公开(公告)号：US20230293523A1

公开(公告)日：2023-09-21

申请号：US18200419

申请日：2023-05-22

Applicant: Purdue Research Foundation

Inventor： Daniel P. Flaherty ,  Richard M. van Rijn ,  Val J. Watts ,  Jason A. Scott

IPC: A61K31/506 ,  C07D403/04

CPC classification number: A61K31/506 ,  C07D403/04

Abstract: The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

公开(公告)号：US20230286952A1

公开(公告)日：2023-09-14

申请号：US17945221

申请日：2022-09-15

Applicant: SYNGENTA CROP PROTECTION AG

Inventor： Sally Elizabeth RUSSELL ,  Sean NG ,  James Alan MORRIS

IPC: C07D403/04 ,  A01N43/54 ,  A01N43/58 ,  A01N43/80 ,  A01N43/90 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  A01N43/56 ,  C07D207/337 ,  C07D207/34 ,  C07D207/325

CPC classification number: C07D403/04 ,  A01N43/54 ,  A01N43/58 ,  A01N43/80 ,  A01N43/90 ,  C07D401/04 ,  C07D401/14 ,  C07D409/14 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  A01N43/56 ,  C07D207/337 ,  C07D207/34 ,  C07D207/325

Abstract: The present disclosure provides compounds of formula (II)




and compositions/methods of use thereof.

公开(公告)号：US11753393B2

公开(公告)日：2023-09-12

申请号：US17742606

申请日：2022-05-12

Applicant: Janssen Biotech, Inc.

Inventor： Scott Kuduk ,  Zhuming Zhang ,  Lindsey DeRatt ,  Aihua Wang

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows:




wherein R1, R2, R3, R4, X, and Y are defined herein.

公开(公告)号：US20230279023A1

公开(公告)日：2023-09-07

申请号：US17959144

申请日：2022-10-03

Applicant: C4 Therapeutics, Inc.

Inventor： Andrew J. Phillips ,  Christopher G. Nasveschuk ,  James A. Henderson ,  Yanke Liang ,  Minsheng He ,  Martin Duplessis ,  Chi-Li Chen

IPC: C07D495/14 ,  C07D207/456 ,  C07D211/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  G07F17/32

CPC classification number: C07D495/14 ,  C07D207/456 ,  C07D211/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  G07F17/3211 ,  G07F17/3225 ,  G07F17/3244 ,  G07F17/3246 ,  G07F17/3272 ,  G07F17/3288

Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

公开(公告)号：US11725000B2

公开(公告)日：2023-08-15

申请号：US17333033

申请日：2021-05-28

Applicant: National Institute of Biological Sciences, Beijing

Inventor： Zhiyuan Zhang ,  Xiaodong Wang ,  Shaoqiang Huang ,  Xian Jiang ,  Li Li ,  Zhaolan Zhang ,  Jianguang Han

IPC: C07D409/04 ,  A61P25/16 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D239/38 ,  C07D239/47 ,  C07D409/14 ,  C07D417/14 ,  C07D495/04 ,  A61K31/506 ,  A61P37/00 ,  A61K31/505 ,  A61P25/00 ,  A61P9/10 ,  A61P25/28 ,  C07D471/04

CPC classification number: C07D409/04 ,  A61K31/505 ,  A61K31/506 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P37/00 ,  C07D239/38 ,  C07D239/47 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

Abstract: The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

公开(公告)号：US20230242511A1

公开(公告)日：2023-08-03

申请号：US17925003

申请日：2021-05-14

Applicant: GLIXOGEN THERAPEUTICS LTD.

Inventor： Yair FISHER ,  William J. GREENLEE ,  Joel Moshe VAN GELDER

IPC: C07D403/04 ,  C07D471/04 ,  C07D519/00 ,  C07D487/04 ,  A61P25/00 ,  A61P29/00

CPC classification number: C07D403/04 ,  C07D471/04 ,  C07D519/00 ,  C07D487/04 ,  A61P25/00 ,  A61P29/00

Abstract: The present invention is directed to a composition and a method for use thereof, such as for the treatment and prevention of a neurological disorder or cancer in a subject.

公开(公告)号：US11713320B2

公开(公告)日：2023-08-01

申请号：US17138098

申请日：2020-12-30

Applicant: BioSplice Therapeutics, Inc.

Inventor： Sunil Kumar Kc ,  Chi Ching Mak ,  Gopi Kumar Mittapalli ,  Brian Joseph Hofilena ,  Brian Walter Eastman ,  Jianguo Cao ,  Chandramouli Chiruta ,  Venkataiah Bollu

IPC: C07D487/04 ,  C07D403/04 ,  C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  A61P19/04 ,  A61P11/00 ,  A61P17/06 ,  A61P35/00

CPC classification number: C07D487/04 ,  A61P19/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61P11/00 ,  A61P17/06 ,  A61P35/00

Abstract: Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., tendinopathy, dermatitis, psoriasis, morphea, ichthyosis, Raynaud's syndrome, Darier's disease, scleroderma, cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

公开(公告)号：US20230233562A1

公开(公告)日：2023-07-27

申请号：US18159176

申请日：2023-01-25

Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Inventor： Irit Snir-Alkalay ,  Joseph P. Vacca ,  Yinon Ben-Neriah

IPC: A61K31/506 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D495/04

CPC classification number: A61K31/506 ,  A61P35/00 ,  C07D403/04 ,  C07D405/14 ,  C07D413/04 ,  C07D495/04

Abstract: Provided herein are heteroaryl compounds, for example, a compound of Formula I or IA, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, ameliorating, or preventing one or more symptoms of a disorder, disease, or condition mediated by a casein kinase 1 (CK1), an interleukin-1 receptor associated kinase (IRAK1), or a cyclin-dependent kinase 9 (CDK9).

公开(公告)号：US11708361B2

公开(公告)日：2023-07-25

申请号：US17497352

申请日：2021-10-08

Applicant: Cyclerion Therapeutics, Inc.

Inventor： Debra Jane Wallace ,  Fenger Zhou ,  Yuguang Wang ,  Takashi Nakai ,  Vishnu Vardhan Reddy Karnati ,  Wayne C. Schairer ,  William Kissel ,  Song Xue ,  Ahmad Hashash

IPC: C07D413/14 ,  C07D403/04 ,  C07D413/12

CPC classification number: C07D413/14 ,  C07D403/04 ,  C07D413/12 ,  C07B2200/13

Abstract: The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulators. These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula I in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.

公开(公告)号：US11708352B2

公开(公告)日：2023-07-25

申请号：US17502954

申请日：2021-10-15

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Csaba J. Peto ,  David Jablons ,  Hassan Lemjabbar-Alaoui

IPC: C07D403/04 ,  A61K31/502 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D403/04 ,  A61K31/502 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

Abstract: This invention provides, among other things, compounds useful for treating diseases such as cancer, pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.