Abstract:
The invention provides a novel microorganism producing pravastatin sodium, as well as the method for producing pravastatin sodium by using this microorganism. Micropolyspora roseoalba CGMCC 0624 of the invention is highly tolerant to mevastatin sodium, and has a high transformation rate of mevastatin sodium, and can produce pravastatin sodium with a high efficiency and low cost.
Abstract:
An exemplary joint mechanism (100) includes a pivot shaft (10), a joint (20), a rotary arm (30), and two bearings (50). The pivot shaft (10) is non-rotatable relative to the joint (20). The joint (20) is received in the rotary arm (30). The rotary arm (30) is rotatable relative to the joint (20). The two bearings (50) are fixed to an inner surface of the rotary arm (30). Each bearing (50) includes a concave inner surface, and the concave inner surface is engaged with a curved outer surface of the joint (20).
Abstract:
Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Genetic material from the target individual is acquired, amplified and the genetic data is measured using known methods. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment of the invention, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment of the invention, the chromosome copy number can be determined from the measured genetic data of a single or small number of cells, with or without genetic information from one or both parents. In another embodiment of the invention, these determinations are made for the purpose of embryo selection in the context of in-vitro fertilization. In another embodiment of the invention, the genetic data can be reconstructed for the purposes of making phenotypic predictions.
Abstract:
of a communication network. A message sender can attach a user-selected profile to a publicly-broadcasted message. A message viewer can read the publicly-broadcasted message only if the viewer's profile matches the sender's profile attached to the message. When a sender profile and viewer profile match, a communication channel is established between the sender and viewer. The sender's and viewer's profiles are registered on an open directory to which all parties, even parties unknown to each other, have access. The open directory structure is used in creating a header file, also referred to herein as a “stamp,” that is attached to messages or requests generated by the users. The selection of categories to be included in the header file is a procedure that is independent from the creation of the message. The header file can be combined dynamically at the point of sending the message by a message sender or at the point of searching messages by a message viewer. The messages may include text, graphics, audio or video. The broadcasting of the messages may occur via the Internet, radio, satellite, cable, and wired or wireless telephone networks.
Abstract:
A lens barren assembly for a camera is disclosed. The lens barrel assembly comprises a lens barrel, at least one optical element disposed within the lens barrel, and an actuator configured to move the optical element. The actuator can be disposed entirely or partially within the lens barrel. The actuator can be a MEMS actuator, such as a MEMS actuator that is formed at least partially of silicon. The optical element can be a lens.
Abstract:
In code division multiple access communications wherein a plurality of data streams carrying a plurality of transmit symbols are spread by a plurality of assigned spread code, the data streams are divided into a plurality of data blocks and a plurality of prefixes in symbol-level are added to the data blocks prior to the data streams being spread and combined for transmission. At the receive side, the prefixes are removed from the received data stream in the time domain and the prefix-removed data stream is converted into a transformed signal in the frequency domain. A feed-forward filter is used to implement a joint equalization and despreading operation by element-by-element multiplications in frequency domain. A feedback filter is used to remove the inter-symbol interference and update the feed-forward filter through a feedback loop.
Abstract:
A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.
Abstract:
Apparatus (systems) and methods are described for generating and displaying a virtual true 3D image viewable by a single eye of a viewer. A fixed-curve mirror is translated along an optical axis in synchrony with a temporally-modulated 2D image generator to generate a virtual image in multiple virtual image planes, enabling depth perception of the image by a single eye of the viewer.
Abstract:
Techniques are disclosed for generating an ensemble model from multiple data sources. In one embodiment, the ensemble model is generated using a global validation sample, a global holdout sample and base models generated from the multiple data sources. An accuracy value may be determined for each base model, on the basis of the global validation dataset. The ensemble model may be generated from a subset of the base models, where the subset is selected on the basis of the determined accuracy values.
Abstract:
Text processing includes: segmenting received text based on a lexicon of smallest semantic units to obtain medium-grained segmentation results; merging the medium-grained segmentation results to obtain coarse-grained segmentation results, the coarse-grained segmentation results having coarser granularity than the medium-grained segmentation results; looking up in the lexicon of smallest semantic units respective search elements that correspond to segments in the medium-grained segmentation results; and forming fine-grained segmentation results based on the respective search elements, the fine-grained segmentation results having finer granularity than the medium-grained segmentation results.