公开(公告)号：US20070155807A1

公开(公告)日：2007-07-05

申请号：US11458648

申请日：2006-07-19

Applicant: Duane Miller ,  James Dalton ,  Veeresa Gududuru ,  Eunju Hurh

Inventor： Duane Miller ,  James Dalton ,  Veeresa Gududuru ,  Eunju Hurh

IPC: A61K31/427 ,  A61K31/426 ,  C07D417/02

CPC classification number: C07D277/06 ,  C07D277/14 ,  C07D277/20 ,  C07D277/34 ,  C07D277/56 ,  C07D417/04

Abstract: Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides according to formulae (I) and (II) are disclosed where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.

Abstract translation: 公开了根据式（I）和（II）的取代的噻唑烷酮羧酸酰胺和取代的噻唑烷羧酸酰胺，其中各种取代基如说明书中所定义。 还公开了制备这些化合物的方法，含有这些化合物的药物组合物及其用途，特别是用于治疗或预防癌症的方法。

公开(公告)号：US20070123563A1

公开(公告)日：2007-05-31

申请号：US11505499

申请日：2006-08-17

Applicant: James Dalton ,  Duane Miller

Inventor： James Dalton ,  Duane Miller

IPC: A61K31/4704 ,  A61K31/404 ,  A61K31/277 ,  A61K31/165 ,  A61K31/195 ,  A61K31/32

CPC classification number: C07D271/12 ,  C07C235/24 ,  C07C255/54 ,  C07C255/60 ,  C07C317/44 ,  C07C323/62 ,  C07C335/18 ,  C07D209/08

Abstract: This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.

公开(公告)号：US20070066568A1

公开(公告)日：2007-03-22

申请号：US11510844

申请日：2006-08-28

Applicant: James Dalton ,  Duane Miller

Inventor： James Dalton ,  Duane Miller

IPC: A61K31/675 ,  A61K31/555 ,  A61K31/4709 ,  A61K31/405 ,  A61K31/4704 ,  A61K31/32 ,  A61K31/277 ,  A61K31/165

CPC classification number: A61K31/165 ,  A61K31/277 ,  A61K31/32 ,  A61K31/405 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/555 ,  A61K31/675

Abstract: This invention provides: 1) a method of treating a subject suffering from, or predisposed to a kidney disease or disorder; 2) a method of treating a subject suffering from a wound, or reducing the incidence of, or mitigating the severity of a wound in a subject; 3) a method of treating a subject suffering from a burn, or reducing the incidence of, or mitigating the severity of a burn in a subject, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound; 4) a method of treating a subject suffering from a spinal cord injury, by administering to the subject a selective androgen receptor modulator (SARM) and/or an analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, impurity or crystal of said SARM compound, or any combination thereof.

Abstract translation: 本发明提供：1）治疗患有或易患肾病或病症的受试者的方法; 2）治疗患有伤口的受试者或降低受试者的伤口的发生或减轻其严重程度的方法; 3）治疗患有烧伤的受试者或降低受试者的烧伤的发生或减轻其严重程度的方法，其包括向所述受试者施用选择性雄激素受体调节剂（SARM）化合物的步骤; 4）通过向受试者施用选择性雄激素受体调节剂（SARM）和/或其类似物，衍生物，异构体，代谢物，药学上可接受的盐，药物产品，水合物N，治疗患有脊髓损伤的受试者的方法 氧化物，前药，多晶型物，杂质或结晶，或其任何组合。

公开(公告)号：US20060287547A1

公开(公告)日：2006-12-21

申请号：US11125159

申请日：2005-05-10

Applicant: James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

Inventor： James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

IPC: C07C237/32 ,  C07C255/56

CPC classification number: C07C235/24

Abstract: The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor. The selective androgen receptor modulators (SARM) are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of chronic muscular wasting; e) decreasing the incidence of, halting or causing a regression of prostate cancer; f) oral androgen relacement and/or other clinical therpauetic and/or diagnostic areas.

Abstract translation: 本发明涉及雄激素和合成代谢活性的雄激素受体靶向剂（ARTA），其是雄激素受体的非甾体配体。 选择性雄激素受体调节剂（SARM）可用于a）男性避孕; b）治疗各种激素相关病症，例如与老年雄性雄激素降低有关的病症（ADAM），如疲劳，抑郁，性欲降低，性功能障碍，勃起功能障碍，性腺机能减退，骨质疏松症，脱发，贫血， 肥胖，肌营养不良，骨质减少，骨质疏松症，良性前列腺增生，情绪和认知和前列腺癌的改变; c）治疗与男性雄激素降低相关的病症（ADIF），如性功能障碍，性欲降低，性腺机能减退，肌营养不良，骨质减少，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发，肥胖，子宫内膜异位症，乳腺癌 癌症，子宫癌和卵巢癌; d）治疗和/或预防慢性肌肉消瘦; e）降低前列腺癌的发生率，停止或导致消退; f）口服雄激素替代和/或其他临床治疗和/或诊断领域。

公开(公告)号：US20060229362A1

公开(公告)日：2006-10-12

申请号：US11355187

申请日：2006-02-16

Applicant: James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

Inventor： James Dalton ,  Duane Miller ,  Yali He ,  Donghua Yin

IPC: A61K31/277

CPC classification number: A61K31/277

Abstract: This invention provides a class of androgen receptor targeting agents. The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM).

Abstract translation: 本发明提供一类雄激素受体靶向剂。 这些药剂定义了一种新的化合物亚类，它们是选择性雄激素受体调节剂（SARM）。

公开(公告)号：US20060155998A1

公开(公告)日：2006-07-13

申请号：US11282945

申请日：2005-11-17

Applicant: James Dalton ,  Stephen Thomas ,  Dmitry Isakbayev

Inventor： James Dalton ,  Stephen Thomas ,  Dmitry Isakbayev

IPC: H04L9/00

CPC classification number: H04M7/006 ,  H04L29/06027 ,  H04L63/0823 ,  H04L65/1069 ,  H04L65/4007 ,  H04M3/38 ,  H04M3/382 ,  H04M15/00 ,  H04M15/49 ,  H04M15/56 ,  H04M2215/202 ,  H04M2215/46

Abstract: A clearinghouse server for routing multi-media communications, including telephony calls, between a source device and a destination device via a distributed computer network, such as the global Internet. The clearinghouse server can authorize the completion of a communication from a source device to a destination device and collect usage-related information for the completed communication. In response to an authorization request issued by an enrolled source device, the clearinghouse server can identify one or more available destination devices available to accept a communication from an authorized source device. The clearinghouse server can provide a list of the identified destination devices, typically organized in a rank order, by sending an authorization response to the source device. In turn, the source device can use this list to select a destination device and contact that selected device via the computer network to complete the communication.

公开(公告)号：US07041596B1

公开(公告)日：2006-05-09

申请号：US10821751

申请日：2004-04-08

Applicant: Jeremie James Dalton ,  Sanjay Gopinath ,  Jason M. Blackburn ,  John Stephen Drewery

Inventor： Jeremie James Dalton ,  Sanjay Gopinath ,  Jason M. Blackburn ,  John Stephen Drewery

IPC: H01L21/4763

CPC classification number: H01L21/76802 ,  C23C16/0245 ,  C23C16/18 ,  H01L21/28556 ,  H01L21/28562 ,  H01L21/76826 ,  H01L21/76843 ,  H01L21/76873 ,  H01L21/76877

Abstract: An excited surfactant species is created by generating plasma discharge in a surfactant precursor gas. A surfactant species typically includes at least one of iodine, led, thin, gallium, and indium. A surface of an integrated circuit substrate is exposed to the excited surfactant species to form a plasma-treated surface. A ruthenium thin film is deposited on the plasma-treated surface using a CVD technique.

Abstract translation: 通过在表面活性剂前体气体中产生等离子体放电产生激发的表面活性剂种类。 表面活性剂物质通常包括碘，铅，薄，镓和铟中的至少一种。 将集成电路基板的表面暴露于被激发的表面活性剂种类以形成等离子体处理的表面。 使用CVD技术将钌薄膜沉积在等离子体处理的表面上。

公开(公告)号：US20060067307A1

公开(公告)日：2006-03-30

申请号：US11229335

申请日：2005-09-16

Applicant: James Dalton ,  Stephen Thomas

Inventor： James Dalton ,  Stephen Thomas

IPC: H04L12/66

CPC classification number: H04L65/40 ,  H04L69/08

Abstract: A system for routing voice telephone calls over IP networks as opposed to traditional switched circuit networks. The voice communications during the telephone call are packaged as digital data and access the Internet through gateways. The system supports the linking of a source gateway in a first clearinghouse to a destination gateway in a second clearinghouse. The system further supports the selection of a destination gateway based on factors such as cost, speed of routing, and transmission quality of the voice data. The components of the system are arranged so as to minimize the number of signals sent between clearinghouses in identifying the optimal destination gateway.

公开(公告)号：US20060014740A1

公开(公告)日：2006-01-19

申请号：US11057099

申请日：2005-02-11

Applicant: Duane Miller ,  James Dalton ,  Veeresa Gududuru ,  Eunju Hurh

Inventor： Duane Miller ,  James Dalton ,  Veeresa Gududuru ,  Eunju Hurh

IPC: A61K31/5377 ,  A61K31/4439 ,  A61K31/426 ,  C07D417/02

CPC classification number: C07D277/06 ,  C07D263/04 ,  C07D263/06 ,  C07D277/04

Abstract: Analogs exhibiting inhibition of cell proliferation are provided. Methods of making the analogs are also included. The analogs can be used to treat cancerous conditions such as prostate, breast, and ovarian cancer.

Abstract translation: 提供了表现出抑制细胞增殖的类似物。 制备类似物的方法也包括在内。 类似物可用于治疗癌症状况，如前列腺癌，乳腺癌和卵巢癌。

公开(公告)号：US20050045175A1

公开(公告)日：2005-03-03

申请号：US10652561

申请日：2003-09-02

Applicant: Michael McCawley ,  Gary Ganser ,  Ian Christie ,  Tal Gottesman ,  James Dalton

Inventor： Michael McCawley ,  Gary Ganser ,  Ian Christie ,  Tal Gottesman ,  James Dalton

IPC: A61B5/08 ,  A61B5/085 ,  A61M11/00

CPC classification number: A61B5/085 ,  A61B5/0813

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract translation: 一种用于测量肺通气的装置，包括：用于测量空气流量的压力装置; 气溶胶发生装置，其提供将在呼吸循环中的确定点释放的气溶胶颗粒; 具有检测器的喉舌，其在呼吸循环期间测量给定体积的气溶胶颗粒的浓度; 以及被配置为提供肺通气数据作为时间常数的函数的计算设备。