公开(公告)号：US5200423A

公开(公告)日：1993-04-06

申请号：US720327

申请日：1991-06-25

申请人： Tetsuya Maeda ,  Toshiyuki Yamamoto ,  Mituo Takase ,  Kazuya Sasaki ,  Tadashi Arika ,  Mamoru Yokoo ,  Rieko Hashimoto ,  Kouji Amemiya ,  Sakae Koshikawa

发明人： Tetsuya Maeda ,  Toshiyuki Yamamoto ,  Mituo Takase ,  Kazuya Sasaki ,  Tadashi Arika ,  Mamoru Yokoo ,  Rieko Hashimoto ,  Kouji Amemiya ,  Sakae Koshikawa

IPC分类号： A61K31/135 ,  A01N33/04 ,  A01N33/10 ,  A01N33/18 ,  A01N43/00 ,  A01N43/10 ,  A01N43/42 ,  A61P31/04 ,  A61P31/10 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C211/30 ,  C07C215/50 ,  C07C217/58 ,  C07D215/12 ,  C07D333/20 ,  C07D333/54 ,  C07D333/58

CPC分类号： C07D215/12 ,  A01N33/04 ,  A01N33/10 ,  A01N33/18 ,  A01N43/10 ,  A01N43/42 ,  C07D333/20 ,  C07D333/54 ,  C07D333/58

摘要： Amine derivatives having the general formula (I): ##STR1## wherein X is selected from the group consisting of ##STR2## wherein Q is oxygen, sulfur or nitrogen atom, and ##STR3## wherein Q is as above; Y is selected from the group consisting of ##STR4## R.sup.1 is hydrogen atom or an alkyl group; R.sup.2 is hydrogen atom or an alkyl group; R.sup.3 is hydrogen atom, a halogen atom or an alkyl group; R.sup.4 is hydrogen atom, an alkyl group, a cycloalkyl group, a halogenated alkyl group or a halogen atom; R.sup.5 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro group or hydroxy group; R.sup.5 is attached to an arbitrary position of X, and R.sup.3 or R.sup.4 is attached to an arbitrary position of Y.The main derivatives (I) are useful as fungicides.

公开(公告)号：US4677115B1

公开(公告)日：1992-11-10

申请号：US86322586

申请日：1986-05-14

申请人： MERCK & CO INC

发明人： JOHN J BALDWIN ,  MARCIA E CHRISTY ,  GERALD S PONTICELLO

IPC分类号： C07D307/64 ,  C07D333/34 ,  C07D333/54 ,  C07D333/62 ,  C07D409/12 ,  C07D495/04 ,  C07D495/10 ,  C07D495/20 ,  A61K31/38

CPC分类号： C07D333/54 ,  C07D307/64 ,  C07D333/34 ,  C07D333/62 ,  C07D409/12 ,  C07D495/04 ,  C07D495/10

公开(公告)号：US5110829A

公开(公告)日：1992-05-05

申请号：US737738

申请日：1991-07-30

申请人： Reiner Kober ,  Hans Theobald ,  Uwe Kardorff ,  Christoph Kuenast ,  Peter Hofmeister ,  Rainer Seele ,  Gerhard Wagenblast

发明人： Reiner Kober ,  Hans Theobald ,  Uwe Kardorff ,  Christoph Kuenast ,  Peter Hofmeister ,  Rainer Seele ,  Gerhard Wagenblast

IPC分类号： A01N43/12 ,  C07D333/54 ,  C07D333/62 ,  C07D333/64

CPC分类号： C07D333/54 ,  A01N43/12

摘要： 2,2'-Thienylbenzothiophenes of the general formula I ##STR1## where R.sup.1 and R.sup.3 independently of one another are each halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, R.sup.2 is hydrogen, halogen, alkyl, haloalkyl, alkoxy or haloalkoxy, n is 0, 1 or 2, and the radicals may be different when n is 2, and m is 0, 1, 2, 3 or 4, and the radicals may be different when m is 2, 3 or 4, processes for their preparation, pesticides containing them and the use thereof.

摘要翻译： 其中R 1和R 3彼此独立地为卤素，烷基，卤代烷基，烷氧基或卤代烷氧基，R 2为氢，卤素，烷基，卤代烷基，烷氧基或卤代烷氧基，n为0,1,2'-噻吩基苯并噻吩， 是0,1或2，当n为2时，基团可以不同，m为0,1,2,3或4，当m为2,3或4时，基团可以不同，其制备方法 ，含有它们的农药及其用途。

公开(公告)号：US5106866A

公开(公告)日：1992-04-21

申请号：US479894

申请日：1990-02-14

申请人： Tetsuya Maeda ,  Toshiyuki Yamamoto ,  Mituo Takase ,  Kazuya Sasaki ,  Tadashi Arika ,  Mamoru Yokoo ,  Rieko Hashimoto ,  Kouji Amemiya ,  Sakae Koshikawa

发明人： Tetsuya Maeda ,  Toshiyuki Yamamoto ,  Mituo Takase ,  Kazuya Sasaki ,  Tadashi Arika ,  Mamoru Yokoo ,  Rieko Hashimoto ,  Kouji Amemiya ,  Sakae Koshikawa

IPC分类号： A61K31/135 ,  A01N33/04 ,  A01N33/10 ,  A01N33/18 ,  A01N43/00 ,  A01N43/10 ,  A01N43/42 ,  A61P31/04 ,  A61P31/10 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C211/30 ,  C07C215/50 ,  C07C217/58 ,  C07D215/12 ,  C07D333/20 ,  C07D333/54 ,  C07D333/58

CPC分类号： C07D215/12 ,  A01N33/04 ,  A01N33/10 ,  A01N33/18 ,  A01N43/10 ,  A01N43/42 ,  C07D333/20 ,  C07D333/54 ,  C07D333/58

摘要： Amine derivatives having the general formula (I): ##STR1## wherein X is selected from the group consisting of ##STR2## Y is selected from the group consisting of ##STR3## R.sup.1 is hydrogen atom or an alkyl group; R.sup.2 is hydrogen atom or an alkyl group; R.sup.3 is hydrogen atom, a halogen atom or an alkyl group; R.sup.4 is hydrogen atom, an alkyl group, a cycloalkyl group, a halogenated alkyl group or a halogen atom; R.sup.5 is hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, nitro group or hydroxy group; R.sup.5 is attached to an arbitrary position of X, and R.sup.3 or R.sup.4 is attached to an arbitrary position of Y.The amine derivatives (I) are useful as fungicides.

公开(公告)号：US4952580A

公开(公告)日：1990-08-28

申请号：US270903

申请日：1988-11-09

申请人： Anthony J. Martinez ,  Thomas G. Cullen

发明人： Anthony J. Martinez ,  Thomas G. Cullen

IPC分类号： A01N31/02 ,  A01N37/02 ,  A01N37/06 ,  A01N37/10 ,  A01N37/32 ,  A01N43/06 ,  A01N43/36 ,  A01N43/78 ,  A01N43/80 ,  C07C33/42 ,  C07C323/52 ,  C07C331/22 ,  C07D207/34 ,  C07D207/40 ,  C07D207/404 ,  C07D271/06 ,  C07D271/07 ,  C07D271/10 ,  C07D271/113 ,  C07D275/06 ,  C07D277/16 ,  C07D277/36 ,  C07D285/08 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D307/71 ,  C07D333/34 ,  C07D333/38 ,  C07D333/54

CPC分类号： C07D207/404 ,  A01N31/02 ,  A01N37/02 ,  A01N37/06 ,  A01N37/10 ,  A01N37/32 ,  A01N43/06 ,  A01N43/36 ,  A01N43/78 ,  A01N43/80 ,  C07C323/52 ,  C07C33/423 ,  C07C331/22 ,  C07C69/63 ,  C07C69/76 ,  C07D207/34 ,  C07D271/07 ,  C07D271/113 ,  C07D275/06 ,  C07D277/16 ,  C07D277/36 ,  C07D285/08 ,  C07D285/125 ,  C07D285/135 ,  C07D307/71 ,  C07D333/34 ,  C07D333/38 ,  C07D333/54

摘要： Polyhaloalkene compounds of the formula: ##STR1## wherein X is sulfur, oxygen, or nitrogen, Y.sup.1 and Y.sup.2 are fluorine, Z is hydrogen or the same as Y.sup.1 and Y.sup.2, and n is 1-4; provided that:(A) when X is sulfur, Z is fluorine and R is thienyl or substituted thienyl, thianaphthyl or substituted thianaphthyl, thiazolinyl or substituted thiazolinyl, oxadiazolyl or substituted oxadiazolyl, 3,4,4-trifluoro-3-butenyloxycarbonylmethyl, thiadiazolyl substituted by halogen or R.sup.2 S, wherein R.sup.2 is 3,4,4-trifluoro-3-butenyl or R.sup.2 is phenylmethyl or phenylthiomethyl each optionally substituted by halogen or nitro; or R is thiadiazolyl substituted by R.sup.3, wherein R.sup.3 is substituted aryl, arylalkyl, aryloxyalkyl, alkylthio, haloalkylthio, haloarylthio, cyanoalkylthio, arylalkylthio, aryloxyalkylthio, arylthioalkylthio, heterocycloalkylthio, alkenylthio, haloalkenylthio, halocycloalkylalkenylthio, wherein said aryl or heterocyclic groups of R.sup.3 may be mono-, di-, tri-, tetra-, or penta-substituted; or R.sup.3 is an amino group mono- or di- substituted with members independently selected from alkyl, alkylcarbonyl, haloalkylcarbonyl, aryl, arylaminocarbonyl, arylalkylcarbonyl, arylalkoxycarbonyl, and 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarbonyl;(B) when X is oxygen, Z is fluorine and R is C(O)R.sup.1, wherein R.sup.1 is perfluoralkyl, phenyl or substituted phenyl, thienyl or substituted thienyl, furanyl or substituted furanyl, pyrollyl or substituted pyrollyl, or dihydrothiazolylthiomethyl; and(C) when X is nitrogen, R taken with the nitrogen is an isothiocyanate, succinimide, or saccharine group.The compounds exhibit activity against plant nematodes and helminths that are indicators of animal anthelmintic activity and therefore are useful in agriculture and veterinary practice.

摘要翻译： 下式的多卤烯化合物：其中X是硫，氧或氮，Y1和Y2是氟，Z是氢或与Y1和Y2相同，n是1-4; 条件是：（A）当X是硫时，Z是氟，R是噻吩基或取代的噻吩基，噻萘基或取代的噻萘基，噻唑啉基或取代的噻唑啉基，恶二唑基或取代的恶二唑基，3,4,4-三氟-3-丁烯氧基羰基甲基，噻二唑基 被卤素或R 2S取代，其中R 2是3,4,4-三氟-3-丁烯基或R 2是各自任选被卤素或硝基取代的苯基甲基或苯硫基甲基; 或R是被R 3取代的噻二唑基，其中R 3是取代的芳基，芳烷基，芳氧基烷基，烷硫基，卤代烷硫基，卤代芳硫基，氰基烷硫基，芳烷硫基，芳氧基烷硫基，芳硫基烷硫基，杂环烷硫基，烯硫基，卤代链烯硫基，卤代环烷基烯基硫基，其中R3的芳基或杂环基可以 单，二，三，四或五取代; 或R 3是独立地选自烷基，烷基羰基，卤代烷基羰基，芳基，芳基氨基羰基，芳基烷基羰基，芳基烷氧基羰基和3-（2,2-二氯乙烯基）-2,2-二甲基环丙烷羰基中的一个或二者取代的氨基。 （B）当X是氧时，Z是氟，R是C（O）R 1，其中R 1是全氟烷基，苯基或取代的苯基，噻吩基或取代的噻吩基，呋喃基或取代的呋喃基，吡咯基或取代的吡咯基或二氢噻唑硫基甲基; 和（C）当X是氮时，用氮取代的R是异硫氰酸酯，琥珀酰亚胺或糖精组。 该化合物表现出对作为动物驱虫活性指标的植物线虫和蠕虫的活性，因此可用于农业和兽医实践。

公开(公告)号：US4914099A

公开(公告)日：1990-04-03

申请号：US235557

申请日：1988-08-24

申请人： Ei Mochida ,  Kazuo Kato ,  Katsuaki Kato ,  Ichitomo Miwa ,  Jun Okuda

发明人： Ei Mochida ,  Kazuo Kato ,  Katsuaki Kato ,  Ichitomo Miwa ,  Jun Okuda

IPC分类号： C07D233/86 ,  A61K31/415 ,  A61K31/4166 ,  A61P3/08 ,  A61P3/10 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  A61P27/02 ,  A61P27/12 ,  A61P43/00 ,  C07C311/19 ,  C07D213/70 ,  C07D233/80 ,  C07D235/28 ,  C07D255/04 ,  C07D261/20 ,  C07D275/04 ,  C07D277/64 ,  C07D307/64 ,  C07D307/82 ,  C07D311/14 ,  C07D333/34 ,  C07D333/54 ,  C07D333/56 ,  C07D333/62 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D213/70 ,  C07C311/19 ,  C07D233/80 ,  C07D235/28 ,  C07D255/04 ,  C07D261/20 ,  C07D275/04 ,  C07D277/64 ,  C07D307/64 ,  C07D307/82 ,  C07D311/14 ,  C07D333/34 ,  C07D333/54 ,  C07D333/56 ,  C07D333/62 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives.The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton.

公开(公告)号：US4868315A

公开(公告)日：1989-09-19

申请号：US141737

申请日：1988-01-11

申请人： Michael E. LeTourneau ,  James R. McCarthy ,  Donald L. Trepanier

发明人： Michael E. LeTourneau ,  James R. McCarthy ,  Donald L. Trepanier

IPC分类号： C07C45/68 ,  C07C45/75 ,  C07C49/653 ,  C07C49/683 ,  C07C49/755 ,  C07D209/08 ,  C07D303/22 ,  C07D303/36 ,  C07D307/79 ,  C07D333/52 ,  C07D333/54 ,  C07D463/00

CPC分类号： C07D303/22 ,  C07C247/00 ,  C07C45/68 ,  C07C45/75 ,  C07C49/683 ,  C07C49/755 ,  C07D209/08 ,  C07D303/36 ,  C07D307/79 ,  C07D333/54

摘要： This invention relates to aryloxycycloalkanolaminoalkylene aryl ketones to the processes for their preparation and to their use as antihypertensive agents.

摘要翻译： 本发明涉及芳氧基环烷醇氨基亚烷基芳基酮与其制备方法及其作为抗高血压剂的用途。

公开(公告)号：US4855316A

公开(公告)日：1989-08-08

申请号：US161563

申请日：1988-02-18

申请人： David C. Horwell ,  Stephen J. Johnson

发明人： David C. Horwell ,  Stephen J. Johnson

IPC分类号： C07D295/135 ,  C07D307/79 ,  C07D333/54

CPC分类号： C07D295/135 ,  C07D307/79 ,  C07D333/54

摘要： Certain 1,2-diamino-4,5-dimethoxycyclohexane amide derivatives have analgesic activity, and bind selectively to the kappa opioid receptor site. Pharmaceutical compositions containing these compounds, and a method of alleviating pain in mammals are also disclosed.

摘要翻译： 某些1,2-二氨基-4,5-二甲氧基环己烷酰胺衍生物具有止痛活性，并与卡帕阿片受体位点有选择性结合。 还公开了含有这些化合物的药物组合物和减轻哺乳动物疼痛的方法。

公开(公告)号：US4847272A

公开(公告)日：1989-07-11

申请号：US007375

申请日：1987-01-27

申请人： Atsusuke Terada ,  Yoshiya Amemiya ,  Keiichi Matsuda ,  Takeshi Oshima

发明人： Atsusuke Terada ,  Yoshiya Amemiya ,  Keiichi Matsuda ,  Takeshi Oshima

IPC分类号： A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61P7/02 ,  C07D333/54 ,  C07D333/56 ,  C07D333/68 ,  C07D409/06 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D409/06

摘要： Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R.sup.1 and R.sup.2 are hydrogen or alkyl, one of A.sup.1 and A.sup.2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A.sub.2 and hence are useful in the treatment or prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.

公开(公告)号：US4845263A

公开(公告)日：1989-07-04

申请号：US764049

申请日：1985-08-09

申请人： Beng S. Ong ,  Dasarao K. Murti

发明人： Beng S. Ong ,  Dasarao K. Murti

IPC分类号： C07C323/12 ,  C07D333/16 ,  C07D333/54 ,  C07D333/76 ,  C07D335/06 ,  G03G5/06

CPC分类号： C07D333/54 ,  C07C323/12 ,  C07D333/16 ,  C07D333/76 ,  C07D335/06 ,  G03G5/062 ,  G03G5/0629 ,  C07C2103/18

摘要： Disclosed are photoresponsive imaging members comprised of sulfur incorporated dicyanomethylenefluorene carboxylate electron transporting compounds of the formula: ##STR1## wherein S is sulfur, A is a spacer group selected from the group consisting of alkylene groups, arylene groups, substituted alkylene groups, and substituted arylene groups, and B is selected from the group consisting of alkyl groups, aryl groups, substituted alkyl groups, and substituted aryl groups.

摘要翻译： 公开的是由硫结合的具有下式的二氰基甲基富芴羧酸盐电子传输化合物的光响应成像构件：其中S是硫，A是选自亚烷基，亚芳基，取代的亚烷基和取代的亚芳基的间隔基 基团，B选自烷基，芳基，取代的烷基和取代的芳基。