公开(公告)号：US20080176251A1

公开(公告)日：2008-07-24

申请号：US12010306

申请日：2008-01-23

申请人： Leopoldo Della Ciana

发明人： Leopoldo Della Ciana

IPC分类号： G01N33/53 ,  C07D279/22 ,  C12Q1/28

CPC分类号： C07D279/22 ,  G01N33/581 ,  G01N2333/908

摘要： A process is described for preparing, efficiently and with a high degree of purity N-alkylsulfonates of phenothiazine. The process consists in (a) the preparation of the phenothiazine anion, and (b) the reaction of said anion with cyclic alkyl sulfonates, such as 1,3-propane sultone and 1,4-butane sultone. This process is simpler, more direct, and more efficient than the procedures currently used for the synthesis of N-alkylsulfonates derivatives of phenothiazine. In addition, the products obtained with this process are far more pure than those obtained through current procedures and therefore ideal for bioanalytical applications that require high sensitivity, such as assays based on the measurement of peroxidase activity using chemiluminescence.

摘要翻译： 描述了制备，有效和高纯度吩噻嗪的N-烷基磺酸盐的方法。 该方法包括（a）吩噻嗪阴离子的制备，和（b）所述阴离子与环烷基磺酸盐如1,3-丙磺酸内酯和1,4-丁烷磺内酯的反应。 该方法比目前用于合成吩噻嗪的N-烷基磺酸酯衍生物的方法更简单，更直接且更有效。 此外，通过该方法获得的产品比通过当前方法获得的产品纯得多，因此对于需要高灵敏度的生物分析应用是理想的，例如基于使用化学发光测量过氧化物酶活性的测定法。

公开(公告)号：US20060183174A1

公开(公告)日：2006-08-17

申请号：US11055668

申请日：2005-02-11

申请人： Leong Ng

发明人： Leong Ng

IPC分类号： G01N33/537

CPC分类号： G01N33/573 ,  G01N33/6893 ,  G01N2333/4737 ,  G01N2333/5751 ,  G01N2333/58 ,  G01N2333/908 ,  G01N2800/325

摘要： A method for screening, diagnosis or prognosis of heart failure in a mammalian subject, for determining the stage or severity of heart failure in a mammalian subject, for identifying a mammalian subject at risk of developing heart failure, or for monitoring the effect of therapy administered to a mammalian subject having heart failure included measuring the level of myeloperoxidase (MPO) in a sample of bodily fluid from the mammalian subject. Methods for monitoring the cardiac health of a mammalian subject are further included. Kits for carrying out such methods are also provided.

摘要翻译： 用于确定哺乳动物受试者心脏衰竭的阶段或严重程度的哺乳动物受试者的心力衰竭的筛选，诊断或预后的方法，用于鉴定患有心力衰竭风险的哺乳动物受试者，或用于监测施用的治疗效果 涉及具有心力衰竭的哺乳动物受试者包括测量来自哺乳动物受试者的体液样品中髓过氧化物酶（MPO）的水平。 进一步包括监测哺乳动物受试者的心脏健康的方法。 还提供了用于执行这种方法的套件。

公开(公告)号：US20060141551A1

公开(公告)日：2006-06-29

申请号：US11359619

申请日：2006-02-23

申请人： Claudio De Simone

发明人： Claudio De Simone

IPC分类号： C12Q1/34

CPC分类号： C12Q1/37 ,  C12Q1/44 ,  G01N33/57419 ,  G01N2333/90206 ,  G01N2333/908 ,  G01N2333/916

摘要： The use of an alkanoyl L-carnitine for preparing a medicament for treating the erectile dysfunction is described.

摘要翻译： 描述了使用烷酰基L-肉毒碱制备用于治疗勃起功能障碍的药物。

公开(公告)号：US06936429B2

公开(公告)日：2005-08-30

申请号：US10726224

申请日：2003-12-01

申请人： Alex M. Saunders

发明人： Alex M. Saunders

IPC分类号： G01N33/536 ,  G01N33/542 ,  G01N33/58 ,  G01N33/53

CPC分类号： G01N33/536 ,  G01N33/542 ,  G01N33/581 ,  G01N2333/908 ,  G01N2333/914

摘要： The present invention provides an assay for an analyte in solution. The assay relies, in part, on associating two catalytic activities in close proximity to each other (e.g., by conjugating each enzyme to a ligand that binds the analyte) and providing substrates that produce a colored product only when both activities are bound to the same molecule in solution.

摘要翻译： 本发明提供了溶液中分析物的测定。 该测定部分地依赖于将彼此非常接近的两种催化活性相关联（例如，通过将每种酶与结合分析物的配体结合），并提供只有当两种活性都结合在一起时产生着色产物的底物 分子在溶液中。

公开(公告)号：US20050042703A1

公开(公告)日：2005-02-24

申请号：US10951683

申请日：2004-09-29

申请人： Kazuhito Miyauchi ,  Shizuyo Takada ,  Tomomi Murakami ,  Akira Miike

发明人： Kazuhito Miyauchi ,  Shizuyo Takada ,  Tomomi Murakami ,  Akira Miike

IPC分类号： C12Q1/44 ,  C12Q1/61 ,  C12Q1/60 ,  C12Q1/26

CPC分类号： C12Q1/61 ,  C12Q1/44 ,  G01N2333/904 ,  G01N2333/908 ,  G01N2333/918

摘要： The present invention relates to a method for conveniently quantitating TGs contained in various lipoproteins. A method for quantitating trigyceride (TG) in a particular lipoprotein which comprises eliminating free glycerol from a sample containing free glycerol and TG in the particular lipoprotein, then allowing the resulting sample to react with lipoprotein lipase and an enzyme system which generates hydrogen peroxide from free glycerol, and quantitating the generated hydrogen peroxide, is provided.

摘要翻译： 本发明涉及方便地定量各种脂蛋白中含有的TG的方法。 一种在特定脂蛋白中定量三环霉素（TG）的方法，其包括从含有游离甘油和特定脂蛋白中的TG的样品中除去游离甘油，然后使得到的样品与脂蛋白脂肪酶和从游离体产生过氧化氢的酶系统反应 甘油，并定量生成的过氧化氢。

公开(公告)号：US5989842A

公开(公告)日：1999-11-23

申请号：US105163

申请日：1998-06-26

申请人： Eberhard Schmidt ,  Christa Weiss

发明人： Eberhard Schmidt ,  Christa Weiss

IPC分类号： G01N33/532 ,  G01N33/535

CPC分类号： G01N33/535 ,  G01N2333/908 ,  Y10S435/964

摘要： The invention is a method for the enzymatic labeling of biomolecules, such as immunoglobulin, peptide, hormone, or hapten, which involves oxidizing horseradishperoxidase (HRP) with a periodate, crosslinking the oxidized HRP with an .alpha.,.OMEGA.-diaminoalkane, and coupling the biomolecule with the crosslinked, oxidized HRP.

摘要翻译： 本发明是用于酶标记生物分子的方法，例如免疫球蛋白，肽，激素或半抗原，其涉及用高碘酸盐氧化辣根过氧化物酶（HRP），用α，OMEGA-二氨基烷烃交联氧化的HRP，并将生物分子 与交联的氧化HRP。

公开(公告)号：US5702911A

公开(公告)日：1997-12-30

申请号：US698384

申请日：1996-08-15

申请人： Robert G. Whalen

发明人： Robert G. Whalen

IPC分类号： C12Q1/04 ,  C12Q1/30 ,  G01N33/569 ,  C12Q1/58 ,  C12Q1/28

CPC分类号： C12Q1/045 ,  C12Q1/30 ,  G01N33/56922 ,  G01N2333/205 ,  G01N2333/908 ,  Y10S514/925 ,  Y10S514/926

摘要： The present invention relates to an improved test composition for the diagnosis of gastric ulcers, duodenal ulcers, gastritis, gastric lymphoma and gastric carcinoma by the detection of the bacteria Helicobacter pylori and the enzyme catalase associated with such conditions. The new test composition differs from the prior art agar compositions in being an aqueous solution containing hydrogen peroxide, urea, monobasic sodium phosphate and bromthymol blue as an indicator, and in being far more rapid than the prior art test compositions.

摘要翻译： 本发明涉及通过检测细菌幽门螺杆菌和与这些病症相关的酶过氧化氢酶来诊断胃溃疡，十二指肠溃疡，胃炎，胃淋巴瘤和胃癌的改进的测试组合物。 作为包含过氧化氢，尿素，磷酸二氢钠和溴百里香兰蓝的水溶液作为指标，新测试组合物与现有技术的琼脂组合物不同，并且比现有技术的测试组合物快得多。

公开(公告)号：US3704206A

公开(公告)日：1972-11-28

申请号：US3704206D

申请日：1971-02-25

申请人： MILES LAB

发明人： FREAKE RONALD ,  GUNTER CLAUDE RAY ,  HADEN BILLY HARPEN ,  MHATRE NAGESH SHAMRAO

IPC分类号： C12M1/34 ,  C12K1/04

CPC分类号： C12Q1/04 ,  G01N2333/908

摘要： A METHOD AND DEVICE FOR DETECTING BACTERIA IN AQUEOUS FLUIDS IS DISCLOSED CONSISTING ESSENTIALLY OF TWO COMPONENT SYSTEM, THE FIRST COMPONENT COMPRISING A STABLE PEROXIDE AND THE SECOND A PEROXIDE DETECTING SYSTEM. IN USE THE FLUID BEING TESTED IN INITIALLY CONTACTED WITH THE FIRST COMPONENT COMPRISING THE PERIOXIDE WHEREBY CERTAIN BACTERIAL COMPONENTS, IF PRESENT IN THE FLUID, REACT WITH AND DEGRADE THE PERIOXIDE. THE TEST FLUID IS THEN CONTACTED WITH THE PERIOXIDE DETECTING SYSTEM FOR MEASUREMENT OF

PEROXIDE DEGRATION. A DETECTED DECREASE IN PEROXIDE IN THE TEST TUBE IS INDICATIVE OF THE PRESENCE OF BACTERIA THEREIN. A PREFERABLE EMBODIEMENT OF THE PRESENT INVENTION COMPRISES A UNITIZED DEVICE WHEREIN THE TWO COMPONENTS ARE CONTAINED IN INDIVIDUAL MATRICES.

公开(公告)号：US20240350047A1

公开(公告)日：2024-10-24

申请号：US18596447

申请日：2024-03-05

申请人： Abbott Diabetes Care Inc.

发明人： Stephen OJA ,  Tianmei OUYANG ,  Hyun CHO ,  Benjamin J. FELDMAN ,  Namvar KIAIE

IPC分类号： A61B5/1486 ,  A61B5/145 ,  C12Q1/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  C12Q1/002 ,  C12Q1/005 ,  G01N2333/9029 ,  G01N2333/904 ,  G01N2333/908

摘要： Multiple enzymes may be present in the active area(s) of an electrochemical sensor to facilitate analysis of one or more analytes. The multiple enzymes may function independently to detect several analytes or in concert to detect a single analyte. One sensor configuration includes a first active area and a second active area, where the first active area has an oxidation-reduction potential that is sufficiently separated from the oxidation-reduction potential of the second active area to allow independent signal production. Some sensor configurations may have an active area overcoated with a multi-component membrane containing two or more different membrane polymers. Sensor configurations having multiple enzymes capable of interacting in concert include those in which a first enzyme converts an analyte into a first product and a second enzyme converts the first product into a second product, thereby generating a signal at a working electrode that is proportional to the analyte concentration.

公开(公告)号：US12072331B2

公开(公告)日：2024-08-27

申请号：US17153425

申请日：2021-01-20

申请人： 7905122 CANADA INC.

发明人： Paul Jollez

IPC分类号： G01N33/52 ,  A01K1/015 ,  B01J20/24 ,  B01J20/28 ,  C12Q1/54

CPC分类号： G01N33/52 ,  A01K1/0152 ,  A01K1/0155 ,  B01J20/24 ,  B01J20/28004 ,  B01J20/28011 ,  B01J20/28069 ,  B01J20/28073 ,  B01J20/28076 ,  C12Q1/54 ,  C12Y101/03004 ,  C12Y111/01007 ,  B01J2220/445 ,  B01J2220/4825 ,  B01J2220/49 ,  B01J2220/68 ,  G01N2333/904 ,  G01N2333/908

摘要： A chromogenic absorbent material for an animal litter includes an oxidizing agent responsive to peroxidatic/pseudoperoxidatic activity in an animal excretion or a first catalytic compound generating the oxidizing agent in situ. The material also includes a chromogenic indicator being chromogenically responsive to the oxidizing activity of the oxidizing agent, and an absorptive material which is porous, for absorbing the animal excretion. The absorptive material includes a water-absorbing polysaccharide providing absorptive properties to the chromogenic absorbent material; and may also include a second polysaccharide and a superabsorbent polymer. The material may be obtained in the form of particles having a low density and a high porosity, and is usable in conjunction with an animal litter for detecting various diseases in animals.