公开(公告)号：US20220001078A1

公开(公告)日：2022-01-06

申请号：US17291248

申请日：2019-11-05

申请人： GDANSKI UNIWERSYTET MEDYCZNY ,  Bowil Biotech sp. z o.o. ,  Centrum Techniki Okretowej S.A. ,  Politechnkia Gdanska ,  Uniwersytet Gdanski ,  Fundacja Roczwoju Kardiochirurglii im. Prof Zbigniewa Religi

发明人： Piotr SIONDALSKI ,  Magdalena KOLACZKOWSKA ,  Waldemar WILANDT ,  Dariusz BOBINSKI ,  Aldona DLUGA ,  Kinga DAWIDOWSA ,  Michal DITRICH ,  Leszek WILCZYNSKI ,  Hanna STAROSZCZYK ,  Paulina DEDERKO ,  Edyta MALINOWSKA-PANCZYK ,  Agata SOMMER ,  Izabela SINKIEWICZ ,  Ilona KOLODZIEJSKA ,  Marek SZKODO ,  Alicja STANISLAWSKA ,  Andrzej BORMAN ,  Artur Hugo SWIERGIEL ,  Paulina PALCZYNSKA ,  Grzegorz JABLONSKI ,  Wojciech GLAC ,  Piotr WILCZEK ,  Maciej GAWLIKOWSKI

IPC分类号： A61L27/36 ,  A61L27/20 ,  A61L27/50

摘要： The subject of the invention is the system of an element used for manufacturing heart valve, the method of manufacturing of modified bacterial cellulose (BC) with the use of Gluconacetobacter xylinus strain for the production of an element used for manufacturing heart valve, the set for implantation and the application of the element in cardio surgery.

公开(公告)号：US20220000752A1

公开(公告)日：2022-01-06

申请号：US17480436

申请日：2021-09-21

申请人： Q-Med AB

发明人： Åsa Wiebensjö ,  Katarina Edsman

IPC分类号： A61K8/60 ,  A61K8/42 ,  A61K8/67 ,  A61K8/73 ,  A61L27/20 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16 ,  A61Q7/00 ,  A61Q19/08 ,  A61K45/06 ,  A61K31/245 ,  A61K31/375 ,  A61K31/445 ,  A61K31/728 ,  A61K31/167 ,  A61K47/24 ,  A61Q19/00 ,  A61K47/61

摘要： An injectable hyaluronic acid composition including a hyaluronic acid; a local anesthetic selected from the group of amide and ester type local anesthetics or a combination thereof; and an ascorbic acid derivative in an amount which prevents or reduces the effect on the viscosity and/or elastic modulus G′ of the composition caused by the local anesthetic upon sterilization by heat. Further, the medical and non-medical, such as cosmetic, use of such a composition, and to a method of manufacturing such a composition.

公开(公告)号：US20210402059A1

公开(公告)日：2021-12-30

申请号：US17471760

申请日：2021-09-10

申请人： CARTIHEAL (2009) LTD.

发明人： Nir ALTSCHULER

IPC分类号： A61L27/36 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/12 ,  A61L27/20 ,  A61L27/40 ,  C01B25/32 ,  C01F11/18 ,  G01N1/00 ,  A61L27/50 ,  A61F2/28 ,  A61F2/30 ,  A61L27/38

摘要： This invention provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by a specific fluid uptake capacity value of at least 75%, which specific fluid uptake capacity value is determined by establishing a spontaneous fluid uptake value divided by a total fluid uptake value. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which solid substrate is characterized by having a contact angle value of less than 60 degrees, when in contact with a fluid. This invention also provides solid substrates for promoting cell or tissue growth or restored function, which said substrate is characterized by a substantial surface roughness (Ra) as measured by scanning electron microscopy or atomic force microscopy. The invention also provides for processes for selection of an optimized coral-based solid substrate for promoting cell or tissue growth or restored function and applications of the same.

公开(公告)号：US20210402050A1

公开(公告)日：2021-12-30

申请号：US17357345

申请日：2021-06-24

申请人： Anika Therapeutics, Inc.

发明人： Stefano Agnello ,  Barton W. Bracy ,  Mark D. Brunsvold ,  Steven Ek ,  Alex Goraltchouk ,  Matthew Mannarino ,  Elvira Marchetto

IPC分类号： A61L17/10 ,  A61L17/00 ,  A61L17/12 ,  A61L27/58 ,  A61L27/20 ,  A61K35/28 ,  D06M16/00

摘要： A composite medical textile such as a suture includes a plurality of bioresorbable hyaluronan-based fibers and a plurality of non-resorbable fibers. The hyaluronan-based fibers can include at least one of hyaluronic acid, sodium hyaluronate, or the esters of hyaluronic acid such as the benzyl esters. The non-resorbable fibers can be Ultra High Molecular Weight Polyethylene (UHMWPE), and other materials. Methods of making a medical textile are also disclosed.

公开(公告)号：US11191869B2

公开(公告)日：2021-12-07

申请号：US16524435

申请日：2019-07-29

申请人： DSM IP Assets B.V.

发明人： Timothy A. Ringeisen ,  William Christopher Wattengel

IPC分类号： A61B17/68 ,  A61F2/28 ,  A61B17/70 ,  C08L89/06 ,  A61L27/16 ,  A61B17/72 ,  A61L26/00 ,  A61L27/46 ,  A61L27/48 ,  A61L27/52 ,  A61L27/58 ,  C08H1/06 ,  C08L5/04 ,  C08L5/08 ,  C08L67/04 ,  A61L27/24 ,  A61L27/56 ,  A61L27/18 ,  A61L27/20 ,  A61L27/22 ,  A61L27/36 ,  A61L27/38 ,  A61F2/00 ,  A61F2/24 ,  A61F2/30 ,  A61F2/44 ,  A61L27/12 ,  A61L27/26 ,  A61L27/54 ,  C08K3/013 ,  A61B17/00 ,  A61F2/42

摘要： This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.

公开(公告)号：US20210283304A1

公开(公告)日：2021-09-16

申请号：US17334350

申请日：2021-05-28

申请人： Tazuke Kofukai ,  Mochida Pharmaceutical Co., Ltd.

发明人： Yoshihisa SUZUKI ,  Masao TANIHARA ,  Mitsuko ISAJI

IPC分类号： A61L27/20 ,  A61L27/18 ,  A61L27/48 ,  A61L27/38 ,  A61L27/58 ,  C08K5/3415 ,  C08L5/04 ,  C08L67/04

摘要： A non-tubular material for nerve regeneration induction, which can be used for the regeneration of a damaged part in a nerve, and which comprises: (A) a crosslinked form produced by crosslinking a low-endotoxin bioabsorbable polysaccharide having a carboxyl group in the molecule with at least one crosslinkable reagent selected from a compound represented by general formula (I) and a salt thereof via covalent bonds; and (B) a bioabsorbable polymer. R1HN—(CH2)n—NHR2 (I) [wherein R1 and R2 independently represent a hydrogen atom or a group represented by formula: —COCH(NH2)—(CH2)4—NH2, and n represents an integer of 2 to 18]. Thus, a medical material that can induce the regeneration of a damaged part in a nerve is provided.

公开(公告)号：US11117879B2

公开(公告)日：2021-09-14

申请号：US16848372

申请日：2020-04-14

申请人： Zhongshan Guanghe Medical Technology Co., Ltd.

发明人： Linyong Zhu ,  Yujie Hua ,  Qiuning Lin ,  Yiqing Zhang ,  Chunyan Bao ,  Xuepeng Zhong

IPC分类号： C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C07D291/08 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L24/08 ,  A61L26/00 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/52 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  C07C235/12 ,  C08B37/08 ,  C08F220/68 ,  C08G69/10 ,  C08G73/06 ,  C08J3/075 ,  C08J3/28

摘要： This invention provides preparations, compositions, products, and applications of photo-crosslinked hydrogels. Component A—a photosensitive polymer derivative, component B—the photoinitiator, and auxiliary component C—other biocompatible polymer derivative each are respectively dissolved in a biocompatible medium to obtain solution A, solution B, and solution C. The solution A, the solution B, and the optional solution C are mixed homogenously to obtain a hydrogel precursor solution. The hydrogel precursor solution is subject to irradiation of the UV light for photocoupled crosslinking to form a photo-crosslinked hydrogel. The photo-crosslinked hydrogel exhibit rapid speed of photo-curing, strong tissue adhesion, excellent mechanical properties, good biocompatibility, and excellent clinical operability. In addition, this invention also provides a kit for making the photo-crosslinked hydrogel, and applications thereof in tissue engineering, regenerative medicine, 3D printing, and as a carrier of cell, protein, or drug.

公开(公告)号：US11109955B2

公开(公告)日：2021-09-07

申请号：US16331226

申请日：2017-03-22

申请人： PHARMARESEARCH PRODUCTS CO., LTD.

发明人： Ik Soo Kim ,  Han Gyu Kim ,  Su Yeon Lee

IPC分类号： A61F2/10 ,  A61L27/50 ,  A61L27/40 ,  A61P7/02 ,  A61L27/36 ,  A61L27/60 ,  A61L27/20

摘要： The present invention relates to a dermal layer which is for grafting and has an improved graft survival rate, and a method for producing the same, wherein the dermal layer for grafting can be produced by filling a filling solution, including a DNA fragment mixture and chitosan, into an acellular dermal matrix from which cells have been removed. It was observed that the dermal layer for grafting produced in this manner, due to the filling solution filled therein and including a DNA fragment mixture and chitosan, increases the rate at which cells flow in from the tissue surrounding the graft and are fixed, and thereby alleviates an initial inflammatory reaction and promotes blending with the surrounding tissue.

公开(公告)号：US20210261693A1

公开(公告)日：2021-08-26

申请号：US17256182

申请日：2019-06-11

申请人： HALLURA LTD.

发明人： Stephane MEUNIER ,  Svetlana SHNEIDER ,  Elena RAGOZIN

IPC分类号： C08B37/08 ,  A61L27/20 ,  C07D257/08 ,  C07D237/26 ,  A61L27/52

摘要： The present invention is directed to a polymer comprising a first hyaluronic acid (HA) chain and a second HA chain crosslinked via a linker comprising an unsaturated moiety or a derivative thereof coupled to a tetrazine moiety or a derivative thereof. In some embodiments, the polymer of the invention is characterized by having a crosslinking degree of 0.2 to 4%.

公开(公告)号：US20210260244A1

公开(公告)日：2021-08-26

申请号：US17255852

申请日：2019-06-28

申请人： Merz Pharma GmbH & Co. KGaA

发明人： Christoph HOENNSCHEIDT ,  Holger KOEHLER

IPC分类号： A61L27/20 ,  A61L27/54 ,  A61L27/52 ,  C08B37/08

摘要： The present invention relates to fatty acid-grafted hyaluronic acid (FA-g-HA), and a sterile microsphere-based dermal filler formulation and a sterile crosslinked hyaluronic acid-based dermal filler formulation each comprising the FA-g-HA. The present invention further relates to processes for the preparation of the FA-g-HA and the dermal filler formulations comprising the FA-g-HA, and their use in cosmetic applications.