公开(公告)号：US20160177366A1

公开(公告)日：2016-06-23

申请号：US14910459

申请日：2014-08-07

Applicant: SERAPH BIOSCIENCES, LLC ,  WAYNE STATE UNIVERSITY

Inventor： Gregory William Auner ,  Charles Shanley ,  Michelle Brusatori ,  Tara Twomey ,  David Sant

IPC: C12Q1/04 ,  G01J3/44 ,  C12Q1/14

CPC classification number: C12Q1/04 ,  A61B5/0075 ,  A61B5/445 ,  A61B5/6815 ,  A61B5/6819 ,  A61B5/682 ,  A61B5/6846 ,  C12Q1/14 ,  G01J3/0208 ,  G01J3/0264 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/44 ,  G01J3/4406 ,  G01J3/4412 ,  G01N21/65 ,  G01N2201/0221 ,  G01N2333/11 ,  G01N2333/31 ,  G01N2333/34

Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.

Abstract translation: 基于拉曼光谱的系统和检查和询问方法提供了用于快速和成本有效地筛选各种基于蛋白质的化合物如细菌，病毒，药物和组织异常的方法。 手持式分光镜包括用于产生拉曼移位采样信号的激光和光学系列，用于信号调节和目标检测的信号处理和识别算法，其中包括超高分辨率微滤器和成像检测器阵列的组合，以提供特定分析 在与目标病原体相关的离散光谱带内的目标光谱峰。

公开(公告)号：US20160169741A1

公开(公告)日：2016-06-16

申请号：US14962100

申请日：2015-12-08

Applicant: Meopta - optika, s.r.o. ,  Univerzita Palackého v Olomouc

Inventor： Josef Kapitán ,  Daniel Vacula ,  Zdenek Losták ,  Vlastislav Svoboda

IPC: G01J3/44 ,  G01J1/04

CPC classification number: G01J3/44 ,  G01J3/0208 ,  G01J3/2823 ,  G01J3/36

Abstract: An optical system of a high-resolution imaging spectrograph intended for deep ultraviolet Raman spectroscopy, including an entrance aperture constituted by a slit, followed by a collimating objective, with a dispersive element located between the collimating objective and the subsequent focusing objective is provided. A multichannel radiation detector is arranged behind the focusing objective. The collimating objective is formed at least by a main mirror, wherein the focussing objective is formed by a set of lenses. The dispersion element is formed at least by one diffraction grating 4 and/or an optical prism.

Abstract translation: 提供了用于深紫外线拉曼光谱的高分辨率成像光谱仪的光学系统，其包括由狭缝构成的入射孔，随后是准直物镜，其中位于准直物镜和后续聚焦目标之间的色散元件。 多通道辐射探测器布置在聚焦目标后面。 至少由主镜形成准直物镜，其中聚焦物镜由一组透镜形成。 色散元件至少由一个衍射光栅4和/或光学棱镜形成。

公开(公告)号：US09366694B2

公开(公告)日：2016-06-14

申请号：US14761726

申请日：2014-01-13

Applicant: Ecole Polytechnique ,  Centre National de la Recherche Scientifique

Inventor： Marc Chaigneau ,  Akli Karar ,  Bernard Drevillon ,  Razvigor Ossikovski

IPC: G01J3/44 ,  G01Q10/00 ,  G01Q10/04 ,  G01Q20/04 ,  G01Q30/02 ,  G01Q60/04 ,  G01Q60/16 ,  G01Q60/26 ,  G01N21/65 ,  G01J3/06 ,  G01Q40/00

CPC classification number: G01Q10/00 ,  G01J3/06 ,  G01J3/44 ,  G01N21/658 ,  G01Q10/045 ,  G01Q20/04 ,  G01Q30/02 ,  G01Q40/00 ,  G01Q60/04 ,  G01Q60/16 ,  G01Q60/26

Abstract: A multimode local probe microscope having a resonator, a first electrode, and a second electrode, an excitation source adapted to generate mechanical resonance in the resonator, a metal tip fastened to the resonator, movement mechanism for imparting relative movement between the local probe and a sample and adapted to bring the end of the tip to within a distance Z lying in the range 0 to 100 nm, and detector for detecting at least one electrical signal representative of friction forces at the terminals of said electrodes. The metal tip is electrically connected to the output second electrode and the microscopy apparatus includes amplifier and filter for amplifying and filtering signals relating to the friction forces and to the tunnelling current in a single electronic circuit, and configured for regulating the distance Z between the end of the tip and the surface of the sample.

Abstract translation: 一种具有谐振器，第一电极和第二电极的多模式局部探针显微镜，适于在谐振器中产生机械共振的激发源，固定到谐振器的金属尖端，用于在局部探针和 采样并适于使尖端的端部处于位于0至100nm范围内的距离Z内;以及检测器，用于检测表示在所述电极的端子处的摩擦力的至少一个电信号。 金属尖端电连接到输出第二电极，显微镜装置包括放大器和滤波器，用于放大和滤除与单个电子电路中的摩擦力和隧道电流相关的信号，并且被配置用于调节端部之间的距离Z 的尖端和样品的表面。

公开(公告)号：US20160116414A1

公开(公告)日：2016-04-28

申请号：US14893322

申请日：2014-05-23

Applicant: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST- NATUURWETENSCHAPPELIJK ONDERZOEK TNO

Inventor： James Peter Robert DAY ,  Marijn SANDTKE

IPC: G01N21/65 ,  B01D53/14 ,  B01D53/18 ,  G01N21/49 ,  G01N1/44

CPC classification number: G01N21/65 ,  B01D53/1425 ,  B01D53/1475 ,  B01D53/1493 ,  B01D53/18 ,  B01D53/62 ,  B01D2252/204 ,  B01D2258/0283 ,  G01J3/44 ,  G01J2003/4424 ,  G01N1/44 ,  G01N21/49 ,  G01N21/658 ,  G01N2021/8416 ,  G01N2201/06113 ,  G01N2201/0697 ,  Y02C10/06

Abstract: The present disclosure concerns a method and detector (10) for detecting an analyte (1) in a sample volume (2), such as nitrosamine in an amine solvent. The method comprises measuring a resonance Raman spectrum (I1) with a first light beam (P1) matching an electronic transition of the analyte (1). The detection of the analyte is enhanced by measuring an off-resonance Raman spectrum (I2) using a second light beam (P2) that is shifted in wavelength at least 10 nm away from the electronic resonance. The resonance Raman signal (S1) of the analyte (1) is isolated from the background (Q1, Q2) by a difference analysis between the resonance and off-resonance Raman spectra (I1, I2). The method and detector (10) can be employed for detecting nitrosamine in a carbon capture process or plant (20) that employs an amine solvent.

Abstract translation: 本公开涉及用于检测样品体积（2）中的分析物（1）的方法和检测器（10），例如胺溶剂中的亚硝胺。 该方法包括利用与分析物（1）的电子跃迁相匹配的第一光束（P1）来测量共振拉曼光谱（I1）。 通过使用第二光束（P2）测量离共振拉曼光谱（I2）来增强分析物的检测，该第二光束（P2）在距离电子谐振至少10nm的波长上移动。 通过谐振和非共振拉曼光谱（I1，I2）之间的差分分析，分析物（1）的共振拉曼信号（S1）与背景（Q1，Q2）隔离。 该方法和检测器（10）可用于在采用胺溶剂的碳捕集过程或植物（20）中检测亚硝胺。

公开(公告)号：US20160109373A1

公开(公告)日：2016-04-21

申请号：US14838376

申请日：2015-08-28

Applicant: DONG-SHYOGN PAN

Inventor： DONG-SHYOGN PAN

IPC: G01N21/87 ,  G01J3/44

CPC classification number: G01N21/87 ,  G01J3/44 ,  G01N21/65

Abstract: This invention is within the technical field of corundum appraisal, and it involves an examination method to determine whether corundum has undergone beryllium diffusion treatment. Procedurally, a highly sensitive Raman spectrometer (S/N>10,000) is used to scan and examine the samples. The spectrometer is fitted with a tailor-made probe having a large facula and surface area. Specially developed software is then used to perform an intensity correction and a background elimination to obtain a specific Raman spectral range (250-120 cm-1) with the corrected intensity and a smooth baseline. The corrected and standardized Raman characteristic peak at 804 cm-1 (side-band) is used as a basis to determine whether the corundum has undergone beryllium diffusion treatment. This invention method has the advantages of being non-destructive, simple, fast, and practical. Also, it can accurately determine whether corundum has been treated.

Abstract translation: 本发明属于刚玉鉴定技术领域，涉及确定刚玉是否经过铍扩散处理的检测方法。 在程序上，使用高灵敏度的拉曼光谱仪（S / N> 10,000）来扫描和检查样品。 光谱仪配有一个具有大光斑和表面积的量身定做的探头。 然后使用专门开发的软件执行强度校正和背景消除，以获得具有校正强度和平滑基线的特定拉曼光谱范围（250-120cm-1）。 使用804cm -1（边带）的校正和标准化的拉曼特征峰作为确定刚玉是否经过铍扩散处理的基础。 本发明方法具有无损，简便，快捷，实用的优点。 此外，它可以准确地确定刚玉是否已经被处理。

公开(公告)号：US20160091429A1

公开(公告)日：2016-03-31

申请号：US14890109

申请日：2014-05-09

Applicant: LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN

Inventor： Robert Alexander Huber ,  Thomas Klein ,  Wolfgang Wieser ,  Sebastian Karpf ,  Matthias Eibl

IPC: G01N21/65 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/44 ,  G01J3/4412 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/0683 ,  G01N2201/0697 ,  H01S3/0064 ,  H01S3/0078 ,  H01S3/06758 ,  H01S3/094069 ,  H01S3/09415 ,  H01S3/10015 ,  H01S3/1618 ,  H01S3/2391 ,  H01S3/302

Abstract: Disclosed herein is a system (10) for measuring light induced transmission or reflection changes, in particular due to stimulated Raman emission. The system comprises a first light source (12) for generating a first light signal having a first wavelength, a second light source (14) for generating a second light signal having a second wavelength, an optical assembly (16) for superposing said first and second light signals at a sample location (18), and a detection means (24) for detecting a transmitted or reflected light signal, in particular a stimulated Raman signal caused by a Raman-active medium when located at said sample location. Here in at least one of the first and second light sources (12, 14) is one or both of actively controllable to emit a time controlled light pattern or operated substantially in CW mode and provided with an extra cavity modulation means (64) for generating a time controlled light pattern. The detection means (24) is capable of recording said transmitted or reflected light signal, in particular stimulated Raman signal, as a function of time.

Abstract translation: 本文公开了一种用于测量光诱导的透射或反射变化的系统（10），特别是由于受激的拉曼发射。 该系统包括用于产生具有第一波长的第一光信号的第一光源（12），用于产生具有第二波长的第二光信号的第二光源（14），用于叠加所述第一波长的光学组件 以及检测装置（24），用于检测发射或反射的光信号，特别是当位于所述采样位置时由拉曼活性介质引起的受激拉曼信号。 这里，第一和第二光源（12,14）中的至少一个是主要可控制的一个或两个以发射时间控制的光图案或基本上以CW模式操作，并且设置有用于产生的额外的空腔调制装置（64） 时间控制的光图案。 检测装置（24）能够作为时间的函数记录特定的受激拉曼信号的所述发射或反射的光信号。

公开(公告)号：US20160091366A1

公开(公告)日：2016-03-31

申请号：US14497307

申请日：2014-09-25

Applicant: Frank Jiann-Fu Yang ,  Ke-Yi Wang

Inventor： Frank Jiann-Fu Yang ,  Ke-Yi Wang

IPC: G01J3/02 ,  G01J3/44 ,  G01J3/10

CPC classification number: G01J3/0237 ,  G01J3/44

Abstract: An autofocus Raman spectrometer system includes a laser probe assembly, a microprocessor, adjustable stages and a driving means. The laser probe assembly includes an excitation means, a focusing optics provided to focus an excitation beam from the excitation means onto a sample and generate Raman scattering spectrum, a collection optics for collecting the Raman scattering spectrum, and a spectrographic detector for generating a Raman spectrum based on the Raman scattering intensity received from the collection optics. The microprocessor receives the Raman spectra signal therefrom. The laser probe assembly is situated on the adjustable stage. The driving means is coupled to the microprocessor and configured to drive the stage to move with respect to the sample. The microprocessor generates a command to the driving means for moving a position of the adjustable stage to achieve an optimal optical focus based on signal intensity of the spectra peaks measured by the spectrographic detector.

Abstract translation: 自动对焦拉曼光谱仪系统包括激光探针组件，微处理器，可调节级和驱动装置。 激光探头组件包括激发装置，聚焦光学元件，用于将来自激发装置的激发光束聚焦到样品上并产生拉曼散射光谱，用于收集拉曼散射光谱的收集光学器件和用于产生拉曼光谱的光谱检测器 基于从收集光学器件接收的拉曼散射强度。 微处理器从其接收拉曼光谱信号。 激光探头组件位于可调节台上。 驱动装置耦合到微处理器并且被配置成驱动平台相对于样品移动。 微处理器根据由光谱检测器测量的光谱峰值的信号强度，产生一个命令给驱动装置，用于移动可调节级的位置以实现最佳的光学焦点。

公开(公告)号：US09295420B2

公开(公告)日：2016-03-29

申请号：US14327553

申请日：2014-07-09

Applicant: Hong Kong Applied Science and Technology Research Institute Co. Ltd.

Inventor： Chun Zhang ,  Ka Cheung Kwok ,  Lydia Lap Wai Leung

IPC: G01J3/44 ,  A61B5/1455 ,  G01N21/63 ,  A61B5/00 ,  G01N21/65 ,  G01J3/02

CPC classification number: A61B5/1455 ,  A61B5/0075 ,  G01J3/0202 ,  G01J3/0216 ,  G01J3/0227 ,  G01J3/0237 ,  G01J3/06 ,  G01J3/44 ,  G01N21/63 ,  G01N21/65 ,  G01N2201/06113

Abstract: A transmission-reflectance swappable Raman device and a method thereof are disclosed. The excitation light is selectively directed to the sample in one direction for generating the transmission Raman signal in transmission mode or in another direction for generating the reflectance Raman signal in reflectance mode. The content of an analyte in a sample can be determined by analyzing transmission and reflectance Raman signal.

Abstract translation: 公开了一种透射反射可交换拉曼装置及其方法。 激发光在一个方向上选择性地导向样品，以在透射模式或另一方向上产生透射拉曼信号，以在反射模式下产生反射拉曼信号。 可以通过分析透射和反射拉曼信号来确定样品中分析物的含量。

公开(公告)号：US09267893B2

公开(公告)日：2016-02-23

申请号：US14499741

申请日：2014-09-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： John Curtis Wright ,  Erin Selene Boyle

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/44 ,  G01N2201/06113 ,  G01N2201/0697

Abstract: Methods of obtaining a multidimensional image of a sample are provided comprising (a) directing a first coherent light pulse having a first frequency ω1 and a first wave vector k1 at a first location in the sample, (b) directing a second coherent light pulse having a second frequency ω2 and a second wave vector k2 at the first location, (c) directing a third coherent light pulse having a third frequency ω3 and a third wave vector k3 at the first location and (d) detecting a coherent output signal having a fourth frequency ω4 and a fourth wave vector k4. At least two, but optionally all three, of the coherent light pulses each excite a different transition to a discrete quantum state (e.g., transitions to vibrational states or to electronic states) of a molecule or molecular functionality in the sample. Steps (a)-(d) are repeated at a sufficient number of other locations in the sample to provide the multidimensional image.

Abstract translation: 提供了获得样本的多维图像的方法，包括：（a）在样本中的第一位置处引导具有第一频率ω1和第一波矢量k1的第一相干光脉冲，（b）引导具有 在第一位置处的第二频率ω2和第二波矢量k2，（c）在第一位置处引导具有第三频率ω3和第三波矢量k3的第三相干光脉冲，以及（d）检测具有 第四频率ω4和第四波矢量k4。 每个相干光脉冲中的至少两个，但可选地，全部三个激发不同的跃迁到样品中分子或分子功能的离散量子态（例如，转变到振动状态或电子状态）。 在样本中的足够数量的其他位置重复步骤（a） - （d）以提供多维图像。

公开(公告)号：US09250180B2

公开(公告)日：2016-02-02

申请号：US14495233

申请日：2014-09-24

Applicant: Nuctech Company Limited ,  Tsinghua University

Inventor： Zhiqiang Chen ,  Li Zhang ,  Jianhong Zhang ,  Hongqiu Wang ,  Ziran Zhao ,  Yumin Yi ,  Jianping Gu ,  Qingping Huang

IPC: G01J3/44 ,  G01N21/47 ,  G01N33/15 ,  G01N21/65

CPC classification number: G01N21/47 ,  G01J3/44 ,  G01N21/65 ,  G01N21/658 ,  G01N33/15

Abstract: A raman spectrum measuring method for drug inspection is provided, comprising: measuring raman spectrum of a sample to be inspected to acquire an original raman spectrum curve of the sample; determining whether the original raman spectrum curve has a characterizing portion, and if not, measuring a mixture of the sample and an enhancing agent to acquire an enhanced raman spectrum curve of the sample; and if the original raman spectrum curve of the sample to be inspected has a characterizing portion, comparing the original raman spectrum curve of the sample with data in an original raman spectrum database of a drug to determine whether the sample contains the drug, otherwise, comparing the enhanced raman spectrum curve of the sample with data in an enhanced raman spectrum database of the drug to determine whether the sample to be inspected contains the drug.

Abstract translation: 提供了用于药物检查的拉曼光谱测量方法，包括：测量被检样品的拉曼光谱以获得样品的原始拉曼光谱曲线; 确定原始拉曼光谱曲线是否具有特征部分，如果不是，则测量样品和增强剂的混合物以获得样品的增强的拉曼光谱曲线; 如果要检查的样本的原始拉曼光谱曲线具有特征部分，则将样品的原始拉曼光谱曲线与药物的原始拉曼光谱数据库中的数据进行比较，以确定样品是否含有药物，否则比较 增强的拉曼光谱曲线的样品与增强的拉曼光谱数据库中的数据，以确定待检样品是否含有药物。