利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

77 条记录 (耗时 0.039 秒)

    NANOPARTICLE CONJUGATES AND USES THEREOF
    71.
    发明申请
    NANOPARTICLE CONJUGATES AND USES THEREOF 审中-公开

    公开(公告)号：US20180133343A1

    公开(公告)日：2018-05-17

    申请号：US15813806

    申请日：2017-11-15

    申请人： Massachusetts Institute of Technology

    发明人： Darrell J. Irvine ,  Yu-Sang Sabrina Yang

    IPC分类号： A61K47/69

    CPC分类号： A61K47/6929 ,  A61K47/6923 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/00 ,  C07K16/2815 ,  C07K2317/22 ,  C07K2317/569

    摘要： The targeted delivery of therapeutic agents to specific cells remains a challenge in drug delivery. Provided herein are nanoparticle-targeting agent conjugates that can be used for the targeted delivery of therapeutic agents to certain cells and target tissues. The conjugates comprise nanoparticles (e.g., metal nanoparticles such as gold nanoparticles) with organic outer shells capable of adsorbing large numbers of therapeutic agents (e.g., small molecule drugs). The nanoparticles are covalently linked to targeting agents (e.g., proteins such as antibodies). The present invention also provides formulations comprising the nanoparticle-targeting agent conjugates, and kits comprising the same. In another aspect, the present invention provides methods of using the conjugates for the delivery of therapeutic agents to cells, and the treatment and/or prevention of diseases (e.g., autoimmune diseases, infectious diseases, proliferative diseases such as cancer). In another aspect, the present invention provides methods of preparing the nanoparticle-targeting agent conjugates described herein.