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982 条记录 (耗时 0.027 秒)

    Simultaneous production of higher chloromethanes
    71.
    发明授权
    Simultaneous production of higher chloromethanes 失效
    同时生产较高的氯甲烷

    公开(公告)号：US4765876A

    公开(公告)日：1988-08-23

    申请号：US99783

    申请日：1987-09-22

    申请人： Jean-Jacques Masini ,  Yvan Verot

    发明人： Jean-Jacques Masini ,  Yvan Verot

    IPC分类号： C07C17/00 ,  C07C17/10 ,  C07C19/03 ,  C07C19/04 ,  C07C19/041 ,  C07C67/00

    CPC分类号： C07C19/041 ,  C07C17/10 ,  C07C19/04

    摘要： The higher chloromethanes, i.e., CH.sub.2 Cl.sub.2, CHCl.sub.3 and CCl.sub.4, are simultaneously produced by chlorinating methyl chloride with chlorine in a first reaction zone A, chlorinating at least one of the higher chloromethanes CH.sub.2 Cl.sub.2 and CHCl.sub.3 with chlorine in a parallel second reaction zone B, combining the reaction products from said first and said second reaction zones A and B, separating higher chloromethanes from said combined reaction products, and recycling at least one of said separated higher chloromethanes CH.sub.2 Cl.sub.2 and CHCl.sub.3 as chlorination feed to said second reaction zone B.

    摘要翻译： 较高的氯甲烷，即CH 2 Cl 2，CHCl 3和CCl 4，通过在第一反应区A中用氯氯化氯甲烷同时制备，在平行的第二反应区B中用氯氯化至少一个较高的氯甲烷CH 2 Cl 2和CHCl 3， 来自所述第一反应区和所述第二反应区A和B的反应产物，将较高的氯甲烷与所述组合的反应产物分离，并将至少一个所述分离的较高氯甲烷CH 2 Cl 2和CHCl 3作为氯化进料再循环到所述第二反应区B。

    Boron, aluminum and gallium perfluoro alkanesulfonate and resinsulfonate catalysts
    72.
    发明授权
    Boron, aluminum and gallium perfluoro alkanesulfonate and resinsulfonate catalysts 失效
    硼，铝和镓全氟链烷磺酸盐和树脂磺酸盐催化剂

    公开(公告)号：US4721559A

    公开(公告)日：1988-01-26

    申请号：US920329

    申请日：1986-10-17

    申请人： George A. Olah

    发明人： George A. Olah

    IPC分类号： B01J31/02 ,  B01J31/10 ,  C07C2/54 ,  C07C2/66 ,  C07C5/22 ,  C07C5/27 ,  C07C5/29 ,  C07C17/10 ,  C08G65/20 ,  C10G35/06

    CPC分类号： C08G65/20 ,  B01J31/0227 ,  B01J31/10 ,  C07C17/10 ,  C07C2/54 ,  C07C2/66 ,  C07C5/2266 ,  C07C5/2794 ,  C07C5/29 ,  B01J2231/321 ,  B01J2231/4205 ,  B01J2231/52 ,  C07C2531/025 ,  C07C2531/10 ,  Y02P20/582

    摘要： Boron, aluminum and gallium C.sub.1 -C.sub.18 perfluoroalkanesulfonates (CF.sub.3 (CF.sub.2).sub.n SO.sub.3).sub.3 M (M=B, A1, Ga; n=0-17) as well as perfluororesin sulfonates such as Nafionates are new, highly effective Friedel-Crafts catalysts. In contrast to volatile aluminum and boron trihalides, the Group III-B perfluoroalkanesulfonates are generally of low or no volatility and, except for boron triflate and some of its homologs, only sparingly soluble incommon organic solvents. This allows their use as solid or supported Friedel-Crafts catalysts of wide utility and scope in continuous heterogenous catalytic processes. At the same time, boron triflate and related lower perfluoroalkanesulfonates are particularly efficient soluble catalysts in solution reactions.

    摘要翻译： 硼，铝和镓C1-C18全氟烷基磺酸盐（CF3（CF2）nSO3）3M（M = B，A1，Ga; n = 0-17）以及全氟化物磺酸盐如Nafionates是新的，高效的Friedel-Crafts催化剂。 与挥发性铝和三卤化硼相反，III-B族全氟烷基磺酸盐通常具有低挥发性或不挥发性，除了三氟甲磺酸硼和其一些同系物外，只有微溶于有机溶剂。 这允许它们用作固体或支持的Friedel-Crafts催化剂，其在连续异质催化过程中具有广泛的用途和范围。 同时，三氟甲磺酸硼和相关的低级全氟烷基磺酸盐在溶液反应中是特别有效的可溶性催化剂。

    Multistage reactor for exothermic or endothermic chemical processes
    73.
    发明授权
    Multistage reactor for exothermic or endothermic chemical processes 失效
    用于放热或吸热化学过程的多级反应器

    公开(公告)号：US4590044A

    公开(公告)日：1986-05-20

    申请号：US539897

    申请日：1983-10-07

    申请人： Arie L. Mos ,  Franciscus H. J. Bukkems

    发明人： Arie L. Mos ,  Franciscus H. J. Bukkems

    IPC分类号： B01J12/00 ,  B01J19/00 ,  B01J19/24 ,  B01J19/26 ,  C07C17/10 ,  B01J10/00 ,  B01J14/00 ,  F28D21/00

    CPC分类号： B01J19/26 ,  B01J12/00 ,  B01J19/0013 ,  B01J19/24 ,  B01J19/243 ,  C07C17/10 ,  B01J2219/00085 ,  B01J2219/00777

    摘要： A reactor is disclosed for carrying out exothermic or endothermic chemical reactions in which the reaction temperature is maintained as constant as possible. The reactor comprises a reaction space, an inlet for at least two reaction components, and an outlet for the reaction products. The reactor according to the invention is characterized in that the reaction space is provided with a plurality of interconnected reactor stages through which the reaction stream passes in succession, that each reactor stage comprises three reaction component guiding means, and that each reactor stage is provided with at least one injection opening for at least one reaction component.

    摘要翻译： 公开了用于进行放热或吸热化学反应的反应器，其中反应温度保持尽可能恒定。 反应器包括反应空间，至少两个反应组分的入口和反应产物的出口。 根据本发明的反应器的特征在于反应空间设置有多个互连的反应器阶段，反应流通过该反应器阶段连续通过，每个反应器阶段包括三个反应组分引导装置，并且每个反应器级设置有 用于至少一个反应组分的至少一个注射开口。

    Coupling reaction involving a Grignard and allylic halide
    78.
    发明授权
    Coupling reaction involving a Grignard and allylic halide 失效

    公开(公告)号：US4292459A

    公开(公告)日：1981-09-29

    申请号：US786973

    申请日：1977-04-13

    申请人： Carlos G. Cardenas ,  Zia Ud Din

    发明人： Carlos G. Cardenas ,  Zia Ud Din

    IPC分类号： C07C1/32 ,  C07C11/21 ,  C07C17/08 ,  C07C17/10 ,  C07C29/09 ,  C07D311/72 ,  C07F3/02 ,  C07C1/26

    CPC分类号： C07C17/10 ,  C07C1/326 ,  C07C11/21 ,  C07C17/08 ,  C07C29/095 ,  C07D311/72 ,  C07F3/02

    摘要： Disclosed is a process for the coupling of a Grignard reagent RMgX with an allylic halide in the presence of a dipolar aprotic solvent wherein the improvement, for obtaining improved yield and selectivity, comprises adding a catalyst to said Grignard or allylic halide and then carrying out the coupling reaction by the addition of the Grignard reagent to the allylic halide, said reaction being characterized by the displacement at the gamma position (relative to the halide) of the allylic halide with R of the Grignard reagent, migration of the allylic double bond in the direction of the halogen atom and loss of halogen. The present invention also resides in the discovery of certain novel procedures for the synthesis of Vitamin E. Specific embodiments of this aspect of the invention reside in the syntheses of 6,7-dehydrophytol, 10,11-dihydrofarnesene, phytone, hexahydropseudoionone, and related compounds as precursors for Vitamin E.

    Chemical process for fluorinating a tertiary carbon atom in the steroid nucleus
    79.
    发明授权
    Chemical process for fluorinating a tertiary carbon atom in the steroid nucleus 失效
    用于氟化类固醇核中叔碳原子的化学方法

    公开(公告)号：US4284558A

    公开(公告)日：1981-08-18

    申请号：US775879

    申请日：1977-03-09

    申请人： Derek H. R. Barton ,  Robert H. Hesse

    发明人： Derek H. R. Barton ,  Robert H. Hesse

    IPC分类号： C07B31/00 ,  C07B39/00 ,  C07C17/00 ,  C07C17/10 ,  C07C19/08 ,  C07C19/10 ,  C07C19/12 ,  C07C23/20 ,  C07C67/00 ,  C07J1/00 ,  C07J5/00 ,  C07J7/00 ,  C07J9/00 ,  C07J41/00 ,  C07J53/00 ,  C07J75/00

    CPC分类号： C07J53/00 ,  C07B39/00 ,  C07C17/10 ,  C07J1/0011 ,  C07J1/0025 ,  C07J41/005 ,  C07J5/0076 ,  C07J7/002 ,  C07J7/0055 ,  C07J9/00

    摘要： Saturated organic compounds containing a hydrogen atom bound to a tertiary carbon atom may be electrophilically fluorinated by reaction with an electrophilic fluorinating agent such as molecular fluorine or trifluoromethyl hypofluorite under conditions whereby the formation of free fluorine radicals is suppressed, e.g. by the presence of a free radical inhibitor such as oxygen or nitrobenzene, the reactants being substantially homogeneously dispersed in a liquid medium, e.g. a solvent medium such as fluorotrichloromethane or chloroform/fluorotrichloromethane, so that the said hydrogen atom is electrophilically replaced by a fluorine atom. The fluorination is highly selective and, in the case of complex substrates such as saturated steroids which contain a number of tertiary C--H bonds, may be substantially completely confined to replacement of the hydrogen atom at the tertiary carbon atom which has the highest electron density about the C--H bond. The electron density and thus the direction of the fluorination may be controlled by appropriate selection of substituent groupings in the substrate molecule.Novel 14.alpha.-fluorosteroids are also disclosed, including compounds having valuable androgenic or progestational activity and useful synthetic intermediates.

    摘要翻译： 含有与叔碳原子结合的氢原子的饱和有机化合物可以通过与亲电氟化剂如分子氟或三氟甲基次氟酸荧光反应，在抑制游离氟自由基形成的条件下进行亲电氟化。 通过存在自由基抑制剂如氧或硝基苯，反应物基本均匀地分散在液体介质中，例如， 溶剂介质如氟三氯甲烷或氯仿/氟三氯甲烷，使所述氢原子被氟原子亲电取代。 氟化是高度选择性的，并且在复杂的底物例如含有多个叔CH键的饱和类固醇的情况下，可以基本上完​​全限制于在具有最高电子密度的叔碳原子上的氢原子的取代 CH键。 可以通过适当选择底物分子中的取代基组来控制电子密度以及氟化方向。 还公开了新的14种α-氟甾类，包括具有有价值的雄激素或促孕活性的化合物和有用的合成中间体。

    13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof
    80.
    发明授权
    13,14-Dihydro-15-alkenyl- and 13,14-dihydro-15-alkynyl prostaglandins and analogs thereof 失效
    13,14-二氢-15-烯基 - 和13,14-二氢-15-炔基前列腺素及其类似物

    公开(公告)号：US4268522A

    公开(公告)日：1981-05-19

    申请号：US85907

    申请日：1979-10-18

    申请人： James F. Eggler ,  Hans-Jurgen E. Hess

    发明人： James F. Eggler ,  Hans-Jurgen E. Hess

    IPC分类号： C07C5/09 ,  C07C17/10 ,  C07C405/00

    CPC分类号： C07C405/00 ,  C07C17/10 ,  C07C5/09

    摘要： The invention discloses certain novel 13,14-dihydro-15-alkenyl prostaglandins and 13,14-dihydro-15-alkynyl prostaglandins and analogs of each as well as the novel intermediates employed in their preparation. The 9-oxo compounds of this novel series demonstrate selective bronchodilator activity, certain of these are also useful as antisecretory agents.

    摘要翻译： 本发明公开了一些新的13,14-二氢-15-烯基前列腺素和13,14-二氢-15-炔基前列腺素及其类似物以及其制备中所用的新型中间体。 该新型系列的9-氧代化合物表现出选择性支气管扩张剂活性，其中某些也可用作抗分泌剂。