Optical probe
    81.
    发明授权
    Optical probe 有权
    光探头

    公开(公告)号:US09131845B2

    公开(公告)日:2015-09-15

    申请号:US12810872

    申请日:2008-12-19

    摘要: The invention relates an optical probe (1) suitable for non-linear optics such as two-photon imaging for medical purposes. The probe has an optical guide (2) and a lens system (6) positioned rigidly at an end portion (2a) of the optical guide. Additionally, a housing (3) with a cavity for the optical guide (2) and the lens system (6), the housing having at its distal end a transparent window (4), is comprised in the probe. The optical guide (2) with the lens system (6) is displaceably mounted within the housing, preferably in a transverse direction. Also, the housing (3) has an auxiliary, peripheral optical guide (5) optically connected to the transparent window (4). The invention is advantageous for obtaining an optical probe with a significantly larger collection efficiency. The optical probe may advantageous be applied in connection with two-photon spectroscopy where both ballisitic photons and diffusing fluorescence photons can be used in the detection of an event.

    摘要翻译: 本发明涉及适用于非线性光学的光学探针(1),例如用于医疗目的的双光子成像。 探针具有光导件(2)和刚性地定位在光导的端部(2a)处的透镜系统(6)。 此外,具有用于光导(2)和透镜系统(6)的空腔的壳体(3),其外壳在其远端处具有透明窗口(4),其包括在探针中。 具有透镜系统(6)的光导(2)优选地在横向方向上可移动地安装在壳体内。 另外,壳体(3)具有与透明窗(4)光学连接的辅助外周光导(5)。 本发明有利于获得具有显着更大收集效率的光学探针。 结合双光子光谱可以有利地应用光探针,其中可以使用Ballisitic光子和扩散荧光光子来检测事件。

    STIMULATED EMISSION DEPLETION (STED) MICROSCOPY SYSTEM
    82.
    发明申请
    STIMULATED EMISSION DEPLETION (STED) MICROSCOPY SYSTEM 审中-公开
    刺激排泄(STED)微观系统

    公开(公告)号:US20140145093A1

    公开(公告)日:2014-05-29

    申请号:US13522038

    申请日:2011-01-13

    IPC分类号: G02B21/00 G01N21/64

    摘要: The invention discloses an optical microscopy system (10) for stimulated emission depletion (STED) of an object (O). An optical element (6) is applied for focusing a first excitation (1) and a second depletion (2) beam on the object thereby defining a common optical path (OP) for both the first and the second beam. A phase modifying member (5) is inserted in the common optical path (OP), and the phase modifying member is optically arranged for leaving the wavefront of the first beam substantially unchanged, and for changing the wavefront of the second beam (2′) so as to create an undepleted region of interest (ROI) in the object. The first beam and the second beam have a common optical path because the phase modifying member adapts the wavefront or phase in such a way that it has no effect on the first beam, while on the second beam it gives rise to a wavefront, or phase change, resulting in a depleted region in the object (e.g. to the donut shaped spot) at the focal plane. The invention facilitates smaller and/or improved optical designs for STED microscopy; this is particularly relevant for medical in-vivo imaging, e.g. endoscopes and catheters.

    摘要翻译: 本发明公开了一种用于对象(O)的受激发射耗尽(STED)的光学显微镜系统(10)。 应用光学元件(6)用于将第一激励(1)和第二耗尽(2)光束聚焦在物体上,从而为第一和第二光束定义公共光路(OP)。 相位调整构件(5)被插入到公共光路(OP)中,并且相位修改构件被光学地布置成使第一光束的波前基本上不变,并且用于改变第二光束(2')的波前, 以便在对象中创建未被删除的兴趣区域(ROI)。 第一光束和第二光束具有共同的光路,因为相位修改构件以这样的方式适配波前或相位,使得其对第一光束没有影响,而在第二光束上,其产生波前或相位 改变,导致焦平面上的物体(例如,环形斑点)中的耗尽区域。 本发明有助于STED显微镜的更小和/或改进的光学设计; 这对于医学体内成像尤其重要,例如, 内窥镜和导管。

    OPTICAL PROBE WITH FEEDBACK CORRECTION
    86.
    发明申请
    OPTICAL PROBE WITH FEEDBACK CORRECTION 失效
    具有反馈校正的光学探头

    公开(公告)号:US20120113491A1

    公开(公告)日:2012-05-10

    申请号:US13320601

    申请日:2010-05-10

    IPC分类号: G02B26/10

    摘要: The present invention relates to an optical probe (1) suitable for miniature applications. An example application is a fibre-based confocal miniaturized microscope. The optical probe comprises a coil-based actuation system (9, 10) comprising drive coils (9) capable of displacing the distal end (3) of an optical guide (2) housed (4) by the optical probe. The probe makes use of a feedback loop which alternate between driving the displacement of the optical guide by driving a current through the drive coils and switching off the current through the drive coils, and while the drive current being switched off, measure the speed of the distal end of the optical guide. The measured speed is compared to the set-point speed, and if a difference is detected, the drive current is adjusted to eliminate, or at least bring down, this difference.

    摘要翻译: 本发明涉及适合于微型应用的光学探头(1)。 一个示例应用是基于光纤的共聚焦微型显微镜。 光探头包括基于线圈的致动系统(9,10),其包括驱动线圈(9),该驱动线圈能够移动由光学探头容纳(4)的光导(2)的远端(3)。 探头利用反馈回路,通过驱动通过驱动线圈的电流驱动光导的位移和切断通过驱动线圈的电流之间的交替,并且在驱动电流被切断时,测量速度 光导的远端。 将测量的速度与设定点速度进行比较,并且如果检测到差异,则调节驱动电流以消除或至少降低该差异。

    Autostereoscopic display device
    87.
    发明授权
    Autostereoscopic display device 有权
    自动立体显示装置

    公开(公告)号:US08139104B2

    公开(公告)日:2012-03-20

    申请号:US10599790

    申请日:2005-04-04

    IPC分类号: H04N13/04

    摘要: The present invention relates to an autostereoscopic display device, comprising an imaging layer (9) and a lens layer (10). The lens layer (10) serves to project different content from the imaging layer (9) to the left and right eyes, respectively, of a user. The lens layer (10) comprises lens cells (12), enclosing two fluids (13, 14) with different refractive indices. The shape of the interface between the fluids may be changed using electrowetting, by means of two individually controllable electrodes (21, 22) at the sides of each lens cell (12). The display device further comprises a user head tracking device and means for controlling the lens cell electrodes depending on a detected user head position. This allows the display device to display a correct 3D-image, even if the user moves his head.

    摘要翻译: 本发明涉及一种包括成像层(9)和透镜层(10)的自动立体显示装置。 透镜层(10)用于将不同的内容从成像层(9)投射到用户的左眼和右眼。 透镜层(10)包括透镜单元(12),包围具有不同折射率的两个流体(13,14)。 可以通过在每个透镜单元(12)的侧面处的两个可独立控制的电极(21,22),使用电润湿来改变流体之间的界面的形状。 显示装置还包括用户头跟踪装置和用于根据检测到的用户头部位置来控制透镜单元电极的装置。 即使用户移动头,也可以使显示装置显示正确的3D图像。

    OPTICAL SCANNING PROBE ASSEMBLY
    88.
    发明申请
    OPTICAL SCANNING PROBE ASSEMBLY 有权
    光学扫描探头组件

    公开(公告)号:US20110201941A1

    公开(公告)日:2011-08-18

    申请号:US13125392

    申请日:2009-10-19

    IPC分类号: A61B6/00

    摘要: The present invention relates to an optical scanning probe assembly for microscopic guide optic scanning and inspection of tissues suitable for application in, e.g. in vivo medical inspection and biopsy. The assembly comprises an outer housing (3) comprising: i) a spring element for a scanning motor, the spring element formed as a hollow tube (5) adapted to receive an optical guide, the hollow tube having mechanical stiffness larger than the optical guide to be received, ii) a lens system (7) and iii) N means for deflecting (6) the distal end of the hollow tube in directions transverse to the longitudinal extension of the hollow tube, so as to form an optical scan pattern. The optical assembly is particularly advantageous as it increases the freedom to optimize the optical and mechanical performance of the system which is defined respectively by the optical guide and by the hollow tube. The probe can be used in resonant and non-resonant scanning modes.

    摘要翻译: 本发明涉及一种光学扫描探针组件,用于微观引导光学扫描和检查适用于例如, 体内检查和活检。 该组件包括外壳(3),包括:i)用于扫描电机的弹簧元件,弹簧元件形成为适于容纳光导的中空管(5),所述中空管的机械刚度大于光导 ii)透镜系统(7),以及iii)用于使中空管的远端沿垂直于中空管的纵向延伸的方向偏转(6)的装置,以形成光学扫描图案。 光学组件是特别有利的,因为它增加了由光导和中空管分别限定的优化系统的光学和机械性能的自由度。 探头可用于谐振和非谐振扫描模式。