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公开(公告)号：US20070154910A1
公开(公告)日：2007-07-05
申请号：US11565909
申请日：2006-12-01
申请人： Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
发明人： Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further re lates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060193861A1
公开(公告)日：2006-08-31
申请号：US11416310
申请日：2006-05-03
申请人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
发明人： Reiner Gentz , Reinhard Ebner , Guo-Liang Yu , Steven Ruben , Jian Ni , Ping Feng
CPC分类号： A61K48/005 , A61K38/00 , A61K48/0058 , C07K14/4703 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides and antibodies that bind TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供TNFR-6α和-6β多肽和结合TNFR-6α和-6β多肽的抗体，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20060099214A1
公开(公告)日：2006-05-11
申请号：US10518039
申请日：2003-06-10
申请人： Reinhard Ebner , Paul Young
发明人： Reinhard Ebner , Paul Young
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/574 , G06F19/00 , C07H21/04 , C12P21/06 , C07K16/46 , C07K16/30 , C07K14/82
CPC分类号： C12Q1/6886 , A61K2039/505 , C07K14/4748 , C12Q2600/136 , C12Q2600/16 , G01N33/5011 , G01N33/5023
摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.
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公开(公告)号：US20050215775A1
公开(公告)日：2005-09-29
申请号：US10979111
申请日：2004-11-02
申请人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
发明人： Steven Ruben , Craig Rosen , Carrie Fischer , Daniel Soppet , Kenneth Carter , Daniel Bednarik , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul Young , John Greene , Ann Ferrie , D. Duan , Jing-Shan Hu , Kimberly Florence , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Yanggu Shi
CPC分类号： C07K14/47 , Y10T436/143333
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US20050208622A1
公开(公告)日：2005-09-22
申请号：US10970493
申请日：2004-10-22
申请人： Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
发明人： Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050186637A1
公开(公告)日：2005-08-25
申请号：US11054539
申请日：2005-02-10
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen , Stephen Ullrich
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig Rosen , Stephen Ullrich
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , C07K14/52 , C07K14/705 , C07K14/715 , C07K16/24 , C07K16/28 , G01N33/564 , A61K39/395 , G01N33/53
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20050026254A1
公开(公告)日：2005-02-03
申请号：US10922101
申请日：2004-08-20
申请人： Guo-Liang Yu , Patrick Dillon , Reinhard Ebner , Gregory Endress
发明人： Guo-Liang Yu , Patrick Dillon , Reinhard Ebner , Gregory Endress
IPC分类号： A61K38/00 , C07K14/475 , A61K38/18
CPC分类号： C07K14/475 , A61K38/00 , C07K2317/92
摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.
摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。
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公开(公告)号：US08212004B2
公开(公告)日：2012-07-03
申请号：US11054539
申请日：2005-02-10
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： C07K14/475 , A61K38/16
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及使用这些抗体特异性结合中枢神经素-α和/或中枢神经素-αSV的抗体或其部分以及诊断和治疗方法。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20120045432A9
公开(公告)日：2012-02-23
申请号：US12952091
申请日：2010-11-22
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。
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80.发明申请NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体公开(公告)号：US20100196360A9
公开(公告)日：2010-08-05
申请号：US12210134
申请日：2008-09-12
申请人： GUO-LIANG YU , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich
发明人： GUO-LIANG YU , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich
IPC分类号： A61K39/395 , C12Q1/00 , A61P35/00 , A61K39/00 , G01N33/536 , A61K31/519
CPC分类号： G01N33/56972 , A61K31/519 , A61K38/00 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/70575 , C07K14/715 , C07K16/24 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N2333/52 , G01N2800/24
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。
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