公开(公告)号：US10358470B2

公开(公告)日：2019-07-23

申请号：US14347222

申请日：2012-09-28

申请人： GLYTECH, INC.

发明人： Izumi Sakamoto ,  Kazuhiro Fukae ,  Katsunari Tezuka ,  Keisuke Tazuru ,  Masatoshi Maeda ,  Yasuhiro Kajihara ,  Takashi Tsuji

IPC分类号： C07K14/565 ,  A61K38/00 ,  C07K1/02 ,  A61K38/21 ,  C07K1/107

摘要： The object of the present invention is to provide a glycosylated polypeptide having uniform sugar chain structure which has interferon β activity. It was found that a glycosylated polypeptide having uniform sugar chain structure as well as having interferon β activity can be prepared by a method comprising a step of synthesizing a glycosylated peptide fragment and at least two peptide fragments and a step of linking the glycosylated peptide fragment and the at least two peptide fragments.

公开(公告)号：US20190125887A1

公开(公告)日：2019-05-02

申请号：US16024993

申请日：2018-07-02

申请人： QuiaPEG Pharmaceuticals AB

发明人： Marek Kwiatkowski

IPC分类号： A61K47/60 ,  A61K39/395 ,  C07K16/42 ,  A61K38/48 ,  C07K1/107 ,  C07K14/62 ,  A61K47/68 ,  A61K38/47 ,  C07K14/705 ,  C07K16/00 ,  A61K38/17 ,  C07K19/00 ,  C12N9/36 ,  A61K38/36 ,  A61K38/18 ,  A61K38/28 ,  C12N9/96 ,  A61K38/37

CPC分类号： A61K47/60 ,  A61K38/1793 ,  A61K38/1816 ,  A61K38/28 ,  A61K38/36 ,  A61K38/37 ,  A61K38/47 ,  A61K38/4846 ,  A61K38/4866 ,  A61K39/395 ,  A61K39/39566 ,  A61K47/68 ,  A61K2039/505 ,  C07K1/1077 ,  C07K14/62 ,  C07K14/70578 ,  C07K16/00 ,  C07K16/4291 ,  C07K19/00 ,  C07K2319/30 ,  C12N9/2462 ,  C12N9/96 ,  C12Y302/01017

摘要： This document relates to conjugates of a biologically active molecule or a derivative thereof and functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such conjugates.

公开(公告)号：US10253062B2

公开(公告)日：2019-04-09

申请号：US15535956

申请日：2015-12-22

申请人： Margaret Anne Brimble ,  Peter Roderick Dunbar ,  Geoffrey Martyn Williams ,  Daniel Verdon

发明人： Margaret Anne Brimble ,  Peter Roderick Dunbar ,  Geoffrey Martyn Williams ,  Daniel Verdon

IPC分类号： A61K38/00 ,  C07K9/00 ,  C07K1/107 ,  A61K39/12 ,  C07C323/58 ,  A61K47/54 ,  C07K14/005 ,  A61K39/00

摘要： The present invention relates to peptides, and amino acid and peptide conjugates, methods for making amino acid and peptide conjugates, conjugates produced by the methods, pharmaceutical compositions comprising the peptides and conjugates, methods of eliciting immune responses in a subject and methods of vaccinating a subject, uses of the peptides and conjugates for the same, and uses of the peptides and conjugates in the manufacture of medicaments for the same.

公开(公告)号：US20190070306A1

公开(公告)日：2019-03-07

申请号：US16079851

申请日：2017-02-24

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： Amy Han ,  William OLSON ,  Christopher D'SOUZA

IPC分类号： A61K47/68 ,  C07K1/107

摘要： Provided herein are methods and compositions for site-specific conjugation of antibodies in the presence of a transglutaminase.

公开(公告)号：US20190048038A1

公开(公告)日：2019-02-14

申请号：US16078525

申请日：2017-02-23

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Loren D. Walensky ,  Gregory H. Bird

IPC分类号： C07K1/107 ,  C07K1/113 ,  C07K19/00

摘要： Methods for generating cell-permeable hydrocarbon-stapled and/or stitched peptides lacking nonspecific membrane lytic properties and methods for using such peptides to target cellular proteins for experimental investigation and/or therapeutic benefit.

公开(公告)号：US20190000909A1

公开(公告)日：2019-01-03

申请号：US15878239

申请日：2018-01-23

申请人： LiveLeaf, Inc.

发明人： ALEXANDER L. HUANG ,  Gin Wu

IPC分类号： A61K36/82 ,  A01N65/08 ,  A61K36/185 ,  A23K20/111 ,  A61K36/22 ,  A61K33/40 ,  A61K31/122 ,  A61K31/05 ,  A01N59/00 ,  A23L33/105 ,  C07K1/107 ,  C07G1/00 ,  A61K38/44

摘要： Methods of and compositions for producing and using plant-based materials are provided. The methods include using biopolymers or their synthetic equivalents combined with a stable source of reactive oxygen species that when applied to or combined with a separate source of oxido-reducing enzyme or catalyst will cause the formation of an activated biopolymer with increased protein binding affinity and microbial control activities.

公开(公告)号：US20180362576A1

公开(公告)日：2018-12-20

申请号：US16047101

申请日：2018-07-27

申请人： BIOATLA, LLC

发明人： Jay M. Short

IPC分类号： C07K1/107 ,  G01N33/68 ,  C12N15/10 ,  G06F19/18

摘要： The present invention is relevant to proteins and novel methods of protein evolution. The present invention further relates to methods of identifying and mapping mutant polypeptides formed from, or based upon, a template polypeptide.

公开(公告)号：US20180305440A1

公开(公告)日：2018-10-25

申请号：US15957703

申请日：2018-04-19

申请人： Momenta Pharmaceuticals, Inc.

发明人： Hetal Sarvaiya ,  Nathaniel J. Washburn ,  Enrique Arevalo ,  Carlos J. Bosques

IPC分类号： C07K16/00 ,  C07K1/107 ,  C07K14/435

CPC分类号： C07K16/00 ,  A61K38/00 ,  C07K1/1077 ,  C07K14/435 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/55 ,  C12P21/005

摘要： Glycoproteins having particular sialylation patterns, and methods of making and using such glycoproteins, are described.

公开(公告)号：US10087221B2

公开(公告)日：2018-10-02

申请号：US14778496

申请日：2014-03-19

申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH

发明人： Bernd Henkel

IPC分类号： C07K14/47 ,  C07K1/04 ,  C07K1/107 ,  C07D233/78

摘要： The present invention relates to a method of synthesizing a peptide product comprising at least one hydantoin group. The peptide product may be used as a reference material for the quality control of pharmaceutical peptides, particularly for the quality control of exendin peptides. Further, the invention relates to hydantoin building blocks, a method for manufacturing such building blocks and their use for the synthesis of peptide products.

公开(公告)号：US20180252714A1

公开(公告)日：2018-09-06

申请号：US15974385

申请日：2018-05-08

申请人： Roche Sequencing Solutions, Inc.

发明人： Thomas Albert ,  Frank Bergmann ,  Victor Lyamichev ,  Jigar Patel ,  Michael Schraeml ,  Wojtek Steffen ,  Thomas Streidl

IPC分类号： G01N33/573 ,  C07K1/107 ,  C07K7/06 ,  C12N9/10

CPC分类号： G01N33/573 ,  C07K1/1075 ,  C07K7/06 ,  C12N9/1044 ,  C12Y203/01013 ,  G01N2333/91085

摘要： In one aspect, the present disclosure provides a system and method for the identification and characterization of a transglutaminase. Further, the present disclosure provides transglutaminase enzymes for forming isopeptide bonds, methods of forming isopeptide bonds in the presence of transglutaminases, and substrate tags for use with transglutaminases.