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公开(公告)号：US20110318839A1
公开(公告)日：2011-12-29
申请号：US13254602
申请日：2010-03-05
申请人： Hiroshi Shiku , Hiroaki Ikeda , Koichi Iwamura , Junichi Mineno , Ikunoshin Kato
发明人： Hiroshi Shiku , Hiroaki Ikeda , Koichi Iwamura , Junichi Mineno , Ikunoshin Kato
IPC分类号： C12N5/0783
CPC分类号： A61K35/17 , A61K2035/124 , A61K2039/5158 , C12N5/0636 , C12N15/113 , C12N2310/14 , C12N2501/48 , C12N2501/599 , C12N2310/531
摘要： Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases.
摘要翻译： 公开了一种增强T细胞功能的方法，其特征在于抑制T细胞中程序性死亡-1配体1（PD-L1）和/或程序性死亡-1配体2（PD-L2）的表达 。 还公开了通过功能增强方法产生的功能增强T细胞。 还公开了包含功能增强T细胞的治疗剂。 T细胞可以增强对癌症的免疫应答，并且可用于对癌症有效的免疫治疗和治疗或预防感染性疾病和自身免疫性疾病。
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72.发明授权公开(公告)号：US07932071B2
公开(公告)日：2011-04-26
申请号：US12493428
申请日：2009-06-29
CPC分类号： C12N9/22
摘要： A polypeptide having an RNaseH activity from Archaeoglobus profundus and being highly useful in gene engineering; a gene encoding this polypeptide; and a genetic engineering process for producing the polypeptide.
摘要翻译： 具有来自古细菌球菌的RNaseH活性并且在基因工程中非常有用的多肽; 编码该多肽的基因; 以及用于产生多肽的遗传工程方法。
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公开(公告)号：US07846703B2
公开(公告)日：2010-12-07
申请号：US11866148
申请日：2007-10-02
申请人： Eiji Kobayashi , Yuki Ueda , Yoshimi Sato , Takashi Uemori , Hiroyuki Mukai , Ikunoshin Kato
发明人： Eiji Kobayashi , Yuki Ueda , Yoshimi Sato , Takashi Uemori , Hiroyuki Mukai , Ikunoshin Kato
CPC分类号： C12N9/1241
摘要： A polymerase activity is effectively enhanced by adding an anionic surfactant, in particular an anionic surfactant having a polyethoxyl group, to a reaction mixture containing a polymerase.
摘要翻译： 通过向含有聚合酶的反应混合物中加入阴离子表面活性剂，特别是具有聚乙氧基的阴离子表面活性剂，可有效提高聚合酶活性。
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公开(公告)号：US20100105867A1
公开(公告)日：2010-04-29
申请号：US12530270
申请日：2008-03-05
摘要： A process for producing an extract containing activated osteocalcin; an extract which can be obtained by this production process; a food, a drink, a drug, an oral cavity-care composition and a feed containing this extract; and a growth enhancer containing osteocalcin originating in a bone.
摘要翻译： 一种生产含有活化骨钙素的提取物的方法; 可以通过该生产过程获得的提取物; 食物，饮料，药物，口腔护理组合物和含有该提取物的饲料; 以及含有源于骨的骨钙素的生长增强剂。
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公开(公告)号：US07678368B2
公开(公告)日：2010-03-16
申请号：US11311341
申请日：2005-12-20
申请人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
发明人： Shigetoshi Mizutani , Suzu Deguchi , Eiji Kobayashi , Eiji Nishiyama , Hiroaki Sagawa , Ikunoshin Kato
CPC分类号： A61Q19/10 , A61K8/60 , A61K8/73 , A61K8/9706 , A61K31/04 , A61K31/08 , A61K31/13 , A61K31/70 , A61K33/20 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61Q19/00 , A61Q19/005 , A61Q19/007 , A61Q19/08 , Y10S514/88
摘要： To find a substance which has a skin cosmeticizing effect such as prevention of skin aging, amelioriation of sensitive skin, or antipruritic action, and can serve as an effective ingredient for a hair-care product, thereby providing cosmetics comprising the effective ingredient. Concretely, there are provided cosmetics characterized in that the cosmetics comprise as an effective ingredient a compound selected from a fucoidan, a degradation product thereof, a sulfated monosaccharide or a salt thereof.
摘要翻译： 为了找到具有防止皮肤老化，敏感性皮肤的改善或止痒作用的皮肤美容效果的物质，可以作为护发品的有效成分，从而提供含有效成分的化妆品。 具体地，提供了化妆品，其特征在于，所述化妆品包含选自岩藻依聚糖，其降解产物，硫酸化单糖或其盐的化合物作为有效成分。
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公开(公告)号：US20090269809A1
公开(公告)日：2009-10-29
申请号：US12493428
申请日：2009-06-29
CPC分类号： C12N9/22
摘要： A polypeptide having an RNaseH activity and being highly useful in gene engineering; a gene encoding this polypeptide; and a genetic engineering process for producing the polypeptide.
摘要翻译： 具有RNaseH活性并且在基因工程中非常有用的多肽; 编码该多肽的基因; 以及用于产生多肽的遗传工程方法。
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公开(公告)号：US07604962B2
公开(公告)日：2009-10-20
申请号：US12027738
申请日：2008-02-07
申请人： Jun Tomono , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
发明人： Jun Tomono , Yoshiko Nomura , Hiroaki Sagawa , Takeshi Sakai , Ikunoshin Kato
CPC分类号： C12Y302/01158 , C12N9/2465 , C12P19/04 , C12P19/24
摘要： A polypeptide having an α-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide.
摘要翻译： 具有α-琼脂糖酶活性的多肽，编码该多肽的基因，通过遗传工程生产该多肽的方法以及使用该多肽制备琼脂低聚糖的方法。
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公开(公告)号：US20090156420A1
公开(公告)日：2009-06-18
申请号：US12230131
申请日：2008-08-25
申请人： Yasuhiro Tsubosa , Kazuhiko Aoyagi , Hiroki Sasaki , Masaaki Terada , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
发明人： Yasuhiro Tsubosa , Kazuhiko Aoyagi , Hiroki Sasaki , Masaaki Terada , Junichi Mineno , Kiyozo Asada , Ikunoshin Kato
IPC分类号： C40B30/04 , C12Q1/68 , G01N33/574 , C40B40/08
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/158
摘要： To provide a method for selecting a marker gene useful for cancer classification; a method for classifying cancer using the gene; a method for detecting cancer; a kit usable for the classification method or detection method; and a DNA array carrying the gene. According to the present invention, there can be obtained a gene, wherein expression of the above gene is altered independently from genes each of which expression is altered specifically during cell proliferation and expression level of the above gene is specifically altered depending on every type of cancer samples to be tested, whereby the classification or detection of cancer can be carried out conveniently and quickly without giving surgical treatment. Therefore, the present invention is useful for the diagnosis, the treatment, and the like of cancer.
摘要翻译： 提供选择用于癌症分类的标记基因的方法; 使用该基因分类癌症的方法; 一种检测癌症的方法; 可用于分类方法或检测方法的试剂盒; 和携带该基因的DNA阵列。 根据本发明，可以获得上述基因的表达独立于在细胞增殖期间特异性改变的基因的各基因的变化，并且根据每种类型的癌症特异性地改变上述基因的表达水平 待测试的样品，从而可以方便快捷地进行癌症的分类或检测，而无需外科治疗。 因此，本发明对癌症的诊断，治疗等有用。
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公开(公告)号：US20090148926A1
公开(公告)日：2009-06-11
申请号：US12272758
申请日：2008-11-17
IPC分类号： C12N1/14
摘要： Problem: To provide a fungal bed culture enabling stable production of a hon-shimeji mushroom in large scale commercial cultivation as well as a method of fungal bed cultivation of a hon-shimeji mushroom using the fungal bed culture.Solution: There is provided a fungal bed culture of a hon-shimeji mushroom inoculated with a liquid seed culture characterized in that the surface of a culture medium for cultivation has a liquid seed culture inoculated portion and a liquid seed culture non-inoculated portion as well as a fungal bed cultivation method of a hon-shimeji mushroom characterized by generating a fruit body from the fungal bed culture. According to the present invention improves the formation rate of budlet in the fungal bed cultivation of a hon-shimeji mushroom, thereby enabling stable production of a hon-shimeji mushroom in large scale commercial cultivation.
摘要翻译： 问题：提供一种真菌床文化，能够在大规模商业栽培中稳定生产一种香菇菇，以及使用真菌床培养方法真菌床栽培枸杞子蘑菇。 解决方案：提供了接种液体种子培养物的枸杞蘑菇的真菌床培养物，其特征在于用于培养的培养基的表面具有液体种子培养接种部分和液体种子培养未接种部分 作为真菌床栽培方法，以真菌床培养物产生果实为特征。 根据本发明，提高了枸杞蘑菇真菌床栽培中芽的形成速率，从而在大规模商业栽培中稳定地生产了一种枸杞子蘑菇。
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公开(公告)号：US20090076136A1
公开(公告)日：2009-03-19
申请号：US12263809
申请日：2008-11-03
申请人： Tatsuji ENOKI , Eiji Kobayashi , Kinuko Ogawa , Yoko Kudo , Masashige Tanabe , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
发明人： Tatsuji ENOKI , Eiji Kobayashi , Kinuko Ogawa , Yoko Kudo , Masashige Tanabe , Hiromu Ohnogi , Hiroaki Sagawa , Ikunoshin Kato
IPC分类号： A61K31/343 , A61K31/225 , A61K31/19 , A61K31/192 , A61K31/11 , A61P3/04 , A61P3/10
摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.
摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，胰岛素模拟作用剂，食物，饮料或饲料，用于增强葡萄糖摄入 细胞和用于诱导分化成脂肪细胞的药剂，其各自包含至少一种选自具有胰岛素模拟作用的特定化合物，其衍生物和其药理学上可接受的盐的至少一种化合物作为有效成分。
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