公开(公告)号：US20240124532A1

公开(公告)日：2024-04-18

申请号：US18274848

申请日：2022-01-28

Applicant: Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Assistance Publique - Hopitaux de Paris ,  Universite Paris Est Creteil Val De Marne ,  Baylor Research Institute

Inventor： Yves LEVY ,  Sandra ZURAWSKI ,  Gérard ZURAWSKI ,  Mireille CENTLIVRE ,  Lydie DIEUDONNE ,  Sylvain CARDINAUD

IPC: C07K14/295 ,  A61K39/118 ,  C07K16/28

CPC classification number: C07K14/295 ,  A61K39/118 ,  C07K16/2878 ,  C07K2319/33 ,  C07K2319/40

Abstract: Chlamydiae are intracellular bacterial pathogens responsible for a variety of infections. The inventors have set up candidate vaccines against Chlamydia trachomatis. In particular, the inventors have identified specific epitopes to be included in vaccine candidates thanks to in silico analysis of the amino-acid sequence of these proteins to map predicted MHC-I and -II epitopes by online software (NetMHC-4.0 and NetMHCII-2.3) and peptide binding prediction software. B cell epitopes were also mapped using online software (BepiPred-2.0 and Discotope). Finally, the inventors have generated some specific CD40 or Langerin antibodies comprising one or more identified epitope(s) of the present invention and that are suitable for vaccine purposes. Therefore, the present invention relates to Chlamydia trachomatis (Ct) antigenic polypeptides and uses thereof for vaccine purposes.

公开(公告)号：US11957734B2

公开(公告)日：2024-04-16

申请号：US17301123

申请日：2021-03-25

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： SangKon Oh ,  Sandra Zurawski ,  Hyemee Joo ,  Gerard Zurawski

IPC: A61K38/20 ,  A61K39/00 ,  C07K14/54 ,  C07K16/28

CPC classification number: A61K38/2066 ,  A61K39/0008 ,  C07K14/5428 ,  C07K16/2851 ,  C07K16/2878 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/57 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2319/00

Abstract: Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.

公开(公告)号：US20240010739A1

公开(公告)日：2024-01-11

申请号：US18036237

申请日：2021-11-10

Applicant: Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Assistance Publique - Hopitaux de Paris (APHP) ,  Baylor Research Institute ,  Universite Paris Est Creteil Val De Marne

Inventor： Yves LEVY ,  Gérard ZURAWSKI ,  Mireille CENTLIVRE ,  Sandra ZURAWSKI ,  Véronique GODOT

IPC: C07K16/28 ,  C12N15/63

CPC classification number: C07K16/2875 ,  C07K16/2851 ,  C12N15/63 ,  C07K2317/24 ,  C07K2317/565 ,  A61K2039/505

Abstract: SARS-CoV-2 vaccines will be essential to reduce morbidity and mortality. The inventors produced an antibody that is directed against a surface antigen (i.e. CD40) of an antigen presenting cell (i.e. dendritic cell) wherein the heavy chain was conjugated to the receptor-binding domain of the Sars-Cov-2 spike protein for its use as vaccine. In particular, the inventors show that said vaccine induces circulating Ab-secreting hu-B cells, elicits S-specific IgG+ hu-B cells, elicits the expansion of central memory CD4+ hu-T cells and the emergence of effector memory CD4+ T cells, elicits the expansion of central memory CD8+ hu-T cells at and the emergence of effector memory CD8+ T cells at and finally induces Stem-cell like memory hu-CD8+ T cells. The present invention thus relates to antibodies that are directed against a surface antigen of an antigen presenting cell wherein the heavy chain and/or the light chain is conjugated or fused to the receptor-binding domain of the Sars-Cov-2 spike protein

公开(公告)号：US11666286B2

公开(公告)日：2023-06-06

申请号：US17305105

申请日：2021-06-30

Applicant: BAYLOR RESEARCH INSTITUTE ,  WRIGHT STATE UNIVERSITY

Inventor： Themistocles Dassopoulos ,  Nikolaos Bourbakis

IPC: G06T7/00 ,  G06T11/00 ,  G06V10/141 ,  G06V10/143 ,  G06V10/82 ,  A61B5/00 ,  G16H50/50 ,  G16H50/20 ,  G16H30/40 ,  G06F16/583 ,  G06N20/00 ,  G06N5/04 ,  G06F18/243 ,  G06V10/42 ,  G06V10/764 ,  A61B1/31 ,  G06V10/10

CPC classification number: A61B5/7267 ,  G06F16/583 ,  G06F18/24317 ,  G06N5/04 ,  G06N20/00 ,  G06T7/0014 ,  G06T11/001 ,  G06V10/141 ,  G06V10/143 ,  G06V10/431 ,  G06V10/764 ,  G06V10/82 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50 ,  A61B1/31 ,  G06T2207/30004 ,  G06V10/16 ,  G06V2201/032

Abstract: Computational techniques are applied to video images of polyps to extract features and patterns from different perspectives of a polyp. The extracted features and patterns are synthesized using registration techniques to remove artifacts and noise, thereby generating improved images for the polyp. The generated images of each polyp can be used for training and testing purposes, where a machine learning system separates two types of polyps.

公开(公告)号：US11571365B2

公开(公告)日：2023-02-07

申请号：US15510161

申请日：2015-09-09

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Steven G. Leeds

IPC: A61J15/00 ,  A61M1/00 ,  A61M25/04 ,  A61M25/00

Abstract: This disclosure includes intraluminal tubes comprising: an elongated tube (e.g., having a proximal portion, a distal portion configured to be disposed inside of an internal cavity of a patient, and a sidewall defining a lumen extending from the proximal portion to the distal portion, the distal portion defining one or more openings in fluid communication with the lumen) and a plurality of deployable tines, each coupled to the tube and disposed outside the sidewall of the distal portion, where each tine is movable from a collapsed state to a deployed state in which a portion of the tine extends laterally away from the distal portion of the tube. In some of the present intraluminal tubes, the sidewall of the distal portion defines a plurality of longitudinal grooves, and each tine is disposed in a different one of the grooves when the tines are in the collapsed state.

公开(公告)号：US20220340670A1

公开(公告)日：2022-10-27

申请号：US17687971

申请日：2022-03-07

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Gerard Zurawski ,  Sandra Zurawski ,  SangKon Oh

IPC: C07K16/28 ,  C07K14/005

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

公开(公告)号：US11406688B2

公开(公告)日：2022-08-09

申请号：US16947126

申请日：2020-07-20

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Jacques F. Banchereau ,  Maria Virginia Pascual

IPC: C07H21/04 ,  A61K38/20 ,  C07K16/24 ,  A61K38/17 ,  C07K14/545 ,  A61P19/02 ,  A61K39/395 ,  G01N33/68

Abstract: The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering at the site of inflammation a therapeutically effective amount of at least one agent that reduces or blocks the bioavailability of interleukin-1β.

公开(公告)号：US20220189598A1

公开(公告)日：2022-06-16

申请号：US17310556

申请日：2020-02-12

Applicant: BAYLOR RESEARCH INSTITUTE

Inventor： Tawanda GUMBO ,  Magombedze GESHAM

IPC: G16H20/10 ,  C12Q1/06 ,  G16H10/60

Abstract: The present disclosure relates to methods, devices, and systems for treating a patient with tuberculosis. In an aspect of the present disclosure, a method includes receiving patient data corresponding to a TB patient. The patient data is associated with sputum time-to-positivity (TTP) data associated with a time period. The method further includes identifying, based on the patient data, a kill rate of semidormant/persistent (Ys) Mycobacterium tuberculosis. The method also includes determining a treatment response prediction result based on the kill rate and generating an output based on the treatment response prediction result.

公开(公告)号：US11219683B2

公开(公告)日：2022-01-11

申请号：US16946390

申请日：2020-06-19

Applicant: INSERM (Institut National de la Santé et de la Recherche Mêdicale) ,  Baylor Research Institute ,  Universite Paris Est Creteil Val De Marne ,  Assistance Publique Hopitaux de Paris

Inventor： Yves Levy ,  Gerard Zurawski ,  Sandra Zurawski ,  Anne-Laure Flamar

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61P31/18 ,  C07K14/005 ,  C12N7/00 ,  C07K16/28 ,  C07K16/10

Abstract: Methods and compositions are provided that can be used to vaccinate against and treat HIV. Specifically contemplated are vaccine compositions and methods of using these compositions treat HIV in patients. Aspects of the disclosure relate to an anti-CD40 antibody-HIV antigen fusion protein comprising (i) an anti-CD40 heavy chain (HCD40)-HIV antigen (Ag) fusion protein comprising the formula: HCD40-Ag, wherein Ag is a polypeptide with at least 80% sequence identity to SEQ ID NO:1; and (ii) an anti-CD40 light chain (LCD40).

公开(公告)号：US20190388379A1

公开(公告)日：2019-12-26

申请号：US16364810

申请日：2019-03-26

Applicant: Baylor Research Institute

Inventor： Charles R. ROE ,  Teodoro G. BOTTIGLIERI

IPC: A61K31/23

Abstract: The present invention describes methods and compositions for the treatment of neurodegenerative conditions including Alzheimer's disease (AD) and aging. The present invention discloses an anaplerotic diet therapy for the treatment of AD. The high fat, low carbohydrate diet described in the various embodiments of the present invention increasing circulating ketone bodies, reduces amyloid-β (Aβ) deposition in AD patients, thereby improving cognition and locomotive skills.