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公开(公告)号：US20180037665A1
公开(公告)日：2018-02-08
申请号：US15706622
申请日：2017-09-15
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Malini Viswanathan
CPC classification number: C07K16/40 , A61K49/0004 , A61K2039/505 , C07K2317/76 , C07K2317/92
Abstract: Plasma kallikrein binding proteins and methods of using such proteins are described.
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公开(公告)号：US20170369557A1
公开(公告)日：2017-12-28
申请号：US15612938
申请日：2017-06-02
Applicant: Dyax Corp.
Inventor： Robert Charles Ladner , Edward H. Cohen , Horacio G. Nastri , Kristin L. Rookey , Rene Hoet , Hendricus Renerus Jacobus Mattheus Hoogenboom
Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
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公开(公告)号：US09845340B2
公开(公告)日：2017-12-19
申请号：US14626188
申请日：2015-02-19
Applicant: Dyax Corp.
Inventor： Daniel T. Dransfield , Aaron K. Sato , Robert Charles Ladner
IPC: C07K7/08 , A61K49/00 , B82Y5/00 , C07K14/475 , A61K51/08 , C07K14/00 , A61K47/60 , A61K47/54 , A61K47/66
CPC classification number: C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
Abstract: A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
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公开(公告)号：US20170240887A1
公开(公告)日：2017-08-24
申请号：US15402724
申请日：2017-01-10
Applicant: Dyax Corp.
CPC classification number: C12N15/1082 , C07K16/00 , C07K2317/56 , C12N15/1058 , C12N15/625 , C12N15/85 , C12N2800/108 , C12N2830/002 , C12N2830/50 , C12N2830/55 , C12N2830/85 , C12N2840/203 , C40B30/04 , G01N33/56983
Abstract: Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second coding region encoding a second immunoglobulin variable domain, and c) a ribosomal binding site disposed between the first and second coding regions for translation of the second polypeptide in a first expression system, wherein the first and second coding regions are in the same translational orientation; (ii) modifying each nucleic acid cassette of the plurality in a single reaction mixture so that it is functional in a second expression system, wherein the first and second region remain physically attached during the modifying; (iii) introducing each modified nucleic acid cassette into a mammalian cell to produce a mixture of transfected cells; and (iv) expressing each modified nucleic acid cassette in the transfected cells.
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公开(公告)号：US09670481B2
公开(公告)日：2017-06-06
申请号：US14048526
申请日：2013-10-08
Applicant: Dyax Corp.
Inventor： Robert Charles Ladner , Shannon Hogan , Kristin L. Rookey
IPC: C40B30/04 , C12N15/10 , B03C1/01 , B03C1/28 , G01N33/569
CPC classification number: C12N15/1037 , B03C1/01 , B03C1/288 , C40B30/04 , G01N33/56983 , G01N2500/10
Abstract: Disclosed are methods for identifying desired members from a display libraries, including bacteriophage display libraries. Display library members can be amplified in the presence of a target compound so that cycles of selection can be rapidly completed.
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Patent Agency Ranking
公开(公告)号：US09629934B2
公开(公告)日：2017-04-25
申请号：US14019241
申请日：2013-09-05
Applicant: Dyax Corp.
Inventor： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert Charles Ladner
CPC classification number: A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
Abstract: The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
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公开(公告)号：US09624301B2
公开(公告)日：2017-04-18
申请号：US15234581
申请日：2016-08-11
Applicant: Acceleron Pharma Inc. , Dyax Corp.
Inventor： Ravindra Kumar , Asya Grinberg , Monique Davies , Diana Martik , Janja Cosic , Rachel Kent , David Buckler
IPC: C07K16/28
CPC classification number: C07K16/2863 , C07K16/40 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92 , C07K2319/30
Abstract: The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.
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公开(公告)号：US09556428B2
公开(公告)日：2017-01-31
申请号：US14718656
申请日：2015-05-21
Applicant: Dyax Corp.
CPC classification number: C12N15/1037 , C12N15/85 , C12N2795/00043 , C12N2800/108 , C12N2830/002 , C12N2840/20 , C40B40/02 , G01N33/554
Abstract: A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity of the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g., biologically active multi-chain polypeptides such as immunoglobulin Fab fragments. The present invention describes and enables the successful display of a multi-chain polypeptide on the surface of a eukaryotic host cell. Preferred vectors are described for expressing the chains of a multi-chain polypeptide in a host cell separately and independently (e.g., under separate vector control elements, and/or on separate expression vectors, thus forming a matched vector set). The use of such matched vector sets provides flexibility and versatility in the generation of eukaryotic display libraries, for example the ability to generate and to display multi-chain polypeptides by combining and recombining vectors that express variegations of the individual chains of a multi-chain polypeptide. Entire repertoires of novel chain combinations can be devised using such vector sets.
Abstract translation: 提供能够在宿主细胞表面上显示多链多肽的真核表达载体，使得多链多肽的生物学活性显示在宿主细胞的表面。 这种载体允许显示复杂的生物活性多肽，例如生物活性多链多肽，例如免疫球蛋白Fab片段。 本发明描述并使得能够在真核宿主细胞的表面上成功显示多链多肽。 描述了优选的载体，用于在宿主细胞中分别且独立地（例如，在单独的载体控制元件下和/或在分开的表达载体上，从而形成匹配的载体集）表达多链多肽的链。 使用这种匹配的载体集提供了在真核生物显示文库的产生中的灵活性和多功能性，例如通过组合和重组表达多链多肽的各个链的多样性的载体来产生和显示多链多肽的能力 。 可以使用这样的矢量集来设计新的链组合的全部曲目。
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89.发明申请PLASMA KALLIKREIN BINDING PROTEINS AND USES THEREOF IN TREATING HEREDITARY ANGIOEDEMA 审中-公开PLASMA KALLIKREIN结合蛋白及其在治疗放疗中的应用公开(公告)号：US20170002094A1
公开(公告)日：2017-01-05
申请号：US15113297
申请日：2015-01-21
Applicant: DYAX CORP.
Inventor： Daniel J. Sexton , Burt Adelman , Yung Chyung , Christopher TenHoor , Jon A. Kenniston , Ryan Faucette , Rayan larrobino , Joe Biedenkapp
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K2039/505 , A61K2039/545 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.
Abstract translation: 本文提供血浆激肽释放酶结合蛋白，例如结合活性血浆激肽释放酶的抗体以及使用这些蛋白质治疗遗传性血管性水肿的方法。
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公开(公告)号：US20160252533A1
公开(公告)日：2016-09-01
申请号：US15030790
申请日：2014-10-17
Applicant: DYAX CORP.
Inventor： Daniel J. Sexton , Burt Adelman , Andrew Nixon
IPC: G01N33/86
CPC classification number: G01N33/86 , G01N33/564 , G01N2333/745 , G01N2333/8139 , G01N2800/065 , G01N2800/102 , G01N2800/52 , G01N2800/56
Abstract: Methods, kits and compositions for diagnosing and treating autoimmune diseases such as rheumatiodi arthritis, Crohn's disease, and ulcerative colitis.
Abstract translation: 用于诊断和治疗自身免疫疾病如风湿性关节炎，克罗恩病和溃疡性结肠炎的方法，试剂盒和组合物。
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