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    NF-kappaB oligonucleotide decoy molecules
    71.
    发明申请
    NF-kappaB oligonucleotide decoy molecules 失效
    NF-κB寡核苷酸诱饵分子

    公开(公告)号：US20050182012A1

    公开(公告)日：2005-08-18

    申请号：US11004512

    申请日：2004-12-02

    申请人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

    发明人： Leslie McEvoy ,  Christi Parham ,  Jie Zhang ,  Rolf Ehrhardt

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/115

    CPC分类号： C12N15/115 ,  C12N15/113 ,  C12N2310/13 ,  C12N2310/315 ,  C12N2310/345 ,  C12N2310/53

    摘要： The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.

    摘要翻译： 本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-kappaB dsODN）分子。 在一个特定方面，本发明涉及在p50 / p50同源二聚体上优先结合p50 / p65和/或cRel / p50异二聚体的NF-kappaB诱饵分子。 另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

    PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
    73.
    发明授权
    PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same 失效
    PARP抑制剂，包含其的药物组合物及其使用方法

    公开(公告)号：US06635642B1

    公开(公告)日：2003-10-21

    申请号：US09145176

    申请日：1998-09-01

    申请人： Paul F. Jackson ,  Jia-He Li ,  Keith M. Maclin ,  Jie Zhang

    发明人： Paul F. Jackson ,  Jia-He Li ,  Keith M. Maclin ,  Jie Zhang

    IPC分类号： A61K3150

    CPC分类号： A61K31/4725 ,  C07C233/65 ,  C07D209/56 ,  C07D217/24 ,  C07D217/26 ,  C07D221/12 ,  C07D221/14 ,  C07D221/18 ,  C07D237/26 ,  C07D237/32 ,  C07D243/14 ,  C07D267/14 ,  C07D491/06 ,  C07D495/04 ,  C07D495/06

    摘要： The present invention relates to PARP inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat tissue damage resulting from cell damage or death due to necrosis or apoptosis, effect neuronal activities not mediated by NMDA toxicity; to treat neural tissue damage resulting from ischemia and reperfusion injury, neurological disorders and neurodegenerative diseases; to prevent or treat vascular stroke; to treat or prevent cardiovascular disorders; to treat other conditions and/or disorders such as age-related macular degeneration, AIDS and other immune senescence diseases, arthritis, atherosclerosis, cachexia, cancer, degenerative diseases of skeletal muscle involving replicative senescence, diabetes, head trauma, immune senescence, inflammatory bowel disorders (such as colitis and Crohn's disease), muscular dystrophy, osteoarthritis, osteoporosis, chronic and/or acute pain (such as neuropathic pain), renal failure, retinal ischemia, septic shock (such as endotoxic shock), organ damage due to transplantation, and skin aging; to extend the lifespan and proliferative capacity of cells; to alter gene expression of senescent cells; or to radiosensitize hypoxic tumor cells.

    摘要翻译： 本发明涉及PARP抑制剂，包含其的药物组合物及其用途，用于治疗由于坏死或凋亡引起的细胞损伤或死亡引起的组织损伤，影响不被NMDA毒性介导的神经元活性; 治疗由缺血和再灌注损伤，神经系统疾病和神经退行性疾病引起的神经组织损伤; 预防或治疗血管中风; 治疗或预防心血管疾病; 治疗年龄相关性黄斑变性，艾滋病和其他免疫衰老疾病，关节炎，动脉粥样硬化，恶病质，癌症，涉及复制衰老的骨骼肌退行性疾病，糖尿病，头部创伤，免疫衰老，炎性肠等其他病症和/或病症 疾病（如结肠炎和克罗恩病），肌营养不良症，骨关节炎，骨质疏松症，慢性和/或急性疼痛（如神经性疼痛），肾衰竭，视网膜缺血，败血性休克（如内毒素性休克），移植器官损伤 ，皮肤老化; 延长细胞的寿命和增殖能力; 改变衰老细胞的基因表达; 或放射性敏感的缺氧性肿瘤细胞。

    Method for manufacturing a heat generating apparatus
    74.
    发明授权
    Method for manufacturing a heat generating apparatus 有权
    制造发热装置的方法

    公开(公告)号：US06453648B1

    公开(公告)日：2002-09-24

    申请号：US09347963

    申请日：1999-07-06

    申请人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    发明人： Jie Zhang ,  Hao Zhang ,  Larry Rigby ,  Wade A. Hull

    IPC分类号： A61F700

    CPC分类号： A61F7/034 ,  A61F2007/0226 ,  A61F2007/0249

    摘要： The present invention relates to a method for manufacturing a heating device which is capable of generating heat when exposed to oxygen. The heat generating element comprises activated carbon and iron is used to generate an exothermic oxidation reaction within the heating device. Introducing an oxidation inhibitor during the manufacturing process allows the manufacturing of the device to take place in ambient atmospheric conditions. The present invention also includes a loading facilitator which allows the heat generating medium to be more easily and efficiently loaded into the heat generating device. When appropriate, the oxidation inhibitor and loading facilitator can be removed.

    摘要翻译： 本发明涉及一种能够在暴露于氧气时产生热量的加热装置的制造方法。 发热元件包括活性炭和铁，用于在加热装置内产生放热氧化反应。 在制造过程中引入氧化抑制剂可使装置的制造在环境大气条件下进行。 本发明还包括能够使发热介质更容易且有效地装载到发热装置中的负载辅助装置。 适当时，可以除去氧化抑制剂和负载促进剂。

    Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity
    76.
    发明授权
    Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity 失效
    烷氧基取代的化合物，用于抑制parp活性的方法和组合物

    公开(公告)号：US06426415B1

    公开(公告)日：2002-07-30

    申请号：US09079508

    申请日：1998-05-15

    申请人： Paul F. Jackson ,  Keith M. Maclin ,  Jie Zhang

    发明人： Paul F. Jackson ,  Keith M. Maclin ,  Jie Zhang

    IPC分类号： C07D23730

    CPC分类号： C07D471/06 ,  C07D217/22 ,  C07D217/24 ,  C07D221/12 ,  C07D221/18 ,  C07D237/30 ,  C07D237/32 ,  C07D237/34 ,  C07D239/88 ,  C07D239/93 ,  C07D239/94 ,  C07D475/02 ,  C07D491/04 ,  C07F9/6561

    摘要： A compound of formula I: or a pharmaceutically acceptable salt, prodrug, metabolite, optical isomer or stereoisomer thereof, wherein: R1, when present, is hydrogen or lower alkyl; R2 is lower alkyl, aryl, aralkyl, lower alkanoyl, or —(CH2)n—(CHOH)y(CH2)mA, wherein n is 1-4, y is 0 or 1, m is 0-5, and A is cycloalkyl, cycloalkenyl, lower alkanoyl, aryl, aralkyl, —NH2, —NH-(lower alkyl), Y represents the atoms necessary to form a fused 5- to 6-membered ring that is aromatic or nonaromatic and carbocyclic or heterocyclic; Z is (i) —CHR2CHR3— where R2 and R3 are independently hydrogen, alkyl, aryl or aralkyl; (ii) —R6C═CR3— where R6 and R3 are independently hydrogen, lower alkyl, aryl, aralkyl, chlorine, bromine or —NR7R8, where R7 and R8 are independently hydrogen or lower alkyl, or, R6 and R3, taken together, form a fused 5- to 6-membered ring that is aromatic or nonaromatic and carbocyclic or heterocyclic; (iii) —R2C═N—; (iv) —CR2(OH)—NR7—; or (v) —C(O)—NR7—.

    摘要翻译： 式I的化合物或其药学上可接受的盐，前药，代谢物，旋光异构体或立体异构体，其中：当存在时，R 1为氢或低级烷基; R 2为低级烷基，芳基，芳烷基，低级烷酰基或 - （ CH2）n-（CHOH）y（CH2）mA，其中n为1-4，y为0或1，m为0-5，A为环烷基，环烯基，低级烷酰基，芳基，芳烷基，-NH2， NH-（低级烷基），Y表示形成芳族或非芳族和碳环或杂环的稠合5-至6-元环所必需的原子; Z为（i）-CHR2CHR3-，其中R2和R3独立地为氢，烷基 ，芳基或芳烷基;（ii）-R6C = CR3-，其中R6和R3独立地为氢，低级烷基，芳基，芳烷基，氯，溴或-NR7R8，其中R7和R8独立地为氢或低级烷基，或R6和 R 3一起形成芳族或非芳族和碳环或杂环的稠合的5-至6-元环;（iii）-R2C = N - ;（iv）-CR2（OH）-NR7-; 或（ⅴ）-C（O）-NR7-。

    Heating stove
    79.
    外观设计
    Heating stove 有权

    公开(公告)号：USD1028195S1

    公开(公告)日：2024-05-21

    申请号：US29832191

    申请日：2022-03-25

    申请人： Jie Zhang

    设计人： Jie Zhang

    摘要： FIG. 1 is a perspective view of a heating stove, showing my new design;
    FIG. 2 is another perspective view thereof;
    FIG. 3 is a front view thereof;
    FIG. 4 is a rear view thereof;
    FIG. 5 is a left side view thereof;
    FIG. 6 is a right side view thereof;
    FIG. 7 is a top plan view thereof;
    FIG. 8 is a bottom plan view thereof; and,
    FIG. 9 is an enlarged view of portion of FIG. 1.
    The dash-dash broken line showing of the heating stove is for the purpose of illustrating the article and forms no part of the claimed design. The dot-dash broken lines shown in FIGS. 1 & 9 define the boundary of the enlargement area and form no part of the claimed design.

    Web development system
    80.
    发明授权
    Web development system 有权

    公开(公告)号：US09904522B2

    公开(公告)日：2018-02-27

    申请号：US15038602

    申请日：2014-11-24

    申请人： Jie Zhang ,  Xun Shao

    发明人： Jie Zhang ,  Xun Shao

    IPC分类号： G06F9/44 ,  G06F17/30 ,  G06F3/048 ,  G06F3/00 ,  G06F9/455 ,  G06F9/445

    CPC分类号： G06F8/31 ,  G06F8/30 ,  G06F8/65 ,  G06F8/656 ,  G06F9/45529

    摘要： The present invention provides a web development system. In a running state of a web application being developed, the development system generates or modifies a script code used to perform a predetermined function. The development system includes a script parser that parses the generated script code or the modified script code to correspondingly generate an object type which performs a new function, or to modify the object type which performs an existing function. The development system also includes an object manager that generates a new function object or modifies the existing function object according to the generated object type and organizes the invoking relationships between the new or modified function object and other objects, so as to generate or modify the predetermined function when the web application is operating.