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    Methods of treatment using antibodies to Neutrokine-alpha
    3.
    发明申请
    Methods of treatment using antibodies to Neutrokine-alpha 审中-公开
    使用Neutrokine-α抗体治疗方法

    公开(公告)号：US20060198784A1

    公开(公告)日：2006-09-07

    申请号：US11377165

    申请日：2006-03-17

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig Rosen

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig Rosen

    IPC分类号： A61K51/00 ,  A61K39/395 ,  G01N33/53

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT
    10.
    发明申请
    NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 有权
    NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体

    公开(公告)号：US20100261207A9

    公开(公告)日：2010-10-14

    申请号：US12295572

    申请日：2007-03-30

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen ,  Stephen Ullrich ,  Marc Chevrier

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen ,  Stephen Ullrich ,  Marc Chevrier

    IPC分类号： G01N33/53 ,  G01N33/566

    CPC分类号： C07K16/24 ,  A61K51/088 ,  A61K51/1021 ,  C07K14/525 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76

    摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.

    摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域Neutrokine-α和/或Neutrokine-αSV多肽的可溶形式，载体，宿主细胞和重组方法 生产相同。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。