公开(公告)号：US5594136A

公开(公告)日：1997-01-14

申请号：US433573

申请日：1995-05-03

申请人： Jonathan L. Sessler ,  Brent L. Iverson ,  Vladimir Kr al ,  Richard E. Thomas ,  Darren Magda ,  Daniel A. Smith

发明人： Jonathan L. Sessler ,  Brent L. Iverson ,  Vladimir Kr al ,  Richard E. Thomas ,  Darren Magda ,  Daniel A. Smith

IPC分类号： A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61L27/40 ,  A61L29/12 ,  A61L31/12 ,  B01J20/32 ,  B01J31/16 ,  B01J31/18 ,  C07D487/22 ,  C07F5/00 ,  C07H15/26 ,  C07H21/00 ,  C12N15/10 ,  C07F15/02

CPC分类号： A61K47/48153 ,  A61K41/0076 ,  A61K47/48069 ,  A61K47/48784 ,  A61K47/48861 ,  A61K49/18 ,  A61L27/40 ,  A61L29/12 ,  A61L31/12 ,  B01J20/223 ,  B01J20/289 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3265 ,  B01J31/1658 ,  B01J31/1815 ,  C07D487/22 ,  C07F5/00 ,  C07H15/26 ,  C07H21/00 ,  C12N15/101 ,  B01J2220/4825 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/62 ,  B01J2220/84 ,  B01J2531/025 ,  B01J2531/36 ,  B01J2531/37 ,  B01J2531/38

摘要： The present invention provides various novel matrix-supported texaphyrins in which a polymeric or solid matrix is covalently modified by the addition of one or more texaphyrins or texaphyrin derivatives. Described are methods of making various polymer-supported texaphyrins, including texaphyrin chromatographic supports, and devices such as catheters, as may be used, for example, in the separation of neutral and anionic species and in applications concerning phosphate ester hydrolysis, other catalytic schemes, MRI, and PDT.

摘要翻译： 本发明提供了各种新型的基质支持的泰克萨克逊，其中聚合物或固体基质通过加入一种或多种泰克萨菲瑞或泰克萨菲瑞衍生物共价修饰。 描述了制备各种聚合物支持的泰克萨菲瑞，包括泰克萨菲林色谱载体和诸如导管的装置的方法，例如可用于中性和阴离子物质的分离以及在磷酸酯水解，其它催化方案中的应用， MRI和PDT。

公开(公告)号：US5275838A

公开(公告)日：1994-01-04

申请号：US898928

申请日：1992-06-12

申请人： Edward W. Merrill

发明人： Edward W. Merrill

IPC分类号： A61K47/48 ,  A61L33/00 ,  A61L33/06 ,  B01D67/00 ,  B01J20/32 ,  C07K1/22 ,  C08G65/329 ,  C08G65/332 ,  C08G65/333 ,  G01N33/545 ,  G02B1/04 ,  G02C7/04

CPC分类号： B01D67/0093 ,  A61K47/48784 ,  A61K47/48992 ,  A61L33/0029 ,  A61L33/0064 ,  A61L33/068 ,  B01D67/0088 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3225 ,  B01J20/3272 ,  B01J20/3282 ,  C07K1/22 ,  C08G65/329 ,  C08G65/332 ,  C08G65/333 ,  G01N33/545 ,  G02B1/043 ,  B01D2323/30 ,  B01D2323/34 ,  Y10S525/937

摘要： A method for immobilizing polyethylene oxide (PEO) star molecules in the form of hydrogel layers and a product thereof are disclosed. The PEO star molecules are biocompatible and demonstrate non-thrombogenic properties. As such, the PEO star molecule layers have numerous biomedical applications, such as on contact lenses. The hydrogel layers contain a high percentage of terminal hydroxyl groups for attachment of affinity ligands and can be used for separating and purifying therapeutic proteins.

摘要翻译： 公开了一种固定水凝胶层形式的聚环氧乙烷（PEO）星形分子及其产物的方法。 PEO星形分子是生物相容性的并且表现出非血栓形成性质。 因此，PEO星形分子层具有许多生物医学应用，例如隐形眼镜。 水凝胶层含有高百分比的用于连接亲和配体的末端羟基，可用于分离和纯化治疗性蛋白质。

公开(公告)号：USRE33997E

公开(公告)日：1992-07-14

申请号：US323361

申请日：1989-03-13

申请人： Petr Kuzma ,  Giovanina Odorisio

发明人： Petr Kuzma ,  Giovanina Odorisio

IPC分类号： A61F2/14 ,  A61L26/00 ,  C08F289/00 ,  G02B1/04

CPC分类号： G02B1/043 ,  A61F2/14 ,  A61K47/48784 ,  A61L26/0009 ,  A61L26/0033 ,  C08F289/00

摘要： Hydrogels are prepared by subjecting to poymerization conditions an aqueous admixture comprising a major amount of an organic monomer which is characterized by a polymerizable ethylenic group ##STR1## as illustrated by N,N-dimethylacrylamide, 2-hydroxyethyl methacrylate, dimethylaminoethyl methacrylate or methoxytriethylene glycol methacrylate, and a minor amount of solubilized collagen. The reactants employed are at least partially soluble in the aqueous reaction medium. The hydrogels thus prepared are novel shaped articles having utility in the medical and cosmetic fields. Contact lenses of such hydrogels exhibit high water content, high oxygen permeability and good mechanical strength characteristics.