公开(公告)号：US20050148498A1

公开(公告)日：2005-07-07

申请号：US10985988

申请日：2004-11-12

Applicant: Philippe Msika ,  Antoine Piccirilli ,  Francois Paul

Inventor： Philippe Msika ,  Antoine Piccirilli ,  Francois Paul

IPC: A23L1/30 ,  A23L1/305 ,  A61K8/06 ,  A61K8/64 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61K36/48 ,  A61K38/55 ,  A61K38/56 ,  A61P1/02 ,  A61P9/00 ,  A61P9/14 ,  A61P17/00 ,  A61P17/02 ,  A61P17/16 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P39/00 ,  A61P43/00 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/08 ,  C07K14/415 ,  C12N9/99 ,  A61K38/16 ,  C07K14/42

CPC classification number: C07K14/415 ,  A61K8/645 ,  A61K36/48 ,  A61K2800/782 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: A composition comprising a hydrolyzed peptide extract of a lupin and a method of producing the same.

Abstract translation: 包含羽扇豆的水解肽提取物的组合物及其制备方法。

公开(公告)号：US20210236574A1

公开(公告)日：2021-08-05

申请号：US17239042

申请日：2021-04-23

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Sophie LECLERE-BIENFAIT ,  Stéphanie BREDIF

IPC: A61K36/185 ,  A61K8/49 ,  A61Q17/04 ,  A61Q19/08 ,  A61Q19/06 ,  A61Q17/00 ,  A61Q19/00 ,  A61K8/9789 ,  A61P17/16 ,  A61P29/00 ,  A61K8/368 ,  A61K31/192 ,  A61K31/353

Abstract: The invention relates to a polyphenolic extract of passion flower seeds, in particular Passiflora incarnata or Passiflora edulis seeds, comprising at least 30 percent by weight polyphenols, expressed as gallic acid equivalent, relative to the weight of the dry extract. The invention also relates to a method for preparing an extract of said type, a composition containing same, and the cosmetic, dermatological or therapeutic use thereof.

公开(公告)号：US11026880B2

公开(公告)日：2021-06-08

申请号：US14652449

申请日：2013-12-18

Applicant: Laboratoires Expanscience

Inventor： Philippe Msika ,  Sophie Leclere-Bienfait ,  Sebastien Debrock ,  Stephanie Bredif ,  Sebastien Garnier

IPC: A61K8/97 ,  A61Q19/08 ,  A61K36/185 ,  A61Q19/06 ,  A61Q17/00 ,  A61K8/60 ,  A61K8/64 ,  A61K45/06 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q7/00

Abstract: The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.

公开(公告)号：US20210093685A1

公开(公告)日：2021-04-01

申请号：US16956220

申请日：2018-12-21

Applicant: Laboratoires Expanscience

Inventor： Sophie Leclere-Bienfait ,  Stéphanie Bredif

IPC: A61K36/185 ,  A61K8/365 ,  A61K8/9789 ,  A61Q19/08 ,  A61Q19/00

Abstract: The invention relates to an extract of flowers, preferably calyxes, from kapok trees, in particular Bombax costatum, to a process for preparing same and to the extract obtainable by said process. The invention also relates to a composition comprising such an extract, the composition being advantageously a cosmetic, pharmaceutical or dermatological composition. The invention also relates to such a composition or such an extract for use in preventing or treating disorders or diseases of the skin, the mucous membranes or keratinous appendages and for use in preventing or treating vascular disorders. The invention finally relates to a cosmetic care process for the skin, the keratinous appendages or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which process consists in administering such a composition or such an extract.

公开(公告)号：US10688142B2

公开(公告)日：2020-06-23

申请号：US16243491

申请日：2019-01-09

Applicant: Laboratoires Expanscience

Inventor： Sophie Leclere-Bienfait ,  Stephanie Bredif ,  Sebastien Debrock ,  Sebastien Garnier

IPC: A61K36/185 ,  A61Q19/00 ,  A61Q19/08 ,  A61K8/97 ,  A23L33/105 ,  A61Q19/06 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A23D9/007 ,  C11B3/00 ,  A61P17/02 ,  A61K8/31 ,  A61K8/36 ,  A61K8/63 ,  A61K8/67 ,  A61K8/92 ,  A61K31/01 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/355 ,  A61K31/56 ,  A61Q19/04 ,  C11B3/02 ,  C11B3/12

Abstract: A method to treat skin or mucosa cells or disorders related to dermal tissue by topically administering to a person in a need thereof a lipid extract from Passiflora seeds selected from Passiflora incarnate seeds, Passiflora edulis seeds, and a combination thereof, wherein said lipid extract is oil of Passiflora seeds concentrated in its unsaponifiable fraction containing 3 to 100 weight % of unsaponifiables relative to the total weight of the extract.

公开(公告)号：US20200085897A1

公开(公告)日：2020-03-19

申请号：US16580826

申请日：2019-09-24

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Alex SAUNOIS ,  Caroline BAUDOUIN ,  Sophie LECLERE-BIENFAIT ,  Sebastien GARNIER ,  Philippe MSIKA

IPC: A61K36/31 ,  A61Q19/08 ,  A61K8/49 ,  A61K8/368 ,  A23L33/105 ,  A61K8/97 ,  A61K31/05 ,  A61K31/197 ,  A61K31/198 ,  A61K31/201 ,  A61K31/341 ,  A61K31/42 ,  A61K31/57 ,  A61K31/585 ,  A61K31/715 ,  A61K31/717 ,  A61K33/30 ,  A61K36/28 ,  A61K36/48 ,  A61K36/54 ,  A61K36/899 ,  A61K38/00 ,  A61K45/00

Abstract: The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.

公开(公告)号：US20190242880A1

公开(公告)日：2019-08-08

申请号：US16062488

申请日：2016-12-16

Applicant: Laboratoires Expanscience

Inventor： Stephanie BREDIF ,  Caroline BAUDOUIN

IPC: G01N33/50 ,  G01N33/68 ,  C12N5/071 ,  C12Q1/6883

CPC classification number: G01N33/5088 ,  C12N5/0698 ,  C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/6881

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US20190008757A1

公开(公告)日：2019-01-10

申请号：US16073728

申请日：2017-01-27

Applicant: Laboratoires Expanscience

Inventor： Sophie LECLERE-BIENFAIT ,  Philippe MSIKA

IPC: A61K8/9789 ,  A61K8/368 ,  A61K8/37 ,  A61Q19/00 ,  A61Q19/08

Abstract: The invention relates to a cosmetic or dermatological composition containing a polyphenol-enriched extract of Vitex Negundo, typically a root extract obtained using a PAT plant milking®process. The invention further relates to a composition of this kind for use in the prevention or treatment of disorders and diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of extrinsic or intrinsic skin aging. Lastly, the invention relates to a cosmetic care method for the skin, skin appendages or mucous membranes, with a view to improving the condition or appearance thereof, said method consisting in administering such a composition or such an extract.

公开(公告)号：US20170241985A1

公开(公告)日：2017-08-24

申请号：US15310303

申请日：2015-05-15

Applicant: Laboratoires Expanscience

Inventor： Nadege Lachman ,  Philippe MSIKA ,  Joachim Fluhr

IPC: G01N33/50 ,  A61B5/00

CPC classification number: G01N33/5026 ,  A61B5/442 ,  A61B5/4848 ,  G01N33/5044 ,  G06T7/0012

Abstract: The present invention relates to a method for determining the relief of the skin surface of a subject, and hence the degree of maturation of the said skin surface. Methods for identifying active agents, raw materials and formulation are also provided.

公开(公告)号：US20160326492A1

公开(公告)日：2016-11-10

申请号：US15110826

申请日：2015-01-12

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Stephanie BREDIF ,  Caroline BAUDOUIN ,  Philippe MSIKA ,  Marisa MELONI

IPC: C12N5/071 ,  G01N33/50 ,  C07K14/78

CPC classification number: C12N5/0629 ,  C07K14/495 ,  C07K14/52 ,  C07K14/78 ,  C12N5/0698 ,  C12N9/0006 ,  C12N2533/54 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2333/47 ,  G01N2333/495 ,  G01N2333/525 ,  G01N2333/7055 ,  G01N2333/904

Abstract: A first subject of the invention is a skin model characterized in that it comprises keratinocytes capable of overexpressing filaggrin. A second subject of the invention is a method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, characterized in that said method comprises at least the following steps: a) bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion; b) measuring the level of production of at least one biological marker in the nipple skin model of step a), characterized in that said biological marker can be chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin; c) comparing the level of production of at least one biological marker obtained in step b) with a reference level of production; evaluating the efficacy of said active agent or of said formulation according to the comparison of step c).

Abstract translation: 本发明的第一主题是皮肤模型，其特征在于其包含能够过表达丝聚蛋白的角质形成细胞。 本发明的第二个主题是用于评估制剂或至少一种活性剂对乳头皮肤愈合和/或降低乳头皮肤炎症的体外活性的方法，其特征在于所述方法至少包括 以下步骤：a）使所述活性剂或所述制剂与包含过表达丝聚蛋白并且还包含病变的角质形成细胞的皮肤模型接触; b）测量步骤a）的乳头皮肤模型中至少一种生物标志物的产生水平，其特征在于所述生物标志物可以选自乳酸脱氢酶（LDH），TNFα，丝聚蛋白，TGFβ1和β1整联蛋白; c）将步骤b）中获得的至少一种生物标志物的产量水平与参考生产水平进行比较; 根据步骤c）的比较评估所述活性剂或所述制剂的功效。