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158 条记录 (耗时 0.043 秒)

    Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide
    73.
    发明授权
    Polysaccharide composition and methods of isolation of the emulsion stabilizing cationic polyelectrolytic polysaccharide 失效
    多糖组成和分离乳液稳定阳离子聚电解多糖的方法

    公开(公告)号：US08609835B2

    公开(公告)日：2013-12-17

    申请号：US12993711

    申请日：2009-05-28

    申请人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    发明人： David L. Kaplan ,  Bruce Panilaitis ,  Michael Mercaldi ,  Hanna Dams-Kozlowska

    IPC分类号： C08B37/00 ,  A61K9/14 ,  A61K31/715 ,  C07H5/04

    CPC分类号： C12P19/04 ,  A61K9/1271 ,  A61K9/5123 ,  A61K47/36 ,  B82Y30/00 ,  C08B37/0003 ,  C08B37/0063

    摘要： The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclosed. In one aspect of the invention, methods are directed to isolating and purifying a high molecular weight exopolysaccharide (EPS) from a cell supernatant. In another aspect, methods are disclosed for isolating a lipopolysaccharide (LPS) and a high molecular weight Acinetobacter polyelectrolyte exopolysaccharide (APE) from Acinetobacter bacteria. Compositions are also directed to lipid nanoparticles comprising a therapeutic agent encapsulated by a high molecular weight polysaccharide and nanoparticles comprising a therapeutic agent bound to a cationic polysaccharide cross-linked with a polyanion.

    摘要翻译： 本发明涉及新型乳化稳定多糖的纯化和应用。 特别地，公开了具有高分子量的聚电解质外多糖，其包含具有三糖重复单元的高分子量聚合物。 在本发明的一个方面，方法涉及从细胞上清液中分离和纯化高分子量外多糖（EPS）。 在另一方面，公开了从不动细菌分离脂多糖（LPS）和高分子量不动杆菌聚电解质外多糖（APE）的方法。 组合物还涉及包含由高分子量多糖包封的治疗剂和包含与聚阴离子交联的阳离子多糖结合的治疗剂的纳米颗粒的脂质纳米颗粒。

    Vitamin C Composition for Use in the Prevention and Treatment of Stretch Marks, Radiation Dermatitis, and Other Skin Conditions and Methods of Using the Same
    75.
    发明申请
    Vitamin C Composition for Use in the Prevention and Treatment of Stretch Marks, Radiation Dermatitis, and Other Skin Conditions and Methods of Using the Same 审中-公开
    用于预防和治疗伸展标记，放射性皮炎和其他皮肤状况的维生素C组合物及其使用方法

    公开(公告)号：US20130131162A1

    公开(公告)日：2013-05-23

    申请号：US13738125

    申请日：2013-01-10

    申请人： David L. Kaplan

    发明人： David L. Kaplan

    IPC分类号： A61K31/341

    CPC分类号： A61K8/676 ,  A61K9/0014 ,  A61K31/34 ,  A61K31/341 ,  A61K47/10 ,  A61Q19/004 ,  A61Q19/06

    摘要： A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars and purpura, among other skin diseases or conditions.

    摘要翻译： 用于稳定的抗坏血酸组合物的制剂，其以简单的形式由溶液中的抗坏血酸与吸湿性化合物（即具有通过吸收或吸附从周围环境吸引水分子的能力的物质）组成。 本文还公开了生产这种化合物的方法和使用这些化合物在预防，抑制和治疗妊娠纹，放射性皮炎，ids ids，，，es，dys ia ia ia，，，damage damage ite，among among among among among among among among among among among among among among among among among among 其他皮肤病或病症。

    Functionalization of silk material by avidin-biotin interaction
    76.
    发明授权
    Functionalization of silk material by avidin-biotin interaction 有权
    丝素材料通过抗生物素蛋白 - 生物素相互作用进行功能化

    公开(公告)号：US08293486B2

    公开(公告)日：2012-10-23

    申请号：US13381687

    申请日：2010-07-20

    申请人： David L. Kaplan ,  Xiaoqin Wang ,  Monica A. Serban

    发明人： David L. Kaplan ,  Xiaoqin Wang ,  Monica A. Serban

    IPC分类号： G01N33/53 ,  C07K1/00

    CPC分类号： C07K14/43586 ,  A61K47/64 ,  A61K47/6903 ,  A61K47/6921

    摘要： The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.

    摘要翻译： 本发明提供通过抗生物素蛋白和生物素之间的特异性相互作用将丝素蛋白与活性剂连接的组合物和方法，提供了基于丝的蛋白质生物材料的功能化。 抗生物素蛋白或生物素修饰的丝是用于与多种相应连接的活性剂如抗体和生长因子进行功能化的生物材料平台。 可以通过本发明的方法制备各种功能性丝绸材料，例如丝素水凝胶，丝微/纳米颗粒和丝膜。 本发明的功能化策略相对容易，快速和可行，因此在许多生物医学应用中是有用的。

    SILK-BASED DRUG DELIVERY SYSTEM
    77.
    发明申请
    SILK-BASED DRUG DELIVERY SYSTEM 有权
    基于SILK的药物递送系统

    公开(公告)号：US20120195967A1

    公开(公告)日：2012-08-02

    申请号：US13443264

    申请日：2012-04-10

    申请人： David L. Kaplan ,  Lorenz Meinel

    发明人： David L. Kaplan ,  Lorenz Meinel

    IPC分类号： A61K47/42 ,  A61K31/7088 ,  A61K9/38 ,  A61K39/395 ,  A61K9/00 ,  A61K9/14 ,  A61K38/02 ,  A61K38/14

    CPC分类号： A61K47/42 ,  A61K9/0002 ,  A61K9/7007 ,  A61K38/17 ,  A61K47/46

    摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.

    摘要翻译： 本发明提供了新颖的持续释放的基于丝的递送系统。 本发明还提供了生产这种制剂的方法。 通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。 然后对该文章进行处理，以改变其构象。 构象的变化增加其胆固醇或液体结晶度，从而控制治疗剂从制剂中的释放。 这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。

    REMOVABLE TAILGATE GAP COVER
    78.
    发明申请
    REMOVABLE TAILGATE GAP COVER 有权
    可拆卸的TAILGATE GAP盖

    公开(公告)号：US20120159857A1

    公开(公告)日：2012-06-28

    申请号：US13328375

    申请日：2011-12-16

    申请人： David L. Kaplan

    发明人： David L. Kaplan

    IPC分类号： B60J9/00

    CPC分类号： B62D33/0273

    摘要： A removable tailgate gap cover for preventing ingress of debris in a tailgate gap. The gap cover comprises an elongated cover plate having a top surface, a bottom surface, two longitudinal edges and an elongated support bar having an upper end and a lower end, wherein the upper end is fixedly attached to and substantially centrally aligned with the lengthwise direction of the bottom surface. The elongated support bar comprises a magnetic attaching means disposed along the lower end of the elongated support bar for attaching the gap cover to the floor of the end portion of the truck bed.

    摘要翻译： 可拆卸的后挡板间隙盖，用于防止尾门间隙中的碎屑进入。 间隙盖包括具有顶表面，底表面，两个纵向边缘和具有上端和下端的细长支撑杆的细长盖板，其中上端固定地附接到基本上与长度方向对齐 的底面。 细长的支撑杆包括沿着细长支撑杆的下端设置的磁性附接装置，用于将间隙盖附接到卡车车厢底部的底部。

    FUNCTIONALIZATION OF SILK MATERIAL BY AVIDIN-BIOTIN INTERACTION
    79.
    发明申请
    FUNCTIONALIZATION OF SILK MATERIAL BY AVIDIN-BIOTIN INTERACTION 有权
    通过AVIDIN-BIOTIN相互作用对丝素材料的功能化

    公开(公告)号：US20120129255A1

    公开(公告)日：2012-05-24

    申请号：US13381687

    申请日：2010-07-20

    申请人： David L. Kaplan ,  Xiaoqin Wang ,  Monica A. Serban

    发明人： David L. Kaplan ,  Xiaoqin Wang ,  Monica A. Serban

    IPC分类号： C07K19/00 ,  C12N5/0783

    CPC分类号： C07K14/43586 ,  A61K47/64 ,  A61K47/6903 ,  A61K47/6921

    摘要： The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a biomaterial platform for functionalization with a variety of correspondingly linked active agents, such as antibodies and growth factors. A variety of functionalized silk materials, such as silk hydrogel, silk micro/nanoparticles and silk films, can be prepared by the methods of the present invention. The functionalization strategies of the present invention are relatively easy, fast and feasible, and are thus useful in many biomedical applications.

    摘要翻译： 本发明提供通过抗生物素蛋白和生物素之间的特异性相互作用将丝素蛋白与活性剂连接的组合物和方法，提供了基于丝的蛋白质生物材料的功能化。 抗生物素蛋白或生物素修饰的丝是用于与多种相应连接的活性剂如抗体和生长因子进行功能化的生物材料平台。 可以通过本发明的方法制备各种功能性丝绸材料，例如丝素水凝胶，丝微/纳米颗粒和丝膜。 本发明的功能化策略相对容易，快速和可行，因此在许多生物医学应用中是有用的。

    Silk-based drug delivery system
    80.
    发明授权
    Silk-based drug delivery system 有权
    丝绸药物输送系统

    公开(公告)号：US08178656B2

    公开(公告)日：2012-05-15

    申请号：US11628930

    申请日：2005-06-13

    申请人： David L. Kaplan ,  Meinel Lorenz

    发明人： David L. Kaplan ,  Meinel Lorenz

    IPC分类号： A61K38/17 ,  A61K9/22

    CPC分类号： A61K47/42 ,  A61K9/0002 ,  A61K9/7007 ,  A61K38/17 ,  A61K47/46

    摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.

    摘要翻译： 本发明提供了新颖的持续释放的基于丝的递送系统。 本发明还提供了生产这种制剂的方法。 通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。 然后对该文章进行处理，以改变其构象。 构象的变化增加其胆固醇或液体结晶度，从而控制治疗剂从制剂中的释放。 这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。