公开(公告)号：US20180020535A1

公开(公告)日：2018-01-18

申请号：US15643865

申请日：2017-07-07

Applicant: Mevion Medical Systems, Inc.

Inventor： James Cooley ,  Gerrit Townsend Zwart ,  Stanley J. Rosenthal ,  Mark R. Jones ,  Lionel G. Bouchet ,  Robert Cessac ,  Joseph Jachinowski

IPC: H05H13/02 ,  A61B5/00 ,  A61N5/10 ,  H05H7/04 ,  H05H7/00

CPC classification number: H05H13/02 ,  A61B5/4836 ,  A61N5/103 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1045 ,  A61N5/1065 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1094 ,  A61N2005/1095 ,  H05H7/04 ,  H05H2007/002 ,  H05H2007/007 ,  H05H2007/043 ,  H05H2007/045 ,  H05H2277/10

Abstract: An example method includes: receiving, from a treatment planning process, information that is based on a dose distribution for an irradiation target; and performing at least one of the following operations: moving structures to trim spots of a particle beam so that the spots of the particle beam approximate pre-trimmed spots for which characteristics are obtained based on the information received; moving structures to produce a trimming curve for a layer of an irradiation target based on a specification of a trimming curve for the layer included in the information received; moving structures to produce a single trimming curve for all radiation fields of an irradiation target based on specifications of the single trimming curve included in the information received; or moving structures based on configuration information for the structures in the information received.

公开(公告)号：US09630025B2

公开(公告)日：2017-04-25

申请号：US14710485

申请日：2015-05-12

Applicant: Varian Medical Systems International AG

Inventor： Karl Otto

IPC: A61N5/10 ,  A61B19/00 ,  A61B34/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

公开(公告)号：US20170001035A1

公开(公告)日：2017-01-05

申请号：US15266193

申请日：2016-09-15

Applicant: Varian Medical Systems International AG

Inventor： Karl OTTO

IPC: A61N5/10

CPC classification number: A61B5/4836 ,  A61B5/08 ,  A61B5/113 ,  A61B34/10 ,  A61B2034/101 ,  A61N5/103 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1039 ,  A61N5/1042 ,  A61N5/1045 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/107 ,  A61N5/1077 ,  A61N5/1082 ,  A61N2005/1032 ,  A61N2005/1034 ,  A61N2005/1035

Abstract: Systems for delivering radiation dose to a target area within a subject comprise: a radiation source for outputting a radiation beam; a support for supporting the subject; a movement mechanism for moving the radiation source relative to the subject along a trajectory; and a controller configured to cause, according to a radiation delivery plan: the radiation source to deliver the radiation beam to the subject while causing the movement mechanism to effect relative movement between the radiation source and the subject along the trajectory; and the radiation source to vary an intensity of the radiation beam by varying a radiation output rate of the radiation source according to the radiation delivery plan over at least a portion of the trajectory while causing the movement mechanism to effect relative movement between the radiation source and the subject, to thereby deliver dose to the subject according to the radiation delivery plan.

Abstract translation: 将放射剂量递送到受试者内的目标区域的系统包括：用于输出辐射束的辐射源; 支持主题; 用于沿着轨迹使辐射源相对于被摄体移动的移动机构; 以及控制器，其被配置为根据辐射传递计划：使所述辐射源将所述辐射束传送到所述对象，同时使所述移动机构沿着所述轨迹实现所述辐射源和所述对象之间的相对运动; 以及辐射源，以通过在轨迹的至少一部分上根据辐射传播平面改变辐射源的辐射输出速率来改变辐射束的强度，同时使得移动机构实现辐射源和 从而根据辐射递送计划向受试者递送剂量。

公开(公告)号：US09393442B2

公开(公告)日：2016-07-19

申请号：US14891074

申请日：2014-05-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Alfonso Agatino Isola ,  Christoph Neukirchen ,  Juergen Weese ,  Matthieu Frédéric Bal

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1045 ,  A61N5/1047 ,  A61N2005/1074

Abstract: The invention relates to a device for determining illumination distributions (18) for IMRT. A layered graph structure is used, which considers which extensions of an illumination distribution along a respective line and thus which illumination distributions are realizable, for determining extensions for the illumination distributions. Moreover, second weights defining fluences of the illumination distributions are determined such that a deviation between a provided fluence map and a fluence map formed by a combination of illumination distributions, which are defined by the respective determined extensions and the respective second weight, is minimized. This determination procedure leads to illumination distributions, which very well correspond to the provided fluence map and which are automatically realizable by the radiation device. This leads to an improved IMRT, wherein a post-processing of the determined illumination distributions for ensuring that the determined illumination distributions are really realizable is not necessarily required.

Abstract translation: 本发明涉及一种用于确定IMRT的照明分布（18）的装置。 使用分层图结构，其考虑沿着相应行的照明分布的哪些延伸，并且因此考虑哪些照度分布是可实现的，以确定照明分布的扩展。 此外，确定照明分布的通量的第二权重被确定为使得通过由相应的确定的扩展和相应的第二权重定义的由照明分布的组合形成的所提供的注量图和通量密度图之间的偏差被最小化。 该确定过程导致照明分布，其非常对应于所提供的注量图并且可由辐射装置自动实现。 这导致改进的IMRT，其中对确定的确定的照明分布真正可实现的所确定的照明分布的后处理不一定是必需的。

公开(公告)号：US20160082287A1

公开(公告)日：2016-03-24

申请号：US14891074

申请日：2014-05-14

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Alfonso Agatino ISOLA ,  Christoph NEUKIRCHEN ,  Juergen WEESE ,  Matthieu Frédéric BAL

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1045 ,  A61N5/1047 ,  A61N2005/1074

Abstract: The invention relates to a device for determining illumination distributions (18) for IMRT. A layered graph structure is used, which considers which extensions of an illumination distribution along a respective line and thus which illumination distributions are realizable, for determining extensions for the illumination distributions. Moreover, second weights defining fluences of the illumination distributions are determined such that a deviation between a provided fluence map and a fluence map formed by a combination of illumination distributions, which are defined by the respective determined extensions and the respective second weight, is minimized. This determination procedure leads to illumination distributions, which very well correspond to the provided fluence map and which are automatically realizable by the radiation device. This leads to an improved IMRT, wherein a post-processing of the determined illumination distributions for ensuring that the determined illumination distributions are really realizable is not necessarily required.

Abstract translation: 本发明涉及一种用于确定IMRT的照明分布（18）的装置。 使用分层图结构，其考虑沿着相应行的照明分布的哪些延伸，并且因此考虑哪些照度分布是可实现的，以确定照明分布的扩展。 此外，确定照明分布的通量的第二权重被确定为使得通过由相应的确定的扩展和相应的第二权重定义的由照明分布的组合形成的所提供的注量图与通量密度图之间的偏差被最小化。 该确定过程导致照明分布，其非常对应于所提供的注量图并且可由辐射装置自动实现。 这导致改进的IMRT，其中对确定的确定的照明分布真正可实现的所确定的照明分布的后处理不一定是必需的。

公开(公告)号：US20160008630A1

公开(公告)日：2016-01-14

申请号：US14763539

申请日：2014-02-03

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Vaitheeswaran RANGANATHAN ,  Uma Satya RANJAN

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1031 ,  A61N5/1045 ,  A61N5/1077

Abstract: The invention relates to an apparatus for determining a number of beams in IMRT. An objective function providing unit (13) provides an objective function of an IMRT procedure, wherein the objective function depends on a target dose to be applied during the IMRT procedure. A sensitivity determination unit (14) determines the sensitivity of the objective function with respect to changes of the target dose, and a beam number determination unit (15) determines the number of beams depending on the determined sensitivity. It has been found that the sensitivity of the objective function with respect to changes of the target dose is an accurate measure for reliably determining an optimized number of beams in IMRT, which allows for generating a high quality treatment plan and which in turn leads to an improved IMRT procedure.

Abstract translation: 本发明涉及一种用于确定IMRT中的多个波束的装置。 目标函数提供单元（13）提供IMRT过程的目标函数，其中目标函数取决于在IMRT过程期间应用的目标剂量。 灵敏度确定单元（14）根据目标剂量的变化确定目标函数的灵敏度，并且波束数确定单元（15）根据所确定的灵敏度确定波束的数量。 已经发现目标函数对目标剂量变化的敏感度是可靠地确定IMRT中优化的束数量的精确测量，其允许产生高质量的治疗计划，并且其又导致 改进的IMRT程序。

公开(公告)号：US09155912B2

公开(公告)日：2015-10-13

申请号：US14147553

申请日：2014-01-05

Applicant: Xinsheng Cedric Yu

Inventor： Xinsheng Cedric Yu

IPC: A61B6/00 ,  A61N5/10

CPC classification number: A61N5/1047 ,  A61B6/032 ,  A61B6/035 ,  A61B6/4429 ,  A61B6/4435 ,  A61B6/4441 ,  A61B6/4452 ,  A61N5/10 ,  A61N5/1036 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1082 ,  A61N2005/1052 ,  A61N2005/1054 ,  A61N2005/1055 ,  A61N2005/1061

Abstract: A method of irradiating a target in a patient comprising directing a beam of radiation from an external source of radiation 24 at the target in the patient from numerous directions in a broad solid angle by longitudinally rotating the external source of radiation 24 around a central axis and simultaneously or sequentially, in either order, latitudinally rotating the external source of radiation 24; a globe gantry 21 comprising (i) a front opening ring 22 with its origin on the central axis of the globe gantry 21, (ii) at least one arc-shaped, gantry support arm 23, which has a front end and a rear end and is part of a circle, (iii) an external source of radiation 24, which is mounted on at least one arc-shaped, gantry support arm 23, (iv) a rear rotational axle 25 with an axis along the central axis of the globe gantry 21, (v) a support base 27, and (vi) a rear housing 26 comprising a source of power, mechanisms for moving components of the globe gantry 21, and controllers for controlling the movement of the components of the globe gantry 21 and the irradiation of the target in the patient; a system 20 comprising the globe gantry 21; and a method of irradiating a target in a patient using the system.

Abstract translation: 一种照射患者中的靶的方法，包括：通过围绕中心轴线纵向旋转外部辐射源24，以宽广立体角度从多个方向将来自外部辐射源24的辐射束定向在患者的目标上;以及 同时或顺序地以任何顺序，横向旋转外部辐射源24; 地球台架21包括（i）其前端开口环22，其原点在球形台架21的中心轴线上，（ii）至少一个弧形的龙门架支撑臂23，其具有前端和后端 并且是圆的一部分，（iii）外部辐射源24，其安装在至少一个弧形龙门架支撑臂23上，（iv）具有沿着中心轴线的轴的后旋转轴25 地球台架21，（v）支撑座27和（vi）包括动力源的后壳体26，用于移动地球台架21的部件的机构，以及用于控制地球台架21的部件的运动的控制器 以及患者中靶标的照射; 包括地球台架21的系统20; 以及使用该系统照射患者中的靶的方法。

公开(公告)号：US20150190658A1

公开(公告)日：2015-07-09

申请号：US14147553

申请日：2014-01-05

Applicant: Xinsheng Cedric Yu

Inventor： Xinsheng Cedric Yu

IPC: A61N5/10

CPC classification number: A61N5/1047 ,  A61B6/032 ,  A61B6/035 ,  A61B6/4429 ,  A61B6/4435 ,  A61B6/4441 ,  A61B6/4452 ,  A61N5/10 ,  A61N5/1036 ,  A61N5/1039 ,  A61N5/1048 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1082 ,  A61N2005/1052 ,  A61N2005/1054 ,  A61N2005/1055 ,  A61N2005/1061

Abstract: A method of irradiating a target in a patient comprising directing a beam of radiation from an external source of radiation 24 at the target in the patient from numerous directions in a broad solid angle by longitudinally rotating the external source of radiation 24 around a central axis and simultaneously or sequentially, in either order, latitudinally rotating the external source of radiation 24; a globe gantry 21 comprising (i) a front opening ring 22 with its origin on the central axis of the globe gantry 21, (ii) at least one arc-shaped, gantry support arm 23, which has a front end and a rear end and is part of a circle, (iii) an external source of radiation 24, which is mounted on at least one arc-shaped, gantry support arm 23, (iv) a rear rotational axle 25 with an axis along the central axis of the globe gantry 21, (v) a support base 27, and (vi) a rear housing 26 comprising a source of power, mechanisms for moving components of the globe gantry 21, and controllers for controlling the movement of the components of the globe gantry 21 and the irradiation of the target in the patient; a system 20 comprising the globe gantry 21; and a method of irradiating a target in a patient using the system.

Abstract translation: 一种照射患者中的靶的方法，包括：通过围绕中心轴线纵向旋转外部辐射源24，以宽广立体角度从多个方向将来自外部辐射源24的辐射束定向在患者的目标上;以及 同时或顺序地以任何顺序，横向旋转外部辐射源24; 地球台架21包括（i）其前端开口环22，其原点在球形台架21的中心轴线上，（ii）至少一个弧形的龙门架支撑臂23，其具有前端和后端 并且是圆的一部分，（iii）外部辐射源24，其安装在至少一个弧形龙门架支撑臂23上，（iv）具有沿着中心轴线的轴的后旋转轴25 地球台架21，（v）支撑座27和（vi）包括动力源的后壳体26，用于移动地球台架21的部件的机构，以及用于控制地球台架21的部件的运动的控制器 以及患者中靶标的照射; 包括地球台架21的系统20; 以及使用该系统照射患者中的靶的方法。

公开(公告)号：US08971489B2

公开(公告)日：2015-03-03

申请号：US13261121

申请日：2010-07-09

Applicant: Dan Ruan ,  Paul J. Keall ,  Amit Sawant

Inventor： Dan Ruan ,  Paul J. Keall ,  Amit Sawant

IPC: A61N5/10 ,  G21K1/04 ,  H05G1/28 ,  A61B6/06 ,  G21K1/02

CPC classification number: G21K1/025 ,  A61N5/1031 ,  A61N5/1036 ,  A61N5/1037 ,  A61N5/1038 ,  A61N5/1045 ,  A61N5/1067 ,  G21K1/04

Abstract: A method of multileaf collimator (MLC) leaf positioning in tracking-based adaptive radiotherapy is provided. The method includes determining a radiotherapy beam pattern by transforming a treatment beam plan into radiotherapy beam coordinates, determining a dose discrepancy between the radiotherapy beam pattern and a deliverable MLC aperture, where the dose discrepancy includes a sum of an overdose cost and an underdose cost to a treatment volume, and minimizing the dose discrepancy, where the dose discrepancy minimization provides a determined deliverable MLC aperture for the radiotherapy beam.

Abstract translation: 提供了一种基于跟踪的自适应放疗的多叶准直器（MLC）叶定位方法。 该方法包括通过将治疗束计划转换为放射治疗束坐标来确定放射治疗束图案，确定放射治疗束图案与可递送MLC孔径之间的剂量差异，其中剂量差异包括过量成本和剂量过低的总和 治疗体积和最小化剂量差异，其中剂量差异最小化为放射治疗束提供确定的可递送MLC孔。

公开(公告)号：US08952346B2

公开(公告)日：2015-02-10

申请号：US13830794

申请日：2013-03-14

Applicant: ViewRay, Incorporated

Inventor： James F. Dempsey ,  Iwan Kawrykow

IPC: G02B5/00 ,  G21K1/00 ,  H01J1/52 ,  H01J3/00 ,  H01J5/18 ,  H01J29/46 ,  A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1036 ,  A61N5/1045 ,  A61N5/1071 ,  A61N5/1077

Abstract: The subject matter described herein provides methods for developing an IMRT treatment plan for a radiotherapy system. In one aspect, the method can include providing initial treatment parameters. These parameters can include a number of isotopic beams, a transmission angle for each beam, a prescribed dose for a target, and dose volume histogram constraints. The method can further include determining an initial fluence map including one or more beamlets. The initial fluence map can specify a fluence value for each beamlet. The method can further include determining a delivery sequence for the fluence values in the initial fluence map. The delivery sequence can include one or more apertures formed by the leaves of a collimator. These apertures can have a specified size constrained to substantially less than a maximum size associated with the collimator, when the isotopic beam is near a critical structure. Related apparatus and systems are also described.

Abstract translation: 本文所述的主题提供了用于开发用于放射治疗系统的IMRT治疗计划的方法。 在一个方面，该方法可以包括提供初始治疗参数。 这些参数可以包括多个同位素束，每个束的传播角，目标的规定剂量以及剂量体积直方图约束。 该方法还可以包括确定包括一个或多个子束的初始注量图。 初始注量图可以为每个子束指定注量值。 该方法还可以包括确定初始注量图中的能量密度值的递送序列。 递送顺序可以包括由准直器的叶形成的一个或多个孔。 当同位素束接近临界结构时，这些孔可以具有被限制为基本上小于与准直器相关联的最大尺寸的规定尺寸。 还描述了相关装置和系统。