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公开(公告)号：US11149068B2
公开(公告)日：2021-10-19
申请号：US16231738
申请日：2018-12-24
摘要： Described herein are membrane permeabilizing peptides, polynucelotides encoding the peptides, and lipid vesicles comprising the peptides. Furthermore, described herein are methods for using the peptides, polynucleotides, and lipid vesicles for research, diagnosis, disease prevention, and therapeutic treatment.
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公开(公告)号：US11045427B2
公开(公告)日：2021-06-29
申请号：US15695387
申请日：2017-09-05
发明人： Vijay John , Gary McPherson
IPC分类号： A61K9/50 , C09B61/00 , C09B67/08 , C09B11/24 , B82Y30/00 , B01J21/06 , B01J35/00 , C09C1/40 , C09C1/24 , C09C1/30 , C09C1/36 , B01J13/22 , B01J23/745 , B01J13/14 , C09B67/02 , A61K9/51 , B01J21/18 , H01M4/36 , H01M4/587 , H01M4/86 , B01J35/02 , B01J35/10 , B01J37/00 , B01J37/08 , H01M4/90 , H01M10/0525 , H01M10/052 , H01G9/20 , B82Y40/00
摘要： The present invention discloses the morphology of hollow, double-shelled submicrometer particles generated through a rapid aerosol-based process. The inner shell is an essentially hydrophobic carbon layer of nanoscale dimension (5-20 nm), and the outer shell is a hydrophilic silica layer of approximately 5-40 nm, with the shell thickness being a function of the particle size. The particles are synthesized by exploiting concepts of salt bridging to lock in a surfactant (CTAB) and carbon precursors together with iron species in the interior of a droplet. This deliberate negation of surfactant templating allows a silica shell to form extremely rapidly, sealing in the organic species in the particle interior. Subsequent pyrolysis results in a buildup of internal pressure, forcing carbonaceous species against the silica wall to form an inner shell of carbon. The incorporation of magnetic iron oxide into the shells opens up applications in external stimuli-responsive nanomaterials.
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公开(公告)号：US10918672B1
公开(公告)日：2021-02-16
申请号：US15481464
申请日：2017-04-07
发明人： Stephen E. Braun , Reza Izadpanah , Eckhard Alt
IPC分类号： A61K35/35 , C12N15/113 , A61K9/00 , C12N15/85 , C12N15/90
摘要： A method of curing (or at least treating) HIV, by obtaining small tissue mesenchymal stem cells (stMSC) from adipose tissue of a patient with HIV or from a syngeneic donor or an immuno-compatible donor, wherein said stMSC are i) 4-6 μm in diameter, ii) pluripotent, and iii) have CD11b−, CD34−, CD45−, CD 29, CD 49, Oct 4 and SSEA 4 surface markers when harvested. Preferred sources are autologous adipose tissue. Next those stMSCs are gene edited to provide CCR5− stMSCs and optionally amplified by growth in culture and/or by cell selection for gene edited stMSCs and then re-introducing into the patient. Preferably, the CCR5− stMSCs will re-populate the patient with stem cells that can no longer act as latent HIV reservoirs and can differentiate into immune cells that are HIV resistant. If desired, the patient can be first treated, e.g., by radiation, to destroy the bone marrow cells before the re-introduction. However, this may not be necessary for patient who already has significant destruction of immunity by HIV.
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公开(公告)号：US10913780B2
公开(公告)日：2021-02-09
申请号：US16087426
申请日：2017-03-23
发明人： Joseph A. Fuselier , David H. Coy
IPC分类号： C07K14/655 , C07D498/08 , A61P37/06 , A61P19/02 , A61P1/04 , C07K14/765 , A61K47/64 , A61K47/65
摘要： Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) including but not limited to conjugates comprising FK-506 and ascomycin. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating. Further embodiments include methods for making the inventive compound. Additional embodiments of the invention are also discussed herein.
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公开(公告)号：US20200306419A1
公开(公告)日：2020-10-01
申请号：US16848814
申请日：2020-04-14
IPC分类号： A61L31/16 , A61L31/10 , A61L31/14 , A61K31/216 , A61K31/407 , A61K31/513 , A61K47/34 , A61K9/70 , B29C39/00 , B29C39/08 , B29C39/12 , B29D7/01
摘要： The disclosure provides drug delivery devices and methods of making and using the drug delivery devices. The devices include single and multi-layer polymer films made by a breath figure technique having therapeutic agents associated therewith. For example, the devices may be a dual layer polymer film wherein the first layer includes a therapeutic agent incorporated into it by spin coating the first agent with a polymer solution and the second agent is incorporated into the second layer by loading the agent into pores of the second layer after it is spin coated onto the first layer. In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile. The devices may take on the form of a surgical mesh with a slow release therapeutic drug.
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公开(公告)号：US10709811B2
公开(公告)日：2020-07-14
申请号：US15523306
申请日：2015-10-31
摘要： The present disclosure relates to surgical grafts for replacing nipples and areolas lost to disease or trauma with surgical grafts of decellularized donor nipples and areolas and to placing and recellularizing such grafts. The disclosure further provides methods for decellularizing epidermis. The decellularized epidermis can be used as a protective cover for skin wounds.
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公开(公告)号：US09801638B2
公开(公告)日：2017-10-31
申请号：US14006661
申请日：2012-03-21
IPC分类号： A61B17/122 , A61B17/00
CPC分类号： A61B17/122 , A61B17/1227 , A61B2017/00477 , A61B2017/00526 , A61B2017/00858 , A61B2017/1225 , Y10T29/49826
摘要： Provided is a jaw tool formed from two separable units and which includes a fastening device that attaches the two units together when the jaw tool is in use and which may automatically separate the units after the device performs its function such as clamping and/or cutting. Also provided is a jaw tool having a cutting blade wherein the contours of the device are shaped so that force is concentrated on the cutting bade when the device is closed. The jaw tool may be manufactured from a single injection molded-component that is used in duplicate to form the jaw tool. The jaw tool may be used in various applications in which it may be beneficial to simultaneously clamp and cut an object, such as various medical applications including vascular, gastrointestinal, respiratory, and placental.
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88.发明申请公开(公告)号：US20170258902A1
公开(公告)日：2017-09-14
申请号：US15591386
申请日：2017-05-10
IPC分类号： A61K39/395 , C07K17/02
CPC分类号： A61K39/3955 , A61K39/12 , A61K2039/6081 , C07K14/005 , C07K16/1018 , C07K17/02 , C07K2317/33 , C12N2760/16122 , C12N2760/16134
摘要： Immunogenic influenza hemagglutinin-derived peptide conjugates described herein induce a specific therapeutic antibody response against influenza virus. The immunogenic peptide conjugates comprise a segment from the fusion initiation region (FIR) domain of an influenza hemagglutinin protein conjugated to an immunogenic carrier protein, such asbovine serum albumin (BSA), an influenza hemagglutinin (HA) protein (i.e., full length HA), and the like. The immunogenic peptide conjugates described herein can be utilized to treat or prevent influenza infection and to prepare influenza-specific therapeutic antibodies that interfere with influenza virus-host cell membrane fusion. The peptide conjugates can be formulated in pharmaceutical compositions useful for broad spectrum treatment or prevention of influenza infections.
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公开(公告)号：US09579090B1
公开(公告)日：2017-02-28
申请号：US14189221
申请日：2014-02-25
申请人： Eric Simms , Joseph Young , Jordan Vance
发明人： Eric Simms , Joseph Young , Jordan Vance
CPC分类号： A61B17/00234 , A61B17/29 , A61B2017/00464 , A61B2017/00876 , A61B2017/3445
摘要： The present invention provides a multi-function laparoscopic surgical instrument that meets niche needs in the expanding field of Minimally Invasive Surgery (MIS). A preferred embodiment of the present invention comprises a sheath that may be inserted into a patient, wherein the sheath contains at least two interchangeable surgical instruments that may be advanced into or retracted from the patient through a single outlet in the sheath. It is intended for use in laparoscopic and thoracoscopic surgical procedures, including intra-abdominal, intra-thoracic, intra-pelvic and arthroscopic MIS procedures, and is particularly well suited to single incision laparoscopic surgery and Natural Orifice Translumenal Endoscopic Surgery (NOTES).
摘要翻译： 本发明提供了一种多功能腹腔镜手术器械，其满足微创外科（MIS）扩大领域的特殊需要。 本发明的优选实施例包括可以插入到患者体内的护套，其中护套包含至少两个可互换的手术器械，其可以通过护套中的单个出口进入或从患者中退出。 它适用于腹腔镜和胸腔镜手术，包括腹腔内，胸内，骨盆内和关节镜下的MIS手术，特别适用于单切口腹腔镜手术和天然门静脉内镜手术（NOTES）。
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90.发明申请APPARATUS, SYSTEMS & METHODS FOR NON-CONTACT RHEOLOGICAL MEASUREMENTS OF BIOLOGICAL MATERIALS 审中-公开生物材料非接触度流变测量装置，系统与方法公开(公告)号：US20170016878A1
公开(公告)日：2017-01-19
申请号：US15068126
申请日：2014-09-15
发明人： Damir Khismatullin , Ray Holt
CPC分类号： G01N33/4905 , G01N11/02 , G01N11/16 , G01N2011/0073
摘要： An acoustical non-contact levitation system and method for eliciting the deformation response of biological samples, coupled with the data analysis to yield quantitative measures of established time-dependent viscoelastic material properties. Embodiments allow for measurement to occur in near-real-time by way of a computer. In use, a biological sample is placed in an acoustic levitator, where it is induced to oscillate, such that material properties of the sample can be observed and analyzed by way of a camera and/or photodiode.
摘要翻译： 用于引发生物样品变形响应的声学非接触悬浮系统和方法，加上数据分析，以产生建立的时间依赖性粘弹性材料性质的定量测量。 实施例允许通过计算机以近似实时的方式进行测量。 在使用中，将生物样品放置在声学漂浮器中，在其中它被诱导振荡，使得可以通过照相机和/或光电二极管观察和分析样品的材料特性。
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