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84 条记录 (耗时 0.091 秒)

    Human DNA topoisomerase I .alpha.
    71.
    发明授权
    Human DNA topoisomerase I .alpha. 失效
    人类DNA拓扑异构酶Iα

    公开(公告)号：US5968803A

    公开(公告)日：1999-10-19

    申请号：US33153

    申请日：1998-03-02

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N1/21 ,  C12N9/90 ,  C12N15/12 ,  C07K14/435

    CPC分类号： C12N9/90 ,  C12Y599/01002 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的的作用的方法，例如抗肿瘤剂，以检测自身免疫疾病或逆转录病毒感染并治疗结肠腺癌。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    DNA encoding human AlkB
    73.
    发明授权
    DNA encoding human AlkB 失效
    编码人类AlkB的DNA

    公开(公告)号：US5618717A

    公开(公告)日：1997-04-08

    申请号：US463975

    申请日：1995-06-05

    申请人： Ying-Fei Wei ,  Granger G. Sutton, III

    发明人： Ying-Fei Wei ,  Granger G. Sutton, III

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N9/22 ,  C12N15/12 ,  C12N5/00 ,  C12N15/00 ,  C12P21/06 ,  C07H17/00

    CPC分类号： C07K14/4702 ,  C07K14/47 ,  C12N9/22 ,  A61K38/00 ,  A61K48/00

    摘要： A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.

    摘要翻译： 公开了编码这种多肽的人hABH多肽和DNA（RNA）以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来治疗由受损的DNA例如癌症引起的疾病的突变和治疗的方法。 还公开了抗这些多肽的拮抗剂及其作为增强癌细胞化疗的治疗剂的用途。

    HUMAN MutY
    74.
    发明申请
    HUMAN MutY 失效
    人类MutY

    公开(公告)号：US20090029380A1

    公开(公告)日：2009-01-29

    申请号：US12204655

    申请日：2008-09-04

    申请人： Ying-Fei Wei

    发明人： Ying-Fei Wei

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/02 ,  C07K14/00 ,  C12P19/34

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12N9/22 ,  C12N9/2471 ,  C12Y302/01023

    摘要： A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了编码这种多肽的人类mutY多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来预防和/或治疗与该基因突变有关的疾病的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Antibodies to Chemokine Alpha-5
    77.
    发明申请
    Antibodies to Chemokine Alpha-5 失效
    趋化因子α-5抗体

    公开(公告)号：US20060008882A1

    公开(公告)日：2006-01-12

    申请号：US11224076

    申请日：2005-09-13

    申请人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    发明人： Ying-Fei Wei ,  Yi Li ,  Jian Ni ,  Craig Rosen ,  Steven Ruben

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C07K14/52 ,  C07K16/24

    CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K14/522 ,  C07K2319/00 ,  C12N2799/026 ,  Y02A50/423 ,  Y10T436/143333

    摘要： The present invention relates to a novel CKα-5 protein which is a member of the alpha chemokine family. In particular, isolated nucleic acid molecules are provided encoding the human CKα-5 protein. CKα-5 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Antibodies and fragments thereof that specifically bind to CKα-5 polypeptides are also disclosed, as are compositions and methods for making such antibodies. The invention further relates to screening methods for identifying agonists and antagonists of CKα-5 activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及作为α趋化因子家族成员的新型CKalpha-5蛋白。 特别地，提供编码人CKalpha-5蛋白的分离的核酸分子。 还提供了CKalpha-5多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还公开了特异性结合CKalpha-5多肽的抗体及其片段，以及制备这种抗体的组合物和方法。 本发明还涉及鉴定CKalpha-5活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Human ABH
    80.
    发明授权
    Human ABH 失效
    人类ABH

    公开(公告)号：US06573360B1

    公开(公告)日：2003-06-03

    申请号：US09296623

    申请日：1999-04-23

    申请人： Ying-Fei Wei ,  Granger G. Sutton, III

    发明人： Ying-Fei Wei ,  Granger G. Sutton, III

    IPC分类号： C07K14435

    CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N9/22 ,  Y02A50/473

    摘要： A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.

    摘要翻译： 公开了编码这种多肽的人hABH多肽和DNA（RNA）以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来治疗由受损的DNA例如癌症引起的疾病的突变和治疗的方法。 还公开了抗这些多肽的拮抗剂及其作为增强癌细胞化疗的治疗剂的用途。