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公开(公告)号：US20180236111A1
公开(公告)日：2018-08-23
申请号：US15961554
申请日：2018-04-24
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services , The Research Foundation of the State University of New York
IPC分类号： A61K51/04 , C07D251/68 , C07B59/00 , A61K31/53
CPC分类号： A61K51/0461 , A61K31/53 , C07B59/002 , C07D251/68
摘要： Disclosed herein are isotopically labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi, including Aspergillus species, such as by positron emission tomography (PET) scanning. In some examples, the disclosed compounds have a formula of wherein R1 is an amine, a hydroxyl group, a sulfide, a carboxylic acid, an amide, an alkyl, or aryl; R2 is —NHC(O)—R3-L or —C(O)NH—R3-L, wherein R3 is an aryl or an aliphatic group (such as alkyl); each R4 independently may be selected from halogen, aliphatic (such as alkyl), aryl, amine, hydroxyl, haloalkyl, carboxylic acid, amide, aralkyl, cyano, ester, thiol, thioether, or alkoxy; each R5 independently may be selected from hydrogen, aralkyl, alkyl, or aryl, with any one of the aralkyl, alkyl, or aryl groups optionally being substituted with any one of the substituents provided for R4; each n independently is 1, 2, 3, 4, or 5; and L is 18F or a chelator capable of chelating a radiolabel (such as chelators for [18F]AlF, 64Cu, 68Ga), 1,4,7,10-tetraazacyclododecane-tetraacetic acid (DOTA) or 1,4,7-triazacyclononane-triacetic acid (NOTA).
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公开(公告)号：US09956278B2
公开(公告)日：2018-05-01
申请号：US15225102
申请日：2016-08-01
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Che-Hung Robert Lee
IPC分类号： A61K47/64 , A61K39/095 , A61K39/00
CPC分类号： A61K39/095 , A61K47/646 , A61K2039/572 , A61K2039/70 , Y02A50/484
摘要： Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.
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公开(公告)号：US20180110798A1
公开(公告)日：2018-04-26
申请号：US15620753
申请日：2017-06-12
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： John McKew , Wei Zheng , Miao Xu , Manju Swaroop , Juan J. Marugan
IPC分类号： A61K31/724 , G01N33/92 , C08B37/16 , A61K45/06 , A61K31/355
CPC分类号： A61K31/724 , A61K31/355 , A61K45/06 , C08B37/0012 , G01N33/92 , A61K2300/00
摘要： The invention provides for methods of treating lysosomal storage disorders and/or reduction of non-cholesterol lipids, using cyclodextrin compounds, including in combination with other therapeutics, including vitamin E.
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84.发明申请公开(公告)号：US20180087041A1
公开(公告)日：2018-03-29
申请号：US15563379
申请日：2016-04-22
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Charles P. Venditti
CPC分类号： C12N9/90 , A01K2217/054 , A01K2217/075 , A01K2217/206 , A01K2227/105 , A01K2267/0306 , A61K38/52 , A61K48/005 , A61K48/0058 , C07K2319/07 , C07K2319/20 , C12N2750/14143 , C12N2830/15 , C12N2830/50 , C12Y504/99002
摘要： Disclosed are polynucleotides, polypeptides, and gene therapy vectors relating to biologically active methylmalonyl-CoA mutase enzymes, internally tagged with an immunoaffinity and detection epitope, which has been designed and tested in mouse models of methylmalonic acidemia (MMA). The polypeptides and polynucleotides of the present invention contain a mitochondrial leader sequence fused to tag, such as an HA, 3xFLAG, or V5 tag placed in a region of the methylmalonyl-CoA mutase enzyme that maintains mitochondrial localization and function, e.g., the 5′ end of a methylmalonyl-CoA mutase polynucleotide is replaced with an engineered nucleotide sequence that encodes the endogenous mitochondrial importation sequence, a mitochondrial protease cleavage site, and a tag. The polynucleotides and polypeptides of the invention are useful to treat conditions such as MMA, and to assay both activity and biodistribution after gene therapy in varied models of MMA.
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85.发明授权公开(公告)号：US09879231B2
公开(公告)日：2018-01-30
申请号：US14837382
申请日：2015-08-27
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Bernard Moss , Linda S. Wyatt , Patricia L. Earl
IPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , C12N15/863 , A61K39/285 , A61K39/00
CPC分类号： C12N7/00 , A61K39/285 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N15/8636 , C12N2710/24121 , C12N2710/24133 , C12N2710/24143 , C12N2710/24152 , C12N2740/16122 , C12N2740/16222
摘要： The present invention relates to recombinant modified vaccinia Ankara (MVA) virus containing restructured sites useful for the integration of heterologous nucleic acid sequences into an intergenic region (IGR) of the virus genome, where the IGR is located between two adjacent, essential open reading frames (ORFs) of the vaccinia virus genome, wherein the adjacent essential ORFs are non-adjacent in a parental MVA virus used to construct the recombinant MVA virus, and to related nucleic acid constructs useful for inserting heterologous DNA into the genome of a vaccinia virus, and further to the use of the disclosed viruses as a medicine or vaccine.
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86.发明申请公开(公告)号：US20180008693A1
公开(公告)日：2018-01-11
申请号：US15650482
申请日：2017-07-14
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： A61K39/12 , C12Q1/70 , C12N7/00 , A61K39/295 , A61K39/00
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
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公开(公告)号：US20170267735A1
公开(公告)日：2017-09-21
申请号：US15411112
申请日：2017-01-20
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Donald P. BOTTARO , Fabiola CECCHI
IPC分类号： C07K14/475 , C07K14/52 , C07K14/71 , A61K38/18
CPC分类号： C07K14/475 , A61K38/1866 , C07K14/52 , C07K14/71
摘要： The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.
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88.发明授权公开(公告)号：US09719080B2
公开(公告)日：2017-08-01
申请号：US14773885
申请日：2014-03-14
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
CPC分类号： A61K38/52 , A61K48/0066 , C12N9/90 , C12Y504/99002
摘要： Synthetic polynucleotides encoding human methylmalonyl-CoA mutase (synMUT) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synMUT under the control of a liver-specific promoter (AAV2/8-HCR-hAAT-synMUT-RBG) successfully rescued the neonatal lethal phenotype displayed by methylmalonyl-CoA mutase-deficient mice, lowered circulating methylmalonic acid levels in the treated animals, and resulted in prolonged hepatic expression of the product of synMUT transgene in vivo, human methylmalonyl-CoA mutase (MUT).
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公开(公告)号：US09707220B2
公开(公告)日：2017-07-18
申请号：US14478442
申请日：2014-09-05
申请人： The United States of America, as represented by the Secretary, Dept. of Health and Human Services
发明人： Maura L. Furey , Wayne C. Drevets
CPC分类号： A61K31/46 , A61K9/0073 , A61K45/06
摘要： Provided are methods and compositions for the treatment of depression and anxiety. The compositions contain scopolamine, or an analog thereof, and can optionally include one or more psychoactive agents. Further provided is an inhaler containing scopolamine, or an analog thereof, in a pharmaceutically acceptable carrier.
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公开(公告)号：US09678074B2
公开(公告)日：2017-06-13
申请号：US14388293
申请日：2013-03-14
申请人： The United States of America, as represented by THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
发明人： Liudmila Prokunina , Thomas R. O'Brien , Brian Muchmore , Raymond P. Donnelly , Patricia A. Porter-Gill
IPC分类号： C07K14/555 , G01N33/569 , C07K16/24 , C12Q1/68 , C12Q1/70
CPC分类号： G01N33/56983 , C07K14/555 , C07K16/249 , C07K2317/76 , C12Q1/6883 , C12Q1/707 , C12Q2600/156 , C12Q2600/158 , G01N2800/52
摘要： The invention is related to identification of an interferon-analog (IFNL4) protein and genetic association with spontaneous clearance of HCV infection and response to treatment for HCV infection.
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