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    THREE DIMENSIONAL MOVING PICTURES WITH A SINGLE IMAGER AND MICROFLUIDIC LENS
    85.
    发明申请
    THREE DIMENSIONAL MOVING PICTURES WITH A SINGLE IMAGER AND MICROFLUIDIC LENS 审中-公开
    三维尺寸移动图像与单个图像和微流体镜头

    公开(公告)号：US20170078559A1

    公开(公告)日：2017-03-16

    申请号：US15308833

    申请日：2015-05-15

    Applicant: Indiana University Research and Technology Corporation

    Inventor： Lauren Christopher ,  Chao Liu

    IPC: H04N5/232 ,  H04N13/02 ,  G06T7/00

    CPC classification number: H04N5/23212 ,  G06T7/571 ,  H04N5/23229 ,  H04N13/236 ,  H04N13/257 ,  H04N13/275 ,  H04N2013/0081

    Abstract: A method and system for determining depth of an image using a single imager and a lens having a variable focal length is provided. The system comprises a microfluidic lens having a variable focal length controlled by a lens controller and an imager receiving an image of an object from the lens, wherein the imager is configured to receive a first image comprising a first plurality of pixels from the lens at a first focal length and a second image comprising a second plurality of pixels from the lens at a second focal length, the second focal length being different than the first focal length, non-volatile memory, wherein the first image and the second image are stored in the non-volatile memory, a depth module configured to determine a distance between the lens and the object based by a comparison of the first image of the object and the second image of the object.

    Abstract translation: 提供了使用单个成像器和具有可变焦距的透镜来确定图像深度的方法和系统。 该系统包括具有由透镜控制器控制的可变焦距的微流体透镜和从透镜接收物体的图像的成像器，其中成像器被配置为在一个透镜控制器处从透镜接收包括第一多个像素的第一图像 第一焦距和第二图像，其包括来自第二焦距的透镜的第二多个像素，第二焦距不同于第一焦距非易失性存储器，其中第一图像和第二图像被存储在 非易失性存储器，深度模块，被配置为通过对象的第一图像和对象的第二图像的比较来确定透镜和对象之间的距离。

    GENERALIZABLE ASSAY FOR VIRUS CAPSID ASSEMBLY
    88.
    发明申请
    GENERALIZABLE ASSAY FOR VIRUS CAPSID ASSEMBLY 审中-公开
    用于病毒组件的通用测定

    公开(公告)号：US20170029907A1

    公开(公告)日：2017-02-02

    申请号：US15304019

    申请日：2015-04-14

    Applicant: Indiana University Research and Technology Corporation

    Inventor： Adam Zlotnick ,  Stella Vieweger

    IPC: C12Q1/70 ,  C12Q1/68

    CPC classification number: C12Q1/703 ,  C12Q1/6818 ,  C12Q1/70 ,  C12Q2600/136 ,  Y02A50/53

    Abstract: Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targetting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. We have developed an in vitro assay for capsid assembly that works on a range of viruses at biologically relevant protein concentrations to facilitate screening large libraries of chemicals for lead compounds.

    Abstract translation: 病毒衣壳保护病毒基因组并在其递送和细胞内运输中发挥作用，使其成为抗病毒治疗的有吸引力的靶标。 靶向衣壳装配的困难是确定干扰促进反应的弱蛋白质 - 蛋白质相互作用的分子。 我们开发了一种用于衣壳组装的体外测定法，其用于生物相关蛋白浓度的一系列病毒，以便筛选铅化合物的大型化学物质文库。

    SINGLE CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR
    89.
    发明申请
    SINGLE CHAIN INSULIN AGONISTS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR 审中-公开
    单链胰岛素激素在胰岛素受体中展示高活性

    公开(公告)号：US20160340400A1

    公开(公告)日：2016-11-24

    申请号：US15229942

    申请日：2016-08-05

    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

    Inventor： Richard D. DiMARCHI ,  Yulia AZRIEL ,  Zachary KAUR ,  Jonathan MEYERS ,  Todd PARODY ,  Yan ZHAO

    IPC: C07K14/62 ,  A61K38/18 ,  A61K38/28 ,  C07K14/475 ,  A61K47/48

    CPC classification number: C07K14/62 ,  A61K38/00 ,  A61K38/18 ,  A61K38/28 ,  A61K47/60 ,  C07K14/475

    Abstract: Single chain insulin analogs are provided having high potency and specificity for the insulin receptor. As disclosed herein optimally sized linking moieties can be used to link human insulin A and B chains, or analogs or derivatives thereof, wherein the carboxy terminus of the B25 amino acid of the B chain is linked to the amino terminus of the A1 amino acid of the A chain via the intervening linking moiety. In on embodiment the linking moiety comprises a polyethylene glycol of 6-16 monomer units and in an alternative embodiment the linking moiety comprises a non-native amino acid sequence derived form the IGF-1 C-peptide and comprising at least 8 amino acids and no more than 12 amino acid in length. Also disclosed are prodrug and conjugate derivatives of the single chain insulin analogs.

    Abstract translation: 提供具有对胰岛素受体具有高效力和特异性的单链胰岛素类似物。 如本文所公开的，优选尺寸的连接部分可用于连接人胰岛素A和B链或其类似物或衍生物，其中B链的B25氨基酸的羧基末端连接到A1氨基酸的氨基末端 A链通过中间连接部分。 在实施方案中，连接部分包含6-16个单体单元的聚乙二醇，并且在替代实施方案中，连接部分包含衍生自IGF-1 C-肽的非天然氨基酸序列，并且包含至少8个氨基酸且不包含 长度超过12个氨基酸。 还公开了单链胰岛素类似物的前药和缀合物衍生物。

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