公开(公告)号：US08476422B2

公开(公告)日：2013-07-02

申请号：US13216942

申请日：2011-08-24

申请人： James C. Carrington ,  Edwards Allen

发明人： James C. Carrington ,  Edwards Allen

IPC分类号： C12N15/113 ,  C12N15/63 ,  C12N15/82

CPC分类号： C12N15/8279 ,  C12N15/111 ,  C12N15/113 ,  C12N15/8218 ,  C12N15/8245 ,  C12N15/8246 ,  C12N15/8247 ,  C12N15/8251 ,  C12N15/8261 ,  C12N15/8271 ,  C12N15/8274 ,  C12N15/8281 ,  C12N15/8283 ,  C12N15/8285 ,  C12N2310/14 ,  C12N2320/11

摘要： A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted duplications or dual promoters so as to form perfect or largely double -stranded RNA. Rather, the method depends on constructs that yield single-stranded RNA transcripts, and exploits endogenous or in vivo-produced miRNAs or siRNAs to initiate production of siRNAs. The miRNAs or siRNAs guide cleavage of the transcript and set the register for production of siRNAs (usually 21 nucleotides in length) encoded adjacent to the initiation cleavage site within the construct. The method results in specific formation of siRNAs of predictable size and register (phase) relative to the initiation cleavage site. The method can be used to produce specific siRNAs in vivo for inactivation or suppression of one or more target genes or other entities, such as pathogens.

公开(公告)号：US08419945B2

公开(公告)日：2013-04-16

申请号：US13412597

申请日：2012-03-05

申请人： David M. Browning ,  James R. Curtis ,  Goran Nadezda Jovanovic ,  Brian Kevin Paul ,  Sundar Atre

发明人： David M. Browning ,  James R. Curtis ,  Goran Nadezda Jovanovic ,  Brian Kevin Paul ,  Sundar Atre

IPC分类号： B01D61/28 ,  B01D61/24

CPC分类号： A61M1/16 ,  A61M2205/0244 ,  B01D61/28 ,  B01D63/081 ,  B01D63/082 ,  B01D2313/08 ,  B01D2313/14

摘要： The present invention provides methods and apparatus for cleansing blood through hemodialysis by the process of diffusion across a membrane into dialysate. This dialyzer also removes solutes from the blood by a process of convection, where fluid and dissolved solutes pass through the membrane out of the blood. In one embodiment in accordance with the present invention, the MECS dialyzer uses a counter-flow between the dialysate and blood through a plurality of microchannels. The dialyzer comprises a plurality of flat semi-permeable membranes interleaved between microchannel sheets to define a plurality of flow channels. The stack of membranes and microchannel sheets are aligned and consolidated to form the MECS dialyzer. The MECS dialyzer acts as a flow manifold with ports and headers to collect the blood and dialysate and direct them to and from the microchannels.

摘要翻译： 本发明提供了通过血液透析清洗血液的方法和装置，该方法和装置通过膜扩散到透析液中。 这种透析器还可以通过对流过程从血液中除去溶质，其中流体和溶解的溶质通过膜离开血液。 在根据本发明的一个实施方案中，MECS透析器通过多个微通道使用透析液和血液之间的逆流。 所述透析器包括在微通道片之间交错以形成多个流动通道的多个平坦的半透膜。 膜和微通道片的堆叠被对准和固结以形成MECS透析器。 MECS透析器充当具有端口和头部的流量歧管，用于收集血液和透析液，并将其引导到微通道和从微通道引导。

公开(公告)号：US20120176681A1

公开(公告)日：2012-07-12

申请号：US13189411

申请日：2011-07-22

申请人： Chih-hung Chang ,  Seung-Yeol Han ,  Brian K. Paul

发明人： Chih-hung Chang ,  Seung-Yeol Han ,  Brian K. Paul

IPC分类号： G02B1/11 ,  B01J19/10 ,  B05D5/06 ,  C23C16/50 ,  B01J19/08 ,  B01J19/12 ,  B82Y20/00 ,  B82Y99/00

CPC分类号： G02B1/118 ,  B01F5/0256 ,  B01F13/0059 ,  B01F13/0066 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/00846 ,  B01J2219/00889 ,  B01J2219/00943 ,  B82Y20/00 ,  B82Y30/00 ,  C23C18/1212 ,  C23C18/1216 ,  C23C18/1225 ,  G02B1/14 ,  Y10T428/25

摘要： Embodiments of the present system and method are useful for chemical deposition, particularly continuous deposition of anti-reflective films. Disclosed systems typically comprise a micromixer and a microchannel applicator. A deposition material or materials is applied to a substrate to form a nanostructured, anti-reflective coating. Uniform and highly oriented surface morphologies of films deposited using disclosed embodiments are clearly improved compared to films deposited by a conventional batch process. In some embodiments, a scratch-resistant, anti-reflective coating is applied to a polycarbonate substrate, such as a lens. In certain embodiments, an anti-reflective coating is applied to a surface of a solar catalytic microreactor suitable for performing endothermic reactions, where energy is provided to the reactor by absorption of solar radiation. The composition and morphology of the material deposited on a substrate can be tailored. The process can be used at low temperatures as a post-deposition, high-temperature annealing step is obviated.

摘要翻译： 本发明的系统和方法的实施例对于化学沉积，特别是抗反射膜的连续沉积是有用的。 公开的系统通常包括微混合器和微通道施加器。 将沉积材料或材料施加到基底以形成纳米结构的抗反射涂层。 使用所公开的实施例沉积的膜的均匀且高度取向的表面形态与通过常规间歇方法沉积的膜相比显然改善。 在一些实施例中，将防刮擦的抗反射涂层施加到聚碳酸酯基底，例如透镜。 在某些实施方案中，将抗反射涂层施加到适于进行吸热反应的太阳能催化微反应器的表面，其中通过吸收太阳辐射将能量提供给反应器。 沉积在基底上的材料的组成和形态可以被定制。 该方法可以在低温下使用，因为后期沉积，高温退火步骤被消除。

公开(公告)号：US08170173B2

公开(公告)日：2012-05-01

申请号：US12121733

申请日：2008-05-15

申请人： Jose N. Reyes, Jr. ,  John T. Groome

发明人： Jose N. Reyes, Jr. ,  John T. Groome

IPC分类号： G21C9/00

CPC分类号： G21C9/012 ,  G21C1/32 ,  G21C9/00 ,  G21C15/18 ,  G21C15/26 ,  G21Y2002/201 ,  G21Y2002/304 ,  G21Y2004/30 ,  G21Y2004/40 ,  Y02E30/40

摘要： A power module assembly includes a reactor vessel containing a reactor core surrounded by a primary coolant. A containment vessel is adapted to be submerged in a containment cooling pool and to prohibit a release of the primary coolant outside of the containment vessel. A secondary cooling system is configured to remove heat generated by the reactor core. The heat is removed by circulating liquid from the containment cooling pool through the primary coolant.

摘要翻译： 功率模块组件包括反应器容器，其包含由主冷却剂包围的反应堆芯。 容纳容器适于浸没在容纳冷却池中，并且禁止将一次冷却剂释放到容纳容器外部。 二级冷却系统构造成去除由反应堆堆芯产生的热量。 通过将液体从容纳冷却池循环通过主冷却剂来除去热量。

公开(公告)号：US08137554B2

公开(公告)日：2012-03-20

申请号：US13068037

申请日：2011-04-29

申请人： Goran Jovanovic ,  Sundar V. Atre ,  Brian Kevin Paul ,  John Simonsen ,  Vincent Thomas Remcho ,  Chih-Hung Chang

发明人： Goran Jovanovic ,  Sundar V. Atre ,  Brian Kevin Paul ,  John Simonsen ,  Vincent Thomas Remcho ,  Chih-Hung Chang

IPC分类号： B01D63/00 ,  B01D61/00 ,  C02F1/44

CPC分类号： B01D61/18 ,  A61M1/16 ,  A61M1/1698 ,  A61M1/3472 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  B01D63/08 ,  B01D63/088 ,  B01D71/10 ,  B01D71/68 ,  B01D2313/21 ,  B01D2313/38

摘要： The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis devices. Generally, such devices comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. The fluids can both be liquids, gases, or a liquid and a gas, such as may be used for gas absorption into a liquid. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters; etc. Examples of devices made according to the present invention included an oxygenator, a dialzyer, microheat exchangers, etc. Particular materials had to be developed for use with certain embodiments of the device disclosed herein. For example, a new composite material was made comprising nanocrystalline cellulose filler and a polysulfone polymeric material. A dialyzer comprising the composite membrane also is disclosed. In order to make the nanocrystalline cellulose-polymer composite, a new method was devised for making an organic dispersion of nanocrystalline cellulose. The method comprised first forming an aqueous dispersion of nanocrystalline cellulose. A mixture was then formed comprising the aqueous dispersion and an organic liquid having a boiling point higher than water. The water was then selectively removed to form a second mixture comprising the nanocrystalline cellulose and the organic liquid.

摘要翻译： 本公开描述了可用于微量流体纯化，分离和合成装置的装置。 通常，这样的装置包括流体膜，其分离流过与膜操作性相关联的多个微通道的两个或更多个流体。 流体可以是液体，气体或液体和气体，例如可以用于气体吸收到液体中。 通常，膜是半透膜，例如可以与过滤装置如透析器一起使用。 本发明的装置可以与其他微型装置组合以制造系统。 例如，所述装置可以与一个或多个微化学微生物，一个或多个微混合器，一个或多个微加热器结合; 根据本发明制造的装置的实例包括氧合器，拨动器，微热交换器等。必须开发特定的材料以用于本文公开的装置的某些实施例。 例如，制备了包含纳米晶纤维素填料和聚砜聚合物材料的新型复合材料。 还公开了包含复合膜的透析器。 为了制备纳米晶纤维素 - 聚合物复合材料，设计了一种制备纳米晶纤维素有机分散体的新方法。 该方法首先形成纳米晶体纤维素的水性分散体。 然后形成包含水分散体和沸点高于水的有机液体的混合物。 然后选择性地除去水以形成包含纳米晶体纤维素和有机液体的第二混合物。

公开(公告)号：USRE42700E1

公开(公告)日：2011-09-13

申请号：US12179865

申请日：2008-07-25

申请人： Marcia Dawson ,  Joseph A. Fontana ,  Xiao-Kun Zhang ,  Mark Leid ,  Ling Jong ,  Peter D. Hobbs

发明人： Marcia Dawson ,  Joseph A. Fontana ,  Xiao-Kun Zhang ,  Mark Leid ,  Ling Jong ,  Peter D. Hobbs

IPC分类号： A61K31/54

CPC分类号： C07D311/82 ,  C07C59/54 ,  C07C59/56 ,  C07C59/72 ,  C07C59/76 ,  C07C235/08 ,  C07C235/52 ,  C07C255/57 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/42 ,  C07D311/66 ,  C07D311/74

摘要： The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of cancer or for treating disease conditions caused by apoptosis of cells.

摘要翻译： 本发明提供作为细胞周期停滞前的细胞凋亡的诱导剂或抑制剂的化合物。 此外，本发明提供了用于治疗白血病或其他形式的癌症的哺乳动物或用于治疗由细胞凋亡引起的疾病状况的药物组合物和方法。

公开(公告)号：US20110203772A1

公开(公告)日：2011-08-25

申请号：US12709266

申请日：2010-02-19

申请人： Terry J. Hendricks ,  Chih-Hung Chang ,  Daniel R. Palo ,  Brian K. Paul

发明人： Terry J. Hendricks ,  Chih-Hung Chang ,  Daniel R. Palo ,  Brian K. Paul

IPC分类号： F28D15/00

CPC分类号： F28F13/185 ,  F28F13/187 ,  F28F2245/02 ,  F28F2255/20 ,  H01L23/367 ,  H01L23/373 ,  H01L23/473 ,  H01L2924/0002 ,  H01L2924/00

摘要： A system and method for performing heat dissipation is disclosed that includes contacting a heat transfer liquid with a heat exchange surface having raised hydrophilic nanoporous nanostructures disposed adjacent a central core upon a substrate. The heat transfer liquid forms a preselected contact angle when placed on the heat exchange surface. The raised nanoporous nanostructures define channels, interconnected pathways, and voids within the nanoporous nanostructures. The nanoporous nanostructures have additional surface irregularities upon the nanostructures themselves. The nanostructures are preferably formed by depositing metal oxides or other materials upon a substrate using a Microreactor Assisted Nanomaterial Deposition (MAND) process.

摘要翻译： 公开了一种用于执行散热的系统和方法，其包括使传热液体与在衬底上邻近中心芯设置的具有升高的亲水纳米多孔纳米结构的热交换表面接触。 当放置在热交换表面上时，传热液体形成预选的接触角。 凸起的纳米多孔纳米结构在纳米多孔纳米结构内限定通道，相互连接的通路和空隙。 纳米多孔纳米结构在纳米结构本身上具有额外的表面不规则性。 纳米结构优选通过使用微反应器辅助纳米材料沉积（MAND）方法将金属氧化物或其它材料沉积在基底上形成。

公开(公告)号：US07339187B2

公开(公告)日：2008-03-04

申请号：US10350819

申请日：2003-01-24

申请人： John F. Wager, III ,  Randy L. Hoffman

发明人： John F. Wager, III ,  Randy L. Hoffman

IPC分类号： H01L29/24

CPC分类号： H01L29/02 ,  H01L29/45 ,  H01L29/458 ,  H01L29/4908 ,  H01L29/66969 ,  H01L29/78681 ,  H01L29/7869

摘要： Enhancement mode, field effect transistors wherein at least a portion of the transistor structure may be substantially transparent. One variant of the transistor includes a channel layer comprising a substantially insulating, substantially transparent, material selected from ZnO, SnO2, or In2O3. A gate insulator layer comprising a substantially transparent material is located adjacent to the channel layer so as to define a channel layer/gate insulator layer interface. A second variant of the transistor includes a channel layer comprising a substantially transparent material selected from substantially insulating ZnO, SnO2 or In2O3, the substantially insulating ZnO, SnO2, or In2O3 being produced by annealing. Devices that include the transistors and methods for making the transistors are also disclosed.

摘要翻译： 增强模式，场效应晶体管，其中晶体管结构的至少一部分可以是基本透明的。 晶体管的一个变体包括沟道层，该沟道层包括基本上绝缘的，基本上透明的材料，其选自ZnO，SnO 2，或In 2 O 3 3 / >。 包括基本上透明的材料的栅极绝缘体层位于与沟道层相邻的位置，以便限定沟道层/栅极绝缘体层界面。 晶体管的第二变体包括沟道层，该沟道层包括基本上透明的材料，其选自基本上绝缘的ZnO，SnO 2或In 2 O 3 3， 通过退火生产的基本绝缘的ZnO，SnO 2 2或In 2 O 3 3 N 3。 还公开了包括晶体管的器件和用于制造晶体管的方法。

公开(公告)号：US20070292574A1

公开(公告)日：2007-12-20

申请号：US11548212

申请日：2006-10-10

申请人： Qingyue Ling ,  Galen D. Kaufman ,  Adam Lindemann

发明人： Qingyue Ling ,  Galen D. Kaufman ,  Adam Lindemann

IPC分类号： A23B7/148 ,  B01F3/04

CPC分类号： F16J13/065 ,  A23B7/148 ,  A23L19/03 ,  F16J13/24

摘要： A carbonation vessel comprising a container for holding a quantity of fruits or vegetables, an insert pan separating a lower space within the container from an upper space and having a gas vent for allowing gas to flow from the upper space to the lower space, a lid covering the upper space and a top opening of the container, a sealing member positionable between the lid and the top opening of the container, and at least one clamp for clamping the lid to the top opening of the container with the sealing member therebetween, thereby sealing the vessel. In one embodiment, the vessel can retain at least thirty pounds per square inch internal pressure. The internal pressure may comprise gaseous carbon dioxide generated in the upper space of the vessel by mixing sodium bicarbonate and citric acid with water, allowing sublimation of dry ice within the upper space, or other carbon dioxide gas generating means. The pressurized carbon dioxide, through absorption into the tissue of the fruits or vegetables, leaves the fruits or vegetables with an effervescent or “fizzy” quality. Various embodiments involve orientation of a gas vent inlet within the upper space so that tipping or inverting the vessel does not allow for the inlet to become blocked by reactants or other non-gaseous substances in the insert pan or upper space of the vessel.

摘要翻译： 一种碳酸化容器，包括用于容纳一定量的水果或蔬菜的容器，将容器内的下部空间与上部空间分开并具有用于允许气体从上部空间流动到下部空间的排气口的插入盘， 覆盖容器的上部空间和顶部开口，可定位在容器的盖和顶部开口之间的密封构件以及至少一个用于将盖紧固到容器的顶部开口的夹具，密封构件在其间，由此 密封容器。 在一个实施例中，容器可以保持至少30磅/平方英寸的内部压力。 内部压力可以包括通过将碳酸氢钠和柠檬酸与水混合而在容器的上部空间中产生的气态二氧化碳，允许上部空间内的干冰升华或其它二氧化碳气体产生装置。 加压二氧化碳通过吸收到水果或蔬菜的组织中，使水果或蔬菜具有泡腾或“起泡”的质量。 各种实施例涉及上部空间内的排气口入口的定向，使得容器的倾翻或翻转不允许入口被容器的插入盘或上部空间中的反应物或其它非气态物质阻塞。

公开(公告)号：US20070203346A1

公开(公告)日：2007-08-30

申请号：US11607477

申请日：2006-12-01

申请人： James White ,  Rich Carter ,  Kurt Sundermann

发明人： James White ,  Rich Carter ,  Kurt Sundermann

IPC分类号： C07D313/00

CPC分类号： C07D417/06

摘要： A method for making epothilones and epothilone analogs is described, as are novel compounds made by the method. One embodiment of the method was used to synthesize epothilone B by a convergent approach that entailed Wittig coupling of an ylide derived from phosphonium bromide with an aldehyde. The former was prepared from propargyl alcohol by a nine-step pathway which installed both trisubstituted double bonds with clean Z configuration. Macrolactonization of a resulting seco acid provided the following intermediate diene epothilone analog. Selective saturation of the 9,10-olefin and subsequent epoxidation provided epothilone B.

摘要翻译： 描述了制备埃坡霉素和埃坡霉素类似物的方法，以及通过该方法制备的新型化合物。 该方法的一个实施方案用于通过收敛方法合成埃坡霉素B，其使得衍生自溴化鏻的内鎓盐与醛的Wittig偶联。 前者由炔丙醇通过九步路径制备，其安装了具有清洁Z构型的三取代双键。 得到的仲酸的大环内酯化得到以下的中间体二烯雌二醇类似物。 9,10-烯烃的选择性饱和和随后的环氧化提供了埃坡霉素B.