公开(公告)号：US10000797B2

公开(公告)日：2018-06-19

申请号：US15230162

申请日：2016-08-05

Applicant: University of Washington Through Its Center for Commercialization

Inventor： Daniel T. Chiu ,  Bryant S. Fujimoto ,  Alexander R. Gansen ,  Gloria S. Yen ,  Robert M. Lorenz

IPC: C12Q1/68

CPC classification number: C12Q1/6851 ,  C12Q1/6806 ,  C12Q2527/146 ,  C12Q2531/113 ,  C12Q2545/114

Abstract: Methods, devices and systems for performing digital measurements are provided.

公开(公告)号：US09997344B2

公开(公告)日：2018-06-12

申请号：US14891620

申请日：2014-05-30

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Dingsheng Liu

IPC: H01J49/10 ,  H01J49/16 ,  H01J49/04 ,  B05B5/025

CPC classification number: H01J49/165 ,  B05B5/025 ,  B05B5/03 ,  H01J49/0445

Abstract: The present disclosure describes devices and methods capable of generating multi-phase emulsions, including double emulsion droplets in a gas phase. The present disclosure also describes interfaces for coupling a multi-phase emulsion droplet source to an analytical instrument such as a mass spectrometer. The present disclosure further describes methods, systems, and apparatuses for using the devices and interfaces described to perform analysis, including mass spectrometry. The present disclosure also describes methods, systems, and apparatuses for generating and using multi-phase emulsions to perform analysis.

公开(公告)号：US20180080863A1

公开(公告)日：2018-03-22

申请号：US15563121

申请日：2016-04-01

Applicant: University of Washington

Inventor： Daniel T. Chiu ,  Chun-Ting Kuo ,  Jiangbo Yu

IPC: G01N15/14 ,  A61K49/00 ,  G01N33/58 ,  G01N21/25 ,  G01N21/64

CPC classification number: G01N15/1475 ,  A61K49/0019 ,  A61K49/0021 ,  C12N13/00 ,  C12Q1/68 ,  G01N15/147 ,  G01N21/25 ,  G01N21/64 ,  G01N33/582 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2015/1497

Abstract: The present disclosure provides a method of optically marking and sorting adherent cells. In some aspects, the method comprises: providing a plurality of adherent cells attached to a substrate, each adherent cell of the plurality of adherent cells comprising an optical marker; selectively applying light energy to a subset of the plurality of adherent cells; detaching the plurality of adherent cells from the substrate; and sorting the plurality of adherent cells.

公开(公告)号：US09797840B2

公开(公告)日：2017-10-24

申请号：US13687813

申请日：2012-11-28

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Fangmao Ye

IPC: B82Y15/00 ,  G01N21/64 ,  G01N33/58

CPC classification number: G01N21/6486 ,  B82Y15/00 ,  G01N33/588 ,  Y10T428/2982

Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.

公开(公告)号：US20130266957A1

公开(公告)日：2013-10-10

申请号：US13687813

申请日：2012-11-28

Applicant: University of Washington through its Center for Commercialization

Inventor： Daniel T. Chiu ,  Changfeng Wu ,  Fangmao Ye

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  B82Y15/00 ,  G01N33/588 ,  Y10T428/2982

Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.

Abstract translation: 提供荧光纳米粒子。 纳米颗粒由聚[2-甲氧基-5-（2-乙基己氧基）-1,4-（1-氰基亚乙烯基-1,4-亚苯基）]形成。 还提供了用于对纳米颗粒结合的靶进行成像的方法。