公开(公告)号：US2905719A

公开(公告)日：1959-09-22

申请号：US2905719D

CPC分类号： C08G65/337 ,  C08G65/3312 ,  C08G65/3342 ,  C11D1/721 ,  Y10S516/01

公开(公告)号：US11952461B2

公开(公告)日：2024-04-09

申请号：US17208057

申请日：2021-03-22

申请人： SunBio, Inc.

发明人： Kwang Nho ,  Minjung Ahn ,  Changmin Hyun ,  Junghoon Lee

IPC分类号： C08G65/26 ,  C08G65/332 ,  C08G65/333 ,  C08G65/334

CPC分类号： C08G65/2639 ,  C08G65/2603 ,  C08G65/3322 ,  C08G65/3326 ,  C08G65/3328 ,  C08G65/33306 ,  C08G65/33331 ,  C08G65/3342

摘要： Disclosed are a novel monofunctional polyethylene glycol (PEG) and derivatives thereof. More particularly, one terminal of each of the monofunctional polyethylene glycol and derivatives thereof is modified with a siloxy group. The novel monofunctional polyethylene glycol (PEG) offers an alternative to methoxy polyethylene glycol.

公开(公告)号：US20180244845A1

公开(公告)日：2018-08-30

申请号：US15758162

申请日：2016-09-09

申请人： INPERIAL INNOVATIONS LIMITED

发明人： Piers Gaffney ,  Andrew Livingston ,  Rongjun Chen ,  Ruijao Dong ,  Ruiyi Liu ,  Patrizia Marchetti

IPC分类号： C08G65/333 ,  C08G65/334 ,  A61K47/60 ,  A61K49/00 ,  A61K49/12

CPC分类号： C08G65/33396 ,  A61K47/60 ,  A61K49/0054 ,  A61K49/128 ,  C08G65/32 ,  C08G65/325 ,  C08G65/333 ,  C08G65/33317 ,  C08G65/3342 ,  C08G65/3344 ,  C08G65/3348

摘要： Processes of preparing defined monomer sequence polymers are disclosed, in which a backbone portion of the polymer is first prepared by performing one or more sequential monomeric coupling reactions with intervening membrane diafiltration purification/isolation steps, followed by a step of decorating the backbone portion with one or more side chains at predetermined positions along its length. The process represents an improvement on prior art techniques, which impose limitations on the size of the side chains that may be present. Defined monomer sequence polymers that are obtainable by the processes are also disclosed.

公开(公告)号：US20170203000A1

公开(公告)日：2017-07-20

申请号：US15476012

申请日：2017-03-31

申请人： STRAUMANN HOLDING AG ,  CAM BIOCERAMICS B.V.

发明人： Corinna MAUTH ,  Aaldert-Rens MOLENBERG

IPC分类号： A61L27/18 ,  A61L27/10 ,  A61L27/58 ,  A61L27/54 ,  C08G65/332 ,  C08G65/334 ,  A61L27/56 ,  A61L27/52

CPC分类号： A61L27/18 ,  A61L27/10 ,  A61L27/425 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/02 ,  C08G65/3322 ,  C08G65/3342 ,  C08G2210/00 ,  C08G2230/00

摘要： Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores.

公开(公告)号：US20150320877A1

公开(公告)日：2015-11-12

申请号：US14544003

申请日：2014-11-13

申请人： Phillip B. Messersmith ,  Iossif A. Strehin ,  Ellen Heber-Katz

发明人： Phillip B. Messersmith ,  Iossif A. Strehin ,  Ellen Heber-Katz

IPC分类号： A61K47/48 ,  A61K31/4745 ,  C12N9/02 ,  C08G65/333

CPC分类号： A61K31/4745 ,  A61K47/48215 ,  A61K47/48784 ,  A61K47/60 ,  C08G65/332 ,  C08G65/333 ,  C08G65/33331 ,  C08G65/33337 ,  C08G65/33396 ,  C08G65/3342 ,  C08G65/3344 ,  C08G65/3348 ,  C08G2210/00 ,  C08G2650/32 ,  C08G2650/58 ,  C08L2203/02 ,  C12N9/0071 ,  C12Y114/11002

摘要： Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.

摘要翻译： 描述了用于增强哺乳动物受试者的组织再生或伤口修复的方法和组合物，其包含组合物，所述组合物包含（a）增加或上调HIF1a的脯氨酸羟化酶抑制剂组分或分子，和（b）包含水凝胶的载体组分。

公开(公告)号：US09125814B2

公开(公告)日：2015-09-08

申请号：US12428411

申请日：2009-04-22

申请人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony Boey ,  Brent Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

发明人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony Boey ,  Brent Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

IPC分类号： A61K9/10 ,  A61K38/20 ,  A61K38/48 ,  A61K38/16 ,  A61K31/445 ,  A61K31/4025 ,  A61K31/10 ,  A61K31/08 ,  C07D403/14 ,  C07C317/00 ,  C07C43/04 ,  A61K9/06 ,  A61K9/00 ,  A61K47/34 ,  A61L24/00 ,  A61L26/00 ,  A61L31/14 ,  A61L31/16 ,  C08G65/331 ,  C08G65/332 ,  C08G65/333 ,  C08G65/334 ,  C08G65/337

CPC分类号： A61L26/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/34 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/204 ,  A61L2300/402 ,  C07D403/14 ,  C08G65/00 ,  C08G65/3312 ,  C08G65/3324 ,  C08G65/33317 ,  C08G65/33337 ,  C08G65/33368 ,  C08G65/3342 ,  C08G65/337 ,  C08J3/075 ,  C08J2371/00 ,  C08L2203/02

摘要： Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.

摘要翻译： 公开了由一个被一个或多个聚乙二醇取代的四甲基甲烷的混合物形成的水凝胶组合物，其中每个聚乙二醇取代基独立地被一个或多个亲电基团进一步取代，和被一个或多个聚乙二醇取代的四甲基甲烷， 聚乙二醇取代基独立地被一个或多个亲核基团进一步取代。 还公开了制备上述水凝胶的方法。 水凝胶组合物可以进一步包含药物，例如止痛剂或局部麻醉剂。 还公开了使用所公开的水凝胶密封伤口，防止手术后粘连和减少手术后疼痛的方法。

公开(公告)号：US08841408B2

公开(公告)日：2014-09-23

申请号：US12106429

申请日：2008-04-21

申请人： Phillip B Messersmith ,  Bi-Huang Hu ,  Jing Su

发明人： Phillip B Messersmith ,  Bi-Huang Hu ,  Jing Su

IPC分类号： C08G69/06 ,  C08G69/40 ,  C08G69/02 ,  C08G69/04 ,  C08G69/08

CPC分类号： C08G69/40 ,  A61K9/06 ,  A61K47/34 ,  C08G65/3322 ,  C08G65/33306 ,  C08G65/33317 ,  C08G65/33337 ,  C08G65/3342 ,  C08G65/3344 ,  C08G65/3348 ,  C08G69/02 ,  C08G69/04 ,  C08G69/08 ,  C08G2650/50 ,  C08L2203/02

摘要： Biocompatible macromonomers, hydrogels, methods of synthesis and methods of use thereof are provided. The biocompatible hydrogels of the present invention are prepared using native chemical ligation (NCL), in which a thioester readily reacts with a N-terminal thiol (cysteine) through transesterification and rearrangement to form an amide bond through a five-member ring intermediate.

摘要翻译： 提供生物相容性大分子单体，水凝胶，合成方法及其使用方法。 使用天然化学连接（NCL）制备本发明的生物相容性水凝胶，其中硫酯通过酯交换和重排容易与N-末端硫醇（半胱氨酸）反应，以通过五元环中间体形成酰​​胺键。

公开(公告)号：US20130289235A1

公开(公告)日：2013-10-31

申请号：US13918528

申请日：2013-06-14

申请人： Angiotech Pharmaceuticals (US), Inc.

发明人： George Y. Daniloff ,  Michael Huy Ngo ,  Olof Mikael Trollsas ,  David M. Gravett ,  Philip M. Toleikis

IPC分类号： C08G65/00

CPC分类号： C08G65/005 ,  A61F2/44 ,  A61F2002/30677 ,  A61K9/0024 ,  A61K9/0048 ,  A61K9/1641 ,  A61K38/00 ,  A61L27/54 ,  A61L31/16 ,  C08G65/332 ,  C08G65/3342 ,  C08G2210/00 ,  C08G2650/32 ,  C08L71/02 ,  C08L2203/02

摘要： Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.

公开(公告)号：US20130012683A1

公开(公告)日：2013-01-10

申请号：US13618989

申请日：2012-09-14

申请人： George Y. Daniloff ,  Michael Huy Ngo ,  Olof Mikael Trollsas ,  David M. Gravett ,  Philip M. Toleikis

发明人： George Y. Daniloff ,  Michael Huy Ngo ,  Olof Mikael Trollsas ,  David M. Gravett ,  Philip M. Toleikis

IPC分类号： C08G65/00

CPC分类号： C08G65/005 ,  A61F2/44 ,  A61F2002/30677 ,  A61K9/0024 ,  A61K9/0048 ,  A61K9/1641 ,  A61K38/00 ,  A61L27/54 ,  A61L31/16 ,  C08G65/332 ,  C08G65/3342 ,  C08G2210/00 ,  C08G2650/32 ,  C08L71/02 ,  C08L2203/02

摘要： Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.

摘要翻译： 提供多功能化合物，其易于原位交联以提供交联的生物材料。 多官能化合物含有在其上具有至少三个反应性官能团的单一组分，其官能团被选择为在初始环境中是非反应性的并且在改性环境中具有互反应性。 多个多官能化合物的反应产生三维交联的基质。 在一个实施方案中，第一官能团是亲核的，第二官能团是亲电子的，并且至少一个另外的官能团是亲核或亲电子的。 还提供了制备和使用多官能化合物的方法，以及包括多官能化合物的试剂盒。 多功能化合物的示例性用途包括组织增加，生物活性剂递送，生物粘附和预防手术或损伤后的粘连。

公开(公告)号：US08303973B2

公开(公告)日：2012-11-06

申请号：US11575484

申请日：2005-09-19

申请人： George Y. Daniloff ,  Michael Huy Ngo ,  Olof Mikael Trollsas ,  David M. Gravett ,  Philip M. Toleikis

发明人： George Y. Daniloff ,  Michael Huy Ngo ,  Olof Mikael Trollsas ,  David M. Gravett ,  Philip M. Toleikis

IPC分类号： A61F2/02

CPC分类号： C08G65/005 ,  A61F2/44 ,  A61F2002/30677 ,  A61K9/0024 ,  A61K9/0048 ,  A61K9/1641 ,  A61K38/00 ,  A61L27/54 ,  A61L31/16 ,  C08G65/332 ,  C08G65/3342 ,  C08G2210/00 ,  C08G2650/32 ,  C08L71/02 ,  C08L2203/02

摘要： Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.

摘要翻译： 提供多功能化合物，其易于原位交联以提供交联的生物材料。 多官能化合物含有在其上具有至少三个反应性官能团的单一组分，其官能团被选择为在初始环境中是非反应性的并且在改性环境中具有互反应性。 多个多官能化合物的反应产生三维交联的基质。 在一个实施方案中，第一官能团是亲核的，第二官能团是亲电子的，并且至少一个另外的官能团是亲核或亲电子的。 还提供了制备和使用多官能化合物的方法，以及包括多官能化合物的试剂盒。 多功能化合物的示例性用途包括组织增加，生物活性剂递送，生物粘附和预防手术或损伤后的粘连。