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公开(公告)号：US11186837B2
公开(公告)日：2021-11-30
申请号：US15373377
申请日：2016-12-08
Applicant: Monsanto Technology LLC
Inventor： James A. Baum , Lex Evan Flagel , Gerrit Cornelis Segers , James K. Roberts
IPC: C12N15/113 , C12N15/82 , A01N57/16
Abstract: The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through RNA interference.
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公开(公告)号：US10233217B2
公开(公告)日：2019-03-19
申请号：US14884469
申请日：2015-10-15
Applicant: MONSANTO TECHNOLOGY LLC
Inventor： James A. Baum , Sara A. Salvador , Jinling Wang , Stanislaw Flasinski , Thomas A. Cerruti , Crystal L. Dart , Leigh H. English , Xiaoran Fu , Victor M. Guzov , Arlene R. Howe , Jay P. Morgenstern , James K. Roberts
IPC: C07K14/325 , A01N47/08 , A01N63/02 , C12N15/82 , C12N15/62
Abstract: Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
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公开(公告)号：US10167484B2
公开(公告)日：2019-01-01
申请号：US15130684
申请日：2016-04-15
Applicant: MONSANTO TECHNOLOGY LLC
Inventor： James A. Baum , Larry A. Gilbertson , David K. Kovalic , Thomas J. LaRosa , Maolong Lu , Tichafa R. I. Munyikwa , James K. Roberts , Wei Wu , Bei Zhang
Abstract: The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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公开(公告)号：US20180087068A1
公开(公告)日：2018-03-29
申请号：US15835346
申请日：2017-12-07
Applicant: Monsanto Technology LLC
Inventor： James A. Baum , Thomas Cerruti , Stanislaw Flasinski , Xiaoran Fu , Arlene R. Howe , Sara Ann Salvador
IPC: C12N15/82 , A01N63/02 , C07K14/325 , A01N47/08
CPC classification number: C12N15/8286 , A01N47/08 , A01N63/02 , C07K14/325 , Y02A40/162
Abstract: Engineered Cry1Da amino acid sequences are provided that exhibit improved Lepidopteran insecticidal activity and an enhanced Lepidopteran spectrum compared to the naturally occurring Cry1Da protein toxin. Polynucleotide sequences intended for use in expression of the improved proteins in plants are also provided. Particular embodiments provide compositions containing insect inhibitory amounts of the engineered proteins, as well as recombinant plants, plant parts, and seeds containing polynucleotide constructs encoding one or more of the improved engineered proteins.
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公开(公告)号：US09814243B2
公开(公告)日：2017-11-14
申请号：US14901003
申请日：2014-03-13
Applicant: Monsanto Technology LLC
Inventor： James A. Baum , Allen T. Christian , Artem Evdokimov , Farhad Moshiri , Lisa Marie Weaver , Haitao Zhang
Abstract: Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis.
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Patent Agency Ranking
公开(公告)号：US09713334B2
公开(公告)日：2017-07-25
申请号：US15015957
申请日：2016-02-04
Applicant: Monsanto Technology LLC
Inventor： James A. Baum , Artem G. Evdokimov , Farhad Moshiri , Timothy J. Rydel , Eric J. Sturman , Moritz von Rechenberg , Halong Vu , Andrew M. Wollacott , Meiying Zheng
IPC: C12N9/00 , A01N63/02 , C12N15/82 , C07K14/00 , C07K14/325 , A01N37/46 , C07K14/435 , C07K14/32
CPC classification number: A01N63/02 , A01N37/46 , C07K14/001 , C07K14/32 , C07K14/325 , C07K14/43577 , C12N15/8286 , Y02A40/162
Abstract: The present invention discloses Hemipteran insect inhibitory proteins, methods of using such proteins, nucleotide sequences encoding such proteins, methods of detecting and isolating such proteins, and their use in agricultural systems.
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公开(公告)号：US09695439B2
公开(公告)日：2017-07-04
申请号：US13855328
申请日：2013-04-02
Applicant: Monsanto Technology LLC
Inventor： James A. Baum , Claire A. CaJacob , Pascale Feldmann , Gregory R. Heck , Irene Maria Antonia Nooren , Geert Plaetinck , Ty T. Vaughn , Wendy Maddelein
IPC: C07H21/04 , C12N15/82 , C07K14/435 , C12N15/113
CPC classification number: C12N15/8286 , C07H21/04 , C07K14/43536 , C07K14/43563 , C12N15/113 , C12N15/8218 , C12N15/8282 , C12N15/8285 , Y02A40/162 , Y02A40/164
Abstract: The present invention relates to control of pest infestation by inhibiting one or more biological functions. The invention provides methods and compositions for such control, By feeding one or more recombinant double stranded RNA molecules provided by the invention to the pest, a reduction in pest infestation is obtained through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation.
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78.发明授权Compositions and methods for the production and delivery of double stranded RNA 有权用于生产和递送双链RNA的组合物和方法公开(公告)号：US09445603B2
公开(公告)日：2016-09-20
申请号：US14208788
申请日：2014-03-13
Applicant: Monsanto Technology LLC
Inventor： James A. Baum , Allen T. Christian , Artem Evdokimov , Farhad Moshiri , Lisa Marie Weaver , Haitao Zhang
Abstract: Compositions and methods for efficiently producing and delivering double stranded RNA (dsRNA) are provided. Vector constructs useful for in vitro and in vivo expression of dsRNA are described. Also described are cell expression systems for efficient and cost-effective production of dsRNA in living cells and methods and compositions for providing the expressed dsRNA to target organisms. The described compositions and methods can be used to produce RNA molecules for screening or other uses, and to amplify RNA sequences for analysis.
Abstract translation: 提供了有效生产和递送双链RNA（dsRNA）的组合物和方法。 描述了可用于dsRNA的体外和体内表达的载体构建体。 还描述了用于在活细胞中有效和成本有效地生产dsRNA的细胞表达系统，以及用于将表达的dsRNA提供给靶生物的方法和组合物。 所述的组合物和方法可用于产生用于筛选或其它用途的RNA分子，并扩增用于分析的RNA序列。
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公开(公告)号：US20160230185A1
公开(公告)日：2016-08-11
申请号：US14207313
申请日：2014-03-12
Applicant: Monsanto Technology LLC
Inventor： James A. Baum , Renata Bolognesi , Lex Evan Flagel , Gerrit Cornelis Segers
IPC: C12N15/82 , C12N15/113 , A01N57/16
CPC classification number: C12N15/8286 , A01N57/16 , C12N15/113 , C12N2310/14 , Y02A40/162
Abstract: The present invention provides methods for controlling invertebrate pest infestations, for instance in plants, and related compositions and polynucleotides useful in such methods. More specifically, the present invention provides polynucleotides and methods of use thereof for modifying the expression of genes in an invertebrate pest, for instance through RNA interference.
Abstract translation: 本发明提供了用于控制无脊椎动物害虫侵染的方法，例如在植物中，以及可用于这些方法的相关组合物和多核苷酸。 更具体地，本发明提供多核苷酸及其用于修改无脊椎动物害虫中基因表达的方法，例如通过RNA干扰。
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80.发明申请Novel Chimeric Insecticidal Proteins Toxic or Inhibitory to Lepidopteran Pests 审中-公开新型嵌合杀虫蛋白对鳞翅目害虫有毒或抑制公开(公告)号：US20160108428A1
公开(公告)日：2016-04-21
申请号：US14884469
申请日：2015-10-15
Applicant: MONSANTO TECHNOLOGY LLC
Inventor： James A. Baum , Thomas A. Cerruti , Crystal L. Dart , Leigh H. English , Xiaoran Fu , Victor M. Guzov , Arlene R. Howe , Jay P. Morgenstern , James K. Roberts , Sara A. Salvador , Jinling Wang
IPC: C12N15/82 , A01N63/02 , A01N47/08 , C07K14/325
CPC classification number: C07K14/325 , A01N47/08 , A01N63/02 , C07K2319/00 , C12N15/62 , C12N15/8286 , Y02A40/162
Abstract: Nucleotide sequences are disclosed that encode novel chimeric insecticidal proteins exhibiting Lepidopteran inhibitory activity. Particular embodiments provide compositions and transformed plants, plant parts, and seeds containing the recombinant nucleic acid molecules encoding one or more of the chimeric insecticidal proteins.
Abstract translation: 公开编码显示鳞翅目抑制活性的新型嵌合杀虫蛋白的核苷酸序列。 具体实施方案提供了组合物和转化的植物，植物部分和含有编码一种或多种嵌合杀虫蛋白的重组核酸分子的种子。
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