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公开(公告)号：US10676509B2
公开(公告)日：2020-06-09
申请号：US12533876
申请日：2009-07-31
Applicant: Phillip B. Messersmith , Annelise E. Barron , Andrea Statz , Nathaniel Chongslriwatana
Abstract: Immobilizable antimicrobial compounds incorporating antimicrobial and/or antifouling components, as can be adhered to various device structures and components.
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公开(公告)号：US20140061135A1
公开(公告)日：2014-03-06
申请号：US14013247
申请日：2013-08-29
Applicant: Phillip B. Messersmith , Haeshin Lee
Inventor： Phillip B. Messersmith , Haeshin Lee
IPC: C02F1/28
CPC classification number: C02F1/288 , B01J20/262 , B01J20/28016 , B01J20/28019 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3272 , B01J20/3293 , B01J20/345 , B01J20/3475 , C02F1/285 , C02F1/286 , C02F2101/006 , C02F2101/20 , C02F2101/22 , C02F2101/30 , C02F2101/38 , C02F2303/16
Abstract: A bio-inspired method for detoxifying contaminated water is disclosed. In the method, polydopamine, a mussel-inspired adhesive catecholamine was used as an adsorbent to effectively remove from contaminated water three major classes of toxic agents: heavy metal ions (e.g., Cr, Hg, Pb, Cu, and Cd), toxic organic species (e.g., 4-aminopyridine), and radioisotopes (e.g., Lutetium-177). Furthermore, the polydopamine adsorbent was regenerated by treatment with acid or hydrogen peroxide.
Abstract translation: 公开了一种用于解毒污染水的生物启发方法。 在这种方法中，使用了聚多巴胺，一种采用贻贝的粘合剂儿茶酚胺作为吸附剂，有效地从受污染的水中去除了三种主要的毒素：重金属离子（如Cr，Hg，Pb，Cu和Cd），有毒有机物 物种（例如4-氨基吡啶）和放射性同位素（例如，镥-177）。 此外，通过用酸或过氧化氢处理再生聚多巴胺吸附剂。
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公开(公告)号：US20100028719A1
公开(公告)日：2010-02-04
申请号：US12533876
申请日：2009-07-31
Applicant: Phillip B. Messersmith , Annellse E. Barron , Andrea Statz , Nathaniel Chongslriwatana
Abstract: Immobilizable antimicrobial compounds incorporating antimicrobial and/or antifouling components, as can be adhered to various device structures and components.
Abstract translation: 包含抗微生物和/或防污组分的可固定的抗微生物化合物，可以粘附到各种装置结构和组分上。
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4.发明授权Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives 有权用于水凝胶和压敏湿粘合剂的改性丙烯酸嵌段共聚物公开(公告)号：US07635737B2
公开(公告)日：2009-12-22
申请号：US12395126
申请日：2009-02-27
Applicant: Kenneth R. Shull , Murat Guvendiren , Phillip B. Messersmith , Bruce P. Lee
Inventor： Kenneth R. Shull , Murat Guvendiren , Phillip B. Messersmith , Bruce P. Lee
IPC: C08F297/02 , C08F4/00 , C08F293/00
CPC classification number: C08F8/30 , C08F297/00
Abstract: A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate).
Abstract translation: 一种制备丙烯酸嵌段共聚物的方法，其包括疏水性聚（低级烷基甲基丙烯酸酯），亲水性聚（低级烷基甲基丙烯酸）和疏水性聚（甲基丙烯酸低级烷基酯）。
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公开(公告)号：US07618937B2
公开(公告)日：2009-11-17
申请号：US11280107
申请日：2005-11-16
Applicant: Phillip B. Messersmith , Annelise Barron , Andrea Statz , Robert Meagher
Inventor： Phillip B. Messersmith , Annelise Barron , Andrea Statz , Robert Meagher
IPC: A61K38/00 , A01N37/18 , A61M36/14 , A61K51/00 , D21H19/50 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC classification number: C07K2/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K17/14 , C08G69/00 , C09D5/1637
Abstract: Peptidomimetic polymers comprising one or more DOPA moieties and related coatings and composites.
Abstract translation: 包含一种或多种DOPA部分和相关涂料和复合材料的拟肽聚合物。
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Patent Agency Ranking
公开(公告)号：US20080247984A1
公开(公告)日：2008-10-09
申请号：US12099254
申请日：2008-04-08
Applicant: Phillip B. Messersmith , Jeffrey L. Dalsin , Bruce P. Lee , Sean A. Burke
Inventor： Phillip B. Messersmith , Jeffrey L. Dalsin , Bruce P. Lee , Sean A. Burke
IPC: A61K31/765 , C08G65/02
CPC classification number: C08G65/33306 , A61B17/00491 , C08G65/3317 , C08G65/3322 , C08G65/33313 , C09J171/02
Abstract: The invention describes DOPA functionalized, branched, polyalkylene oxide materials that are useful as adhesives.
Abstract translation: 本发明描述了可用作粘合剂的DOPA官能化，支化的聚环氧烷材料。
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7.发明授权Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation 有权可注射和生物粘附的聚合物水凝胶以及相关的酶制剂方法公开(公告)号：US07208171B2
公开(公告)日：2007-04-24
申请号：US10699584
申请日：2003-10-31
Applicant: Phillip B. Messersmith , Bi-Huang Hu , Marsha Ritter Jones
Inventor： Phillip B. Messersmith , Bi-Huang Hu , Marsha Ritter Jones
CPC classification number: C07K5/06086 , A61K47/6903 , C07K5/0808 , C07K5/0812 , C07K7/06
Abstract: The invention is related to biomimetic gels that are prepared enzymatically, using a transglutaminase to cross-link polymer-peptide conjugates of rational design.
Abstract translation: 本发明涉及使用转谷氨酰胺酶交联合成设计的聚合物 - 肽缀合物的酶促制备的仿生性凝胶。
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公开(公告)号：US20170273971A1
公开(公告)日：2017-09-28
申请号：US15618715
申请日：2017-06-09
Applicant: Phillip B. Messersmith , lossif A. Strehin , Ellen Heber-Katz
Inventor： Phillip B. Messersmith , lossif A. Strehin , Ellen Heber-Katz
IPC: A61K31/4745 , C12N9/02 , C08G65/333
CPC classification number: A61K31/4745 , A61K47/60 , C08G65/332 , C08G65/333 , C08G65/33331 , C08G65/33337 , C08G65/33396 , C08G65/3342 , C08G65/3344 , C08G65/3348 , C08G2210/00 , C08G2650/32 , C08G2650/58 , C08L2203/02 , C12N9/0071 , C12Y114/11002
Abstract: Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
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9.发明授权Catalyst and byproduct-free native chemical ligation using cyclic thioester precursors 有权使用环状硫酯前体的催化剂和不含副产物的天然化学连接公开(公告)号：US09012594B2
公开(公告)日：2015-04-21
申请号：US13090416
申请日：2011-04-20
Applicant: Phillip B. Messersmith , Jing Su , Bi-Huang Hu
Inventor： Phillip B. Messersmith , Jing Su , Bi-Huang Hu
IPC: C08G69/06 , A61K38/00 , G01N1/36 , C07D333/36 , C08G65/334 , C08L71/02 , A61K47/34
CPC classification number: G01N1/36 , A61K47/34 , C07D333/36 , C08G65/3348 , C08L71/02
Abstract: A method of synthesizing a biocompatible hydrogel by covalently cross-linking an effective amount of a first macromonomer including a cyclic thioester group with an effective amount of a second macromonomer including a terminal cysteine group is disclosed. In addition, the synthesis and use of the following specific cyclic thioester macromonomer that can be used in the method, as well as specific hydrogels made using this macromonomer are disclosed. The disclosed method produces a biocompatible hydrogel, while producing substantially no toxic free thiol by-product. Accordingly, the method can be used in making biomedical products, such as sutures and tissue replacement biomaterials, and for encapsulating therapeutic cells and pharmaceuticals.
Abstract translation: 公开了通过共价交联有效量的包含环状硫酯基团的第一大分子单体与有效量的包含末端半胱氨酸基团的第二大分子单体合成生物相容性水凝胶的方法。 此外，公开了可用于该方法的以下特定环状硫酯大分子单体的合成和使用，以及使用该大分子单体制备的特定水凝胶。 所公开的方法产生生物相容的水凝胶，同时基本上不产生无毒的硫醇副产物。 因此，该方法可用于制造生物医学产品，例如缝线和组织置换生物材料，以及用于包封治疗细胞和药物。
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10.发明申请MULTIFUNCTIONAL METAL NANOPARTICLES HAVING A POLYDOPAMINE-BASED SURFACE AND METHODS OF MAKING AND USING THE SAME 有权具有聚多异氰酸酯基表面的多官能金属纳米颗粒及其制备和使用方法公开(公告)号：US20140271889A1
公开(公告)日：2014-09-18
申请号：US14294636
申请日：2014-06-03
Applicant: Phillip B. Messersmith , Kvar C.L. Black, IV , Ji Yi , Jose G. Rivera
Inventor： Phillip B. Messersmith , Kvar C.L. Black, IV , Ji Yi , Jose G. Rivera
CPC classification number: A61K41/0052 , A61K9/0092 , A61K9/1611 , A61K9/1641 , A61K9/1676 , A61K9/1682 , A61K9/5094 , A61K9/51 , A61K31/69 , A61K33/00 , A61K33/26 , A61K33/38 , A61K39/39558 , A61K39/40 , A61K41/0057 , A61K45/06 , A61K47/6923 , A61K49/1857 , A61K49/1875 , A61N5/062 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C07K16/00 , C07K16/2863 , C07K16/30 , G01N21/4795 , G01N21/554 , G01N33/54346 , G01N33/553 , G01N33/587
Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.
Abstract translation: 本发明提供纳米颗粒，其包括金属芯，每个轴的长度为1至100纳米，涂层设置在金属芯的至少部分表面上，其中涂层包括聚多巴胺以及制备和使用方法 这样的纳米颗粒。 金属芯可以是金，银或氧化铁，并且聚多巴胺涂层可以具有与其结合的其它物质，例如银，靶向配体或抗体，或其它治疗或成像造影剂。 所公开的纳米颗粒可以靶向用于治疗癌症或细菌感染的细胞，并用于诊断成像。
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