公开(公告)号：US20140330365A1

公开(公告)日：2014-11-06

申请号：US14267620

申请日：2014-05-01

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Ni Ding

IPC: A61L31/16 ,  B65B3/00 ,  A61F2/82

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L27/50 ,  A61L27/505 ,  A61L27/54 ,  A61L31/022 ,  A61L31/143 ,  A61L2300/00 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/604 ,  A61L2300/802 ,  B65B3/003 ,  Y10T29/49993

Abstract: A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.

Abstract translation: 用于装载到支架的结构元件中的组合物，其中所述结构元件由内腔和至少一个开口限定以进入所述内腔。 组合物可以包含治疗剂，螯合剂，沉淀剂或其组合。 还描述了填充有组合物的医疗装置，例如具有由内腔限定的结构元件和用于进入内腔的至少一个开口的支架。

公开(公告)号：US20140294912A1

公开(公告)日：2014-10-02

申请号：US14307316

申请日：2014-06-17

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Syed Faiyaz Ahmed Hossainy ,  David C. Gale

IPC: A61L31/10 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16

CPC classification number: A61L31/10 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  C08L101/00 ,  C09D167/04 ,  C08L67/04 ,  C08L2666/02

Abstract: Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

Abstract translation: 提供由包含由诸如内消旋-D，L-丙交酯的原料形成的无定形聚（D，L-丙交酯）的材料形成或涂覆的可植入装置。 可植入装置可用于治疗，缓解，预防或抑制动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，卵圆孔未闭，跛行， 静脉和人造移植物的吻合增殖，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

公开(公告)号：US20140255451A1

公开(公告)日：2014-09-11

申请号：US13788584

申请日：2013-03-07

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen D. Pacetti ,  Sherry Xuan Guo

IPC: A61L31/08 ,  B29D99/00 ,  A61L31/16

CPC classification number: A61L31/08 ,  A61L31/143 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  B29D99/00 ,  Y10T29/4998

Abstract: The present invention relates to an oxygen-sensitive macrocyclic triene lactone that is protected by addition of an appropriate amount of an antioxidant stabilizer during fabrication of an implantable medical device comprising the macrocyclic triene lactone, wherein the amount of the antioxidant stabilizer has been reduced to a minimal, preferably, non-detect, level in the final packaged product.

Abstract translation: 本发明涉及通过在包含大环三烯内酯的可植入医疗装置的制造过程中加入适量的抗氧化剂稳定剂来保护的氧敏感性大环三烯内酯，其中抗氧化剂稳定剂的量已经被还原成 最小，优选地，未检测的水平。

公开(公告)号：US20140238293A1

公开(公告)日：2014-08-28

申请号：US14268834

申请日：2014-05-02

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： Stephen D. Pacetti

IPC: A61F2/06 ,  B05C11/00

CPC classification number: A61F2/958 ,  A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61F2002/9522 ,  A61F2240/001 ,  A61L31/022 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/06 ,  B05C11/00 ,  B21D39/048 ,  Y10T29/49863 ,  Y10T29/49865 ,  Y10T29/49925 ,  Y10T29/49927 ,  Y10T29/53996

Abstract: An apparatus is disclosed including a workspace for receiving a stent and a delivery device for the stent; a source for exposing the stent in the workspace to a plasticizing agent, vapor, or moisture, wherein the stent can be reduced in diameter in the workspace while under exposure of the plasticizing agent, vapor or moisture; and a device for reducing the diameter of the stent in the workspace to position the stent on or within the delivery device.

Abstract translation: 公开了一种包括用于接收支架的工作空间和用于支架的输送装置的装置; 用于将工作空间中的支架暴露于增塑剂，蒸汽或水分的源，其中在塑化剂，蒸气或水分暴露的同时，支架可以在工作空间中直径减小; 以及用于在工作空间中减小支架的直径以将支架定位在输送装置上或内部的装置。

公开(公告)号：US20140134323A1

公开(公告)日：2014-05-15

申请号：US14158628

申请日：2014-01-17

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  B29C48/09 ,  B29L2031/7542 ,  Y10T29/49865 ,  Y10T29/49885 ,  Y10T29/49925 ,  Y10T29/49927

Abstract: Methods of making bioabsorbable stents with grooved lumenal surfaces for enhanced re-endothelialization are disclosed. Methods include molding grooves on the lumenal surface of coated bioresorbable and durable stents. Methods further include molding grooves on lumenal surfaces of a bioresorbable tube and forming a scaffold from the tube.

Abstract translation: 公开了制备具有槽腔腔表面以增强再内皮化的生物可吸收支架的方法。 方法包括在经涂覆的生物可再吸收和耐久支架的内腔表面上形成凹槽。 方法还包括在生物可再吸收管的腔表面上模制凹槽并从管形成支架。

公开(公告)号：US20140004250A1

公开(公告)日：2014-01-02

申请号：US13953656

申请日：2013-07-29

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Syed F.A. Hossainy ,  Fuh-Wei Tang ,  Lothar W. Kleiner ,  Thierry Glauser ,  Yiwen Tang ,  Wouter E. Roorda ,  Stephen D. Pacetti ,  Gina Zhang ,  Yung-Ming Chen ,  Andrew F. McNiven ,  Sean A. McNiven ,  Brandon J. Yoe

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L27/40 ,  A61L27/44 ,  A61L27/50 ,  A61L27/54 ,  A61L31/12 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/00

Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.

Abstract translation: 本公开教导了控制来自聚合物基质的试剂的释放速率的方法，其包括在聚合物基质中设计和产生预定的初始形态（IM）分布。 教导尤其表明，对药剂释放速率的控制可以提供对药剂施用的改进控制，以及对聚合物基质的机械完整性和吸收速率的影响。

公开(公告)号：US20130344047A1

公开(公告)日：2013-12-26

申请号：US14014659

申请日：2013-08-30

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS, INC.

Inventor： Stephen D. Pacetti ,  Jeffrey B. Huff ,  Paul Consigny

IPC: A61K35/14 ,  A61K38/19 ,  A61K45/06

CPC classification number: A61K35/19 ,  A61K38/195 ,  A61K38/196 ,  A61K45/06 ,  A61M25/104 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2025/105 ,  A61K2300/00

Abstract: Methods and compositions for treating heart failure by administration of beneficial agents to the heart.

Abstract translation: 通过向心脏施用有益剂治疗心力衰竭的方法和组合物。

公开(公告)号：US20130138081A1

公开(公告)日：2013-05-30

申请号：US13741049

申请日：2013-01-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： John J. Stankus ,  Michael J. Leonard ,  Stephen D. Pacetti

IPC: A61M25/10

CPC classification number: A61M25/10 ,  A61F2/958 ,  A61F2002/9583 ,  A61F2250/0067 ,  A61M25/104 ,  A61M2025/1081 ,  A61M2025/1086

Abstract: Method of delivering a therapeutic agent includes delivering at least a portion of a medical device within a vasculature. The medical device includes a tubular member having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member proximate the distal end of the tubular member, a tissue engaging member proximate the expandable member, a sheath disposed over the tissue engaging member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The method further includes deploying the tissue engaging member at a select location by displacement of the sheath relative the tissue engaging member, inflating the expandable member to engage the therapeutic agent with a vessel wall, deflating the expandable member, and withdrawing the medical device from the vasculature.

Abstract translation: 递送治疗剂的方法包括在脉管系统内输送医疗装置的至少一部分。 医疗装置包括管状构件，其具有限定其间的纵向轴线的近端和远端，靠近管状构件的远端的可扩张构件，靠近可膨胀构件的组织接合构件，设置在组织接合构件上方的护套， 以及设置在至少所述可扩张构件或所述组织接合构件上的治疗剂。 该方法还包括通过相对于组织接合构件移动护套来将组织接合构件部署在选择位置，使可膨胀构件膨胀以使治疗剂与血管壁接合，使可膨胀构件放气，以及将医疗装置从 脉管系统

公开(公告)号：US10441448B2

公开(公告)日：2019-10-15

申请号：US15015945

申请日：2016-02-04

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Yunbing Wang

IPC: A61F2/958 ,  A61M25/10 ,  A61M39/24 ,  A61M5/168

Abstract: An apparatus and method for controlling inflation pressure, pressurization rate, and volumetric flow rate of a balloon during deployment of a stent or scaffold is disclosed.

公开(公告)号：US10278844B2

公开(公告)日：2019-05-07

申请号：US15688486

申请日：2017-08-28

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Rommel Lumauig ,  Stephen D. Pacetti ,  Ni Ding ,  Joel Harrington ,  Xiao Ma ,  James P. Oberhauser ,  Jill McCoy ,  Chad J. Abunassar ,  Senthil Eswaran ,  Diem Ta

IPC: A61F2/915 ,  C08G63/08 ,  B29C71/02 ,  A61L31/06 ,  A61L31/14 ,  B29C71/00 ,  B29K67/00 ,  B29L31/00 ,  B29C35/04 ,  B29C35/08

Abstract: Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.