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公开(公告)号：US07116798B1
公开(公告)日：2006-10-03
申请号：US11176346
申请日：2005-07-08
Applicant: Manmohan Singh Chawla
Inventor： Manmohan Singh Chawla
IPC: G06K9/00
CPC classification number: G06Q20/4014 , G01N33/0057 , G07F7/08 , G07F7/0813 , G07F7/086
Abstract: A substrate card, in the form of a Metrocard®, farecard, keycard, passport, boarding pass or the like, presented for controlled gateway passage at an automatic reader, is photographed and the captured card image is digitized. The card then is heated to a point where trace explosive present on the card is subjected to an energetic reaction imparting a char smudge signature. The card is cooled and a second image is captured and digitized. The digitized images are subjected to a subtractor stage resulting in an isolated char smudge signature image possibly in the form of at least a partial fingerprint residue recognizable by a computer. Upon char image detection, which may include a fingerprint matching process, the computer directs the controlled gateway to restrain the card presenter and secure the card as evidence. The card may be pre-coated to avoid ignition and to enhance trace material adhesion.
Abstract translation: 在自动阅读器上呈现用于受控网关通道呈现的基于卡片的Metrocard（R）卡，卡片卡，钥匙卡，护照，登机牌等形式的基板被拍照，并且所拍摄的卡片图像被数字化。 然后将卡片加热到卡片上存在的痕量爆炸物经受赋予炭黑痕迹签名的精力充沛的反应。 卡被冷却，第二个图像被捕获并数字化。 数字化图像经受减法器阶段，导致可能以计算机可识别的至少部分指纹残留的形式的孤立的炭黑涂片签名图像。 在可以包括指纹匹配处理的字符图像检测中，计算机引导受控网关来限制卡片主持人并将该卡片固定为证据。 该卡可以预涂，以避免点燃并增强痕量的材料附着力。
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公开(公告)号：US20050107322A1
公开(公告)日：2005-05-19
申请号：US10837117
申请日：2004-04-29
Applicant: Derek O'Hagan , Manmohan Singh
Inventor： Derek O'Hagan , Manmohan Singh
CPC classification number: A61K39/39 , A61K2039/55511 , A61K2039/55555
Abstract: The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
Abstract translation: 本发明尤其提供包含第一抗原，至少两种佐剂的免疫原性组合物，其中第一佐剂包含衍生自聚（丙交酯）和/或聚（丙交酯 - 共 - 乙交酯）的聚合物，并且其中第二佐剂包含 咪唑并喹啉，其中所述第一抗原包被在所述第一佐剂中并被共冻干或混合，吸附或缀合，以及药学上可接受的赋形剂，其中所述组合物在施用于脊椎动物受试者时引起细胞免疫应答。 本发明还提供产生免疫原性组合物的方法，在脊椎动物受试者中产生细胞毒性T淋巴细胞（CTL）应答的方法和免疫方法。
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公开(公告)号：US06534064B1
公开(公告)日：2003-03-18
申请号：US09686345
申请日：2000-10-10
Applicant: Derek O'Hagan , Manmohan Singh
Inventor： Derek O'Hagan , Manmohan Singh
IPC: A61K3912
CPC classification number: A61K39/245 , A61K39/00 , A61K39/12 , A61K2039/54 , A61K2039/545 , A61K2039/55555 , A61K2039/57 , A61K2039/6081 , A61K2039/6093 , C12N2710/16634 , Y10S977/802 , Y10S977/918
Abstract: A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a pharmaceutically acceptable excipient is disclosed.
Abstract translation: 公开了一种在脊椎动物对象中产生细胞免疫应答的方法，包括对脊椎动物给药包含蛋白质颗粒抗原和药学上可接受的赋形剂的疫苗组合物。
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公开(公告)号：US09950062B2
公开(公告)日：2018-04-24
申请号：US13394036
申请日：2010-09-01
Applicant: Manmohan Singh , David Skibinski , Simona Cianetti , Francesco Doro , Siddhartha Jain
Inventor： Manmohan Singh , David Skibinski , Simona Cianetti , Francesco Doro , Siddhartha Jain
IPC: A61K39/39 , A61K31/66 , A61K33/08 , A61K45/06 , A61K31/4375 , A61K33/42 , A61K39/095 , A61K39/00
CPC classification number: A61K39/39 , A61K31/4375 , A61K31/66 , A61K33/08 , A61K33/42 , A61K39/095 , A61K45/06 , A61K2039/55505 , A61K2039/55511 , Y02A50/386 , Y02A50/41 , A61K2300/00
Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
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公开(公告)号：US09517263B2
公开(公告)日：2016-12-13
申请号：US13377511
申请日：2010-06-10
Applicant: Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
Inventor： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
IPC: A61K39/02 , C07D471/00 , A61K39/39 , A61K39/00 , A61K39/12
CPC classification number: A61K39/39 , A61K2039/55511 , A61K2039/6093
Abstract: The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
Abstract translation: 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
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Patent Agency Ranking
公开(公告)号：US20150225432A1
公开(公告)日：2015-08-13
申请号：US14696165
申请日：2015-04-24
Applicant: Alex Cortez , Yongkai Li , Manmohan Singh , David Skibinski , Kathy Yue , Tom Yao-Hsiang Wu , Xiaoyue Zhang
Inventor： Alex Cortez , Yongkai Li , Manmohan Singh , David Skibinski , Kathy Yue , Tom Yao-Hsiang Wu , Xiaoyue Zhang
IPC: C07F9/6561
CPC classification number: C07F9/6561 , C07D471/04
Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
Abstract translation: 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US20130274465A1
公开(公告)日：2013-10-17
申请号：US13820370
申请日：2011-09-01
Applicant: Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
Inventor： Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
IPC: C07F9/6561 , C07F9/645 , C07F9/6558 , C07F9/6512
CPC classification number: A61K39/39 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/13 , A61K39/145 , A61K39/292 , A61K2039/55505 , A61K2039/55511 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/65583 , C07F9/6561 , C07F9/65616 , Y02A50/466
Abstract: Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
Abstract translation: 可以将免疫增强剂吸附到不溶性金属盐如铝盐上，以改变其药代动力学，药效学，肌内留置时间和/或免疫刺激作用。 修饰免疫增强剂以引入可介导吸附的部分，例如膦酸酯基团。 即使以吸附形式递送，这些改性化合物也可以保留或改善其体内免疫活性。
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公开(公告)号：US20120263753A1
公开(公告)日：2012-10-18
申请号：US13377511
申请日：2010-06-10
Applicant: Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
Inventor： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Sushma Kommareddy
CPC classification number: A61K39/39 , A61K2039/55511 , A61K2039/6093
Abstract: The invention provides, inter alia, immunogenic compositions that comprise (a) a first antigen, (b) polymeric particles and (c) a benzonaphthyridine compound, which compositions elicits an immune response when administered to a vertebrate subject. The invention also provides, inter alia, methods of producing immunogenic compositions and methods for using immunogenic compositions (e.g., for treatment), among other benefits.
Abstract translation: 本发明尤其提供了免疫原性组合物，其包含（a）第一抗原，（b）聚合物颗粒和（c）苯并萘啶化合物，该组合物在施用于脊椎动物受试者时引起免疫应答。 本发明尤其提供产生免疫原性组合物的方法和使用免疫原性组合物（例如用于治疗）的方法以及其它益处。
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公开(公告)号：US08206749B1
公开(公告)日：2012-06-26
申请号：US09914279
申请日：2000-02-09
Applicant: Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
Inventor： Derek O'Hagan , Gary S. Ott , John Donnelly , Jina Kazzaz , Mildred Ugozzoli , Manmohan Singh , John Barackman
IPC: A61K9/50
CPC classification number: A61K39/39 , A61K9/1075 , A61K9/167 , A61K39/0208 , A61K39/21 , A61K39/245 , A61K39/29 , Y02A50/411 , Y02A50/471
Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.
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90.发明申请COMPOSITIONS COMPRISING CATIONIC MICROPARTICLES AND HCV E1E2 DNA AND METHODS OF USE THEREOF 审中-公开包含阳离子MICROPARTICLESES和HCV E1E2 DNA的组合物及其使用方法公开(公告)号：US20110177110A1
公开(公告)日：2011-07-21
申请号：US13051217
申请日：2011-03-18
Applicant: DEREK O' HAGAN , MICHAEL HOUGHTON , MANMOHAN SINGH
Inventor： DEREK O' HAGAN , MICHAEL HOUGHTON , MANMOHAN SINGH
CPC classification number: A61K31/7088 , A61K9/0019 , A61K9/1617 , A61K9/1647 , A61K39/12 , A61K39/29 , A61K39/39 , A61K47/6927 , A61K48/00 , A61K2039/53 , A61K2039/545 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C12N2770/24222 , C12N2770/24234
Abstract: Immunogenic HCV E1E2809 DNA compositions and methods of using the same are described. The compositions comprise HCV E1E2809 DNA adsorbed to cationic microparticles, such as poly(lactide-co-glycolide) (PLG) microparticles.
Abstract translation: 描述了免疫原性HCV E1E2809 DNA组合物及其使用方法。 组合物包含吸附在阳离子微粒上的HCV E1E2809 DNA，如聚（丙交酯 - 共 - 乙交酯）（PLG）微粒。
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