摘要:
A procedure is provided by which a worker is able to alter his or her work schedule using a computer system. The worker accesses work shift positions that have been designated as being alterable and chooses one as a selected work shift position. That selection may also specify a wage at the worker is willing to be compensated for staffing the selected work shift position. The computer system determines whether the worker is qualified to perform the tasks associated with the selected work shift position. If qualified, the worker is scheduled into the selected work shift position. The computer system also may provide a mechanism by which two workers can trade previously scheduled work shift positions.
摘要:
An apparatus for heating and cooling an article is provided. The apparatus comprises an enclosure having top, bottom, and side walls and an entrance and an exit. A first belt system comprising one or more belts extends from a loading position through a portion of the enclosure. The first belt system has a loading end and an unloading end. A second belt system comprising one or more belts extends from the unloading end of the first belt system to an unloading position. The second belt system has a loading end and an unloading end. The enclosure includes one or more heating sources positioned adjacent the first belt system for heating the first belt system.
摘要:
A carbon monoxide detector for making automobiles, vans, SUVs, pickups, and heavy trucks safer by equipping them with an automatically functioning carbon-monoxide detector and early warning system whereupon the presence of a dangerous level of carbon monoxide in the interior of a vehicle will shut off the engine, lower the windows and issue a warning for occupants to leave the vehicle.
摘要:
According to one example, there is provided a printing system. The printing system comprises a support having a plurality of spaced apertures and a color sensor moveable to measure light from each aperture. The printing system further comprises a controller to control the color sensor to measure characteristics of light emitted through each aperture, and to determine, for each aperture, light calibration data. The printing system is particularly adapted for use with substrates that are intended to be viewed when backlit, that is in conjunction with backlighting.
摘要:
The present invention relates to a method to improve the activity of engineered U7 snRNAs used in the context of RNA-based therapeutics; particularly in exon skipping, exon inclusion, and mRNA eradication strategies. The resulting modified U7 snRNAs are useful for treating neuromuscular diseases, in particular Duchenne neuromuscular dystrophy, myotonic dystrophy DM1 and spinal muscular atrophy.
摘要:
When it is determined that a first estimate of the total level of interference towards transmissions associated with a first access node from transmissions associated with other access nodes exceeds a predetermined target maximum value; then in dependence on the extent to which said first estimate exceeds said target maximum value, selecting one or more of said other access nodes to which to make a request to reduce the transmission power of interfering transmissions, and/or selecting an amount by which to request any one or more of said other access nodes to reduce the transmission power of interfering transmissions.
摘要:
In a communication network including a plurality of base stations, a method including the steps of: sending a signal from said base station indicating that it will enter a period of inactivity, to at least one other base station; storing at that least one current parameter(s) relating to interference between base stations and/or updating said parameter(s) for forward use. The parameter(s) may relate to interference between first base station and at least one operationally neighboring base station and may be Background Interference Matrix (BIM) data.
摘要:
An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.
摘要:
The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.
摘要:
Methods for increasing the efficiency of target tissue penetration of an adeno-associated virus (AAV) vector in a patient are provided. In some aspects, the methods involve inhibiting the interaction of the serum protein galectin 3 binding protein (G3BP) with AAV vector. Further provided are methods for reducing tissue distribution of a virus or for neutralizing a virus harbored by an organ destined for transplant, or newly transplanted, by administering a composition comprising G3BP.