公开(公告)号：US20060084677A1

公开(公告)日：2006-04-20

申请号：US11291867

申请日：2005-11-30

申请人： Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

发明人： Chris Broka ,  Woongki Kim ,  David Smith ,  Kevin McLaren

IPC分类号： A61K31/47 ,  C07D215/60

CPC分类号： C07D215/36

摘要： This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a CH2, CH(OH), C(O), C═NOR4, NR5, O, S, S(O), or S(O)2, and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents

摘要翻译： 本发明涉及通常为抗炎和止痛化合物的化合物，其由式I表示：其中A是CH 2，CH（OH），C（O），C- NOR 4，NR 5，O，S，S（O）或S（O）2，其它取代基如所定义 在规范中; 或前药，各异构体，异构体的混合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法

公开(公告)号：US20060040890A1

公开(公告)日：2006-02-23

申请号：US11208510

申请日：2005-08-22

申请人： Joseph Martin ,  Keshab Sarma ,  David Smith

发明人： Joseph Martin ,  Keshab Sarma ,  David Smith

IPC分类号： A61K31/7072 ,  C07H19/12

CPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/12

摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

摘要翻译： 4-氨基-1 - （（2R，3S，4S，5R）-5-叠氮基-3,4-二羟基-5-羟甲基 - 四氢 - 呋喃-2-基）-1H-嘧啶-2-酮（I ：R 1 = R 2 = R 3 = R 4 = H），其前药是丙型肝炎（C） HCV）聚合酶抑制剂。 还公开了用于抑制HCV和治疗HCV介导的疾病的组合物和方法，用于制备该方法中使用的化合物和合成中间体的方法。

公开(公告)号：US20060001681A1

公开(公告)日：2006-01-05

申请号：US11156626

申请日：2005-06-21

申请人： David Smith

发明人： David Smith

IPC分类号： G09G5/00

CPC分类号： G06T15/503 ,  G06T11/60 ,  G06T15/30

摘要： Methods of rendering an object-based image are described. The methods receive a list of objects (951-955) in the image (950), the list ordering the objects in priority order from a lowest-priority object (951) to a highest-priority object (955). The objects are assigned to a first set of objects (951, 952) and/or a second set of objects (953-955). The first set of objects is rendered to an image store using a first rendering method that only renders a portion of an object if the portion is visible in the first set of objects and the second set of objects is rendered to the image store using a second rendering method that renders each object independently of the other objects in the second set. The assignment may be based on a priority order of a highest-compositing object (952). The assignment may be based on a group of overlapping objects (1101, 1102, 1103, 1105), where an object (1105) in the group requires compositing.

摘要翻译： 描述呈现基于对象的图像的方法。 该方法在图像（950）中接收对象（951-955）的列表，该列表以优先顺序从最低优先级对象（951）到最高优先级对象（955）排序对象。 对象被分配给第一组对象（951,952）和/或第二组对象（953-955）。 使用第一渲染方法将第一组对象呈现到图像存储器，该第一渲染方法仅在第一组对象中显示该部分时呈现对象的一部分，并且使用第二渲染方法将第二组对象渲染到图像存储器 渲染方法，使每个对象独立于第二个集合中的其他对象。 分配可以基于最高合成对象的优先顺序（952）。 分配可以基于一组重叠对象（1101,1102,1103,1105），其中该组中的对象（1105）需要合成。

公开(公告)号：US20060000701A1

公开(公告)日：2006-01-05

申请号：US10884336

申请日：2004-07-01

申请人： David Smith ,  Allen Ferrell

发明人： David Smith ,  Allen Ferrell

IPC分类号： C10B7/10

CPC分类号： C10B7/10 ,  C10B53/02 ,  C10B57/02 ,  C10J3/32 ,  C10J2300/0909 ,  C10J2300/092 ,  Y02E50/14

摘要： A wood gasification apparatus in which cellulosic material is transported by an auger through a housing and heated to vaporize at least a portion of the cellulosic material by frictional heating. The auger and housing define a spiral void through which the cellulosic material is propelled from the inlet to the outlet, and which continually decreases in volume from the inlet to the outlet. The ever decreasing volume of the void increases the pressure on the cellulosic material and maximizes the frictional heating until the material reaches a vaporization temperature.

摘要翻译： 木材气化装置，其中纤维素材料通过螺旋钻通过壳体输送并通过摩擦加热被加热以蒸发至少一部分纤维素材料。 螺旋推运器和壳体限定了螺旋空隙，纤维素材料从入口到出口被推进，并且从入口到出口不断地减小体积。 空隙的不断减小的体积增加了纤维素材料上的压力，并使摩擦加热最大化直到材料达到蒸发温度。

公开(公告)号：US06957789B2

公开(公告)日：2005-10-25

申请号：US10683705

申请日：2003-10-14

申请人： Paul Bowman ,  Alan George Smithson ,  George Brotherson Routledge ,  David Smith ,  Terry Nichol

发明人： Paul Bowman ,  Alan George Smithson ,  George Brotherson Routledge ,  David Smith ,  Terry Nichol

IPC分类号： B60R22/36 ,  B60R22/28

CPC分类号： B60R22/36

摘要： A U-shaped frame for a seat belt retractor has two spaced arms made from a material of a predetermined thickness and having a cutout in the material of each arm for receiving a lockbar. Each cutout has an edge comprising a land portion for supporting the lockbar, which land portion is of a reduced thickness compared to the thickness of the material of the arms, to present a reduced surface area to the lockbar. The frame may be of pressed steel and the lockbar of die-cast non-ferrous material.

摘要翻译： 用于安全带卷收器的U形框架具有由预定厚度的材料制成的两个间隔开的臂，并且在每个臂的材料中具有用于接收锁定杆的切口。 每个切口具有包括用于支撑锁定杆的陆部部分的边缘，所述陆部部分与臂的材料的厚度相比具有减小的厚度，以将减小的表面面积提供给锁定杆。 框架可以是压制钢和压铸有色金属材料的锁定杆。

公开(公告)号：US20050226584A1

公开(公告)日：2005-10-13

申请号：US10430058

申请日：2003-05-05

申请人： Jerry Williams ,  David Smith ,  Jeffrey Muhs

发明人： Jerry Williams ,  David Smith ,  Jeffrey Muhs

IPC分类号： G01D5/353 ,  G01L5/10 ,  G02B6/10

CPC分类号： D04C1/02 ,  D07B1/145 ,  D07B2201/2096 ,  D07B2301/5577 ,  D07B2501/2061 ,  G01D5/35316 ,  G01D5/35354 ,  G01L5/105

摘要： A method for the direct measurement of large strains in ropes in situ using a plastic optical fiber, for example, perfluorocarbon or polymethyl methacrylate and Optical Time-Domain Reflectometer or other light time-of-flight measurement instrumentation. Protective sheaths and guides are incorporated to protect the plastic optical fiber. In one embodiment, a small rope is braided around the plastic optical fiber to impose lateral compressive forces to restrain the plastic optical fiber from slipping and thus experience the same strain as the rope. Methods are described for making reflective interfaces along the length of the plastic optical fiber and to provide the capability to measure strain within discrete segments of the rope. Interpretation of the data allows one to calculate the accumulated strain at any point in time and to determine if the rope has experienced local damage.

摘要翻译： 使用塑料光纤例如全氟化碳或聚甲基丙烯酸甲酯和光时域反射计或其他轻型飞行时间测量仪器直接测量原位绳索中的大应变的方法。 整合护套和引导件以保护塑料光纤。 在一个实施例中，围绕塑料光纤编织小绳索以施加横向压缩力以限制塑料光纤滑动，并因此经历与绳索相同的应变。 描述了用于沿着塑料光纤的长度制造反射界面的方法，并提供测量绳索的离散段内的应变的能力。 数据解释可以计算任何时间点的累积应变，并确定绳索是否遭受局部损坏。

公开(公告)号：US20050174946A1

公开(公告)日：2005-08-11

申请号：US11025298

申请日：2004-12-29

申请人： David Smith

发明人： David Smith

IPC分类号： H04L12/26

CPC分类号： H04L43/00

摘要： The present invention is a system and method of providing a GR303 interface to a digital central office. A virtual line group is installed within a line frame holding a plurality of line groups for communicating with analog subscriber telephones. The digital central office utilizes internal proprietary signals to operate the line groups and route calls to a public switched telecommunications network. The virtual line group emulates a line group within the digital central office and provides an GR303 interface for communicating with remote digital loop carriers. The virtual line group provides the GR303 interface without modifying or adding software or hardware to the digital central office.

摘要翻译： 本发明是向数字中心局提供GR303接口的系统和方法。 虚拟线路组安装在保持多个线路组的线路框架内，以与模拟用户电话进行通信。 数字中心局利用内部专有信号来操作线路组并将呼叫路由到公共交换电信网络。 虚拟线路组模拟数字中心局内的一个线路组，并提供一个用于与远程数字环路载波进行通信的GR303接口。 虚拟线路组提供GR303接口，无需修改或添加软件或硬件到数字中心局。

公开(公告)号：US20050149654A1

公开(公告)日：2005-07-07

申请号：US10841581

申请日：2004-05-06

申请人： Marty Holloway ,  David Smith

发明人： Marty Holloway ,  David Smith

IPC分类号： G06F13/00 ,  G06F13/40 ,  H04N5/00

CPC分类号： G06F13/409 ,  H04N21/4143 ,  H04N21/4307

摘要： Disclosed are a modular audio/video assembly and method of assembly. The modular audio/video assembly can include a housing and a main board disposed within the housing. A plurality of interfaces can be associated with the main board and each interface can be coupleable to a module that provides audio/video functionality for the assembly. The main board and the respective modules are cooperative to provide a set of selected audio/video functions. The assembly can operate on all digitized signals for optimum fidelity. A host within the assembly has an interface to a remote control to transmit to said remote control information for the modules in the assembly.

摘要翻译： 公开了一种模块化音频/视频组件和组装方法。 模块化音频/视频组件可以包括壳体和设置在壳体内的主板。 多个接口可以与主板相关联，并且每个接口可以耦合到为组件提供音频/视频功能的模块。 主板和相应的模块是协作的，以提供一组选定的音频/视频功能。 组件可以对所有数字化信号进行操作，以实现最佳保真度。 组件内的主机具有到远程控制器的接口，以向组件中的模块传输所述远程控制信息。

公开(公告)号：US20050140938A1

公开(公告)日：2005-06-30

申请号：US11067783

申请日：2005-03-01

申请人： Mark Wagner ,  Daniel Andrews ,  David Gerding ,  Henrik Schutz ,  Jennifer Shanks ,  David Smith ,  Curtis Deckert

发明人： Mark Wagner ,  Daniel Andrews ,  David Gerding ,  Henrik Schutz ,  Jennifer Shanks ,  David Smith ,  Curtis Deckert

IPC分类号： G01B11/27 ,  G03B23/08

CPC分类号： B24B13/005 ,  G01B11/27

摘要： A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage. The actuator shifts the carriage between the first position and the second position and shifts the block holder between the third position and the fourth position, and the display image on the screen is superimposed over an image of the object on the stage when the carriage is in the second position.

公开(公告)号：US20050138899A1

公开(公告)日：2005-06-30

申请号：US10510771

申请日：2003-04-01

申请人： Allan Draisey ,  Ryan Grimes ,  David Smith ,  George Tidy

发明人： Allan Draisey ,  Ryan Grimes ,  David Smith ,  George Tidy

IPC分类号： A61J3/07 ,  B29C49/00 ,  B29C65/04 ,  B29C65/74 ,  B65B9/04 ,  B65B51/22

CPC分类号： B29C66/83413 ,  A61J3/07 ,  B29C49/0047 ,  B29C65/04 ,  B29C65/7435 ,  B29C65/7455 ,  B29C65/749 ,  B29C66/1122 ,  B29C66/43 ,  B29C66/71 ,  B29C66/73521 ,  B29C66/73793 ,  B29C66/8122 ,  B29C66/81423 ,  B29C66/81431 ,  B29C66/81871 ,  B29C66/83415 ,  B29C66/83417 ,  B29C66/83513 ,  B29C66/849 ,  B29C2049/4655 ,  B29C2795/002 ,  B29K2995/0062 ,  B29L2031/7174 ,  B65B9/042 ,  B65B51/22 ,  B65B61/00 ,  Y10S53/02 ,  Y10T156/1052 ,  Y10T156/1054 ,  B29K2909/02 ,  B29K2001/08 ,  B29K2003/00

摘要： Capsules, for example for the delivery of pharmaceuticals, are produced from two films (18) of a water-soluble polymeric material, by deforming the films to form a multiplicity of recesses, and filling the recesses, using two adjacent rotary dies (14, 15; 42) with recesses (16) into which the films (18) are deformed. The dies (14, 15; 42) act as electrodes for welding the films together by dielectric welding to form filled capsules (30). The capsules (30) can be separated from the resulting web either by coating at least one of the dies (14) with an electrical insulator (21), or by transferring the web from the dies (14, 15; 42) to a second pair of dies which cut the capsules (30) free. The polymeric material may be gelatin, or a water-soluble cellulose derivative such as hydroxypropyl methyl cellulose, and may also contain a plasticiser.

摘要翻译： 例如用于输送药物的胶囊由两种水溶性聚合物材料薄膜（18）制成，通过使膜变形以形成多个凹部，并使用两个相邻的旋转模具（14,14）填充凹部， 15; 42），其中薄膜（18）变形到其中的凹部（16）。 模具（14,15; 42）用作电极，用于通过电介质焊接将膜焊接在一起以形成填充胶囊（30）。 胶囊（30）可以通过用电绝缘体（21）涂覆至少一个模具（14）或通过将纤维网从模具（14,15; 42）转移到第二 一对切割胶囊（30）的模具是自由的。 聚合物材料可以是明胶，或水溶性纤维素衍生物如羟丙基甲基纤维素，也可以含有增塑剂。