公开(公告)号：US09358211B2

公开(公告)日：2016-06-07

申请号：US14292314

申请日：2014-05-30

Applicant: Howard University

Inventor： Emmanuel Oyekanmi Akala ,  Oluyomi Modupe Okunola

IPC: A61K9/16 ,  A61K31/135 ,  A61K31/337 ,  A61K31/704 ,  C08F220/68 ,  C08F8/00 ,  C08F8/30 ,  A61K9/51 ,  C08F290/06

CPC classification number: A61K9/1641 ,  A61K9/5146 ,  A61K31/135 ,  A61K31/337 ,  A61K31/704 ,  C08F8/00 ,  C08F8/30 ,  C08F220/68 ,  C08F290/062 ,  Y10T428/2982 ,  C08F120/14 ,  C08F220/18 ,  C08F222/00

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.

Abstract translation: 本发明涉及交联聚合物颗粒或非交联聚合物颗粒，其中交联聚合物颗粒包含由至少一种可水解单体或交联剂交联的聚（亚烷基二醇 - 接枝 - 丙烯酸酯）的共聚物。 本发明还涉及包含交联聚合物颗粒的聚合物颗粒，其是起始材料的产物，其包含（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂（交联剂可以 在非交联颗粒的情况下不存在）。 本发明还涉及包含交联共聚物的聚合物颗粒，其中交联共聚物包括如说明书中所定义的由式（I），（II）和（III）表示的结构。 本发明的其它实施方案还包括制备聚合物颗粒的方法。

公开(公告)号：US09248118B2

公开(公告)日：2016-02-02

申请号：US14626126

申请日：2015-02-19

Applicant: Howard University

Inventor： Harpal S. Mangat ,  Pradeep K. Karla

IPC: A61K31/4178 ,  C07D405/12 ,  A61K45/06 ,  A61K38/05

CPC classification number: A61K31/4178 ,  A61K31/13 ,  A61K31/355 ,  A61K31/40 ,  A61K31/5513 ,  A61K31/5517 ,  A61K31/59 ,  A61K31/765 ,  A61K38/05 ,  A61K45/06 ,  A62B17/00 ,  C07D405/12 ,  Y10T428/2982 ,  A61K2300/00

Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.

公开(公告)号：US20160009623A1

公开(公告)日：2016-01-14

申请号：US14689827

申请日：2015-04-17

Applicant: Howard University

Inventor： Evaristus A. Nwulia ,  Amol Kulkarni

IPC: C07C49/255 ,  C07D265/02 ,  C07D307/60 ,  C07D207/36 ,  C07D333/32 ,  C07D279/02 ,  C07D237/14

CPC classification number: C07C49/255 ,  A61K9/0043 ,  A61K31/12 ,  A61K31/122 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4025 ,  A61K45/06 ,  A61M31/00 ,  C07C323/22 ,  C07D207/36 ,  C07D237/14 ,  C07D265/02 ,  C07D279/02 ,  C07D307/60 ,  C07D333/32

Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.

Abstract translation: 本文描述了具有式（I）至（VIII）的化合物，其盐或其组合以及包含一种或多种这些化合物的药物组合物用于治疗由HIV引起的HIV和神经变性作用。 本文还提供了用于抑制HIV-1，治疗脑中潜伏性HIV并防止HIV介导的认知衰退和HIV痴呆的方法和试剂盒，其包括施用具有式（I）至（VIII）的化合物和包含 具有这些式的化合物。 具有式I至VIII的化合物是姜黄素类似物，其有利地表征为具有抗逆转录病毒，神经保护，抗葡萄糖苷酶和抗HIV整合酶性质。 一方面，药物组合物是鼻内递送的。

公开(公告)号：US09101652B2

公开(公告)日：2015-08-11

申请号：US13793592

申请日：2013-03-11

Applicant: Howard University

Inventor： Evaristus A. Nwulia

IPC: A01N65/00 ,  A61K36/752 ,  A61K36/54 ,  A61K36/53 ,  A61K9/00 ,  A61M16/00 ,  A61M16/12 ,  A61K36/00 ,  A61M16/06 ,  A61M21/00

CPC classification number: A61K36/752 ,  A61K9/0043 ,  A61K9/007 ,  A61K36/00 ,  A61K36/53 ,  A61K36/54 ,  A61M16/0003 ,  A61M16/0057 ,  A61M16/0666 ,  A61M16/0875 ,  A61M16/107 ,  A61M16/12 ,  A61M16/122 ,  A61M16/208 ,  A61M21/00 ,  A61M2016/003 ,  A61M2021/0016 ,  A61M2205/8206 ,  A61M2205/8237

Abstract: A method, apparatus and kit have been discovered which regenerate with the use of odorants the connections of the neurons of the brain and central nervous system in the treatment of such person afflicted neuro-disorders caused by disease or trauma.

Abstract translation: 已经发现一种方法，装置和试剂盒，其使用气味剂再生，脑和神经系统的神经元的连接在这种人的治疗中受到疾病或创伤引起的神经障碍的影响。

公开(公告)号：US20150209287A1

公开(公告)日：2015-07-30

申请号：US14575517

申请日：2014-12-18

Applicant: Howard University

Inventor： Emmanuel Oyekanmi Akala ,  Simeon Kolawole Adesina

IPC: A61K9/16 ,  A61K31/337 ,  C08G63/85

CPC classification number: C08G63/78 ,  A61K9/1635 ,  A61K9/5153 ,  A61K31/337 ,  A61K31/7034 ,  A61K31/704 ,  B01J13/06 ,  B01J13/16 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00 ,  C08F299/024 ,  C08G63/06 ,  C08G63/82 ,  C08G63/85 ,  C08G63/912 ,  Y10S977/773 ,  Y10T428/2982

Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.

Abstract translation: 本发明涉及交联或非交联聚合物颗粒，其中交联聚合物颗粒包含由至少一种可水解单体交联的聚（烷二醇 - 接枝 - 乳酸）共聚物。 本发明的另一个实施方案是包含交联聚合物颗粒的聚合物颗粒，其是起始材料的产物，其包含（a）亲水性单体，（b）疏水性单体和（c）可水解交联剂。 本发明的另一个实施方案是包含交联共聚物的聚合物颗粒，其包含由式（I），（II）和（III）表示的结构，其中式（I），（II）和（III） 规范。 本发明的其它实施方案包括制备甲基丙烯酸酯封端的大分子单体的方法，制备交联剂的方法，以及通过分散聚合制备负载纳米球的治疗剂的方法。

公开(公告)号：US20150119250A1

公开(公告)日：2015-04-30

申请号：US14390743

申请日：2013-03-15

Applicant: Howard University ,  Georgetown University

Inventor： Sivanesan Dakshanamurthy ,  Hemayet Ullah

IPC: A01N43/653 ,  A01N43/38

CPC classification number: A01N43/653 ,  A01N43/38

Abstract: Compounds and methods are described herein that are effective to modulate plant response (e.g., plant susceptibility) to environmentally-induced stress. The compounds and methods described herein advantageously may be used to modulate environmental stress resistance in a wide variety of plants. Environmental stresses include, for example, high light intensity (UV exposure), temperature (e.g., high heat), high soil salinity, and low soil moisture (e.g., drought). As used herein, environmental stresses include any conditions that result in increased generation of reactive oxygen species (ROS) and accumulation of ROS in the plant cells. The compounds described herein that are effective to modulate resistance to the stress prevent, directly or indirectly, or increase phosphorylation of Tyr248 of the RACK1A protein.

Abstract translation: 本文描述了有效调节植物对环境胁迫的响应（例如，植物敏感性）的化合物和方法。 本文所述的化合物和方法有利地可用于调节各种植物中的耐环境胁迫性。 环境胁迫包括例如高光强度（UV暴露），温度（例如高热），高土壤盐分和低土壤湿度（例如干旱）。 如本文所用，环境应力包括导致活性氧（ROS）的产生增加和ROS在植物细胞中积累的任何条件。 本文所述的有效调节抗原的化合物直接或间接地阻止或增加RACK1A蛋白的Tyr248的磷酸化。

公开(公告)号：US20140289318A1

公开(公告)日：2014-09-25

申请号：US14294883

申请日：2014-06-03

Applicant: Howard University

Inventor： Legand L. Burge, III

IPC: H04L29/08

CPC classification number: H04L67/2852 ,  G06F12/0862 ,  G06Q30/0224 ,  H04L29/0854 ,  H04L67/1095 ,  H04L67/2857 ,  H04L67/306 ,  H04M2242/40 ,  H04W4/02 ,  H04W4/50

Abstract: A context of a mobile device is determined. A context preference of a user associated with the mobile device is determined. The context of the mobile device and the user context preference is transmitted to another node and responsively returned data is received. Available free space in the mobile device is determined. All data whose timestamp is within a predetermined threshold is cached. The data is cached in at least a portion of the free space.

Abstract translation: 确定移动设备的上下文。 确定与移动设备相关联的用户的上下文偏好。 移动设备的上下文和用户上下文偏好被发送到另一个节点，并且响应地返回的数据被接收。 确定移动设备中的可用空间。 其时间戳在预定阈值内的所有数据被缓存。 数据被缓存在可用空间的至少一部分中。

公开(公告)号：US20240180867A1

公开(公告)日：2024-06-06

申请号：US18439896

申请日：2024-02-13

Applicant: Howard University

Inventor： Xinbin GU

IPC: A61K31/343 ,  A61K31/704 ,  A61P35/00

CPC classification number: A61K31/343 ,  A61K31/704 ,  A61P35/00

Abstract: The present disclosure provides methods related to treating triple-negative breast cancer (TNBC) in a mammal by administering salvianolic acid B (or a salt or solvate thereof) to promote ceramide-mediated apoptosis. In one form, the ceramide-mediated apoptosis of TNBC cells occurs by decreasing the level of one or more of glucosylceramide synthase and GM3 synthase in the subject through the use of an effective amount of salvianolic acid B. In another aspect, salvianolic acid B or its pharmaceutically acceptable salt or solvate is used as a medicament or in the manufacture of a medicament for treating TNBC.

公开(公告)号：US20220309810A1

公开(公告)日：2022-09-29

申请号：US17706252

申请日：2022-03-28

Applicant: HOWARD UNIVERSITY

Inventor： Tsang-Wei TU ,  Yi-YU HSU ,  Chao-Hsiung HSU ,  Artur AGARONYAN ,  Paul C. WANG

IPC: G06V20/69 ,  G06T5/00 ,  G06T7/00 ,  G06T7/149 ,  G06T7/194

Abstract: A method and apparatus for morphological analysis of neural cells may include receiving an immunohistochemistry (IHC) image of one or more neural cells; detecting the one or more neural cells in the IHC image using a first neural network, wherein the detecting includes identifying boundaries of the one or more neural cells; generating a segmentation cell mask using a second neural network based on the identified boundaries of the one or more neural cells; and classifying the one or more neural cells based on the generated segmentation cell mask using a trained classification model.

公开(公告)号：US20220249602A1

公开(公告)日：2022-08-11

申请号：US17729502

申请日：2022-04-26

Applicant: HOWARD UNIVERSITY

Inventor： Yousef TIZABI

IPC: A61K38/16

Abstract: C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) provides therapeutic effects in motor impairments associated with Parkinson disease (PD), and provides long lasting antidepressant effects, thus useful in treating and mitigating depression, particularly PD-depression co-morbid condition. A method for treating or mitigating depression, including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof. A method for treating or mitigating motor impairments associated with Parkinson's disease (PD), including administrating an effective amount of C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) to a subject in need thereof.