 ,  C12N15/00

CPC classification number: C07D498/18 ,  C07K2319/00 ,  C12N9/1029 ,  C12N9/1205 ,  C12N15/52 ,  C12P17/188 ,  C12P19/32

Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.

Abstract translation: 包含编码FK-520聚酮化合物合成酶和FK-520修饰酶的重组载体的宿主细胞可用于产生FK-520聚酮化合物。 包含一个或多个FK-520聚酮化合物结构域，模块，开放阅读框及其变体的重组DNA构建体可用于生产重组聚酮化合物合酶和各种不同的聚酮化合物，作为药物和兽用产品的应用。

公开(公告)号：US20080213308A1

公开(公告)日：2008-09-04

申请号：US11662984

申请日：2005-09-14

Applicant: Nicholas Valiante ,  Feng Xu ,  Xiaodong Lin ,  Daniel Chu ,  Xiaojing Michael Wang

Inventor： Nicholas Valiante ,  Feng Xu ,  Xiaodong Lin ,  Daniel Chu ,  Xiaojing Michael Wang

IPC: C07D471/04 ,  A61K31/437 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K39/245 ,  A61K39/29 ,  A61P31/12

CPC classification number: C07D471/14 ,  C07D471/04 ,  Y02P20/55

Abstract: The invention provides novel compositions comprising imidazoquinoline compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an)other agent(s).

Abstract translation: 本发明提供包含咪唑并喹啉化合物的新型组合物。 还提供了以有效量施用组合物以增强受试者的免疫应答的方法。 进一步提供了组合物与（一种或多种）其它试剂组合施用的新组合物和方法。

公开(公告)号：US07382591B2

公开(公告)日：2008-06-03

申请号：US11133648

申请日：2005-05-20

Applicant: Bi Han ,  Daniel Chu ,  Mase Taub

Inventor： Bi Han ,  Daniel Chu ,  Mase Taub

IPC: H02H9/00

CPC classification number: G11C16/12 ,  G11C16/30 ,  Y10T307/964

Abstract: A double cascode protected switchable voltage source may be used to selectively provide positive or negative voltage sources, for example, to a flash memory. The positive supply may be connected through a PMOS pass device to a first cascode protection device. A negative supply may be connected through an NMOS pass device and an NMOS cascode protection device to an output. The circuits may be designed so that exceeding snapback limits and gate aided drain breakdown are less likely.

Abstract translation: 可以使用双共源共栅保护的可切换电压源来选择性地将正或负电压源例如提供给闪存。 正电源可以通过PMOS通道器件连接到第一共源共栅保护器件。 负电源可以通过NMOS通道器件和NMOS共源共栅保护器件连接到输出端。 这些电路可以被设计成使得超过回跳限制和栅极辅助漏极击穿不太可能。

公开(公告)号：US20070185015A1

公开(公告)日：2007-08-09

申请号：US11361682

申请日：2006-02-24

Applicant: Daniel Chu ,  Yaohui Lei ,  Yu Bai ,  Zhi-Jie Ni ,  John Wang

Inventor： Daniel Chu ,  Yaohui Lei ,  Yu Bai ,  Zhi-Jie Ni ,  John Wang

IPC: A61K38/14 ,  C07K9/00

CPC classification number: C07K9/008 ,  A61K38/00

Abstract: Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. In addition, compounds of the invention include desmethyl-vancomycin scaffolds on which the acid moiety on the macrocyclic ring is converted to certain substituted amides and the amino substituent on the amino-substituted sugar moiety is alkylated with certain alkyl groups. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Abstract translation: 具有抗菌活性的半合成糖肽基于脱甲基万古霉素支架的修饰，特别是在该支架上具有某些酰基的氨基取代的糖部分上的氨基取代基的酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 此外，本发明的化合物包括去甲基 - 万古霉素支架，大环上的酸部分转化为某些取代的酰胺，氨基取代的糖部分上的氨基取代基被某些烷基烷基化。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。

公开(公告)号：US07163924B2

公开(公告)日：2007-01-16

申请号：US10831522

申请日：2004-04-23

Applicant: Matthew Burger ,  Daniel Chu

Inventor： Matthew Burger ,  Daniel Chu

IPC: A61K31/70 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antimicrobial ketolide compounds are provided having the formula (A): as well as pharmaceutically acceptable salts, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds, methods of treating bacterial infections by the administration of such compounds, and processes for the preparation of the compounds.

Abstract translation: 提供具有式（A）的抗微生物酮内酯化合物：以及其药学上可接受的盐，酯或前药，包含这些化合物的药物组合物，通过施用这些化合物治疗细菌感染的方法，以及制备化合物的方法 。

公开(公告)号：US20060267414A1

公开(公告)日：2006-11-30

申请号：US11133648

申请日：2005-05-20

Applicant: Bi Han ,  Daniel Chu ,  Mase Taub

Inventor： Bi Han ,  Daniel Chu ,  Mase Taub

IPC: H01H3/34

CPC classification number: G11C16/12 ,  G11C16/30 ,  Y10T307/964

Abstract: A double cascode protected switchable voltage source may be used to selectively provide positive or negative voltage sources, for example, to a flash memory. The positive supply may be connected through a PMOS pass device to a first cascode protection device. A negative supply may be connected through an NMOS pass device and an NMOS cascode protection device to an output. The circuits may be designed so that exceeding snapback limits and gate aided drain breakdown are less likely.

Abstract translation: 可以使用双共源共栅保护的可切换电压源来选择性地将正或负电压源例如提供给闪存。 正电源可以通过PMOS通道器件连接到第一共源共栅保护器件。 负电源可以通过NMOS通道器件和NMOS共源共栅保护器件连接到输出端。 这些电路可以被设计成使得超过回跳限制和栅极辅助漏极击穿不太可能。