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71.发明申请公开(公告)号：US20180071537A1
公开(公告)日：2018-03-15
申请号：US15793913
申请日：2017-10-25
Applicant: Valencia Technologies Corporation
Inventor： David K. L. Peterson , Jeffrey H. Greiner
CPC classification number: A61N1/378 , A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782
Abstract: An implantable electroacupuncture device for treating a medical condition of a patient through application of electroacupuncture stimulation pulses to a target tissue location within the patient includes 1) a housing configured to be implanted beneath a skin surface of the patient, 2) pulse generation circuitry located within the housing and electrically coupled to at least two electrodes, the pulse generation circuitry being adapted to deliver stimulation sessions by way of the at least two electrodes to the target tissue location in accordance with a stimulation regimen, and 3) a primary battery contained within the housing and electrically coupled to the pulse generation circuitry, the primary battery having an internal impedance greater than 5 ohms and a capacity of less than 60 mAh, wherein the primary battery is the only battery that provides power to the pulse generation circuitry.
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72.发明申请公开(公告)号：US20180043163A1
公开(公告)日：2018-02-15
申请号：US15793891
申请日：2017-10-25
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy Greiner Chambliss
CPC classification number: A61N1/36071 , A61N1/0551 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3758 , A61N1/3782 , H01L2224/48091 , Y10T29/49002 , H01L2924/00014
Abstract: An exemplary method treating a chronic low back pain condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a target tissue location within the patient by way of an electrode array located within the patient at an acupoint corresponding to the target tissue location.
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73.发明授权公开(公告)号：US09603773B2
公开(公告)日：2017-03-28
申请号：US14805346
申请日：2015-07-21
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61H39/002 , A61H39/00 , A61H2201/01 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3782 , A61N1/3787 , Y10T29/49002
Abstract: An exemplary method treating a cardiovascular disease in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a median nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4, each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and the electroacupuncture device comprises a central electrode of a first polarity and an annular electrode of a second polarity and that is spaced apart from the central electrode; and 2) applying, by the electroacupuncture device, the stimulation sessions to the median nerve by way of the central electrode and the annular electrode in accordance with the duty cycle.
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74.发明申请Methods and Systems for Wireless Communication with a Subcutaneous Medical Device 审中-公开与皮下医疗器械无线通信的方法和系统公开(公告)号：US20170056679A1
公开(公告)日：2017-03-02
申请号：US15246489
申请日：2016-08-24
Applicant: Valencia Technologies Corporation
Inventor： David K. L. Peterson
CPC classification number: A61N1/37223 , A61H23/0218 , A61H39/002 , A61H2039/005 , A61H2201/0157 , A61H2201/1207 , A61H2201/165 , A61H2201/5012 , A61H2201/5033 , A61H2201/5038 , A61H2201/5043 , A61H2201/5058 , A61H2201/5066 , A61H2201/5097 , A61N1/0551 , A61N1/37205 , A61N1/37247 , A61N1/37276 , H04W48/10 , H04W52/0235 , H05K3/325 , H05K2201/09027 , H05K2201/10037 , Y02D70/00
Abstract: An exemplary subcutaneous medical device implanted within a patient uses a coil-less magnetic field sensor included within the subcutaneous medical device to detect a toggling sequence between a presence and an absence of an externally-generated static magnetic field. The toggling sequence is representative of a digital data stream according to a digital wireless communication protocol. The subcutaneous medical device identifies, based on the detected toggling sequence and in accordance with the digital wireless communication protocol, a multi-bit command encoded within the digital data stream represented by the toggling sequence. The subcutaneous medical device further performs, in response to the identifying of the multi-bit command, an action associated with the multi-bit command. Corresponding methods and a corresponding external controller are also disclosed.
Abstract translation: 植入患者体内的示例性皮下医疗装置使用包括在皮下医疗装置内的无线圈磁场传感器来检测存在和不存在外部产生的静磁场之间的切换顺序。 切换序列代表根据数字无线通信协议的数字数据流。 皮下医疗装置基于检测到的切换序列并根据数字无线通信协议来识别在由切换序列表示的数字数据流内编码的多比特命令。 皮下医疗装置还响应于多位命令的识别，执行与多位命令相关联的动作。 还公开了相应的方法和相应的外部控制器。
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75.发明授权Implantable electroacupuncture system and method for treating dyslipidemia and obesity 有权植入式电针系统及治疗血脂异常和肥胖的方法公开(公告)号：US09566212B2
公开(公告)日：2017-02-14
申请号：US14859088
申请日：2015-09-18
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy Greiner Chambliss
CPC classification number: A61H39/002 , A61F5/0026 , A61H2201/50 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61N1/36085 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
Abstract: An exemplary method of treating obesity or dyslipidemia of a patient using a small implantable electroacupuncture device (IEAD) includes 1) implanting the IEAD below the skin surface of the patient at or near a target tissue location selected from the group of target tissue locations comprising acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, LR8 and their underlying nerves, the saphenous nerve and the peroneal nerve, and 2) enabling the IEAD to provide EA stimulation pulses in accordance with a stimulation regimen that provides a stimulation session having a duration of T3 minutes at a rate of once every T4 minutes, where the ratio of T3/T4 is no greater than 0.05, and wherein T3 is at least 10 minutes and no greater than 60 minutes.
Abstract translation: 使用小型可植入电针装置（IEAD）治疗患者的肥胖症或血脂异常的示例性方法包括：1）在选自包括穴位的目标组织位置组中的目标组织位置处或附近将患者的皮肤表面植入患者的皮肤表面 ST36，SP4，ST37，ST40，SP6，SP9，K16，LR8及其潜在的神经，隐神经和腓神经，以及2）使IEAD能够根据提供刺激疗程的刺激方案提供EA刺激脉冲 以T3 / T4比不大于0.05的速度每T4分钟一次持续T3分钟，其中T3至少为10分钟且不大于60分钟。
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Patent Agency Ranking
76.发明申请Methods and Systems for Predicting Patient Responsiveness to Subcutaneous Neuromodulation Therapy as a Treatment for Hypertension 审中-公开用于预测患者对皮下神经调节治疗作为高血压治疗的反应的方法和系统公开(公告)号：US20160256115A1
公开(公告)日：2016-09-08
申请号：US15057106
申请日：2016-02-29
Applicant: Valencia Technologies Corporation
Inventor： David K. L. Peterson
Abstract: An exemplary method includes determining a variability of a plurality of measurements of a cardiovascular parameter of a patient suffering from hypertension, the plurality of measurements recorded one at a time over a predetermined time period. The method further includes comparing the determined variability with a predetermined reference value. If the comparing indicates that the determined variability is less than the predetermined reference value, the method includes designating the patient to be within a first class of patients representative of patients that are likely to be responsive to subcutaneous neuromodulation therapy as a treatment for hypertension. If the comparing indicates that the determined variability is greater than the predetermined reference value, the method includes designating the patient to be within a second class of patients representative of patients that are likely to be unresponsive to subcutaneous neuromodulation therapy as a treatment for hypertension. Corresponding systems and methods are also described.
Abstract translation: 示例性方法包括确定患有高血压的患者的心血管参数的多个测量的可变性，所述多个测量在预定时间段内一次记录一次。 该方法还包括将所确定的变异性与预定参考值进行比较。 如果比较表明确定的变异性小于预定参考值，则该方法包括指定患者在代表可能对皮下神经调节治疗作出响应的患者的第一类患者中作为高血压的治疗。 如果比较表明确定的变异性大于预定参考值，则该方法包括将患者指定为代表可能对皮下神经调节治疗无反应的患者的第二类患者作为高血压的治疗。 还描述了相应的系统和方法。
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77.发明申请公开(公告)号：US20150328460A1
公开(公告)日：2015-11-19
申请号：US14811633
申请日：2015-07-28
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy Greiner Chambliss
CPC classification number: A61N1/36071 , A61N1/0551 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3758 , A61N1/3782 , H01L2224/48091 , Y10T29/49002 , H01L2924/00014
Abstract: An exemplary method of treating a chronic low back pain condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at at least one of acupoints BL22, BL23, BL24, BL25, and BL26 within the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4 and each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and 2) applying, by the electroacupuncture device, the stimulation sessions to the target tissue location in accordance with the duty cycle.
Abstract translation: 一种治疗患者慢性腰痛症状的示例性方法包括：通过在患者体内植入患者皮肤表面下方的电针BL22，BL23，BL24，BL25和BL26中的至少一个产生电刺激装置 ，小于0.05的占空比的刺激会话，其中占空比是T3到T4的比例，并且包括在刺激会话中的每个刺激会话具有T3分钟的持续时间并以每T4分钟一次的速率发生， 和2）根据占空比通过电针装置将刺激会话应用于目标组织位置。
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78.发明申请Implantable Electroacupuncture Device and Method for Treating Erectile Dysfunction 有权植入式电针装置及治疗勃起功能障碍的方法公开(公告)号：US20150313750A1
公开(公告)日：2015-11-05
申请号：US14799492
申请日：2015-07-14
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61F5/41 , A61F2005/418 , A61H39/002 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61H2205/087 , A61N1/18 , A61N1/36107 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/362 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49002
Abstract: An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD includes an IEAD housing having an electrode configuration thereon that includes at least two electrodes, and pulse generation circuitry located within the IEAD housing and electrically coupled to the at least two electrodes. The pulse generation circuitry is adapted to deliver EA stimulation pulses to the patient's body tissue at or near the target tissue location in accordance with a specified stimulation regimen, the stimulation regimen requiring that the stimulation session have a duration of T3 minutes and a rate of occurrence of once every T4 minutes, and wherein a ratio of T3/T4 is no greater than 0.05.
Abstract translation: 可植入电针装置（IEAD）通过施加施加在穴位BL52，BL23或GV4中的至少一个穴位下方或附近的目标组织位置处的刺激脉冲来治疗患者的勃起功能障碍状况。 IEAD包括其上具有电极配置的IEAD外壳，其包括至少两个电极，以及位于IEAD外壳内并电耦合到至少两个电极的脉冲发生电路。 脉冲发生电路适于根据指定的刺激方案将EA刺激脉冲输送到目标组织位置处或附近的患者身体组织，刺激方案要求刺激疗程具有T3分钟的持续时间和出现发生率 每T4分钟一次，其中T3 / T4的比例不大于0.05。
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公开(公告)号：US20150265498A1
公开(公告)日：2015-09-24
申请号：US14722345
申请日：2015-05-27
Applicant: Valencia Technologies Corporation
Inventor： David K. L. Peterson , Chuladatta H. Thenuwara
CPC classification number: A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/04 , A61N1/0504 , A61N1/36117 , A61N1/36125 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782
Abstract: An implantable electroacupuncture device (IEAD) treats a disease or medical condition of a patient through application of stimulation pulses applied at a specified acupoint or other target tissue location at a very low duty cycle. In a preferred implementation, the IEAD is an implantable, coin-sized, self-contained, leadless device having at least two electrodes attached to an outside surface of its housing, with at least one electrode on the top or bottom surface of the housing functioning as a cathode, and at least one electrode on the perimeter edge of the housing functioning as an anode. The electrodes may be segmented to include an array of smaller cathodic or anodic electrodes, each of which may be selectively turned ON or OFF so as to provide a convenient mechanism for adjusting the density of the stimulus current flowing through the cathodic electrode surface area.
Abstract translation: 可植入电针装置（IEAD）通过在非常低的占空比下施加在特定穴位或其他目标组织位置施加的刺激脉冲来治疗患者的疾病或医疗状况。 在优选的实施方案中，IEAD是可植入的，硬币尺寸的独立的无引线装置，其具有附接到其壳体的外表面的至少两个电极，其中壳体的顶部或底部表面上的至少一个电极起作用 作为阴极，并且在壳体的周边边缘上的至少一个电极用作阳极。 电极可以被分段以包括更小的阴极或阳极电极的阵列，每个电极可被选择性地导通或关闭，以便提供用于调节流过阴极电极表面区域的刺激电流的密度的方便的机构。
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80.发明申请公开(公告)号：US20150231030A1
公开(公告)日：2015-08-20
申请号：US14669145
申请日：2015-03-26
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61H39/002 , A61H39/00 , A61H2201/01 , A61N1/3606 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/37223 , A61N1/3756 , A61N1/3782 , A61N1/3787 , Y10T29/49002
Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats cardiovascular disease through application of stimulation pulses applied at at least one of acupoints EX-HN1, BL14, HT7, HT5, PC6, ST36, LI11, LU7, and LU2. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4 is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在穴位EX-HN1，BL14，HT7，HT5，PC6，ST36，LI11，LU7和LU2中的至少一个上施加的刺激脉冲来治疗心血管疾病。 IEAD包括可植入的硬币尺寸的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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