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    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS
    82.
    发明申请
    APPARATUS AND METHODS FOR PERFORMING ELECTROCHEMICAL REACTIONS 有权

    公开(公告)号：US20230101252A1

    公开(公告)日：2023-03-30

    申请号：US18077404

    申请日：2022-12-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： John NOBILE ,  George Thomas ROTH ,  Todd REARICK ,  Jonathan SCHULTZ ,  Jonathan M. ROTHBERG ,  David MARRAN

    IPC: G01N27/30 ,  B01L3/00 ,  G01N27/414

    Abstract: An apparatus includes a reaction vessels coupled to an electronic sensor for monitoring a reaction product in the reaction vessel; a fluidics system for sequentially delivering a plurality of reagents to the reaction vessel, the fluidics system including a plurality of reagent reservoirs in fluidic communication via a plurality of flow paths with a fluidics circuit and to a common passage in fluidic communication between the fluidics circuit and the reaction vessel, a solution reservoir in fluidic communication with the common passage via a branch passage connected with the common passage at a junction between the fluidics circuit and the reaction vessel; and an electrode in contact with a solution within the branch passage, the electrode being in electrical communication with the reaction vessel through fluid extending from the branch passage and through the common passage, the electronic sensor generating an output signal depending on a voltage of the electrode.

    Umbrella check valve assembly having retention plate
    86.
    发明授权
    Umbrella check valve assembly having retention plate 有权

    公开(公告)号：US11598434B2

    公开(公告)日：2023-03-07

    申请号：US17147586

    申请日：2021-01-13

    Applicant: Life Technologies Corporation

    Inventor： Charles R. Rhodes ,  Jonathan O. Schultz

    IPC: F16K15/14

    Abstract: A check valve assembly includes a first port fitting and a second port fitting with a base secured therebetween. The base has an annular sleeve encircling a seat, the seat having a central mounting hole and one or more flow channels passing therethrough. An umbrella valve includes a flexible sealing disk having an outer surface and an opposing inner surface, a mounting stem extending from the inner surface and projecting into the mounting hole of the base, the sealing disk being movable between a first position wherein at least a portion of the sealing disk sits on the seat so as to cover the one or more flow channels and a second position wherein the sealing disk is resiliently flexed so as to at least partially uncover the one or more flow channels. A retention plate is disposed between first port fitting and the seat of the base so that the retention plate sits against the outer surface of the sealing disk.

    Line volume calibration systems and methods
    87.
    发明授权
    Line volume calibration systems and methods 有权

    公开(公告)号：US11573118B2

    公开(公告)日：2023-02-07

    申请号：US16892502

    申请日：2020-06-04

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Glen Davis

    IPC: G01N29/22 ,  G01F25/17 ,  G01F15/00

    Abstract: Provided are systems and methods for line volume calibration, and measurement of fluid samples delivered to an interrogation point. In various embodiments, a known fluid volume comprising a sample line fluid and a secondary fluid is delivered to a fluid boundary sensor. The fluid boundary sensor assists in determining the position of the boundaries between the various fluids, and the positions of these boundaries are used to determine the sample line fluid volume.

    VISUALIZATION TOOLS FOR DIGITAL PCR DATA
    88.
    发明申请
    VISUALIZATION TOOLS FOR DIGITAL PCR DATA 有权

    公开(公告)号：US20230022224A1

    公开(公告)日：2023-01-26

    申请号：US17861854

    申请日：2022-07-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Harrison LEONG ,  Nivedita Sumi MAJUMDAR ,  Jeffrey A. MARKS ,  Theodore E. STRAUB ,  Ryan J. TALBOT ,  Kevin S. BODNER ,  David HOARD

    IPC: G06T11/20 ,  G16B45/00

    Abstract: A method comprises displaying, on a graphical user interface (GUI), a first data visualization comprising a positional representation of a plurality of reaction sites from at least a portion of a substrate, wherein the positional representation of the first data visualization simultaneously indicates relative data quality of the plurality of reaction sites; and altering the first data visualization displayed on the GUI to a second data visualization, the second data visualization comprising the positional representation of the plurality of reaction sites from the at least the portion of the substrate, wherein the positional representation of the second data visualization simultaneously indicates relative data quality of the plurality of reaction sites from at least the portion of the substrate based on a comparison of the data quality values of the plurality of reaction sites an adjusted quality value threshold.

    Control nucleic acids, and compositions, kits, and uses thereof
    90.
    发明授权
    Control nucleic acids, and compositions, kits, and uses thereof 有权

    公开(公告)号：US11542540B2

    公开(公告)日：2023-01-03

    申请号：US16622113

    申请日：2018-06-12

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Dalia Dhingra ,  Richard Chien

    IPC: C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6869

    Abstract: Provided are methods, as well as compositions, kits, and systems for preparing optimized control nucleic acids (polynucleotides) having reduce nucleic acid damage. Provided nucleic acid compositions provide reduced artifacts as compared to nucleic acid compositions prepared by conventional methods. Provided compositions are useful control in a variety of applications, including, but not limited to sequencing workflows to effectively monitor sensitivity, accuracy and/or precision of data.

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