公开(公告)号：US20140277075A1

公开(公告)日：2014-09-18

申请号：US13795248

申请日：2013-03-12

申请人： MEDRAD, INC.

发明人： Michael J. Bonnette

IPC分类号： A61F2/01 ,  A61M25/10

CPC分类号： A61F2/013 ,  A61F2230/0058 ,  A61F2230/0071 ,  A61F2230/0091 ,  A61F2250/0003 ,  A61M25/1002 ,  A61M2025/1081

摘要： A catheter system includes an inflatable structural balloon and collapsible filter. The collapsible filter is deployable into an expanded configuration using the inflatable distal balloon. In the expanded configuration, one or more flow cells are formed between inflated portions of the balloon to provide continuous fluid flow between proximal and distal ends of the structural balloon. In the expanded configuration, the filter is configured to prevent particulates (e.g., dislodged thrombus, or other particulate material) from migrating beyond the filter. In the expanded configuration, the inflated structural balloon biases a perimeter of the filter toward or against a subject vessel wall.

摘要翻译： 导管系统包括可充气结构气囊和可折叠过滤器。 可折叠过滤器可使用充气远端气囊展开成扩展配置。 在膨胀构造中，在气囊的膨胀部分之间形成一个或多个流动池，以在结构气囊的近端和远端之间提供连续的流体流动。 在扩展配置中，过滤器被配置为防止颗粒（例如，移出的血栓或其它颗粒材料）迁移到过滤器之外。 在膨胀构型中，膨胀的结构气囊朝向或抵靠主体血管壁偏压过滤器的周边。

公开(公告)号：US20140276550A1

公开(公告)日：2014-09-18

申请号：US13839864

申请日：2013-03-15

申请人： MEDRAD, INC.

发明人： Martin J. URAM ,  Michael J. YANNIELLO ,  Barry L. TUCKER ,  David A. MISHLER ,  Edward J. RHINEHART

IPC分类号： A61M5/172 ,  A61M5/142

CPC分类号： A61M5/1723 ,  A61M5/1452 ,  A61M5/14566 ,  A61M5/16877 ,  A61M2205/18 ,  A61M2205/3576 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/005

摘要： Systems and methods for intelligently delivering fluid to a targeted tissue. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

摘要翻译： 将流体智能输送到目标组织的系统和方法。 系统和方法可以包括引导泵将流体分配到目标组织并从体内感测系统接收一个或多个信号，其中一个或多个信号对应于目标组织处的一个或多个感测到的反馈参数。 系统和方法还可以包括确定一个或多个感测到的反馈参数是否在可接受的范围内。 如果一个或多个感测到的反馈参数不在可接受的范围内，则系统和方法可以包括确定用于调节泵中的流体压力所需的柱塞的调节速度，使得一个或多个感测到的反馈参数在 可接受的范围并引导泵以调节的速度分配流体。

公开(公告)号：US20140276452A1

公开(公告)日：2014-09-18

申请号：US13799169

申请日：2013-03-13

申请人： MEDRAD, INC.

发明人： Kevin P. COWAN ,  Raymond C. HOFFMAN

IPC分类号： A61M39/10 ,  A61M5/14

CPC分类号： A61M5/3291 ,  A61J1/2089 ,  A61M5/162

摘要： Spikes, spike and tubing sets and fluid administrations systems are disclosed. A fluid administration system may include a fluid container having a septum and containing a fluid, a spike, and a flexible tube. The spike may include a hollow access tube extending from a proximal end to a distal end of the spike, a platform surrounding the hollow access tube at a location between the distal and proximal ends, and a sharp tip-end at the distal end. The access tube has a central bore and a sidewall, each extending from the proximal to the distal end. The access tube may include at least one opening extending from the central bore to the sidewall and located between the platform and the sharp tip-end. The flexible tube is configured to connect to the access tube and to deliver fluid from the access tube to a fluid administration location.

摘要翻译： 公开了尖峰，尖峰和管道组和流体管理系统。 流体给药系统可以包括具有隔膜并且包含流体，尖峰和柔性管的流体容器。 尖钉可以包括从尖端的近端延伸到远端的中空进入管，在远端和近端之间的位置处围绕中空进入管的平台和在远端处的尖锐尖端。 进入管具有中心孔和侧壁，每个从近端延伸到远端。 进入管可以包括从中心孔延伸到侧壁并且位于平台和锋利尖端之间的至少一个开口。 柔性管构造成连接到进入管并将流体从进入管输送到流体管理位置。

公开(公告)号：US20140276451A1

公开(公告)日：2014-09-18

申请号：US13797959

申请日：2013-03-12

申请人： MEDRAD, INC.

发明人： Kevin P. COWAN ,  Barry L. TUCKER

IPC分类号： A61M5/315

CPC分类号： A61M5/3148 ,  A61M5/007 ,  A61M5/14526 ,  A61M5/16877 ,  A61M5/2053 ,  A61M5/3137 ,  A61M5/31515 ,  A61M5/36 ,  A61M5/48 ,  A61M2005/3123 ,  A61M2005/3128 ,  A61M2005/3139 ,  A61M2202/0007

摘要： Various syringe systems are disclosed. One such syringe system may include a body having a hollow lumen and a distal end, a vacuum chamber disposed within the hollow lumen of the syringe body, a first plunger connected to a distal portion of the vacuum chamber, the first plunger forming a first seal against an inner surface of the syringe body and defining a fluid delivery volume between the first plunger and the distal end of the syringe body, a second plunger disposed within the vacuum chamber, the second plunger forming a second seal against an inner surface of the vacuum chamber and defining a proximal and distal volume compartments within the vacuum chamber, and a piston affixed to the second plunger, the piston configured to move the second plunger within the vacuum chamber, thereby altering a volume of the proximal volume compartment and a volume of the distal volume compartment.

摘要翻译： 公开了各种注射器系统。 一个这样的注射器系统可以包括具有中空内腔和远端的本体，设置在注射器主体的中空腔内的真空室，连接到真空室的远端部分的第一柱塞，第一柱塞形成第一密封件 抵靠注射器主体的内表面并且在第一柱塞和注射器主体的远端之间限定流体输送体积，设置在真空室内的第二柱塞，第二柱塞形成抵靠真空内表面的第二密封 并且限定真空室内的近端和远端容积隔室，以及固定到第二柱塞的活塞，活塞构造成使第二柱塞在真空室内移动，由此改变近端容积隔室的体积和 远端容积室。

公开(公告)号：US20140261713A1

公开(公告)日：2014-09-18

申请号：US13799426

申请日：2013-03-13

申请人： MEDRAD, INC.

发明人： Ralph H. Schriver ,  Andreas Maihoefer ,  James A. Dedig ,  Michael A. Spohn ,  Herbert M. Grubic ,  Michael J. Swantner ,  Adam Caruso

IPC分类号： B01F5/06

CPC分类号： B01F5/061 ,  A61M5/007 ,  A61M5/16827 ,  A61M39/105 ,  A61M2039/0027 ,  A61M2039/1077 ,  A61M2206/14 ,  A61M2206/16 ,  B01F3/0861 ,  B01F5/0077 ,  B01F5/0256 ,  B01F5/0615 ,  B01F5/0645 ,  B01F5/0651 ,  B01F5/0653 ,  B01F5/0688 ,  B01F5/0696 ,  B01F5/0698 ,  B01F7/00241 ,  B01F7/00908 ,  B01F7/00916 ,  B01F13/0023 ,  B01F15/00831 ,  B01F2005/0025 ,  B01F2005/0091 ,  B01F2005/0622 ,  B01F2005/0636 ,  B01F2005/0639 ,  B01F2215/0034 ,  B01F2215/0459 ,  B01F2215/0468 ,  Y10T137/0329

摘要： A fluid path set includes a first fluid line having a proximal end fluidly connectable to a source of a first fluid and a second fluid line having a proximal end fluidly connectable to a source of a second fluid. A flow mixing device is in fluid communication with distal ends of the first and second fluid lines. The flow mixing device includes a housing, a first fluid port provided for receiving the first fluid, and a second fluid port for receiving the second fluid. A mixing chamber is disposed within the housing and is in fluid communication with the first and second fluid ports. A third fluid port in fluid communication with the mixing chamber for discharging a mixed solution of the first and second fluids. A turbulent flow inducing member is disposed within the mixing chamber for promoting turbulent mixing of the first and second fluids.

摘要翻译： 流体路径组包括具有可流体连接到第一流体源的近端的第一流体管线和具有可流体连接到第二流体源的近端的第二流体管线。 流动混合装置与第一和第二流体管线的远端流体连通。 流动混合装置包括壳体，设置用于接收第一流体的第一流体端口和用于接收第二流体的第二流体端口。 混合室设置在壳体内并且与第一和第二流体端口流体连通。 与混合室流体连通以排出第一和第二流体的混合溶液的第三流体端口。 湍流引导构件设置在混合室内，用于促进第一和第二流体的湍流混合。

公开(公告)号：US20140248159A1

公开(公告)日：2014-09-04

申请号：US13784615

申请日：2013-03-04

申请人： MEDRAD, INC.

发明人： Charles MARSH ,  Larry McCUTCHAN

IPC分类号： F04B7/02

CPC分类号： A61M5/172 ,  A61M5/14228 ,  A61M2205/33 ,  A61M2205/3379 ,  A61M2205/505 ,  A61M2205/52 ,  F04B43/02 ,  F04B43/12 ,  F04B49/065 ,  F04B49/106

摘要： Methods and systems for dispensing a fluid using an automated fluid delivery system are disclosed. A pump may be configured to force an aliquot of fluid into a fluid delivery channel. A processor may receive values of a property for the aliquot and the source of the aliquot. The processor may use the values to determine the volume of the aliquot. The determined volume is compared by the processor against an expected volume to establish the amount of fluid being pumped by the pump per unit, such as time or revolutions. The processor controls operation of the pump to dispense a predetermined dose based on the amount of fluid being pumped by the pump per unit.

摘要翻译： 公开了使用自动化流体输送系统分配流体的方法和系统。 泵可以被配置成迫使一分液体流入流体输送通道。 处理器可以接收等分试样的属性值和等分试样的来源。 处理器可以使用这些值来确定等分试样的体积。 所确定的体积被处理器与预期体积进行比较，以建立每单位泵泵送的流体的量，例如时间或转数。 处理器控制泵的操作，以基于每单位由泵泵送的流体的量来分配预定剂量。

公开(公告)号：US20140230368A1

公开(公告)日：2014-08-21

申请号：US13773586

申请日：2013-02-21

申请人： MEDRAD, INC.

发明人： Mark TROCKI ,  David A. MISHLER

IPC分类号： B65B69/00

CPC分类号： G01F23/24 ,  A61J1/1406 ,  A61J1/1475 ,  A61J1/201 ,  A61J2200/10 ,  G01F23/0038 ,  G01F23/268

摘要： Systems and methods for enabling high fluid rate injections are disclosed. The system includes a hollow dip tube, an introducer and a sharp tip-end. The introducer has a hollow sleeve that includes an opening at a proximal end. The sharp-tip end is located at a distal end of the introducer and is configured to pierce a septum of a container. The introducer is configured to receive the dip tube through the opening. Fluid may be withdrawn from the container through the dip tube upon insertion. In some cases, the dip tube separates the tip-end from the introducer when it is inserted through the opening. In other cases, the tip-end remains seated in the introducer and allows fluid to pass through it as it is withdrawn from the container.

摘要翻译： 公开了用于实现高流体速率喷射的系统和方法。 该系统包括中空汲取管，导引器和锋利的尖端。 导引器具有中空套筒，其包括在近端的开口。 尖端末端位于导引器的远端，并且构造成刺穿容器的隔膜。 引导器构造成通过开口接收汲取管。 插入时，流体可以通过汲取管从容器中取出。 在一些情况下，汲取管当插入穿过开口时将前端与导引器分开。 在其他情况下，尖端保持安置在导引器中，并允许流体从容器中取出时通过它。

公开(公告)号：US20140163475A1

公开(公告)日：2014-06-12

申请号：US13845713

申请日：2013-03-18

申请人： MEDRAD, INC.

发明人： Arthur E. Uber, III ,  Mark Trocki ,  Frederick W. Trombley, III ,  Kevin P. Cowan

IPC分类号： A61J1/14 ,  A61M5/31

CPC分类号： A61J1/1443 ,  A61J1/1456 ,  A61J1/1475 ,  A61M5/142 ,  A61M5/1723 ,  A61M5/3145 ,  A61M31/005 ,  B01L3/502 ,  B01L2300/044 ,  B01L2300/0681 ,  G06F19/3468

摘要： A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.

摘要翻译： 用于处理细胞（和/或其它注射组分）的系统​​包括适于可滑动地定位在容器内的容器和柱塞。 该系统包括至少一个入口，流体可以通过该入口进入系统和至少一个流出物端口，流出物可通过该至少一个出口端口离开系统。 柱塞部分形成与容器的内壁的密封接合，使得柱塞的向后运动适于经由入口将流体引入系统，并且柱塞的向前运动适于通过流出物强制流出系统的流出物 港口。

公开(公告)号：US20140107481A1

公开(公告)日：2014-04-17

申请号：US14133500

申请日：2013-12-18

申请人： MEDRAD, Inc.

发明人： Edward I. Wulfman

IPC分类号： A61M25/10 ,  A61M1/00 ,  A61B17/3207

CPC分类号： A61M25/104 ,  A61B17/3207 ,  A61B17/320725 ,  A61B17/320758 ,  A61B2017/22061 ,  A61B2017/22082 ,  A61B2017/320733 ,  A61B2017/320741 ,  A61M1/008 ,  A61M25/0082 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/109

摘要： Systems and methods for delivery of therapeutic and/or diagnostic compositions to an interventional site having diseased or newly treated tissue are provided. Integrated interventional catheter systems incorporating surfaces coated with a diagnostic or therapeutic composition, or ports for infusing a diagnostic or therapeutic composition prior to, during or following an interventional procedure are provided.

摘要翻译： 提供了将治疗和/或诊断组合物递送到具有患病或新治疗组织的介入部位的系统和方法。 提供了包括用诊断或治疗组合物涂覆的表面或用于在介入手术之前，期间或之后灌注诊断或治疗组合物的口的综合介入导管系统。

公开(公告)号：US20140094835A1

公开(公告)日：2014-04-03

申请号：US14100155

申请日：2013-12-09

申请人： MEDRAD, Inc.

发明人： John Riles ,  Douglas J. Ball ,  Michael J. Bonnette ,  Eric J. Thor ,  John L. Teschendorf ,  Hieu V. Le

IPC分类号： A61B17/3203

CPC分类号： A61B17/32037 ,  A61B2017/22038 ,  A61B2017/22049 ,  A61M2025/09083

摘要： An infusion flow guidewire and a system including an infusion flow guidewire. The minimal cross section flexible infusion flow guidewire includes a nitinol hypotube, a flexible tip having a closed distal end, a coil, a core wire and at least one distally located rearwardly directed jet orifice for infusion of fibrinolytics and for introduction of high pressure fluids for maceration and rearwardly directed flow of thrombus debris located in tortuous small sized vessels. Apparatus, some of which is removably attachable, is provided in the system for grasping members of the invention for rotational torqueing and for longitudinal actuation along and within the vasculature.

摘要翻译： 输液流动导丝和包括输注流导丝的系统。 最小横截面柔性灌注流导丝包括镍钛诺海波管，具有封闭远端的柔性末端，线圈，芯线和至少一个向远侧位于的向后指向的喷射孔，用于输注纤维蛋白溶解剂并引入高压流体 位于曲折的小型血管中的浸润和向后的血栓碎屑流。 在系统中设置有一些可移除地附接的装置，用于将本发明的构件用于旋转扭矩并沿着和在脉管系统内沿纵向致动。