公开(公告)号：US08119839B2

公开(公告)日：2012-02-21

申请号：US12669584

申请日：2008-07-19

Applicant: Hiroyuki Yoshimura ,  Kiyoshi Okihara ,  Satoshi Kawatake ,  Hiroko Tani ,  Tomoki Tatefuji ,  Ken Hashimoto ,  Hiromasa Tanaka ,  Akinori Inoue ,  Miyako Yanagihara

Inventor： Hiroyuki Yoshimura ,  Kiyoshi Okihara ,  Satoshi Kawatake ,  Hiroko Tani ,  Tomoki Tatefuji ,  Ken Hashimoto ,  Hiromasa Tanaka ,  Akinori Inoue ,  Miyako Yanagihara

IPC: C07C57/02 ,  C07C69/52 ,  A01N37/00 ,  A01N37/06

CPC classification number: C07C69/732 ,  C07C59/42 ,  C07C69/73

Abstract: The present invention provides a novel compound and antidepressant composition that can be effectively used for improving depressed mood and depressed state, particularly for depressed mood and depressed state in menopausal women. The compound of the present invention is represented by the following formula (1): wherein R1 and R2 are identical or different and represent a hydrogen atom, a hydroxyl group or an acetyloxy group, and n is an integer of 2 to 7, or a pharmaceutically acceptable salt or ester thereof. This compound is used as an active ingredient in the antidepressant composition. Examples of the compound of the invention include (2E)-9,10-dihydroxy-2-decenoic acid, (2Z)-9,10-dihydroxy-2-decenoic acid, (2E)-9-hydroxy-2-decenoic acid, and (2E)-7-acetoxy-2-heptenoic acid.

Abstract translation: 本发明提供一种新的化合物和抗抑郁药组合物，其可有效地用于改善抑郁状态和抑郁状态，特别是对绝经期妇女的抑郁情绪和抑郁状态。 本发明的化合物由下式（1）表示：其中R1和R2相同或不同，表示氢原子，羟基或乙酰氧基，n为2〜7的整数，或 其药学上可接受的盐或酯。 该化合物用作抗抑郁组合物中的活性成分。 本发明化合物的实例包括（2E）-9,10-二羟基-2-癸烯酸，（2Z）-9,10-二羟基-2-癸烯酸，（2E）-9-羟基-2-癸烯酸 ，和（2E）-7-乙酰氧基-2-庚烯酸。

公开(公告)号：US20100184860A1

公开(公告)日：2010-07-22

申请号：US12669584

申请日：2008-07-19

Applicant: Hiroyuki Yoshimura ,  Kiyoshi Okihara ,  Satoshi Kawatake ,  Hiroko Tani ,  Tomoki Tatefuji ,  Ken Hashimoto ,  Hiromasa Tanaka ,  Akinori Inoue ,  Miyako Yanagihara

Inventor： Hiroyuki Yoshimura ,  Kiyoshi Okihara ,  Satoshi Kawatake ,  Hiroko Tani ,  Tomoki Tatefuji ,  Ken Hashimoto ,  Hiromasa Tanaka ,  Akinori Inoue ,  Miyako Yanagihara

IPC: A61K31/19 ,  C07C59/00 ,  C07C59/10 ,  A61P25/24

CPC classification number: C07C69/732 ,  C07C59/42 ,  C07C69/73

Abstract: The present invention provides a novel compound and antidepressant composition that can be effectively used for improving depressed mood and depressed state, particularly for depressed mood and depressed state in menopausal women. The compound of the present invention is represented by the following formula (1): wherein R1 and R2 are identical or different and represent a hydrogen atom, a hydroxyl group or an acetyloxy group, and n is an integer of 2 to 7, or a pharmaceutically acceptable salt or ester thereof. This compound is used as an active ingredient in the antidepressant composition. Examples of the compound of the invention include (2E)-9,10-dihydroxy-2-decenoic acid, (2Z)-9,10-dihydroxy-2-decenoic acid, (2E)-9-hydroxy-2-decenoic acid, and (2E)-7-acetoxy-2-heptenoic acid.

Abstract translation: 本发明提供一种新的化合物和抗抑郁药组合物，其可有效地用于改善抑郁状态和抑郁状态，特别是对绝经期妇女的抑郁情绪和抑郁状态。 本发明的化合物由下式（1）表示：其中R1和R2相同或不同，表示氢原子，羟基或乙酰氧基，n为2〜7的整数，或 其药学上可接受的盐或酯。 该化合物用作抗抑郁组合物中的活性成分。 本发明化合物的实例包括（2E）-9,10-二羟基-2-癸烯酸，（2Z）-9,10-二羟基-2-癸烯酸，（2E）-9-羟基-2-癸烯酸 ，和（2E）-7-乙酰氧基-2-庚烯酸。

公开(公告)号：US20090325891A1

公开(公告)日：2009-12-31

申请号：US12462998

申请日：2009-08-11

Applicant: Hiroyuki Yoshimura ,  Taisuke Koike

Inventor： Hiroyuki Yoshimura ,  Taisuke Koike

IPC: A61K31/70 ,  A61K31/05

CPC classification number: A61K31/05 ,  A61K31/351 ,  A61K31/7008 ,  A61K2300/00

Abstract: An object of the present invention is to provide an excellent cartilage regeneration-promoting agent that can promote regeneration of cartilage efficiently and is highly safe, and a medicine and a food that utilizes the cartilage regeneration-promoting agent. Thus, the present invention relates to a cartilage regeneration-promoting agent that includes at least one of hydroxytyrosol and a precursor of hydroxytyrosol, and to a medicine and a food that includes the cartilage regeneration-promoting agent.

Abstract translation: 本发明的目的是提供一种能够有效促进软骨再生，高度安全的优异的软骨再生促进剂，以及利用软骨再生促进剂的药物和食品。 因此，本发明涉及包含羟基酪醇和羟基酪醇前体中的至少一种的软骨再生促进剂，以及包含软骨再生促进剂的药物和食品。

公开(公告)号：US20090046489A1

公开(公告)日：2009-02-19

申请号：US12081695

申请日：2008-04-18

Applicant: Hiroyuki Yoshimura ,  Katsunori Ueno ,  Masaharu Edo

Inventor： Hiroyuki Yoshimura ,  Katsunori Ueno ,  Masaharu Edo

IPC: H02M7/00 ,  H02M5/06

CPC classification number: H01F17/0013 ,  H01F27/2804 ,  H01F27/323 ,  H01F30/08 ,  H01F41/041 ,  H01F2038/006 ,  H01L23/5227 ,  H01L28/10 ,  H01L2924/0002 ,  H01L2924/09701 ,  H02M1/08 ,  H01L2924/00

Abstract: An insulated transformer, which can suppress aging deterioration and can reduce the influence of noise caused by external magnetic flux, while improving reliability and environmental resistance, and can send and receive signals while electrically insulating a low-voltage side and a high-voltage side. A secondary coil is formed on a semiconductor substrate, and a primary coil is formed on one face of a glass substrate. The primary coil fixes the glass substrate formed on one face onto the semiconductor substrate through the other face of the glass substrate by an adhesive layer.

Abstract translation: 一种绝缘变压器，其可以抑制老化劣化，并且可以降低由外部磁通量引起的噪声的影响，同时提高可靠性和耐环境性，并且可以在电压绝缘低压侧和高压侧时发送和接收信号。 次级线圈形成在半导体衬底上，初级线圈形成在玻璃衬底的一个面上。 初级线圈通过粘合剂层将形成在一个面上的玻璃基板通过玻璃基板的另一面固定在半导体基板上。

公开(公告)号：US20080108587A1

公开(公告)日：2008-05-08

申请号：US11975875

申请日：2007-10-22

Applicant: Hiroyuki Yoshimura ,  Taisuke Koike

Inventor： Hiroyuki Yoshimura ,  Taisuke Koike

IPC: A61K31/70 ,  A61K31/05 ,  A61P19/00

CPC classification number: A61K31/05 ,  A61K31/351 ,  A61K31/7008 ,  A61K2300/00

Abstract: An object of the present invention is to provide an excellent cartilage regeneration-promoting agent that can promote regeneration of cartilage efficiently and is highly safe, and a medicine and a food that utilizes the cartilage regeneration-promoting agent. Thus, the present invention relates to a cartilage regeneration-promoting agent that includes at least one of hydroxytyrosol and a precursor of hydroxytyrosol, and to a medicine and a food that includes the cartilage regeneration-promoting agent.

Abstract translation: 本发明的目的是提供一种能够有效促进软骨再生，高度安全的优异的软骨再生促进剂，以及利用软骨再生促进剂的药物和食品。 因此，本发明涉及包含羟基酪醇和羟基酪醇前体中的至少一种的软骨再生促进剂，以及包含软骨再生促进剂的药物和食品。

公开(公告)号：US06583138B1

公开(公告)日：2003-06-24

申请号：US09622458

申请日：2001-01-04

Applicant: Mitsuaki Miyamoto ,  Tatsuya Yoshiuchi ,  Keizo Sato ,  Motohiro Soejima ,  Takashi Sato ,  Koichi Kikuchi ,  Hiroyuki Yoshimura ,  Katsuhiro Moriya ,  Yoshinori Sakuma ,  Shigeru Akasofu ,  Koji Yamada

Inventor： Mitsuaki Miyamoto ,  Tatsuya Yoshiuchi ,  Keizo Sato ,  Motohiro Soejima ,  Takashi Sato ,  Koichi Kikuchi ,  Hiroyuki Yoshimura ,  Katsuhiro Moriya ,  Yoshinori Sakuma ,  Shigeru Akasofu ,  Koji Yamada

IPC: C07D51304

CPC classification number: C07D513/04

Abstract: The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of the present invention or a pharmacologically acceptable salt thereof is effective for prevention or remedy of disease, in which a chemical mediator, such as histamine, leukotriene and the like, participate, for example, asthma, allergic coryza, atopic dermatitis, hives, hay fever, gastrointestinal allergy, food allergy and the like. Further, the heterocyclic ring condensed benzothiazine compound of the present invention, its pharmacologically acceptable salt or hydrates thereof is represented by the following formula: In the formula, the ring Het represents an unsaturated heterocyclic ring; R1 and R2 are the same as or different from each other, and each represents halogen atom, a lower alkyl group that may be substituted with a halogen atom, a lower alkoxy group that may be substituted with a halogen atom, a lower alkyl lower alkoxy group, cyano group; D represents a lower alkylene group and the like that may have a substituent; Q represents, for example, the formula —NR20R2 (in the formula, R20 and R21 are the same as or different from each other, and each represents hydrogen atom, a lower alkyl group that may be substituted with a halogen atom, an aryl group that may have a substituent, an arylalkyl group that may have a substituent, a heteroaryl group that may have a substituent or a heteroarylalkyl group that may have a substituent, or R20 and R21 may form a 3- to 8-membered ring along with the nitrogen atom to which they are bound); and x represents an integer of from 1 to 2.

Abstract translation: 本发明提供一种新颖的杂环稠合苯并噻嗪化合物，其对组胺，白细胞三烯等参与的疾病的预防或治疗有效。 本发明的杂环稠合苯并噻嗪化合物或其药理学上可接受的盐对于预防或治疗其中化学介质如组胺，白三烯等参与的疾病是有效的，例如哮喘，过敏性鼻炎， 特应性皮炎，荨麻疹，花粉症，胃肠道过敏，食物过敏等。 此外，本发明的杂环稠合苯并噻嗪化合物，其药理学上可接受的盐或其水合物由下式表示：式中，环Het表示不饱和杂环; R1和R2彼此相同或不同，各自表示卤素原子，可以被卤素原子取代的低级烷基，可被卤素原子取代的低级烷氧基，低级烷基低级烷氧基 基团，氰基; D表示可以具有取代基的低级亚烷基等; Q表示例如式-NR20R2（式中，R20和R21彼此相同或不同，各自表示氢原子，可被卤素原子取代的低级烷基，芳基 可以具有取代基的芳基烷基，可以具有取代基的芳基烷基，可以具有取代基的杂芳基或可以具有取代基的杂芳基烷基，或者R20和R21可以与 氮原子）; x表示1〜2的整数。

公开(公告)号：US06541474B2

公开(公告)日：2003-04-01

申请号：US09910012

申请日：2001-07-23

Applicant: Kouichi Kikuchi ,  Katsuya Tagami ,  Hiroyuki Yoshimura ,  Shigeki Hibi ,  Mitsuo Nagai ,  Shinya Abe ,  Makoto Okita ,  Takayuki Hida ,  Seiko Higashi ,  Naoki Tokuhara ,  Seiichi Kobayashi

Inventor： Kouichi Kikuchi ,  Katsuya Tagami ,  Hiroyuki Yoshimura ,  Shigeki Hibi ,  Mitsuo Nagai ,  Shinya Abe ,  Makoto Okita ,  Takayuki Hida ,  Seiko Higashi ,  Naoki Tokuhara ,  Seiichi Kobayashi

IPC: A61K314965

CPC classification number: C07D401/04 ,  C07D209/14 ,  C07D231/12 ,  C07D241/24 ,  C07D241/44 ,  C07D249/10 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04

Abstract: Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, for example, a heteroarylene group, a —CONH— group or a group represented by the formula —CR6═CR7— in which R6 and R7 represents H, a lower alkyl group or the like, D represents an arylene group, a heteroarylene group or the like, n1 stands for 0 or 1, M represents, for example, a hydroxyl group or a lower alkoxy group; or a physiologically acceptable salt thereof. As a retinoic-related compound replacing retinoic acid, it permits the provision of a preventive and/or therapeutic for various diseases.

Abstract translation: 描述了由下式（I）表示的含杂环羧酸衍生物：其中A表示例如含有至少一个氮原子并且可以具有取代基的杂芳基，B表示例如亚杂芳基 -CONH-基或由式-CR 6 = CR 7 - 表示的基团，其中R 6和R 7表示H，低级烷基等，D表示亚芳基，亚杂芳基等，n1表示 0或1，M表示例如羟基或低级烷氧基; 或其生理上可接受的盐。 作为视黄酸相关化合物代替视黄酸，它允许为各种疾病提供预防和/或治疗。

公开(公告)号：US06329402B1

公开(公告)日：2001-12-11

申请号：US09313087

申请日：1999-05-17

Applicant: Kouichi Kikuchi ,  Katsuya Tagami ,  Hiroyuki Yoshimura ,  Shigeki Hibi ,  Mitsuo Nagai ,  Shinya Abe ,  Makoto Okita ,  Takayuki Hida ,  Seiko Higashi ,  Naoki Tokuhara ,  Seiichi Kobayashi

Inventor： Kouichi Kikuchi ,  Katsuya Tagami ,  Hiroyuki Yoshimura ,  Shigeki Hibi ,  Mitsuo Nagai ,  Shinya Abe ,  Makoto Okita ,  Takayuki Hida ,  Seiko Higashi ,  Naoki Tokuhara ,  Seiichi Kobayashi

IPC: A61K31415

CPC classification number: C07D401/04 ,  C07D209/14 ,  C07D231/12 ,  C07D241/24 ,  C07D241/44 ,  C07D249/10 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04

Abstract: Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, for example, a heteroarylene group, a —CONH— group or a group represented by the formula —CR6═CR7— in which R6 and R7 represents H, a lower alkyl group or the like, D represents an arylene group, a heteroarylene group or the like, n1 stands for 0 or 1, M represents, for example, a hydroxyl group or a lower alkoxy group; or a physiologically acceptable salt thereof. As a retinoic-related compound replacing retinoic acid, it permits the provision of a preventive and/or therapeutic for various diseases.

Abstract translation: 描述了由下式（I）表示的含杂环羧酸衍生物：其中A表示例如含有至少一个氮原子并且可以具有取代基的杂芳基，B表示例如亚杂芳基 -CONH-基或由式-CR 6 = CR 7 - 表示的基团，其中R 6和R 7表示H，低级烷基等，D表示亚芳基，亚杂芳基等，n1表示 0或1，M表示例如羟基或低级烷氧基; 或其生理上可接受的盐。 作为视黄酸相关化合物代替视黄酸，它允许为各种疾病提供预防和/或治疗。

公开(公告)号：US6133283A

公开(公告)日：2000-10-17

申请号：US236644

申请日：1999-01-26

Applicant: Shigeki Hibi ,  Kouichi Kikuchi ,  Hiroyuki Yoshimura ,  Mitsuo Nagai ,  Katsuya Tagami ,  Shinya Abe ,  Ieharu Hishinuma ,  Junichi Nagakawa ,  Norimasa Miyamoto ,  Takayuki Hida ,  Aichi Ogasawara ,  Seiko Higashi ,  Kenji Tai ,  Takashi Yamanaka ,  Makoto Asada

Inventor： Shigeki Hibi ,  Kouichi Kikuchi ,  Hiroyuki Yoshimura ,  Mitsuo Nagai ,  Katsuya Tagami ,  Shinya Abe ,  Ieharu Hishinuma ,  Junichi Nagakawa ,  Norimasa Miyamoto ,  Takayuki Hida ,  Aichi Ogasawara ,  Seiko Higashi ,  Kenji Tai ,  Takashi Yamanaka ,  Makoto Asada

IPC: A61P19/02 ,  C07C57/03 ,  C07C229/44 ,  C07D209/08 ,  C07D213/69 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D223/16 ,  C07D225/06 ,  C07D231/12 ,  C07D241/38 ,  C07D241/42 ,  C07D241/46 ,  C07D261/18 ,  C07D263/32 ,  C07D265/36 ,  C07D333/76 ,  C07D405/14 ,  C07D455/04 ,  C07D487/04 ,  C07D495/04 ,  G06F17/30 ,  C07D455/06 ,  A61K31/44

CPC classification number: C07D213/69 ,  C07C229/44 ,  C07C57/03 ,  C07D209/08 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D223/16 ,  C07D225/06 ,  C07D231/12 ,  C07D233/16 ,  C07D241/38 ,  C07D241/42 ,  C07D241/46 ,  C07D261/18 ,  C07D263/32 ,  C07D265/36 ,  C07D333/76 ,  C07D405/14 ,  C07D455/04 ,  C07D487/04 ,  C07D495/04 ,  G06F17/30607 ,  Y02P20/55

Abstract: To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof:Z--(CR.sup.3 .dbd.CR.sup.2).sub.n --COOR.sup.1-- (1-I)Compounds represented by the general formula (2-I) or physiologically acceptable salts thereof: ##STR1## The compounds according to the present invention exhibit extremely high ability to bind RARs and are effective for treating various kind of diseases such as abnormality in cornification and rheumatoid arthritis.

Abstract translation: 提供与维甲酸相关的新化合物，其可以代替用于预防和治疗几种疾病并对类视黄醇具有拮抗作用的视黄酸。 由通式（1-I）表示的杂环化合物或其生理学上可接受的盐：Z-（CR 3 = CR 2）n -COOR1-（1-I）由通式（2-I）表示的化合物或其生理学上可接受的盐 ：根据本发明的化合物显示出极高的结合RAR的能力，并且对于治疗各种类型的疾病如角质化和类风湿性关节炎的异常是有效的。

公开(公告)号：US6030964A

公开(公告)日：2000-02-29

申请号：US106112

申请日：1998-06-29

Applicant: Shigeki Hibi ,  Kouichi Kikuchi ,  Hiroyuki Yoshimura ,  Mitsuo Nagai ,  Katsuya Tagami ,  Shinya Abe ,  Ieharu Hishinuma ,  Junichi Nagakawa ,  Norimasa Miyamoto ,  Takayuki Hida ,  Aichi Ogasawara ,  Seiko Higashi ,  Kenji Tai ,  Takashi Yamanaka ,  Makoto Asada

Inventor： Shigeki Hibi ,  Kouichi Kikuchi ,  Hiroyuki Yoshimura ,  Mitsuo Nagai ,  Katsuya Tagami ,  Shinya Abe ,  Ieharu Hishinuma ,  Junichi Nagakawa ,  Norimasa Miyamoto ,  Takayuki Hida ,  Aichi Ogasawara ,  Seiko Higashi ,  Kenji Tai ,  Takashi Yamanaka ,  Makoto Asada

IPC: A61P19/02 ,  C07C57/03 ,  C07C229/44 ,  C07D209/08 ,  C07D213/69 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D223/16 ,  C07D225/06 ,  C07D231/12 ,  C07D241/38 ,  C07D241/42 ,  C07D241/46 ,  C07D261/18 ,  C07D263/32 ,  C07D265/36 ,  C07D333/76 ,  C07D405/14 ,  C07D455/04 ,  C07D487/04 ,  C07D495/04 ,  G06F17/30 ,  A61K31/55

CPC classification number: C07D213/69 ,  C07C229/44 ,  C07C57/03 ,  C07D209/08 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D223/16 ,  C07D225/06 ,  C07D231/12 ,  C07D233/16 ,  C07D241/38 ,  C07D241/42 ,  C07D241/46 ,  C07D261/18 ,  C07D263/32 ,  C07D265/36 ,  C07D333/76 ,  C07D405/14 ,  C07D455/04 ,  C07D487/04 ,  C07D495/04 ,  G06F17/30607 ,  Y02P20/55

Abstract: Compounds of the formula and compounds of the formula ##STR1## or their salts have the potent ability to bind to retinoic acid receptors thus useful in treating psoriasis and rheumatoid arthritis.

Abstract translation: 下式的化合物和下式化合物或其盐具有结合视黄酸受体的有效能力，因此可用于治疗牛皮癣和类风湿性关节炎。